Detailed information for compound 518075

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 437.876 | Formula: C23H20ClN3O4
  • H donors: 3 H acceptors: 3 LogP: 3.75 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)COc1ccc(cc1)/C=N/NC(=O)c1ccc(c(c1)Cl)O
  • InChi: 1S/C23H20ClN3O4/c1-15(28)26-19-7-2-17(3-8-19)14-31-20-9-4-16(5-10-20)13-25-27-23(30)18-6-11-22(29)21(24)12-18/h2-13,29H,14H2,1H3,(H,26,28)(H,27,30)/b25-13+
  • InChiKey: DAZQBAMNGQYHNP-DHRITJCHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus prostaglandin H2 D isomerase 0.0047 0.0346 0.0332
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0055 0.0413 0.2116
Echinococcus multilocularis tumor protein p63 0.0188 0.1626 0.1614
Echinococcus multilocularis cyclin B 0.0014 0.0042 0.0028
Schistosoma mansoni hypothetical protein 0.0021 0.0104 0.021
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0123 0.1036 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0123 0.1036 1
Echinococcus granulosus nmda type glutamate receptor 0.0201 0.1738 0.1727
Schistosoma mansoni cyclin B 0.0014 0.0042 0.0066
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0026 0.0155 0.3421
Schistosoma mansoni hypothetical protein 0.0059 0.0457 0.1029
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0123 0.1036 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0019 0.0088 0.0444
Schistosoma mansoni metabotropic glutamate receptor 0.0028 0.0169 0.0361
Echinococcus granulosus metabotropic glutamate receptor 5 0.0045 0.0324 0.031
Brugia malayi sulfakinin receptor protein 0.0059 0.0453 0.232
Schistosoma mansoni hypothetical protein 0.0012 0.0029 0.0035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Giardia lamblia Kinase, CMGC CDK 0.0014 0.0047 1
Echinococcus granulosus glutamate receptor NMDA 0.0121 0.1017 0.1005
Echinococcus multilocularis SWI:SNF matrix associated 0.0012 0.0029 0.0015
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0009 0.0001 0.0014
Schistosoma mansoni hypothetical protein 0.0019 0.0089 0.0174
Trypanosoma cruzi cdc2-related kinase 3 0.0014 0.0047 0.0044
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0098 0.0803 0.1834
Trypanosoma brucei cdc2-related kinase 1 0.0014 0.0047 0.0044
Echinococcus multilocularis survival motor neuron protein 1 0.0093 0.076 0.0747
Brugia malayi von Willebrand factor type A domain containing protein 0.0021 0.0104 0.0528
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0009 0.0001 0.0014
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0123 0.1036 1
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1028 0.9255 1
Brugia malayi glutathione transferase 0.0011 0.0014 0.0065
Schistosoma mansoni serine-rich repeat protein 0.0261 0.2285 0.528
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0029 0.0035
Loa Loa (eye worm) RGC/RGC protein kinase 0.0019 0.0088 0.0444
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0059 0.0457 0.0443
Trypanosoma cruzi cdc2-related kinase 3 0.0014 0.0047 0.0044
Brugia malayi Kelch motif family protein 0.0014 0.0042 0.0208
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0021 0.0104 0.2272
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0021 0.0104 0.0747
Chlamydia trachomatis glutamine binding protein 0.002 0.0098 1
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0011 0.0013 0.0128
Brugia malayi Cache domain containing protein 0.0224 0.1947 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0019 0.0088 0.0444
Plasmodium falciparum plasmepsin IV 0.0026 0.0155 0.1385
Echinococcus multilocularis integrin beta 2 0.0067 0.0526 0.0513
Loa Loa (eye worm) hypothetical protein 0.0059 0.0453 0.232
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0051 0.0378 0.3374
Wolbachia endosymbiont of Brugia malayi phosphoribosylamine--glycine ligase 0.0041 0.0293 0.2693
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0021 0.0104 0.009
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0116 0.0975 0.0962
Loa Loa (eye worm) glutamate receptor 2 0.0161 0.1376 0.7064
Echinococcus granulosus glutamate NMDA receptor subunit 0.026 0.2275 0.2265
Echinococcus multilocularis SWI:SNF matrix associated 0.0012 0.0029 0.0015
Loa Loa (eye worm) hypothetical protein 0.0129 0.1089 0.5591
Echinococcus multilocularis SWI:SNF matrix associated 0.0012 0.0029 0.0015
Plasmodium falciparum thrombospondin-related anonymous protein 0.0021 0.0104 0.0882
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0059 0.0457 0.0443
Loa Loa (eye worm) hypothetical protein 0.0119 0.1001 0.5135
Schistosoma mansoni brg-1 associated factor 0.0012 0.0029 0.0035
Mycobacterium tuberculosis Hypothetical protein 0.0059 0.0449 0.4337
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0011 0.002 0.0094
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.002 0.0098 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0021 0.0104 0.0528
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0213
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.002 0.0098 0.0947
Echinococcus granulosus integrin beta 2 0.0067 0.0526 0.0513
Echinococcus multilocularis cyclin dependent kinase 5 0.0014 0.0047 0.0033
Trypanosoma cruzi cdc2-related kinase 1 0.0014 0.0047 0.0044
Brugia malayi thymidylate synthase 0.0123 0.1036 0.5316
Echinococcus granulosus cyclin dependent kinase 5 0.0014 0.0047 0.0033
Schistosoma mansoni glutamate receptor kainate 0.0161 0.1376 0.3166
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0019 0.0088 0.0848
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0014 0.0047 0.0178
Echinococcus granulosus cyclin dependent kinase 1 0.0014 0.0047 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0024
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0012 0.0029 0.0015
Schistosoma mansoni ATP-binding cassette transporter 0.0161 0.1376 0.3166
Onchocerca volvulus 0.0021 0.0104 0.1006
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0505 0.4503 0.4495
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0014 0.0047 0.044
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0014 0.0047 0.044
Echinococcus multilocularis glutamate receptor NMDA 0.0121 0.1017 0.1005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0013 0.0228
Brugia malayi von Willebrand Factor 0.0021 0.0104 0.0528
Schistosoma mansoni metabotropic glutamate receptor 0.0036 0.0242 0.053
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0021 0.0104 0.0528
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0014 0.0047 0.0033
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0059 0.0449 0.4095
Brugia malayi hypothetical protein 0.0014 0.0042 0.0208
Leishmania major extracellular receptor, putative 0.0019 0.0088 0.0835
Brugia malayi hypothetical protein 0.0021 0.0104 0.0528
Entamoeba histolytica cell division protein kinase 2, putative 0.0014 0.0047 0.4424
Brugia malayi cell division control protein 2 homolog 0.0014 0.0047 0.0234
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0014 0.0042 0.0397
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.0129 0.1089 1
Schistosoma mansoni hypothetical protein 0.0261 0.2285 0.528
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.002 0.0098 0.0947
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0029 0.0587
Loa Loa (eye worm) hypothetical protein 0.0068 0.0539 0.2763
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0179 0.1547 0.1535
Schistosoma mansoni cellular tumor antigen P53 0.0028 0.0167 0.0356
Trichomonas vaginalis cyclins, putative 0.0014 0.0042 0.089
Entamoeba histolytica cyclin, putative 0.0014 0.0042 0.3996
Echinococcus granulosus survival motor neuron protein 1 0.0093 0.076 0.0747
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0021 0.0104 0.0882
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Mycobacterium ulcerans phosphoribosylamine--glycine ligase 0.0041 0.0293 0.2832
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0036 0.0242 0.0228
Echinococcus granulosus thymidylate synthase 0.0123 0.1036 0.1023
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0021 0.0104 0.0747
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0021 0.0104 0.0528
Echinococcus multilocularis voltage dependent calcium channel subunit 0.111 1 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0021 0.0104 0.0528
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0123 0.1036 0.2375
Onchocerca volvulus 0.0009 0.0001 0.0014
Brugia malayi hypothetical protein 0.0059 0.0453 0.232
Echinococcus granulosus metabotropic glutamate receptor 2 0.0036 0.0242 0.0228
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0179 0.1547 0.1535
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0444
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0051 0.0378 0.3374
Brugia malayi Protein kinase domain containing protein 0.0014 0.0047 0.0234
Echinococcus granulosus receptor type guanylyl cyclase 0.0019 0.0088 0.0074
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0021 0.0104 0.0882
Trichomonas vaginalis cyclin B, putative 0.0014 0.0042 0.089
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0019 0.0088 0.0454
Plasmodium falciparum plasmepsin VI 0.0026 0.0155 0.1385
Brugia malayi metabotropic glutamate receptor type 2 0.0028 0.0169 0.0864
Brugia malayi hypothetical protein 0.0019 0.0088 0.0444
Onchocerca volvulus 0.0019 0.0089 0.0858
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0059 0.0457 0.0443
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.026 0.2275 0.2265
Echinococcus granulosus tumor protein p63 0.0188 0.1626 0.1614
Brugia malayi Phospholipase A2 family protein 0.0068 0.0539 0.2763
Schistosoma mansoni hypothetical protein 0.0021 0.0104 0.021
Brugia malayi Immunoglobulin I-set domain containing protein 0.0021 0.0104 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Loa Loa (eye worm) integrin beta-2 0.0091 0.0739 0.379
Brugia malayi von Willebrand factor type A domain containing protein 0.0021 0.0104 0.0528
Echinococcus multilocularis tyrosine kinase 0.0019 0.0088 0.0074
Echinococcus granulosus nmda type glutamate receptor 0.014 0.1188 0.1176
Trichomonas vaginalis cyclin A, putative 0.0014 0.0042 0.089
Leishmania major cyclin 0.0014 0.0042 0.0397
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Schistosoma mansoni hypothetical protein 0.0012 0.0029 0.0035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Loa Loa (eye worm) hypothetical protein 0.0045 0.0324 0.1657
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0021 0.0104 0.0747
Brugia malayi brahma associated protein 60 kDa 0.0012 0.0029 0.0142
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0179 0.1547 0.1535
Brugia malayi Protein kinase domain containing protein 0.0055 0.0413 0.2116
Schistosoma mansoni glutamate receptor AMPA 0.0161 0.1376 0.3166
Onchocerca volvulus 0.0028 0.0167 0.1613
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0009 0.0001 0.0014
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0021 0.0104 0.0747
Loa Loa (eye worm) CUTiclin family member 0.0021 0.0104 0.0528
Trypanosoma brucei wee1-like protein kinase 0.0019 0.0088 0.0454
Entamoeba histolytica hypothetical protein 0.0019 0.0088 0.8409
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0051 0.0378 0.3374
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0019 0.0088 0.0454
Mycobacterium ulcerans short chain dehydrogenase 0.0097 0.0797 0.7693
Echinococcus granulosus leukotriene A 4 hydrolase 0.0098 0.0803 0.079
Echinococcus multilocularis nmda type glutamate receptor 0.014 0.1188 0.1176
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0026 0.0155 0.0142
Echinococcus granulosus glutamate receptor 2 0.012 0.1007 0.0994
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0009 0.0001 0.0014
Echinococcus granulosus glutamate receptor 2 0.0179 0.1547 0.1535
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Schistosoma mansoni tyrosine kinase 0.0019 0.0088 0.0172
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Toxoplasma gondii microneme protein MIC2 0.0021 0.0104 0.0747
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0019 0.0088 0.0074
Brugia malayi von Willebrand factor type A domain containing protein 0.0021 0.0104 0.0528
Brugia malayi SWIB/MDM2 domain containing protein 0.0012 0.0029 0.0142
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0019 0.0088 0.0454
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0059 0.0457 0.0443
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0211
Plasmodium falciparum plasmepsin II 0.0026 0.0155 0.1385
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Trichomonas vaginalis cyclins, putative 0.0014 0.0042 0.089
Plasmodium vivax thrombospondin-related anonymous protein 0.0021 0.0104 0.0747
Trichomonas vaginalis cyclin B, putative 0.0014 0.0042 0.089
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0001 0.0014
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0019 0.0088 0.0833
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0444
Trichomonas vaginalis cyclin B, putative 0.0014 0.0042 0.089
Schistosoma mansoni protein kinase 0.0019 0.0088 0.0172
Leishmania major malonyl-coa decarboxylase-like protein 0.0051 0.0378 0.3637
Echinococcus multilocularis glutathione S transferase 0.0037 0.0249 0.0235
Entamoeba histolytica cell division protein kinase 2, putative 0.0014 0.0047 0.4424
Brugia malayi Guanylyl cyclase protein 23 0.0019 0.0088 0.0444
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0065
Schistosoma mansoni cathepsin D (A01 family) 0.0077 0.062 0.1409
Entamoeba histolytica hypothetical protein, conserved 0.0021 0.0104 1
Brugia malayi hypothetical protein 0.0059 0.0449 0.2301
Brugia malayi Zona pellucida-like domain containing protein 0.0021 0.0104 0.0528
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0012 0.0029 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0444
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0019 0.0088 0.0444
Onchocerca volvulus 0.0021 0.0104 0.1006
Plasmodium falciparum protein kinase 5 0.0014 0.0047 0.0322
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0244 0.2134 0.4929
Schistosoma mansoni glutamate receptor kainate 0.0161 0.1376 0.3166
Echinococcus granulosus SWI:SNF matrix associated 0.0012 0.0029 0.0015
Echinococcus multilocularis thymidylate synthase 0.0123 0.1036 0.1023
Brugia malayi Cyclin, N-terminal domain containing protein 0.0014 0.0042 0.0211
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT 0.0041 0.0293 0.2832
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0011 0.002 0.0094
Brugia malayi Integrin beta pat-3 precursor 0.0091 0.0739 0.379
Brugia malayi hypothetical protein 0.0093 0.076 0.3897
Schistosoma mansoni glutamate receptor kainate 0.0161 0.1376 0.3166
Loa Loa (eye worm) hypothetical protein 0.0093 0.076 0.3897
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0059 0.0457 0.0443
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0014 0.0047 0.0234
Onchocerca volvulus 0.0019 0.0088 0.0848
Schistosoma mansoni Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) 0.0047 0.0346 0.0771
Schistosoma mansoni cathepsin D (A01 family) 0.0077 0.062 0.1409
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0179 0.1547 0.1535
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0276 0.141
Onchocerca volvulus Phospholipase A2 homolog 0.0068 0.0539 0.5205
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0211
Brugia malayi putative malonyl-CoA decarboxylase 0.0129 0.1089 0.5591
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0076 0.061 0.1386
Trichomonas vaginalis CMGC family protein kinase 0.0014 0.0047 0.0988
Trichomonas vaginalis cyclins, putative 0.0014 0.0042 0.089
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0444
Brugia malayi hypothetical protein 0.0045 0.0324 0.1659
Mycobacterium ulcerans hypothetical protein 0.0009 0.0001 0.0014
Brugia malayi von Willebrand factor type A domain containing protein 0.0021 0.0104 0.0528
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0208
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0045 0.0324 0.031
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0014 0.0047 0.0234
Brugia malayi Receptor family ligand binding region containing protein 0.0019 0.0088 0.0444
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0014 0.0042 0.0208
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0123 0.1036 1
Schistosoma mansoni tyrosine kinase 0.0019 0.0088 0.0172
Onchocerca volvulus Phospholipase A2 homolog 0.0068 0.0539 0.5205
Plasmodium vivax aspartyl proteinase, putative 0.0026 0.0155 0.1257
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Trichomonas vaginalis CMGC family protein kinase 0.0014 0.0047 0.0988
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0001 0.0014
Loa Loa (eye worm) CUTiclin-Like family member 0.0021 0.0104 0.0528
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0059 0.0457 0.0443
Echinococcus multilocularis glutamate receptor 2 0.012 0.1007 0.0994
Onchocerca volvulus 0.0123 0.1036 1
Toxoplasma gondii aspartyl protease ASP1 0.0026 0.0155 0.1257
Loa Loa (eye worm) glutamate receptor 0.004 0.0276 0.141
Brugia malayi brahma associated protein 60 kDa 0.0012 0.0029 0.0142
Entamoeba histolytica hypothetical protein 0.0021 0.0104 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0014 0.0047 0.0234
Echinococcus multilocularis NMDA receptor 0.0059 0.0457 0.0443
Onchocerca volvulus 0.0021 0.0104 0.1006
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0001 0.0014
Echinococcus multilocularis glutamate receptor 2 0.0161 0.1376 0.1364
Loa Loa (eye worm) hypothetical protein 0.0023 0.0121 0.0617
Echinococcus granulosus cyclin B 0.0014 0.0042 0.0028
Treponema pallidum hypothetical protein 0.0021 0.0104 0.0007
Entamoeba histolytica hypothetical protein, conserved 0.0021 0.0104 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0019 0.0088 0.0833
Treponema pallidum 76K protein 0.0021 0.0104 0.0007
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0021 0.0105 0.0532
Brugia malayi Glutamate receptor 1 precursor 0.0161 0.1376 0.7064
Loa Loa (eye worm) hypothetical protein 0.0079 0.0636 0.3261
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0029 0.0035
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0484 0.4316 1
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0047 0.0076
Plasmodium vivax glutathione S-transferase, putative 0.0047 0.0346 0.3146
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0019 0.0088 0.0444
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0528
Onchocerca volvulus 0.0012 0.0029 0.028
Brugia malayi Zona pellucida-like domain containing protein 0.0021 0.0104 0.0528
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0444
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0012 0.0029 0.0146
Brugia malayi von Willebrand factor type A domain containing protein 0.0021 0.0104 0.0528
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0026 0.0155 0.0329
Trypanosoma cruzi cdc2-related kinase 1 0.0014 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0224 0.1947 1
Trichomonas vaginalis cyclins, putative 0.0014 0.0042 0.089
Echinococcus granulosus glutamate receptor subunit protein glur 0.0059 0.0457 0.0443
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0179 0.1547 0.1535
Echinococcus granulosus atrial natriuretic peptide receptor 0.0019 0.0088 0.0074
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0123 0.1036 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0009 0.0001 0.0014
Onchocerca volvulus 0.0021 0.0104 0.1006
Brugia malayi von Willebrand factor type A domain containing protein 0.0021 0.0104 0.0528
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0026 0.0155 0.0142
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0179 0.1547 0.1535
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0098 0.0803 0.4119
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0413 0.0928
Schistosoma mansoni integrin beta subunit 0.0053 0.0401 0.0899
Echinococcus multilocularis glutamate receptor 2 0.0179 0.1547 0.1535
Echinococcus multilocularis cyclin dependent kinase 1 0.0014 0.0047 0.0033
Onchocerca volvulus 0.0021 0.0104 0.1006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.002 0.0006
Brugia malayi Cyclin, N-terminal domain containing protein 0.0014 0.0042 0.0211
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0121 0.0617
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0021 0.0104 0.0528
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0009 0.0001 0.0014
Echinococcus granulosus tyrosine kinase 0.0019 0.0088 0.0074
Schistosoma mansoni hypothetical protein 0.0012 0.0029 0.0035
Plasmodium vivax protein kinase Crk2 0.0014 0.0047 0.0178
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0011 0.0013 0.0128
Brugia malayi Glutamate receptor 2 precursor 0.0161 0.1376 0.7064
Trichomonas vaginalis CMGC family protein kinase 0.0014 0.0047 0.0988
Echinococcus granulosus glutathione S transferase 0.0037 0.0249 0.0235
Schistosoma mansoni glutamate receptor NMDA 0.026 0.2275 0.5257
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0013 0.0228
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0012 0.0029 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0167 0.0851
Echinococcus granulosus voltage dependent calcium channel subunit 0.0505 0.4503 0.4495
Echinococcus multilocularis receptor type guanylyl cyclase 0.0019 0.0088 0.0074
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.002 0.0006
Schistosoma mansoni glutamate receptor NMDA 0.0301 0.2647 0.6121
Trypanosoma cruzi extracellular receptor, putative 0.0019 0.0088 0.0457
Trichomonas vaginalis cyclin B, putative 0.0014 0.0042 0.089
Schistosoma mansoni glutamate receptor AMPA 0.0161 0.1376 0.3166
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0121 0.0617
Echinococcus granulosus cyclin dependent kinase 0.0014 0.0047 0.0033
Loa Loa (eye worm) thymidylate synthase 0.0123 0.1036 0.5316
Loa Loa (eye worm) brahma associated protein 0.0012 0.0029 0.0142
Echinococcus multilocularis prostaglandin H2 D isomerase 0.0047 0.0346 0.0332
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0009 0.0001 0.0014
Echinococcus multilocularis cyclin dependent kinase 0.0014 0.0047 0.0033
Plasmodium vivax plasmepsin IV, putative 0.0026 0.0155 0.1257
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0123 0.1036 1
Mycobacterium ulcerans thymidylate synthase 0.0123 0.1036 1
Giardia lamblia Kinase, CMGC CDK 0.0014 0.0047 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0123 0.1036 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0444
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0026 0.0155 0.0792
Loa Loa (eye worm) glutamate receptor 1 0.0161 0.1376 0.7064
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0019 0.0089 0.0449
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0444
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0026 0.0155 0.1257
Echinococcus granulosus collagen alpha 1VII chain 0.0021 0.0104 0.009
Onchocerca volvulus 0.0021 0.0104 0.1006
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0098 0.0803 0.079
Mycobacterium ulcerans acyl-CoA synthetase 0.0009 0.0001 0.0014
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0012 0.0029 0.0142
Echinococcus multilocularis cyclin dependent kinase 1 0.0014 0.0047 0.0033
Entamoeba histolytica elongation factor-2 kinase, putative 0.0021 0.0104 1
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0104 0.0747
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0026 0.0153 0.0323
Loa Loa (eye worm) hypothetical protein 0.0068 0.0539 0.2763
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0079 0.0638 0.0625
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0121 0.0617
Echinococcus multilocularis nmda type glutamate receptor 0.0201 0.1738 0.1727
Onchocerca volvulus 0.0021 0.0104 0.1006
Schistosoma mansoni survival motor neuron protein 0.0019 0.0089 0.0174
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0179 0.1547 0.1535
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0047 0.0076
Trypanosoma brucei cdc2-related kinase 3 0.0014 0.0047 0.0044
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0797 0.7693
Onchocerca volvulus 0.0014 0.0042 0.041
Onchocerca volvulus 0.0019 0.0088 0.0848
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0179 0.1547 0.1535
Plasmodium falciparum plasmepsin I 0.0026 0.0155 0.1385
Loa Loa (eye worm) hypothetical protein 0.0026 0.0155 0.0792
Loa Loa (eye worm) hypothetical protein 0.0109 0.0904 0.464

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) 0 Displacement of [125I]PACAP27 from PAC1R (unknown origin) expressed in HEK293f cells ChEMBL. 18272364

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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