Detailed information for compound 514479

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 580.589 | Formula: C29H33F5N4O3
  • H donors: 0 H acceptors: 2 LogP: 5.02 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(CN(CCn1c(=O)c2CN(CCc2n(c1=O)Cc1c(F)cccc1F)Cc1ccc(cc1)OC(F)(F)F)C)C
  • InChi: 1S/C29H33F5N4O3/c1-19(2)15-35(3)13-14-37-27(39)23-17-36(16-20-7-9-21(10-8-20)41-29(32,33)34)12-11-26(23)38(28(37)40)18-22-24(30)5-4-6-25(22)31/h4-10,19H,11-18H2,1-3H3
  • InChiKey: WGUOBMQAEOVIPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei unspecified product 0.0019 0.0213 0.1931
Brugia malayi PAS domain containing protein 0.0048 0.0701 0.0668
Onchocerca volvulus Cathepsin L homolog 0.0017 0.017 0.0251
Brugia malayi Cathepsin L-like precursor 0.0011 0.0078 0.0043
Schistosoma mansoni cpg binding protein 0.0028 0.0369 0.0413
Leishmania major cathepsin L-like protease 0.0017 0.017 0.0863
Plasmodium vivax SET domain protein, putative 0.0029 0.0387 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0726 0.0846
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0213 0.1355
Leishmania major cathepsin L-like protease 0.0017 0.017 0.0863
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.017 0.1472
Loa Loa (eye worm) ctsf protein 0.0017 0.017 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0035 0.0094
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0102 0.0273
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0035 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0035 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.028 0.2665
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0953 1
Onchocerca volvulus 0.0017 0.017 0.0251
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0726 0.7528
Leishmania major protein kinase, putative 0.0013 0.011 0.0155
Loa Loa (eye worm) fibroinase 0.0017 0.017 0.0133
Leishmania major cathepsin L-like protease 0.0017 0.017 0.0863
Onchocerca volvulus Cathepsin F homolog 0.0017 0.017 0.0251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.017 0.0455
Onchocerca volvulus 0.0013 0.0102 0.0065
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0726 0.8639
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0213 0.1931
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0035 0.0009
Leishmania major cathepsin L-like protease 0.0063 0.0953 1
Brugia malayi hypoxia-induced factor 1 0.0149 0.2397 0.237
Trichomonas vaginalis set domain proteins, putative 0.0229 0.3748 1
Mycobacterium leprae Possible regulatory protein 0.0013 0.0102 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Echinococcus multilocularis cysteine protease 0.0017 0.017 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0953 1
Onchocerca volvulus 0.0036 0.0491 0.1124
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0726 0.1938
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0102 0.0273
Leishmania major cathepsin L-like protease 0.0063 0.0953 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0102 0.0273
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0055 0.002
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.017 0.0133
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0601 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0078 0.0043
Echinococcus granulosus cathepsin l1 0.0017 0.017 0.0172
Loa Loa (eye worm) hypothetical protein 0.0017 0.017 0.0133
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0213 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.017 0.0172
Echinococcus granulosus single minded 2 0.0036 0.0491 0.0561
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0102 0.0728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Leishmania major DNA polymerase eta, putative 0.0019 0.0213 0.1355
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Loa Loa (eye worm) cysteine protease 0.0017 0.017 0.0133
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0387 0.0435
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0102 0.0273
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0491 0.0457
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0102 0.009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Onchocerca volvulus 0.0029 0.0387 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0102 0.0273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0387 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0726 0.7528
Leishmania major cathepsin L-like protease 0.0017 0.017 0.0863
Onchocerca volvulus 0.0017 0.017 0.0251
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0057 0.0035
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0097 0.0059
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0387 0.0435
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0213 0.2944
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0102 0.0065
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0213 0.0178
Echinococcus multilocularis cpg binding protein 0.003 0.0396 0.0446
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.017 1
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0097 0.0059
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0726 0.7352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Plasmodium vivax vivapain-2 0.0017 0.017 0.3842
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0213 0.0223
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0726 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0213 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0213 0.1931
Loa Loa (eye worm) histone methyltransferase 0.001 0.0057 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0102 0.0273
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.017 0.0172
Echinococcus multilocularis cysteine protease 0.0017 0.017 0.0172
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0726 0.0846
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.017 0.0455
Loa Loa (eye worm) hypothetical protein 0.0013 0.0102 0.0065
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.011 0.081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0387 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.017 0.0455
Echinococcus granulosus cpg binding protein 0.003 0.0396 0.0446
Brugia malayi Cathepsin L-like precursor 0.0017 0.017 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.017 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0113 0.0846
Leishmania major cysteine peptidase A (CPA) 0.0017 0.017 0.0863
Leishmania major DNA polymerase kappa, putative 0.0019 0.0213 0.1355
Onchocerca volvulus 0.0229 0.3748 1
Echinococcus granulosus cathepsin l1 0.0011 0.0078 0.0061
Onchocerca volvulus 0.0017 0.017 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.017 0.0455
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.017 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Echinococcus granulosus dna polymerase eta 0.0019 0.0213 0.0223
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0922 0.1083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0035 0.0094
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0213 0.0567
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0726 0.7528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Brugia malayi Pre-SET motif family protein 0.0202 0.3281 0.3257
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Onchocerca volvulus 0.0017 0.017 0.0251
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.017 0.0172
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0213 0.0223
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0213 0.0176
Loa Loa (eye worm) POT family protein 0.0201 0.3273 0.3248
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0953 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0213 0.0223
Brugia malayi Cathepsin L-like precursor 0.0011 0.0078 0.0043
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0726 0.7352
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.3281 0.3256
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.017 0.7621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.017 0.0136
Echinococcus multilocularis dna polymerase eta 0.0019 0.0213 0.0223
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0726 0.7528
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.017 0.7621
Onchocerca volvulus 0.0017 0.017 0.0251
Onchocerca volvulus 0.0017 0.017 0.0251
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0097 0.0666
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0102 0.0273
Brugia malayi CXXC zinc finger family protein 0.0028 0.0369 0.0335
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0726 0.0846
Echinococcus granulosus geminin 0.0499 0.8278 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0726 0.1938
Schistosoma mansoni hypothetical protein 0.0499 0.8278 1
Leishmania major cathepsin L-like protease 0.0063 0.0953 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.017 0.0133
Echinococcus multilocularis cathepsin L 0.0009 0.0035 0.0009
Brugia malayi Cathepsin L-like precursor 0.0017 0.017 0.0136
Schistosoma mansoni hypothetical protein 0.0499 0.8278 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0057 0.0035
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0726 0.7528
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0097 0.0666
Echinococcus granulosus dnaJ subfamily B 0.0405 0.669 0.8075
Brugia malayi GnHR receptor homolog 0.0558 0.9276 0.9274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.017 0.0455
Brugia malayi hypothetical protein 0.0162 0.2607 0.2581
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.011 0.081
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.669 0.8075
Brugia malayi Cytochrome P450 family protein 0.0012 0.0097 0.0061
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0213 0.0567
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.017 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0078 0.0209
Onchocerca volvulus 0.0017 0.017 0.0251
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.011 0.081
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0113 0.0846
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0102 0.0066
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0213 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.017 0.0172
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0213 0.1931
Echinococcus granulosus cathepsin L 0.0009 0.0035 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0078 0.2425
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0387 0.0435
Brugia malayi cathepsin L-like precursor 0.0011 0.0078 0.0043
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0369 0.0333
Leishmania major cathepsin L-like protease 0.0017 0.017 0.0863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0113 0.0846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0078 0.0041
Echinococcus granulosus cysteine protease 0.0009 0.0035 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0726 0.0846
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0102 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.2397 0.2368
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0701 0.0816
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0102 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0953 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0726 0.1938
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0861 0.8997
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0491 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0035 0.0009
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0726 0.0846
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.017 0.0172
Trypanosoma brucei unspecified product 0.0013 0.0113 0.0846
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0102 0.009
Echinococcus multilocularis geminin 0.0499 0.8278 1
Trypanosoma brucei protein kinase, putative 0.005 0.0726 0.7528
Schistosoma mansoni single-minded 0.0048 0.0701 0.0816
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0726 0.0691
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0213 0.1931
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0097 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0102 0.0273
Loa Loa (eye worm) hypothetical protein 0.0011 0.0078 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0213 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.017 0.0136
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0102 0.0273
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.017 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0213 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0359 0.04
Plasmodium vivax vivapain-2 0.0017 0.017 0.3842
Brugia malayi Cathepsin L-like precursor 0.0017 0.017 0.0136
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0097 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0491 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Brugia malayi Cathepsin L-like precursor 0.0017 0.017 0.0136
Brugia malayi POT family protein 0.0201 0.3273 0.3249
Schistosoma mansoni DNA polymerase eta 0.0019 0.0213 0.0223
Onchocerca volvulus Cathepsin L homolog 0.0017 0.017 0.0251
Brugia malayi MAP kinase sur-1 0.005 0.0726 0.0693
Leishmania major protein kinase, putative 0.0013 0.011 0.0155
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0102 0.0273
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.017 0.0172
Schistosoma mansoni hypothetical protein 0.0405 0.669 0.8075
Loa Loa (eye worm) hypothetical protein 0.0162 0.2607 0.2579
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.017 0.0455
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.011 0.081
Schistosoma mansoni cpg binding protein 0.003 0.0396 0.0446
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0726 0.7525
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0078 0.0061
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.017 0.0172
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0213 0.2944
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Trypanosoma brucei unspecified product 0.0013 0.0113 0.0846
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0814 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0078 0.0209
Leishmania major hypothetical protein, conserved 0.0023 0.028 0.2142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0387 0.0435
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0213 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0213 0.1931
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0213 0.0223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.017 0.0455
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0387 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0953 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0387 0.0351
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0102 0.009
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0726 0.1938
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.017 0.0455
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0387 0.3364
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0213 0.5
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0102 0.0728
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0213 0.1931
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.017 1
Onchocerca volvulus 0.0028 0.0369 0.0793
Brugia malayi Cytochrome P450 family protein 0.0012 0.0097 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.028 0.2665
Brugia malayi Pre-SET motif family protein 0.0029 0.0387 0.0353
Loa Loa (eye worm) hypothetical protein 0.0011 0.0078 0.0041
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0102 0.5
Brugia malayi Cathepsin L-like precursor 0.0017 0.017 0.0136
Entamoeba histolytica cysteine protease, putative 0.0017 0.017 0.7621
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.017 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.017 0.0455
Schistosoma mansoni cpg binding protein 0.003 0.0396 0.0446

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 73 % Inhibition of GnRH receptor (unknown origin) at 10 uM ChEMBL. 17920281
Inhibition (binding) = 73 % Inhibition of GnRH receptor (unknown origin) at 10 uM ChEMBL. 17920281
Ki (binding) = 2.5 uM Inhibition of GnRH receptor (unknown origin) ChEMBL. 17920281
Ki (binding) = 2.5 uM Inhibition of GnRH receptor (unknown origin) ChEMBL. 17920281

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.