TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 580.589 | Formula: C29H33F5N4O3
H donors: 0 H acceptors: 2 LogP: 5.02 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CC(CN(CCn1c(=O)c2CN(CCc2n(c1=O)Cc1c(F)cccc1F)Cc1ccc(cc1)OC(F)(F)F)C)C
InChi: 1S/C29H33F5N4O3/c1-19(2)15-35(3)13-14-37-27(39)23-17-36(16-20-7-9-21(10-8-20)41-29(32,33)34)12-11-26(23)38(28(37)40)18-22-24(30)5-4-6-25(22)31/h4-10,19H,11-18H2,1-3H3
InChiKey: WGUOBMQAEOVIPD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gonadotropin-releasing hormone receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	GnHR receptor homolog	Get druggable targets OG5_131719	All targets in OG5_131719

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0013	0.0102	0.0273
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0102	0.0728
Onchocerca volvulus		0.0017	0.017	0.0251
Loa Loa (eye worm)	cysteine protease	0.0017	0.017	0.0133
Onchocerca volvulus		0.0017	0.017	0.0251
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.017	0.0172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.017	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0078	0.0041
Loa Loa (eye worm)	fibroinase	0.0017	0.017	0.0133
Trypanosoma brucei	unspecified product	0.0013	0.0113	0.0846
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0213	0.0223
Leishmania major	cathepsin L-like protease	0.0017	0.017	0.0863
Brugia malayi	Pre-SET motif family protein	0.0029	0.0387	0.0353
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0097	0.0061
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0078	0.0041
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0953	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0387	0.0435
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0213	0.1355
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0013	0.0102	0.0273
Schistosoma mansoni	cpg binding protein	0.003	0.0396	0.0446
Trypanosoma brucei	unspecified product	0.0019	0.0213	0.1931
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0387	0.0435
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0387	0.0435
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0057	0.002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0726	0.1938
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.3281	0.3256
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0035	0.0009
Onchocerca volvulus		0.0017	0.017	0.0251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0387	0.0351
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0113	0.0846
Brugia malayi	MAP kinase sur-1	0.005	0.0726	0.0693
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0097	0.0059
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0213	0.1931
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0013	0.0102	0.0273
Onchocerca volvulus		0.0029	0.0387	0.0841
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0726	0.7528
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0387	0.3364
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0726	0.7528
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.017	0.0455
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0726	0.7528
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Loa Loa (eye worm)	ctsf protein	0.0017	0.017	0.0133
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.017	0.0863
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.017	0.0455
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0213	0.0223
Leishmania major	cathepsin L-like protease	0.0017	0.017	0.0863
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Brugia malayi	Cathepsin L-like precursor	0.0017	0.017	0.0136
Onchocerca volvulus		0.0017	0.017	0.0251
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0213	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0078	0.0209
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0078	0.0209
Echinococcus granulosus	geminin	0.0499	0.8278	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0387	0.0435
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Leishmania major	cathepsin L-like protease	0.0017	0.017	0.0863
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.017	0.0455
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0102	0.0273
Brugia malayi	Pre-SET motif family protein	0.0202	0.3281	0.3257
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.017	0.0455
Brugia malayi	Cathepsin L-like precursor	0.0017	0.017	0.0136
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0113	0.0846
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.017	0.0172
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0213	0.0223
Leishmania major	cathepsin L-like protease	0.0063	0.0953	1
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0213	0.0223
Mycobacterium ulcerans	putative regulatory protein	0.0036	0.0491	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0953	1
Plasmodium vivax	vivapain-2	0.0017	0.017	0.3842
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.017	1
Entamoeba histolytica	cysteine protease, putative	0.0017	0.017	0.7621
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0726	0.0846
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0097	0.0666
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0149	0.2397	0.2368
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0213	0.1931
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.0861	0.8997
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0078	0.0043
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.017	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0017	0.017	0.0133
Leishmania major	protein kinase, putative	0.0013	0.011	0.0155
Echinococcus multilocularis	geminin	0.0499	0.8278	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0013	0.0102	0.0273
Schistosoma mansoni	hypothetical protein	0.0499	0.8278	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0213	0.0223
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.3748	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0726	0.0846
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0035	0.0009
Leishmania major	cathepsin L-like protease	0.0017	0.017	0.0863
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0726	0.0846
Brugia malayi	cathepsin L-like precursor	0.0011	0.0078	0.0043
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0726	0.7352
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0726	0.7528
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0078	0.2425
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.017	0.0455
Onchocerca volvulus		0.0028	0.0369	0.0793
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.017	0.0455
Leishmania major	cathepsin L-like protease	0.0017	0.017	0.0863
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.017	0.1472
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0057	0.0035
Onchocerca volvulus		0.0036	0.0491	0.1124
Echinococcus multilocularis	cysteine protease	0.0017	0.017	0.0172
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0013	0.0102	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0102	0.0273
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0078	0.0041
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0097	0.0666
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.017	1
Brugia malayi	hypothetical protein	0.0162	0.2607	0.2581
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.017	0.0133
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0387	0.0435
Echinococcus granulosus	single minded 2	0.0036	0.0491	0.0561
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.017	0.0172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.017	0.0455
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Trypanosoma brucei	unspecified product	0.0013	0.0113	0.0846
Echinococcus granulosus	cysteine protease	0.0009	0.0035	0.0009
Schistosoma mansoni	cpg binding protein	0.003	0.0396	0.0446
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.0953	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0726	0.0846
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0078	0.0043
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0213	0.0567
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.017	0.0172
Brugia malayi	POT family protein	0.0201	0.3273	0.3249
Trypanosoma brucei	protein kinase, putative	0.005	0.0726	0.7528
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0726	0.7525
Onchocerca volvulus		0.0017	0.017	0.0251
Echinococcus granulosus	cathepsin l1	0.0011	0.0078	0.0061
Brugia malayi	hypoxia-induced factor 1	0.0149	0.2397	0.237
Echinococcus granulosus	dna polymerase eta	0.0019	0.0213	0.0223
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0726	0.0691
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.017	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0213	0.0176
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Brugia malayi	GnHR receptor homolog	0.0558	0.9276	0.9274
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0726	1
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.017	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Echinococcus granulosus	cpg binding protein	0.003	0.0396	0.0446
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0035	0.0009
Echinococcus multilocularis	transfer RNA-Lys	0.0036	0.0491	0.0561
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0097	0.0059
Trichomonas vaginalis	guanylate cyclase, putative	0.0013	0.0102	0.0273
Loa Loa (eye worm)	POT family protein	0.0201	0.3273	0.3248
Echinococcus granulosus	cathepsin l1	0.0017	0.017	0.0172
Trichomonas vaginalis	guanylate cyclase, putative	0.0013	0.0102	0.0273
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.017	0.0172
Leishmania major	hypothetical protein, conserved	0.0023	0.028	0.2142
Trichomonas vaginalis	adenylate cyclase, putative	0.0013	0.0102	0.0273
Schistosoma mansoni	hypothetical protein	0.0405	0.669	0.8075
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0726	0.1938
Onchocerca volvulus		0.0229	0.3748	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Schistosoma mansoni	aryl hydrocarbon receptor	0.0048	0.0701	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0102	0.0065
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0213	0.1931
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0213	0.0223
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0359	0.04
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Schistosoma mansoni	cpg binding protein	0.0028	0.0369	0.0413
Schistosoma mansoni	single-minded	0.0048	0.0701	0.0816
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0213	0.0176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0369	0.0333
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0013	0.011	0.081
Echinococcus multilocularis	cysteine protease	0.0017	0.017	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0102	0.0273
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0213	0.5
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0726	0.7352
Echinococcus multilocularis	cathepsin L	0.0009	0.0035	0.0009
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.017	0.7621
Schistosoma mansoni	hypothetical protein	0.0499	0.8278	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0035	0.0094
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0013	0.0102	0.0273
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0035	0.0009
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0726	0.8639
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0055	0.002
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.011	0.081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Echinococcus granulosus	cathepsin L	0.0009	0.0035	0.0009
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0213	0.2944
Onchocerca volvulus		0.0017	0.017	0.0251
Leishmania major	DNA polymerase eta, putative	0.0019	0.0213	0.1355
Leishmania major	protein kinase, putative	0.0013	0.011	0.0155
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0953	1
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0369	0.0335
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0102	0.0066
Echinococcus granulosus	dnaJ subfamily B	0.0405	0.669	0.8075
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0726	0.1938
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0057	0.0035
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0078	0.0061
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0726	0.1938
Onchocerca volvulus		0.0013	0.0102	0.0065
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0601	1	1
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0013	0.0102	0.0065
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.017	0.0133
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0726	0.0846
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0213	0.1355
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0213	0.1931
Brugia malayi	Cathepsin L-like precursor	0.0017	0.017	0.0136
Brugia malayi	Cathepsin L-like precursor	0.0017	0.017	0.0136
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0387	0.0435
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0102	0.0728
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.0097	0.0666
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0213	0.0178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Echinococcus granulosus	aryl hydrocarbon receptor	0.0013	0.0102	0.009
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.017	0.0455
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0097	0.0059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0035	0.0094
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0213	0.0567
Leishmania major	cathepsin L-like protease	0.0063	0.0953	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0213	0.1931
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0078	0.0043
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0213	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0387	0.0435
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.017	0.7621
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0213	0.0223
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.017	0.0172
Plasmodium vivax	SET domain protein, putative	0.0029	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.2607	0.2579
Echinococcus multilocularis	dnaJ subfamily B	0.0405	0.669	0.8075
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.028	0.2665
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0213	0.0223
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0922	0.1083
Leishmania major	cathepsin L-like protease	0.0063	0.0953	1
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0213	0.2944
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.017	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0213	0.1931
Brugia malayi	Cathepsin L-like precursor	0.0017	0.017	0.0136
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.017	0.0251
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0814	1
Mycobacterium leprae	Possible regulatory protein	0.0013	0.0102	0.5
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0013	0.0102	0.009
Onchocerca volvulus		0.0017	0.017	0.0251
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0213	0.0178
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.011	0.081
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0013	0.0102	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.017	0.0455
Brugia malayi	Cathepsin L-like precursor	0.0017	0.017	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.028	0.2665
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.017	0.0172
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0013	0.0102	0.009
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0013	0.011	0.081
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.017	0.0172
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.017	0.0251
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0097	0.0061
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0953	1
Plasmodium vivax	vivapain-2	0.0017	0.017	0.3842
Brugia malayi	PAS domain containing protein	0.0048	0.0701	0.0668
Brugia malayi	bHLH-PAS transcription factor	0.0036	0.0491	0.0457
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.017	0.0455
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0726	0.7528
Echinococcus multilocularis	cpg binding protein	0.003	0.0396	0.0446
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0113	0.0846

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 73 %	Inhibition of GnRH receptor (unknown origin) at 10 uM	ChEMBL.	17920281
Inhibition (binding)	= 73 %	Inhibition of GnRH receptor (unknown origin) at 10 uM	ChEMBL.	17920281
Ki (binding)	= 2.5 uM	Inhibition of GnRH receptor (unknown origin)	ChEMBL.	17920281
Ki (binding)	= 2.5 uM	Inhibition of GnRH receptor (unknown origin)	ChEMBL.	17920281

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL260058

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 514479