TDR Targets

Basic information

Technical information

TDR Targets ID: 520063
Name: 1-[(1R,2R)-2-methoxy-2-(3-methoxyphenyl)cyclo hexyl]-N,N-dimethylmethanamine
MW: 277.402 | Formula: C17H27NO2
H donors: 0 H acceptors: 0 LogP: 3.08 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CO[C@@]1(CCCC[C@@H]1CN(C)C)c1cccc(c1)OC
InChi: 1S/C17H27NO2/c1-18(2)13-15-8-5-6-11-17(15,20-4)14-9-7-10-16(12-14)19-3/h7,9-10,12,15H,5-6,8,11,13H2,1-4H3/t15-,17+/m1/s1
InChiKey: VWXSFQRIRPPNDO-WBVHZDCISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[(1R,2R)-2-methoxy-2-(3-methoxyphenyl)cyclohexyl]-N,N-dimethyl-methanamine
[(1R,2R)-2-methoxy-2-(3-methoxyphenyl)cyclohexyl]methyl-dimethyl-amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	opioid receptor, mu 1	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 2	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 2	617 aa	638 aa	32.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.0177
Echinococcus granulosus	serotonin receptor	0.0021	0.0093	0.0093
Echinococcus granulosus	glycogen phosphorylase	0.0671	0.4369	0.4369
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0093	0.0213
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Toxoplasma gondii	hypothetical protein	0.0031	0.0159	0.6163
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0077	0.0077
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0013	0.0043	0.0043
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0093	0.0093
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0093	0.0213
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0182	0.1156	0.2646
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0019	0.0077	0.0177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0093	0.0213
Brugia malayi	GnHR receptor homolog	0.0021	0.0093	0.0213
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0021	0.0093	0.0093
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0093	0.0213
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0077	0.0177
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0021	0.0093	0.0213
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0077	0.0077
Echinococcus multilocularis	somatostatin receptor	0.0021	0.0093	0.0093
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1156	0.2646
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0093	0.0093
Plasmodium vivax	amine transporter, putative	0.0031	0.0159	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.0177
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0077	0.0177
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0031	0.0159	0.0363
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0031	0.0159	0.0363
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0077	0.0077
Brugia malayi	hypothetical protein	0.0021	0.0093	0.0213
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0093	0.0213
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0093	0.0093
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0093	0.0213
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0021	0.0093	0.0213
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0077	0.0177
Echinococcus multilocularis	geminin	0.0152	0.0958	0.0958
Brugia malayi	putative neuropeptide receptor NPR1	0.0021	0.0093	0.0213
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Brugia malayi	hypothetical protein	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0043	0.0098
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0013	0.0043	0.0098
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0077	0.0077
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0031	0.016	1
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0031	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Brugia malayi	CXXC zinc finger family protein	0.0024	0.0115	0.0262
Echinococcus granulosus	G protein coupled receptor 139	0.0021	0.0093	0.0093
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Echinococcus granulosus	Glycosyl transferase family 35	0.0671	0.4369	0.4369
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0031	0.016	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0093	0.0093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Echinococcus multilocularis	serotonin receptor	0.0021	0.0093	0.0093
Brugia malayi	follicle stimulating hormone receptor	0.0021	0.0093	0.0213
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0093	0.0093
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0013	0.0043	0.0043
Schistosoma mansoni	amine GPCR	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	allatostatin A receptor	0.0021	0.0093	0.0093
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0077	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.0177
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0093	0.0093
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Brugia malayi	PXA domain containing protein	0.0019	0.0077	0.0177
Echinococcus multilocularis	dro:myosuppressin receptor	0.0021	0.0093	0.0093
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0031	0.0159	0.0363
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0077	0.0077
Schistosoma mansoni	histamine h1 receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0031	0.0159	0.0363
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0077	0.0177
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0093	0.0093
Schistosoma mansoni	hypothetical protein	0.0021	0.0093	0.0213
Onchocerca volvulus		0.0182	0.1156	0.2486
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0031	0.0159	0.0363
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0051	0.0294	0.0672
Schistosoma mansoni	glycogen phosphorylase	0.0671	0.4369	1
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0159	0.0363
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0077	0.0177
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0028	0.0139	1
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	dnaJ subfamily B	0.0346	0.2231	0.2231
Schistosoma mansoni	opsin-like receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0004	0.0004
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0021	0.0093	0.0093
Echinococcus granulosus	sex peptide receptor	0.0021	0.0093	0.0093
Echinococcus granulosus	expressed protein	0.0362	0.2336	0.2336
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0093	0.0093
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0021	0.0093	0.0093
Brugia malayi	Serotonin receptor	0.0021	0.0093	0.0213
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0077	0.0077
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.0077	0.0177
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0013	0.0043	0.0043
Brugia malayi	G-protein coupled receptor	0.0021	0.0093	0.0213
Giardia lamblia	Glycogen phosphorylase	0.0671	0.4369	0.5
Loa Loa (eye worm)	histone methyltransferase	0.0008	0.0004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0671	0.4369	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0077	0.0177
Echinococcus granulosus	neuropeptide receptor A26	0.041	0.2653	0.2653
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0031	0.0159	0.0159
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0077	0.0177
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0093	0.0093
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0021	0.0093	0.0213
Loa Loa (eye worm)	norepinephrine transporter	0.0182	0.1156	0.2646
Schistosoma mansoni	hypothetical protein	0.0346	0.2231	0.5106
Plasmodium falciparum	transporter, putative	0.0031	0.0159	0.5
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0182	0.1156	0.2646
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0031	0.0159	0.0159
Brugia malayi	Serotonin receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	adenoreceptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0144	0.0331
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Entamoeba histolytica	glycogen phosphorylase, putative	0.0671	0.4369	1
Echinococcus multilocularis	expressed protein	0.0362	0.2336	0.2336
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Brugia malayi	hypothetical protein	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0004	0.0004
Brugia malayi	ORL1-like opioid receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0159	0.0363
Brugia malayi	hypothetical protein	0.0031	0.0159	0.0363
Echinococcus multilocularis	serotonin transporter	0.0182	0.1156	0.1156
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0021	0.0093	0.0213
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0021	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Schistosoma mansoni	hypothetical protein	0.0013	0.0043	0.0098
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0031	0.016	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0093	0.0213
Echinococcus granulosus	somatostatin receptor	0.0021	0.0093	0.0093
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0031	0.016	0.0194
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1156	0.2646
Onchocerca volvulus		0.0031	0.0159	0.0153
Echinococcus granulosus	dro:myosuppressin receptor	0.0021	0.0093	0.0093
Brugia malayi	larval opioid receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	inositol monophosphatase	0.0031	0.016	0.0367
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	allatostatin A receptor	0.0021	0.0093	0.0093
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0031	0.016	0.6225
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0093	0.0093
Echinococcus granulosus	cpg binding protein	0.0026	0.0124	0.0124
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0077	0.0177
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0093	0.0093
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0013	0.0043	0.0098
Brugia malayi	G protein-coupled receptor	0.0021	0.0093	0.0213
Brugia malayi	latrophilin 2 splice variant baaae	0.0029	0.0144	0.0331
Echinococcus granulosus	dnaJ subfamily B	0.0346	0.2231	0.2231
Brugia malayi	Dopamine receptor	0.0021	0.0093	0.0213
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0093	0.0093
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0021	0.0093	0.0093
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0077	0.0077
Brugia malayi	hypothetical protein	0.0021	0.0093	0.0213
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0093	0.0213
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.0177
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.029	0.1863	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0021	0.0093	0.0093
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0077	0.0077
Schistosoma mansoni	myosin xvIII	0.0021	0.0093	0.0213
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.029	0.1863	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0031	0.016	0.016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0013	0.0043	0.0043
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0031	0.0159	0.0363
Schistosoma mansoni	hypothetical protein	0.0021	0.0093	0.0213
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0077	0.0177
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	orexin receptor type 2	0.0021	0.0093	0.0093
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0021	0.0093	0.0213
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0031	0.0159	0.0363
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0031	0.016	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Brugia malayi	neuropeptide F receptor	0.0021	0.0093	0.0213
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0046	0.0258	1
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0671	0.4369	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0077	0.0077
Echinococcus multilocularis	serotonin receptor	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	fmrfamide receptor	0.0021	0.0093	0.0093
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0077	0.0177
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0021	0.0093	0.0213
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0021	0.0093	0.0213
Echinococcus granulosus	g-protein coupled receptor	0.0021	0.0093	0.0093
Brugia malayi	AKH receptor	0.0021	0.0093	0.0213
Brugia malayi	Dopamine receptor protein 1	0.0021	0.0093	0.0213
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0077	0.0177
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0031	0.0159	0.6163
Schistosoma mansoni	glycogen phosphorylase	0.0671	0.4369	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0093	0.0093
Echinococcus granulosus	glycogen phosphorylase	0.0671	0.4369	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	g-protein coupled receptor	0.0021	0.0093	0.0093
Echinococcus granulosus	7TM GPCR rhodopsin	0.0021	0.0093	0.0093
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0093	0.0213
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0077	0.0077
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0159	0.0363
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0159	0.0363
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0077	0.0177
Loa Loa (eye worm)	melatonin receptor type 1A	0.0021	0.0093	0.0213
Schistosoma mansoni	amine GPCR	0.0021	0.0093	0.0213
Echinococcus multilocularis	neuropeptide s receptor	0.041	0.2653	0.2653
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0021	0.0093	0.0213
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0021	0.0093	0.0093
Onchocerca volvulus		0.0031	0.0159	0.0153
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0021	0.0093	0.0213
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0021	0.0093	0.0213
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0671	0.4369	1
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0093	0.0093
Onchocerca volvulus		0.0024	0.0115	0.005
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0031	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	G protein coupled receptor 139	0.0021	0.0093	0.0093
Echinococcus granulosus	orexin receptor type 2	0.0021	0.0093	0.0093
Brugia malayi	F/Y-rich N-terminus family protein	0.0007	0.0004	0.0008
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0159	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0021	0.0093	0.0093
Entamoeba histolytica	glycogenphosphorylase, putative	0.029	0.1863	0.4162
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0093	0.0093
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0077	0.0077
Brugia malayi	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	hypothetical protein	0.0021	0.0093	0.0093
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0671	0.4369	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0021	0.0093	0.0093
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0077	0.0177
Brugia malayi	Inositol-1	0.0031	0.016	0.0367
Echinococcus granulosus	inositol monophosphatase 1	0.0031	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0232	0.0531
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	glycogen phosphorylase	0.0671	0.4369	0.4369
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	GPCR family 2	0.0013	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0077	0.0077
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0093	0.0213
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0021	0.0093	0.0093
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0021	0.0093	0.0093
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0031	0.016	0.0861
Brugia malayi	Melatonin receptor type 1A	0.0021	0.0093	0.0213
Schistosoma mansoni	hypothetical protein	0.0152	0.0958	0.2192
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.0177
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0031	0.016	0.0194
Trichomonas vaginalis	inositol monophosphatase, putative	0.0031	0.016	0.0194
Schistosoma mansoni	neuropeptide f receptor 76f	0.0021	0.0093	0.0213
Schistosoma mansoni	amine GPCR	0.0021	0.0093	0.0213
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0021	0.0093	0.0093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0031	0.0159	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0093	0.0093
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0077	0.0077
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0031	0.0159	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0077	0.0177
Brugia malayi	G-protein coupled receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0159	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Brugia malayi	Latrophilin receptor protein 2	0.0013	0.0043	0.0098
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0077	0.0177
Onchocerca volvulus		0.0031	0.0159	0.0153
Brugia malayi	sulfakinin receptor protein	0.0021	0.0093	0.0213
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0024	0.0115	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Schistosoma mansoni	opsin-like receptor	0.0021	0.0093	0.0213
Echinococcus granulosus	geminin	0.0152	0.0958	0.0958
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0093	0.0213
Echinococcus granulosus	sodium and chloride dependent glycine	0.0031	0.0159	0.0159
Echinococcus multilocularis	neuropeptide receptor A26	0.041	0.2653	0.2653
Brugia malayi	RE15519p	0.0021	0.0093	0.0213
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0021	0.0093	0.0093
Schistosoma mansoni	sodium/chloride dependent transporter	0.0031	0.0159	0.0363
Chlamydia trachomatis	glycogen phosphorylase	0.0671	0.4369	1
Schistosoma mansoni	hypothetical protein	0.0013	0.0043	0.0098
Brugia malayi	carbohydrate phosphorylase	0.0671	0.4369	1
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0077	0.0177
Loa Loa (eye worm)	serotonin transporter b	0.0182	0.1156	0.2646
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0182	0.1156	0.2646
Brugia malayi	neuropeptide F receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0031	0.0159	0.0159
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0031	0.0159	0.0363
Schistosoma mansoni	hypothetical protein	0.0013	0.0043	0.0098
Schistosoma mansoni	hypothetical protein	0.0152	0.0958	0.2192
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Plasmodium falciparum	amino acid transporter, putative	0.0031	0.0159	0.5
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0031	0.0159	0.0159
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0021	0.0093	0.0093
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0093	0.0213
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0093	0.0093
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0093	0.0213
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0031	0.016	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	glycogen phosphorylase	0.0671	0.4369	0.4369
Schistosoma mansoni	sodium/chloride dependent transporter	0.0031	0.0159	0.0363
Schistosoma mansoni	cpg binding protein	0.0026	0.0124	0.0283
Brugia malayi	hypothetical protein	0.0019	0.0077	0.0177
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0093	0.0213
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0093	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0093	0.0093
Brugia malayi	PXA domain containing protein	0.0019	0.0077	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Schistosoma mansoni	cpg binding protein	0.0026	0.0124	0.0283
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0077	0.0077
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0077	0.0177
Brugia malayi	G protein-coupled receptor F59B2.13	0.0021	0.0093	0.0213
Schistosoma mansoni	hypothetical protein	0.0013	0.0043	0.0098
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0093	0.0213
Brugia malayi	hypothetical protein	0.0021	0.0093	0.0213
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.0077	0.0177
Entamoeba histolytica	glycogen phosphorylase, putative	0.0671	0.4369	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0031	0.0159	0.0363
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1526	1	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0031	0.0159	0.0363
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0077	0.0177
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0021	0.0093	0.0093
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0031	0.0159	0.0159
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0042	0.0232	0.0531
Echinococcus multilocularis	GPCR, family 2	0.0013	0.0043	0.0043
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0093	0.0213
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0093	0.0093
Entamoeba histolytica	glycogen phosphorylase, putative	0.029	0.1863	0.4162
Brugia malayi	Dopamine receptor protein 2	0.0021	0.0093	0.0213
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0077	0.0177
Echinococcus multilocularis	cpg binding protein	0.0026	0.0124	0.0124
Echinococcus granulosus	neuropeptide s receptor	0.041	0.2653	0.2653
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0093	0.0093
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0021	0.0093	0.0213
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0031	0.0159	0.0363
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0031	0.0159	0.6163
Echinococcus granulosus	serotonin transporter	0.0182	0.1156	0.1156
Schistosoma mansoni	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	sodium and chloride dependent glycine	0.0031	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0031	0.0159	0.6163
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0159	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0159	0.0363
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1156	0.2646
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0042	0.0232	0.0531
Treponema pallidum	sodium- and chloride- dependent transporter	0.0182	0.1156	0.5
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	TYRA-2 protein	0.0021	0.0093	0.0213
Schistosoma mansoni	opsin-like receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0021	0.0093	0.0213
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0031	0.0159	0.0159
Brugia malayi	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0093	0.0093
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0021	0.0093	0.0213
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0021	0.0093	0.0213
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0021	0.0093	0.0213
Brugia malayi	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0093	0.0093
Schistosoma mansoni	glycogen phosphorylase	0.029	0.1863	0.4265
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0077	0.0177
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0021	0.0093	0.0213
Schistosoma mansoni	hypothetical protein	0.0029	0.0144	0.0331
Schistosoma mansoni	inositol monophosphatase	0.0031	0.016	0.0367
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0077	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0093	0.0093
Toxoplasma gondii	hypothetical protein	0.0031	0.0159	0.6163
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	amine GPCR	0.0021	0.0093	0.0213
Loa Loa (eye worm)	inositol-1	0.0031	0.016	0.0367
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0093	0.0093
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0031	0.0159	0.0363
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0031	0.0159	0.0159
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0042	0.0232	0.0531
Entamoeba histolytica	glycogen phosphorylase, putative	0.029	0.1863	0.4162
Loa Loa (eye worm)	glycogen phosphorylase	0.0671	0.4369	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0077	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Brugia malayi	putative neuropeptide receptor	0.0021	0.0093	0.0213
Schistosoma mansoni	cpg binding protein	0.0024	0.0115	0.0262
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0028	0.0139	0.0745
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0077	0.0177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0093	0.0213
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0093	0.0093
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0031	0.016	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0182	0.1156	0.2646
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.0077	0.0077
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0093	0.0213
Echinococcus multilocularis	sex peptide receptor	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0031	0.0159	0.0363
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0093	0.0213
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0021	0.0093	0.0093
Schistosoma mansoni	amine GPCR	0.0021	0.0093	0.0213

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 0.7 mg kg-1	Analgesic activity in iv dosed Sprague-Dawley rat by tail-flick model of pain	ChEMBL.	18242987
F (ADMET)	= 11 %	Bioavailability in iv dosed Sprague-Dawley rat	ChEMBL.	18242987
IC50 (binding)	= 161 nM	Inhibition of NET (unknown origin) mediated norepinephrine uptake	ChEMBL.	18242987
IC50 (binding)	= 161 nM	Inhibition of NET (unknown origin) mediated norepinephrine uptake	ChEMBL.	18242987
IC50 (binding)	= 927 nM	Inhibition of SERT (unknown origin) mediated 5-hydroxytryptamine uptake	ChEMBL.	18242987
IC50 (binding)	= 927 nM	Inhibition of SERT (unknown origin) mediated 5-hydroxytryptamine uptake	ChEMBL.	18242987
IC50 (binding)	= 7870 nM	Binding affinity to mu opioid receptor (unknown origin)	ChEMBL.	18242987
IC50 (binding)	= 7870 nM	Binding affinity to mu opioid receptor (unknown origin)	ChEMBL.	18242987
Stability (ADMET)	= 85 %	Stability in human liver S9 fraction after 60 mins	ChEMBL.	18242987
Stabilty (ADMET)	= 12 %	Stability in rat liver S9 fraction after 60 mins	ChEMBL.	18242987
Stabilty (ADMET)	= 17 %	Stability in rat liver microsome after 60 mins	ChEMBL.	18242987
Stabilty (ADMET)	= 82 %	Stability in human liver microsome after 60 mins	ChEMBL.	18242987
Stabilty (ADMET)	= 85 %	Stability in human liver S9 fraction after 60 mins	ChEMBL.	18242987
Time (functional)	= 20 min	Analgesic activity in iv dosed Sprague-Dawley rat assessed as duration of effect by tail-flick model of pain	ChEMBL.	18242987

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL272533
PubChem: 12149037

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 520063