Detailed information for compound 511384

Basic information

Technical information
  • TDR Targets ID: 511384
  • Name: 3-[[1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidi n-4-yl]amino]-N,4-dimethylbenzamide
  • MW: 376.387 | Formula: C20H17FN6O
  • H donors: 2 H acceptors: 4 LogP: 3.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1ccc(c(c1)Nc1ncnc2c1cnn2c1ccc(cc1)F)C
  • InChi: 1S/C20H17FN6O/c1-12-3-4-13(20(28)22-2)9-17(12)26-18-16-10-25-27(19(16)24-11-23-18)15-7-5-14(21)6-8-15/h3-11H,1-2H3,(H,22,28)(H,23,24,26)
  • InChiKey: NNFVDULXSDUDGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N,4-dimethyl-benzamide
  • 3-[[1-(4-fluorophenyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N,4-dimethylbenzamide
  • 3-[[1-(4-fluorophenyl)pyrazolo[4,5-e]pyrimidin-4-yl]amino]-N,4-dimethylbenzamide
  • 3-[[1-(4-fluorophenyl)pyrazolo[4,5-e]pyrimidin-4-yl]amino]-N,4-dimethyl-benzamide
  • 3-[[1-(4-fluorophenyl)-4-pyrazolo[4,5-e]pyrimidinyl]amino]-N,4-dimethylbenzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0141 0.0832 0.1506
Echinococcus granulosus intermediate filament protein 0.0031 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.004 0.0081 0.0081
Onchocerca volvulus 0.0175 0.1083 0.1072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0037 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.0191 0.0191
Onchocerca volvulus 0.0141 0.0832 0.082
Toxoplasma gondii transporter, major facilitator family protein 0.0175 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus granulosus sex peptide receptor 0.0141 0.0832 0.094
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0141 0.0832 0.0832
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.0191 0.0713
Loa Loa (eye worm) hypothetical protein 0.004 0.0081 0.0081
Brugia malayi sodium-independent organic anion transporter family protein 0.0175 0.1083 0.1083
Schistosoma mansoni growth hormone secretagogue receptor 0.0141 0.0832 0.3107
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0191 0.0191
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.092 0.6121
Echinococcus granulosus allatostatin A receptor 0.0141 0.0832 0.094
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.0191 0.0713
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0081 0.0091
Onchocerca volvulus 0.0141 0.0832 0.082
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.0191 0.0191
Echinococcus multilocularis serotonin receptor 0.0141 0.0832 0.1506
Echinococcus multilocularis mitogen activated protein kinase 3 0.0118 0.0664 0.1202
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0081 0.0146
Echinococcus multilocularis neuropeptides capa receptor 0.0141 0.0832 0.1506
Schistosoma mansoni biogenic amine receptor 0.0141 0.0832 0.3107
Brugia malayi neuropeptide F receptor 0.0141 0.0832 0.0832
Brugia malayi follicle stimulating hormone receptor 0.0674 0.4773 0.4773
Loa Loa (eye worm) RGS-3 protein 0.004 0.0081 0.0081
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0093 0.0168
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0141 0.0832 0.3107
Echinococcus multilocularis expressed protein 0.0774 0.552 1
Echinococcus multilocularis g-protein coupled receptor 0.0141 0.0832 0.1506
Echinococcus multilocularis Protein lozenge 0.0057 0.0205 0.0372
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.0832 0.094
Echinococcus granulosus mitogen activated protein kinase 0.0118 0.0664 0.075
Brugia malayi P38 map kinase family protein 2 0.0153 0.092 0.092
Echinococcus granulosus FTZ F1 alpha 0.0055 0.0191 0.0216
Loa Loa (eye worm) hypothetical protein 0.004 0.0081 0.0081
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0175 0.1083 0.1224
Schistosoma mansoni coup transcription factor 0.0055 0.0191 0.0713
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Brugia malayi neuropeptide F receptor 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0175 0.1083 0.1083
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0093 0.0347
Loa Loa (eye worm) hypothetical protein 0.0175 0.1083 0.1083
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0153 0.092 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0081 0.0146
Echinococcus granulosus follistatin 0.0058 0.0217 0.0245
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0141 0.0832 0.3107
Echinococcus granulosus serotonin receptor 0.0141 0.0832 0.094
Schistosoma mansoni biogenic amine (5HT) receptor 0.0141 0.0832 0.3107
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0153 0.0153
Brugia malayi secreted modular calcium-binding protein 1 0.0058 0.0217 0.0217
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0058 0.0217 0.0217
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0012 0.0012
Schistosoma mansoni axis inhibition protein axin 0.004 0.0081 0.0302
Brugia malayi Serotonin receptor 0.0141 0.0832 0.0832
Echinococcus granulosus expressed protein 0.0774 0.552 0.6239
Loa Loa (eye worm) hypothetical protein 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0153 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0191 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.0832 0.3107
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.0191 0.0216
Brugia malayi hypothetical protein 0.0185 0.1154 0.1154
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0141 0.0832 0.1506
Schistosoma mansoni lamin 0.0031 0.0012 0.0046
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0153 0.092 0.092
Echinococcus multilocularis g protein coupled receptor 0.0141 0.0832 0.1506
Loa Loa (eye worm) melatonin receptor type 1A 0.0141 0.0832 0.0832
Onchocerca volvulus 0.0141 0.0832 0.082
Brugia malayi bHLH-PAS transcription factor 0.0041 0.0088 0.0088
Onchocerca volvulus 0.0141 0.0832 0.082
Echinococcus multilocularis lamin dm0 0.0031 0.0012 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0055 0.0191 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.0191 0.0191
Schistosoma mansoni lamin 0.0031 0.0012 0.0046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0691 1
Onchocerca volvulus 0.0141 0.0832 0.082
Brugia malayi hypothetical protein 0.0175 0.1083 0.1083
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni alpha-1 adrenergic receptor 0.0141 0.0832 0.3107
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Brugia malayi SPARC precursor 0.0058 0.0217 0.0217
Brugia malayi Dopamine receptor protein 1 0.0141 0.0832 0.0832
Echinococcus granulosus agrin 0.0058 0.0217 0.0245
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.039 0.2676 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.0191 0.0191
Loa Loa (eye worm) G-protein coupled receptor 0.0141 0.0832 0.0832
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.0832 0.1506
Echinococcus granulosus dro:myosuppressin receptor 0.0141 0.0832 0.094
Brugia malayi putative neuropeptide receptor 0.0141 0.0832 0.0832
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0141 0.0832 0.3107
Echinococcus granulosus hypothetical protein 0.0141 0.0832 0.094
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0691 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0141 0.0832 0.1506
Echinococcus multilocularis thyroid hormone receptor alpha 0.0055 0.0191 0.0346
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0141 0.0832 0.094
Loa Loa (eye worm) G-protein coupled receptor 0.0141 0.0832 0.0832
Brugia malayi hypoxia-induced factor 1 0.017 0.1048 0.1048
Schistosoma mansoni amine GPCR 0.0141 0.0832 0.3107
Schistosoma mansoni amine GPCR 0.0141 0.0832 0.3107
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni histamine h1 receptor 0.0141 0.0832 0.3107
Onchocerca volvulus 0.0141 0.0832 0.082
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Brugia malayi AKH receptor 0.0141 0.0832 0.0832
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0141 0.0832 0.094
Onchocerca volvulus Neuropeptide F receptor homolog 0.0141 0.0832 0.082
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus granulosus 7TM GPCR rhodopsin 0.0141 0.0832 0.094
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0141 0.0832 0.1506
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0691 0.0781
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni hypothetical protein 0.0141 0.0832 0.3107
Onchocerca volvulus 0.0141 0.0832 0.082
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0081 0.0091
Schistosoma mansoni lozenge 0.0057 0.0205 0.0767
Onchocerca volvulus 0.0141 0.0832 0.082
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.0832 0.094
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0141 0.0832 0.1506
Schistosoma mansoni neuropeptide F-like receptor 0.0141 0.0832 0.3107
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0175 0.1083 0.1083
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0141 0.0832 0.0832
Onchocerca volvulus 0.0141 0.0832 0.082
Schistosoma mansoni regulator of G protein signaling 0.004 0.0081 0.0302
Echinococcus granulosus neuropeptide Y receptor 0.0141 0.0832 0.094
Brugia malayi sodium-independent organic anion transporter family protein 0.0175 0.1083 0.1083
Brugia malayi hypothetical protein 0.0451 0.3125 0.3125
Echinococcus granulosus biogenic amine 5HT receptor 0.0141 0.0832 0.094
Brugia malayi PAS domain containing protein 0.0055 0.0194 0.0194
Echinococcus multilocularis orexin receptor type 2 0.0141 0.0832 0.1506
Brugia malayi sodium-independent organic anion transporter family protein 0.0175 0.1083 0.1083
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0141 0.0832 0.0832
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0664 1
Echinococcus granulosus neuropeptide Y receptor 0.0141 0.0832 0.094
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0141 0.0832 0.3107
Brugia malayi hypothetical protein 0.004 0.0081 0.0081
Brugia malayi ORL1-like opioid receptor 0.0141 0.0832 0.0832
Brugia malayi G protein-coupled receptor F59B2.13 0.0141 0.0832 0.0832
Onchocerca volvulus 0.0175 0.1083 0.1072
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0141 0.0832 0.1506
Onchocerca volvulus 0.0055 0.0191 0.0179
Echinococcus granulosus geminin 0.0169 0.1034 0.1169
Onchocerca volvulus Putative organic anion transporter 0.138 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0191 0.0191
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0081 0.0146
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Brugia malayi Tachykinin-like peptides receptor 99D 0.0141 0.0832 0.0832
Brugia malayi steroid hormone receptor 0.0055 0.0191 0.0191
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0141 0.0832 0.1506
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.0191 0.0179
Echinococcus granulosus neuropeptide s receptor 0.0141 0.0832 0.094
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0141 0.0832 0.3107
Brugia malayi hypothetical protein 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Onchocerca volvulus 0.0175 0.1083 0.1072
Loa Loa (eye worm) hypothetical protein 0.004 0.0081 0.0081
Schistosoma mansoni neuropeptide receptor 0.0141 0.0832 0.3107
Brugia malayi G protein-coupled receptor 0.0141 0.0832 0.0832
Echinococcus multilocularis fmrfamide receptor 0.0141 0.0832 0.1506
Loa Loa (eye worm) hypothetical protein 0.004 0.0081 0.0081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.0832 0.1506
Echinococcus granulosus axis inhibition protein axin 0.004 0.0081 0.0091
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.0832 0.094
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0691 0.1072
Brugia malayi hypothetical protein 0.0175 0.1083 0.1083
Schistosoma mansoni intermediate filament proteins 0.0031 0.0012 0.0046
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0141 0.0832 0.3107
Loa Loa (eye worm) hypothetical protein 0.0451 0.3125 0.3125
Brugia malayi Dopamine receptor 0.0141 0.0832 0.0832
Brugia malayi G-protein coupled receptor 0.0141 0.0832 0.0832
Schistosoma mansoni biogenic amine (5HT) receptor 0.0141 0.0832 0.3107
Echinococcus multilocularis g protein coupled receptor 0.0141 0.0832 0.1506
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0012 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.0191 0.0179
Schistosoma mansoni hypothetical protein 0.0141 0.0832 0.3107
Brugia malayi hypothetical protein 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0058 0.0217 0.0217
Loa Loa (eye worm) agrin synaptic family protein 0.0058 0.0217 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0191 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0169 0.1034 0.3863
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0664 0.248
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.0191 0.0713
Echinococcus granulosus Solute carrier organic anion transporter family 0.0175 0.1083 0.1224
Schistosoma mansoni regulator of G protein signaling 0.004 0.0081 0.0302
Brugia malayi PXA domain containing protein 0.004 0.0081 0.0081
Schistosoma mansoni neuropeptide receptor 0.0141 0.0832 0.3107
Echinococcus granulosus tm gpcr rhodopsin 0.0141 0.0832 0.094
Echinococcus granulosus neuropeptide FF receptor 2 0.0141 0.0832 0.094
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0141 0.0832 0.0832
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.0832 0.094
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.0191 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.138 1 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.092 0.1667
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0191 0.0191
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0081 0.0302
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.0191 0.0216
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni amine GPCR 0.0141 0.0832 0.3107
Brugia malayi Serotonin receptor 0.0141 0.0832 0.0832
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0141 0.0832 0.3107
Loa Loa (eye worm) hypothetical protein 0.0185 0.1154 0.1154
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0058 0.0217 0.0217
Brugia malayi larval opioid receptor 0.0141 0.0832 0.0832
Schistosoma mansoni amine GPCR 0.0141 0.0832 0.3107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.0191 0.0191
Schistosoma mansoni single-minded 0.0055 0.0194 0.0725
Echinococcus multilocularis geminin 0.0169 0.1034 0.1873
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0141 0.0832 0.3107
Brugia malayi intermediate filament protein 0.0031 0.0012 0.0012
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0175 0.1083 0.1083
Schistosoma mansoni regulator of G protein signaling 0.004 0.0081 0.0302
Brugia malayi hypothetical protein 0.0141 0.0832 0.0832
Onchocerca volvulus Putative organic anion transporter 0.0175 0.1083 0.1072
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.0191 0.0346
Schistosoma mansoni follistatin 0.0058 0.0217 0.081
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0141 0.0832 0.0832
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0691 0.5478
Echinococcus granulosus peptide allatostatin:somatostatin 0.0141 0.0832 0.094
Echinococcus granulosus neuropeptide receptor A26 0.0141 0.0832 0.094
Brugia malayi hypothetical protein 0.0141 0.0832 0.0832
Onchocerca volvulus 0.0141 0.0832 0.082
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0081 0.0146
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0141 0.0832 0.3107
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0093 0.0105
Onchocerca volvulus 0.0041 0.0088 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.0832 0.1506
Schistosoma mansoni neuropeptide f receptor 76f 0.0141 0.0832 0.3107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.0832 0.3107
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0175 0.1083 0.1961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.0191 0.0191
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0081 0.0091
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0141 0.0832 0.1506
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0081 0.0146
Schistosoma mansoni adenoreceptor 0.0141 0.0832 0.3107
Schistosoma mansoni hypothetical protein 0.0169 0.1034 0.3863
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.092 0.1667
Onchocerca volvulus 0.0141 0.0832 0.082
Brugia malayi GnHR receptor homolog 0.0141 0.0832 0.0832
Echinococcus multilocularis serotonin receptor 0.0141 0.0832 0.1506
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0093 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.0832 0.3107
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Loa Loa (eye worm) runx1 0.0057 0.0205 0.0205
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.0832 0.1506
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.0832 0.3107
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0058 0.0217 0.0217
Echinococcus granulosus g protein coupled receptor 0.0141 0.0832 0.094
Brugia malayi nuclear receptor NHR-88 0.0055 0.0191 0.0191
Brugia malayi Dopamine receptor protein 2 0.0141 0.0832 0.0832
Echinococcus granulosus lamin dm0 0.0031 0.0012 0.0014
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.0191 0.0216
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.0191 0.0713
Loa Loa (eye worm) hypothetical protein 0.0058 0.0217 0.0217
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0141 0.0832 0.1506
Echinococcus granulosus mitogen activated protein kinase 3 0.0118 0.0664 0.075
Onchocerca volvulus 0.0451 0.3125 0.3117
Loa Loa (eye worm) hypothetical protein 0.005 0.0153 0.0153
Echinococcus granulosus single minded 2 0.0041 0.0088 0.01
Onchocerca volvulus 0.0141 0.0832 0.082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.0832 0.3107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.0832 0.1506
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Echinococcus multilocularis neuropeptide s receptor 0.0141 0.0832 0.1506
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0141 0.0832 0.1506
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0081 0.0302
Brugia malayi Melatonin receptor type 1A 0.0141 0.0832 0.0832
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0175 0.1083 0.1961
Schistosoma mansoni agrin 0.0058 0.0217 0.081
Loa Loa (eye worm) hypothetical protein 0.0175 0.1083 0.1083
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0141 0.0832 0.3107
Loa Loa (eye worm) hypothetical protein 0.0058 0.0217 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.0832 0.3107
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Onchocerca volvulus 0.0141 0.0832 0.082
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.0191 0.0191
Schistosoma mansoni opsin-like receptor 0.0141 0.0832 0.3107
Loa Loa (eye worm) neuropeptide F receptor 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Onchocerca volvulus 0.0058 0.0217 0.0205
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.0832 0.094
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0191 0.0713
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0141 0.0832 0.3107
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0118 0.0664 0.0664
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0191 0.0346
Onchocerca volvulus 0.0175 0.1083 0.1072
Echinococcus multilocularis neuropeptide receptor 0.0141 0.0832 0.1506
Onchocerca volvulus 0.0141 0.0832 0.082
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0081 0.0081
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0141 0.0832 0.094
Echinococcus multilocularis allatostatin A receptor 0.0141 0.0832 0.1506
Loa Loa (eye worm) hypothetical protein 0.0055 0.0191 0.0191
Brugia malayi MAP kinase sur-1 0.0118 0.0664 0.0664
Brugia malayi sulfakinin receptor protein 0.0141 0.0832 0.0832
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0191 0.0216
Echinococcus granulosus tm gpcr rhodopsin 0.0141 0.0832 0.094
Brugia malayi nuclear hormone receptor 0.0055 0.0191 0.0191
Echinococcus multilocularis follistatin 0.0058 0.0217 0.0393
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0691 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.0191 0.0191
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.0191 0.0346
Onchocerca volvulus 0.0141 0.0832 0.082
Onchocerca volvulus 0.0141 0.0832 0.082
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0093 0.0093
Brugia malayi hypothetical protein 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0175 0.1083 0.1083
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0141 0.0832 0.094
Echinococcus multilocularis neuropeptide receptor 0.0141 0.0832 0.1506
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0191 0.0713
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0664 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus multilocularis G protein coupled receptor 139 0.0141 0.0832 0.1506
Brugia malayi hypothetical protein 0.0141 0.0832 0.0832
Echinococcus granulosus G protein coupled receptor 139 0.0141 0.0832 0.094
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.0832 0.094
Schistosoma mansoni organic anion transporter 0.0175 0.1083 0.4045
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0194 0.0725
Echinococcus granulosus alpha 1A adrenergic receptor 0.0141 0.0832 0.094
Onchocerca volvulus Putative organic anion transporter 0.0175 0.1083 0.1072
Echinococcus granulosus mitogen activated protein kinase 14 0.0153 0.092 0.104
Schistosoma mansoni amine GPCR 0.0141 0.0832 0.3107
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0081 0.0146
Schistosoma mansoni hypothetical protein 0.0141 0.0832 0.3107
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0153 0.092 1
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0691 0.2582
Brugia malayi PXA domain containing protein 0.004 0.0081 0.0081
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.0191 0.0713
Brugia malayi ecdysteroid receptor 0.0055 0.0191 0.0191
Brugia malayi G-protein coupled receptor 0.0141 0.0832 0.0832
Echinococcus granulosus neuropeptides capa receptor 0.0141 0.0832 0.094
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0141 0.0832 0.3107
Echinococcus granulosus g protein coupled receptor 0.0141 0.0832 0.094
Brugia malayi hypothetical protein 0.0141 0.0832 0.0832
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0081 0.0146
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.0191 0.0346
Echinococcus granulosus g-protein coupled receptor 0.0141 0.0832 0.094
Echinococcus multilocularis musashi 0.0031 0.0012 0.0022
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0081 0.0091
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0118 0.0664 0.516
Echinococcus multilocularis g protein coupled receptor 0.0141 0.0832 0.1506
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.0191 0.0216
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0141 0.0832 0.0832
Echinococcus multilocularis neuropeptide receptor A26 0.0141 0.0832 0.1506
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0055 0.0191 0.0191
Echinococcus multilocularis agrin 0.0058 0.0217 0.0393
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0093 0.0347
Schistosoma mansoni biogenic amine receptor 0.0141 0.0832 0.3107
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0191 0.0713
Schistosoma mansoni opsin-like receptor 0.0141 0.0832 0.3107
Schistosoma mansoni regulator of G protein signaling 0.004 0.0081 0.0302
Schistosoma mansoni regulator of G protein signaling 0.004 0.0081 0.0302
Brugia malayi hypothetical protein 0.0141 0.0832 0.0832
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0081 0.0081
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.0191 0.0713
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus granulosus orexin receptor type 2 0.0141 0.0832 0.094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.0832 0.3107
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0664 1
Echinococcus multilocularis fmrfamide receptor 0.0141 0.0832 0.1506
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0141 0.0832 0.0832
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.0191 0.0191
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0175 0.1083 0.1083
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0081 0.0081
Loa Loa (eye worm) neuropeptide F receptor 0.0141 0.0832 0.0832
Echinococcus multilocularis G-protein coupled receptor, putative 0.0141 0.0832 0.1506
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0081 0.0302
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.0832 0.3107
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.0191 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus granulosus tachykinin peptides receptor 99D 0.0141 0.0832 0.094
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.0088 0.016
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0141 0.0832 0.1506
Schistosoma mansoni axis inhibition protein axin 0.004 0.0081 0.0302
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.0191 0.0346
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0191 0.0346
Entamoeba histolytica hypothetical protein 0.004 0.0081 0.5
Schistosoma mansoni organic anion transporter 0.0175 0.1083 0.4045
Schistosoma mansoni hypothetical protein 0.0034 0.0037 0.0139
Loa Loa (eye worm) hypothetical protein 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus multilocularis mitogen activated protein kinase 0.0118 0.0664 0.1202
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.0191 0.0713
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0141 0.0832 0.1506
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0141 0.0832 0.082
Brugia malayi hypothetical protein 0.0141 0.0832 0.0832
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.092 0.6121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.0832 0.1506
Echinococcus granulosus rhodopsin orphan GPCR 0.0141 0.0832 0.094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni neuropeptide receptor 0.0141 0.0832 0.3107
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0081 0.0081
Echinococcus multilocularis neuropeptides capa receptor 0.0141 0.0832 0.1506
Schistosoma mansoni opsin-like receptor 0.0141 0.0832 0.3107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.0832 0.1506
Schistosoma mansoni neuropeptide F-like receptor 0.0141 0.0832 0.3107
Echinococcus multilocularis sex peptide receptor 0.0141 0.0832 0.1506
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0012 0.0012
Echinococcus granulosus neuropeptides capa receptor 0.0141 0.0832 0.094
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0691 0.2582
Echinococcus multilocularis neuropeptide Y receptor 0.0141 0.0832 0.1506
Echinococcus granulosus g protein coupled receptor 0.0141 0.0832 0.094
Echinococcus granulosus 7tm_1 domain containing protein 0.0141 0.0832 0.094
Echinococcus granulosus lamin 0.0031 0.0012 0.0014
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0081 0.0081
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0058 0.0217 0.0217
Brugia malayi putative neuropeptide receptor NPR1 0.0141 0.0832 0.0832
Echinococcus multilocularis neuropeptide Y receptor 0.0141 0.0832 0.1506
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0081 0.0146
Echinococcus granulosus biogenic amine 5HT receptor 0.0141 0.0832 0.094
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0058 0.0217 0.0217
Loa Loa (eye worm) hypoxia-induced factor 1 0.017 0.1048 0.1048
Schistosoma mansoni biogenic amine receptor 0.0141 0.0832 0.3107
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0093 0.0347
Echinococcus granulosus somatostatin receptor 0.0141 0.0832 0.094
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0191 0.0713
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0691 0.5
Brugia malayi hypothetical protein 0.0141 0.0832 0.0832
Echinococcus multilocularis expressed protein 0.0058 0.0217 0.0393
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0081 0.0146
Entamoeba histolytica hypothetical protein 0.004 0.0081 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0037 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.0191 0.0191
Echinococcus granulosus tm gpcr rhodopsin 0.0141 0.0832 0.094
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0141 0.0832 0.1506
Echinococcus granulosus Solute carrier family 22 5 0.1224 0.8848 1
Onchocerca volvulus 0.0175 0.1083 0.1072
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0141 0.0832 0.3107
Brugia malayi RE15519p 0.0141 0.0832 0.0832
Schistosoma mansoni neuropeptide receptor 0.0141 0.0832 0.3107
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0141 0.0832 0.094
Trypanosoma cruzi MFS transporter, putative 0.0175 0.1083 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0153 0.092 0.104
Schistosoma mansoni myosin xvIII 0.0141 0.0832 0.3107
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.0191 0.0216
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0664 1
Loa Loa (eye worm) hypothetical protein 0.0451 0.3125 0.3125
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus multilocularis lamin 0.0031 0.0012 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0141 0.0832 0.1506
Brugia malayi hypothetical protein 0.004 0.0081 0.0081
Echinococcus granulosus axis inhibition protein axin 0.004 0.0081 0.0091
Entamoeba histolytica hypothetical protein 0.004 0.0081 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.0191 0.0713
Giardia lamblia Kinase, CMGC MAPK 0.0118 0.0664 0.5
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0081 0.0091
Echinococcus granulosus fmrfamide receptor 0.0141 0.0832 0.094
Echinococcus multilocularis somatostatin receptor 0.0141 0.0832 0.1506
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.0191 0.0346
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0081 0.0091
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0141 0.0832 0.1506
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0081 0.0081
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0141 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0141 0.0832 0.3107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0191 0.0216
Echinococcus granulosus neuropeptide receptor 0.0141 0.0832 0.094
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0141 0.0832 0.3107
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0691 0.1252
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0674 0.4773 0.4773
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0058 0.0217 0.0217
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0141 0.0832 0.094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0141 0.0832 0.1506
Echinococcus granulosus neuropeptide receptor 0.0141 0.0832 0.094
Loa Loa (eye worm) hypothetical protein 0.004 0.0081 0.0081
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.092 0.1667
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.092 0.1667
Loa Loa (eye worm) TYRA-2 protein 0.0141 0.0832 0.0832
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0081 0.0302
Loa Loa (eye worm) hypothetical protein 0.0141 0.0832 0.0832
Onchocerca volvulus 0.0141 0.0832 0.082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.0191 0.0216
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0141 0.0832 0.1506

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9 nM Inhibition of human recombinant p38alpha-mediated myelin basic protein phosphorylation ChEMBL. 18359226
IC50 (binding) = 9 nM Inhibition of human recombinant p38alpha-mediated myelin basic protein phosphorylation ChEMBL. 18359226
IC50 (functional) = 220 nM Inhibition of LPS-induced TNFalpha production in human PBMC ChEMBL. 18359226
IC50 (functional) = 220 nM Inhibition of LPS-induced TNFalpha production in human PBMC ChEMBL. 18359226

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18359226

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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