TDR Targets

Basic information

Technical information

TDR Targets ID: 520520
Name: N-[5-(2,3-difluorophenyl)-1-(2-methoxyethyl)- 2-oxopyridin-3-yl]-4-(2-oxo-3H-imidazo[4,5-b] pyridin-1-yl)piperidine-1-carboxamide
MW: 524.519 | Formula: C26H26F2N6O4
H donors: 2 H acceptors: 4 LogP: 1.35 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: COCCn1cc(cc(c1=O)NC(=O)N1CCC(CC1)n1c(=O)[nH]c2c1cccn2)c1cccc(c1F)F
InChi: 1S/C26H26F2N6O4/c1-38-13-12-33-15-16(18-4-2-5-19(27)22(18)28)14-20(24(33)35)30-25(36)32-10-7-17(8-11-32)34-21-6-3-9-29-23(21)31-26(34)37/h2-6,9,14-15,17H,7-8,10-13H2,1H3,(H,30,36)(H,29,31,37)
InChiKey: HDSIIFGJFJZGPL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[5-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxo-3-pyridyl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide
N-[5-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxo-3-pyridyl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxamide
N-[5-(2,3-difluorophenyl)-1-(2-methoxyethyl)-2-oxo-pyridin-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide
N-[5-(2,3-difluorophenyl)-2-keto-1-(2-methoxyethyl)-3-pyridyl]-4-(2-keto-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calcitonin receptor-like	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	calcitonin receptor-like	461 aa	434 aa	28.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Toxoplasma gondii	transporter, major facilitator family protein	0.0064	0.0211	0.0305
Leishmania major	glucose transporter, lmgt1	0.014	0.0615	0.867
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0061	0.0725
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0061	0.0573
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0061	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0061	0.0268
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0139	0.0606	0.1655
Toxoplasma gondii	protein kinase, putative	0.128	0.6615	1
Leishmania major	hypothetical protein, conserved	0.0035	0.0061	0.0854
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0163	0.0733	0.324
Onchocerca volvulus		0.0064	0.0211	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0101	0.0408	0.5689
Echinococcus granulosus	solute carrier family 22	0.0064	0.0211	0.0558
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0453	0.2261	0.6247
Brugia malayi	hypothetical protein	0.0074	0.0263	0.1164
Trichomonas vaginalis	sugar transport protein, putative	0.0064	0.0211	0.0894
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0061	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Plasmodium vivax	hexose transporter	0.0453	0.2261	0.2253
Entamoeba histolytica	protein kinase, putative	0.0139	0.0606	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0732	0.373	0.5632
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0051	0.0147	0.038
Trichomonas vaginalis	conserved hypothetical protein	0.014	0.0615	0.269
Echinococcus multilocularis	tumor protein p63	0.0337	0.1648	0.4546
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Onchocerca volvulus		0.0064	0.0211	1
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0025	0.001	0.0241
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0453	0.2261	0.6247
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0025	0.001	0.0166
Plasmodium falciparum	lysine--tRNA ligase	0.0101	0.0408	0.0399
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0025	0.001	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Echinococcus granulosus	GPCR family 2	0.0051	0.0147	0.038
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0263	0.0703
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0101	0.0408	1
Echinococcus granulosus	calcium dependent protein kinase	0.013	0.0561	0.1529
Onchocerca volvulus		0.0064	0.0211	1
Schistosoma mansoni	hypothetical protein	0.0051	0.0147	0.038
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0061	0.0573
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0139	0.0606	0.1655
Echinococcus granulosus	survival motor neuron protein 1	0.0229	0.1082	0.2977
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0025	0.001	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Entamoeba histolytica	hypothetical protein	0.0074	0.0263	0.4343
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.1057	1
Trichomonas vaginalis	sugar transporter, putative	0.014	0.0615	0.269
Brugia malayi	lysyl-tRNA synthetase	0.0101	0.0408	0.1805
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0163	0.0733	0.324
Echinococcus multilocularis	GPCR, family 2	0.0051	0.0147	0.038
Echinococcus granulosus	lysyl tRNA synthetase	0.0101	0.0408	0.1105
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0136	0.0591	0.1613
Brugia malayi	glycyl-tRNA synthetase	0.0025	0.001	0.0043
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0061	0.0141
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0061	0.0226
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0139	0.0606	0.1655
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0061	0.0573
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0453	0.2261	0.6247
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0061	0.0226
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0086	0.0328	0.31
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0732	0.373	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0061	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0733	0.324
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0139	0.0606	0.268
Trypanosoma brucei	glucose transporter 2A	0.014	0.0615	0.8651
Loa Loa (eye worm)	sugar transporter	0.0064	0.0211	0.0933
Echinococcus granulosus	solute carrier family 22	0.0064	0.0211	0.0558
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0101	0.0408	0.5689
Leishmania major	myo-inositol/proton symporter (MIT)	0.0064	0.0211	0.2973
Leishmania major	glucose transporter, lmgt3	0.014	0.0615	0.867
Schistosoma mansoni	sugar transporter	0.0064	0.0211	0.0558
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0453	0.2261	0.6247
Onchocerca volvulus		0.0035	0.0061	0.2871
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Onchocerca volvulus		0.0035	0.0061	0.2871
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0211	0.0894
Trypanosoma brucei	glucose transporter 1E	0.014	0.0615	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0211	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0139	0.0606	0.1655
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0061	0.0226
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0139	0.0606	0.0597
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0139	0.0606	0.0597
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0051	0.0147	0.038
Onchocerca volvulus		0.0049	0.0135	0.6401
Trypanosoma brucei	sugar transporter, putative	0.0064	0.0211	0.2874
Schistosoma mansoni	lysyl-tRNA synthetase	0.0101	0.0408	0.1105
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0732	0.373	0.3724
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0064	0.0211	0.0558
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0061	0.1485
Onchocerca volvulus		0.0064	0.0211	1
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0122	0.0311
Entamoeba histolytica	hypothetical protein	0.0074	0.0263	0.4343
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0263	0.0703
Brugia malayi	beta-lactamase family protein	0.0035	0.0061	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0061	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0061	0.0268
Mycobacterium ulcerans	integral membrane transport protein	0.0064	0.0211	0.5172
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0139	0.0606	0.0597
Loa Loa (eye worm)	hypothetical protein	0.011	0.0457	0.2022
Onchocerca volvulus		0.0064	0.0211	1
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0061	0.1485
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Schistosoma mansoni	glucose transport protein	0.0453	0.2261	0.6247
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0025	0.001	0.0162
Trichomonas vaginalis	esterase, putative	0.0035	0.0061	0.0226
Onchocerca volvulus		0.0064	0.0211	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0453	0.2261	0.6247
Trichomonas vaginalis	conserved hypothetical protein	0.014	0.0615	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1923	1	1
Echinococcus granulosus	General substrate transporter	0.0389	0.1926	0.5316
Onchocerca volvulus		0.0064	0.0211	1
Echinococcus multilocularis	solute carrier family 22	0.0064	0.0211	0.0558
Echinococcus granulosus	solute carrier family 22	0.0064	0.0211	0.0558
Giardia lamblia	Hexose transporter	0.0064	0.0211	0.346
Schistosoma mansoni	glucose transport protein	0.0453	0.2261	0.6247
Toxoplasma gondii	sugar transporter ST3	0.0064	0.0211	0.0305
Echinococcus multilocularis	solute carrier family 22	0.0064	0.0211	0.0558
Echinococcus multilocularis	solute carrier family 22	0.0064	0.0211	0.0558
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.014	0.0615	0.269
Brugia malayi	latrophilin 2 splice variant baaae	0.0111	0.0461	0.2041
Schistosoma mansoni	protein kinase	0.0139	0.0606	0.1655
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0591	0.2615
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0051	0.0147	0.0649
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0061	0.0268
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0025	0.001	0.0043
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0101	0.0408	0.6902
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0136	0.0591	0.1613
Onchocerca volvulus		0.0064	0.0211	1
Brugia malayi	Major Facilitator Superfamily protein	0.0064	0.0211	0.0933
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0061	0.0725
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0061	0.0573
Onchocerca volvulus		0.0064	0.0211	1
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0025	0.001	0.0241
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0064	0.0211	0.2874
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0101	0.0408	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.014	0.0615	0.8651
Trypanosoma brucei	glucose transporter, putative	0.014	0.0615	0.8651
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0158	0.071	1
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Schistosoma mansoni	hypothetical protein	0.0051	0.0147	0.038
Chlamydia trachomatis	lysine--tRNA ligase	0.0101	0.0408	1
Echinococcus multilocularis	General substrate transporter	0.0389	0.1926	0.5316
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0061	0.0573
Echinococcus multilocularis	solute carrier family 22	0.0064	0.0211	0.0558
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0139	0.0606	0.1655
Plasmodium falciparum	hexose transporter	0.0453	0.2261	0.2253
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Trypanosoma cruzi	sugar transporter, putative	0.0064	0.0211	0.2874
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Trypanosoma cruzi	glucose transporter, putative	0.0064	0.0211	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0139	0.0606	0.1655
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Schistosoma mansoni	hypothetical protein	0.0051	0.0147	0.038
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0139	0.0606	0.0597
Schistosoma mansoni	serine/threonine protein kinase	0.0139	0.0606	0.1655
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0136	0.0591	0.2615
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0139	0.0606	0.1655
Giardia lamblia	Lysyl-tRNA synthetase	0.0101	0.0408	0.6849
Trichomonas vaginalis	conserved hypothetical protein	0.0453	0.2261	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0101	0.0408	0.1105
Trichomonas vaginalis	sugar transporter, putative	0.014	0.0615	0.269
Onchocerca volvulus		0.0064	0.0211	1
Trichomonas vaginalis	myo-inositol transporter, putative	0.0064	0.0211	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0606	0.268
Trypanosoma brucei	glucose transporter, putative	0.014	0.0615	0.8651
Entamoeba histolytica	hypothetical protein	0.0074	0.0263	0.4343
Brugia malayi	hypothetical protein	0.0064	0.0211	0.0933
Trypanosoma cruzi	hexose transporter	0.014	0.0615	0.8651
Brugia malayi	Sugar transporter family protein	0.0453	0.2261	1
Trypanosoma brucei	glucose transporter, putative	0.014	0.0615	0.8651
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0061	0.1025
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0263	0.0703
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0056	0.0169	0.0749
Trichomonas vaginalis	glucose transporter, putative	0.014	0.0615	0.269
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0136	0.0591	0.2583
Entamoeba histolytica	hypothetical protein	0.0074	0.0263	0.4343
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0064	0.0211	1
Plasmodium vivax	sugar transporter, putative	0.0064	0.0211	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0061	0.0268
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0061	0.0226
Schistosoma mansoni	hypothetical protein	0.0047	0.0122	0.0311
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0163	0.0733	0.324
Echinococcus granulosus	solute carrier family 22	0.0064	0.0211	0.0558
Onchocerca volvulus		0.0064	0.0211	1
Chlamydia trachomatis	proline--tRNA ligase	0.0048	0.0128	0.2978
Trichomonas vaginalis	sugar transporter, putative	0.014	0.0615	0.269
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0158	0.071	1
Echinococcus granulosus	microtubule associated protein 2	0.071	0.3614	1
Loa Loa (eye worm)	sugar transporter	0.0453	0.2261	1
Onchocerca volvulus		0.0064	0.0211	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0061	0.1025
Onchocerca volvulus		0.0064	0.0211	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.014	0.0615	0.867
Onchocerca volvulus		0.0035	0.0061	0.2871
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0158	0.071	1
Plasmodium falciparum	protein kinase 7	0.128	0.6615	0.6612
Schistosoma mansoni	microtubule-associated protein tau	0.071	0.3614	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0158	0.071	1
Brugia malayi	Sugar transporter family protein	0.0064	0.0211	0.0933
Schistosoma mansoni	hypothetical protein	0.0453	0.2261	0.6247
Brugia malayi	Cam kinase protein 1	0.0139	0.0606	0.268
Brugia malayi	beta-lactamase	0.0035	0.0061	0.0268
Trypanosoma cruzi	hexose transporter, putative	0.014	0.0615	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Toxoplasma gondii	ABC1 family protein	0.0035	0.0061	0.0077
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0064	0.0211	0.5172
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0211	0.0894
Entamoeba histolytica	hypothetical protein	0.0101	0.0408	0.6733
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0025	0.001	0.0043
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	0.1082	0.2977
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Brugia malayi	hypothetical protein	0.0229	0.1082	0.4788
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0061	0.0268
Brugia malayi	major facilitator superfamily protein	0.0064	0.0211	0.0933
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Mycobacterium ulcerans	lipase LipD	0.0035	0.0061	0.1485
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0101	0.0408	0.1769
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0061	0.0573
Trypanosoma cruzi	hexose transporter, putative	0.014	0.0615	0.8651
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0453	0.2261	0.6247
Leishmania major	threonyl-tRNA synthetase, putative	0.0025	0.001	0.0138
Entamoeba histolytica	protein kinase, putative	0.0139	0.0606	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0061	0.0268
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0139	0.0606	0.268
Schistosoma mansoni	protein kinase	0.0139	0.0606	0.1655
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0139	0.0606	0.0597
Trichomonas vaginalis	CAMK family protein kinase	0.0139	0.0606	0.2648
Trypanosoma brucei	glucose transporter, putative	0.014	0.0615	0.8651
Echinococcus granulosus	tumor protein p63	0.0337	0.1648	0.4546
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0591	0.2615
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0139	0.0606	0.0903
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0139	0.0606	0.0597
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0122	0.0539
Brugia malayi	hypothetical protein	0.0064	0.0211	0.0933
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Toxoplasma gondii	sugar transporter ST1	0.0064	0.0211	0.0305
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0061	0.0141
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0139	0.0606	0.8517
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0061	0.1485
Echinococcus multilocularis	microtubule associated protein 2	0.071	0.3614	1
Plasmodium falciparum	proline--tRNA ligase	0.0158	0.071	0.0701
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0064	0.0211	0.0558
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0048	0.0128	0.3147
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0051	0.0147	0.038
Toxoplasma gondii	sugar transporter ST2	0.0064	0.0211	0.0305
Toxoplasma gondii	facilitative glucose transporter GT1	0.0453	0.2261	0.3408
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0061	0.0573
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0453	0.2261	0.6247
Schistosoma mansoni	hypothetical protein	0.0074	0.0263	0.0703
Trypanosoma brucei	glucose transporter, putative	0.014	0.0615	0.8651
Giardia lamblia	Prolyl-tRNA synthetase	0.0136	0.0591	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0061	0.0573
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0136	0.0591	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0139	0.0606	0.268
Giardia lamblia	Sugar-proton symporter	0.0064	0.0211	0.346
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0211	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0025	0.001	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0061	0.0268
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0064	0.0211	0.1996
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0086	0.0328	0.5544
Leishmania major	lysyl-tRNA synthetase, putative	0.0101	0.0408	0.5749
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0139	0.0606	0.0597
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0064	0.0211	0.5172
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Brugia malayi	beta-lactamase family protein	0.0035	0.0061	0.0268
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0064	0.0211	0.0558
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0061	0.1485
Schistosoma mansoni	glucose transport protein	0.0453	0.2261	0.6247
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0158	0.071	0.106
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0135	0.0348
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0136	0.0591	0.2615
Trypanosoma brucei	THT1 - hexose transporter, putative	0.014	0.0615	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0211	0.0894
Trypanosoma brucei	glucose transporter, putative	0.014	0.0615	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Trypanosoma brucei	glucose transporter, putative	0.014	0.0615	0.8651
Brugia malayi	Major Facilitator Superfamily protein	0.0064	0.0211	0.0933
Schistosoma mansoni	hypothetical protein	0.0051	0.0147	0.038
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0064	0.0211	0.1996
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Leishmania major	hypothetical protein, conserved	0.0064	0.0211	0.2973
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0064	0.0211	0.0933
Schistosoma mansoni	sugar transporter	0.0064	0.0211	0.0558
Plasmodium vivax	lysine--tRNA ligase, putative	0.0101	0.0408	0.0399
Trypanosoma brucei	glucose transporter, putative	0.014	0.0615	0.8651
Brugia malayi	major facilitator superfamily protein	0.0064	0.0211	0.0933
Schistosoma mansoni	glucose transporter	0.0064	0.0211	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0461	0.2041
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0025	0.001	0.0043
Treponema pallidum	prolyl-tRNA synthetase	0.0048	0.0128	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0061	0.0141
Schistosoma mansoni	hypothetical protein	0.0111	0.0461	0.1253
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0051	0.0147	0.038
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0229	0.1082	0.4788
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0064	0.0211	0.0558
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Plasmodium vivax	proline--tRNA ligase, putative	0.0158	0.071	0.0701
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0136	0.0591	0.9756
Onchocerca volvulus		0.0064	0.0211	1
Onchocerca volvulus		0.0064	0.0211	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0061	0.0268
Brugia malayi	hypothetical protein	0.0064	0.0211	0.0933
Schistosoma mansoni	sugar transporter	0.0064	0.0211	0.0558
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0211	0.0894
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0136	0.0591	0.1613
Trypanosoma cruzi	hexose transporter, putative	0.014	0.0615	0.8651
Onchocerca volvulus	Putative transporter	0.0064	0.0211	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.014	0.0615	0.8651
Brugia malayi	Latrophilin receptor protein 2	0.0051	0.0147	0.0649
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0139	0.0606	0.0597
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0089	0.0342	0.1477
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0086	0.0328	0.31
Mycobacterium ulcerans	sugar transporter	0.0064	0.0211	0.5172
Onchocerca volvulus		0.0064	0.0211	1
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0139	0.0606	0.0903
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0453	0.2261	0.6247
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0139	0.0606	0.1655
Brugia malayi	Major Facilitator Superfamily protein	0.0064	0.0211	0.0933
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0147	0.0649
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0061	0.0141
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0061	0.0573
Trypanosoma cruzi	hexose transporter, putative	0.0077	0.028	0.386
Echinococcus granulosus	synaptic vesicle 2 protein	0.0064	0.0211	0.0558
Leishmania major	glucose transporter, lmgt2	0.014	0.0615	0.867
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0158	0.071	1
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Brugia malayi	Sugar transporter family protein	0.0064	0.0211	0.0933
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0064	0.0211	0.0201
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0064	0.0211	0.0933
Trichomonas vaginalis	glucose transporter, putative	0.0064	0.0211	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0139	0.0606	0.0903
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0061	0.0573
Echinococcus multilocularis	calcium dependent protein kinase	0.013	0.0561	0.1529
Echinococcus multilocularis	lysyl tRNA synthetase	0.0101	0.0408	0.1105
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0025	0.001	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0135	0.0597
Onchocerca volvulus		0.0047	0.0122	0.5771
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0408	0.1805
Leishmania major	protein kinase, putative	0.0139	0.0606	0.8538
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0211	0.0933
Schistosoma mansoni	sugar transporter	0.0064	0.0211	0.0558
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0136	0.0591	0.1613
Toxoplasma gondii	lysine-tRNA ligase	0.0101	0.0408	0.0603
Schistosoma mansoni	protein kinase	0.0139	0.0606	0.1655
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0211	0.0894
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0051	0.0147	0.0649
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0139	0.0606	0.0597

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 164 nM	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	ChEMBL.	18039571
IC50 (functional)	= 164 nM	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation by cell based assay	ChEMBL.	18039571
IC50 (functional)	= 1004 nM	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assay	ChEMBL.	18039571
IC50 (functional)	= 1004 nM	Antagonist activity at human recombinant CL receptor /RAMP1 assessed as inhibition of cAMP accumulation in presence of 50% human serum by cell based assay	ChEMBL.	18039571
Ki (binding)	= 41 nM	Displacement of [125I]CGRP from human recombinant CL receptor /RAMP1	ChEMBL.	18039571
Ki (binding)	= 41 nM	Displacement of [125I]CGRP from human recombinant CL receptor /RAMP1	ChEMBL.	18039571

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL257094
PubChem: 11848908

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 520520