Detailed information for compound 52150

Basic information

Technical information
  • TDR Targets ID: 52150
  • Name: S-ethyl (2E,4E)-11-methoxy-3,7,11-trimethyldo deca-2,4-dienethioate
  • MW: 312.51 | Formula: C18H32O2S
  • H donors: 0 H acceptors: 1 LogP: 5.53 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSC(=O)/C=C(/C=C/CC(CCCC(OC)(C)C)C)\C
  • InChi: 1S/C18H32O2S/c1-7-21-17(19)14-16(3)11-8-10-15(2)12-9-13-18(4,5)20-6/h8,11,14-15H,7,9-10,12-13H2,1-6H3/b11-8+,16-14+
  • InChiKey: YGBMMMOLNODPBP-GWGZPXPZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • S-ethyl (2E,4E)-11-methoxy-3,7,11-trimethyl-dodeca-2,4-dienethioate
  • (2E,4E)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienethioic acid S-ethyl ester
  • (2E,4E)-11-methoxy-3,7,11-trimethyl-dodeca-2,4-dienethioic acid S-ethyl ester
  • ZR 0619
  • 42583-44-8
  • 40596-80-3
  • 11-Methoxy-3,7,11-trimethyl-2,4-dodecadienethioic acid, S-ethyl ester
  • (E,E)-11-Methoxy-3,7,11-trimethyl-2,4-dodecadienethioic acid S-ethyl ester
  • (E,E)-S-Ethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienethioate
  • 2,4-Dodecadienethioic acid, 11-methoxy-3,7,11-trimethyl-, S-ethyl ester, (E,E)-
  • 2,4-Dodecadienethioic acid, 11-methoxy-3,7,11-trimethyl-, S-ethyl ester, (E,E)- (9CI)
  • BRN 1877917
  • ENT 70513
  • FR 619
  • RZ 619
  • S-Ethyl (E,E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienethioate
  • S-Ethyl 11-methoxy-3,7,11-trimethyl-2E,4E-dodecadienethioate
  • Triprene
  • Triprene [ANSI]
  • ZR-619
  • ZR-0619

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0142 0.0656 0.105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0647 0.1037
Brugia malayi hypothetical protein 0.0105 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Echinococcus granulosus endothelin converting enzyme 1 0.0186 0.0885 0.1419
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0098
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0244 0.0244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Echinococcus multilocularis adenylate cyclase type IX 0.008 0.033 0.0526
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.006 0.009
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0045 0.0067
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0142 0.0656 0.105
Loa Loa (eye worm) neuropeptide F receptor 0.0142 0.0656 0.0652
Echinococcus granulosus neuropeptide s receptor 0.0142 0.0656 0.105
Trichomonas vaginalis set domain proteins, putative 0.0231 0.112 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0045 0.0067
Echinococcus granulosus neuropeptides capa receptor 0.0142 0.0656 0.105
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0656 0.105
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0186 0.0885 0.0885
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0015 0.0098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0015 0.0098
Schistosoma mansoni hypothetical protein 0.0136 0.0625 0.1001
Brugia malayi G-protein coupled receptor 0.0142 0.0656 0.0656
Echinococcus granulosus geminin 0.0329 0.1633 0.2626
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0045 0.0045
Brugia malayi AKH receptor 0.0142 0.0656 0.0656
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0142 0.0656 0.105
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.4158 0.6692
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0244 0.024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0656 0.105
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0094 0.0404 0.0645
Echinococcus granulosus dnaJ subfamily B 0.1205 0.6211 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0142 0.0656 0.105
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0254 0.2064
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0057 0.0086
Brugia malayi G protein-coupled receptor F59B2.13 0.0142 0.0656 0.0656
Schistosoma mansoni neuropeptide receptor 0.0142 0.0656 0.105
Echinococcus granulosus tm gpcr rhodopsin 0.0142 0.0656 0.105
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0142 0.0656 0.0652
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0142 0.0656 0.105
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0656 0.105
Schistosoma mansoni neprilysin-2 (M13 family) 0.0094 0.0404 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0045 0.0045
Brugia malayi nuclear receptor NHR-88 0.0025 0.0045 0.0045
Echinococcus granulosus tumor protein p63 0.0344 0.1714 0.2756
Schistosoma mansoni hypothetical protein 0.0142 0.0656 0.105
Brugia malayi peptidase family M13 containing protein 0.0045 0.0151 0.0151
Echinococcus multilocularis g protein coupled receptor 0.0142 0.0656 0.105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0075 0.0115
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.003 0.0042
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0075 0.0115
Brugia malayi Pre-SET motif family protein 0.0203 0.0975 0.0975
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0656 0.105
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0142 0.0656 0.0656
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0142 0.0656 0.105
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.0357 0.0353
Loa Loa (eye worm) neuropeptide F receptor 0.0142 0.0656 0.0652
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0045 0.0067
Brugia malayi neuropeptide F receptor 0.0142 0.0656 0.0656
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0142 0.0656 0.1392
Echinococcus multilocularis allatostatin A receptor 0.0142 0.0656 0.105
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0098
Schistosoma mansoni amine GPCR 0.0142 0.0656 0.105
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0142 0.0656 0.0656
Echinococcus granulosus G protein coupled receptor 139 0.0142 0.0656 0.105
Echinococcus granulosus serotonin receptor 0.0142 0.0656 0.105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0015 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0647 0.1037
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0092 0.0395 0.0392
Loa Loa (eye worm) hypothetical protein 0.0199 0.0954 0.0951
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0142 0.0656 0.105
Schistosoma mansoni neuropeptide F-like receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0042
Schistosoma mansoni biogenic amine (5HT) receptor 0.0142 0.0656 0.105
Onchocerca volvulus 0.0142 0.0656 0.1392
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0254 0.2064
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0015
Schistosoma mansoni adenoreceptor 0.0142 0.0656 0.105
Brugia malayi larval opioid receptor 0.0142 0.0656 0.0656
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0244 0.0386
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0045 0.0067
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0045 0.0067
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0045 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.0142 0.0656 0.105
Echinococcus multilocularis neuropeptides capa receptor 0.0142 0.0656 0.105
Schistosoma mansoni neuropeptide receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) peptidase family M13 containing protein 0.0137 0.0631 0.0628
Onchocerca volvulus 0.0142 0.0656 0.1392
Schistosoma mansoni neprilysin 0.0048 0.0168 0.0264
Onchocerca volvulus 0.0142 0.0656 0.1392
Loa Loa (eye worm) peptidase family M13 containing protein 0.0137 0.0631 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0048 0.0168 0.0264
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Echinococcus granulosus orexin receptor type 2 0.0142 0.0656 0.105
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0142 0.0656 0.105
Echinococcus granulosus dna polymerase kappa 0.0019 0.0013 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Onchocerca volvulus 0.0054 0.0198 0.0415
Loa Loa (eye worm) hypothetical protein 0.014 0.0648 0.0645
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0045 0.0067
Loa Loa (eye worm) hypothetical protein 0.1004 0.516 0.5158
Schistosoma mansoni hypothetical protein 0.0063 0.0244 0.0386
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0142 0.0656 0.105
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0094 0.0404 0.0645
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0647 0.1037
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Echinococcus granulosus hypothetical protein 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Onchocerca volvulus 0.0092 0.0395 0.0836
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0656 0.105
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0625 0.0625
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.0954 0.0951
Brugia malayi ecdysteroid receptor 0.0025 0.0045 0.0045
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0004 0.0004
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0047 0.0282
Echinococcus multilocularis dnaJ subfamily B 0.1205 0.6211 1
Echinococcus multilocularis sex peptide receptor 0.0142 0.0656 0.105
Onchocerca volvulus 0.0142 0.0656 0.1392
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0045 0.0067
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0075 0.0115
Loa Loa (eye worm) hypothetical protein 0.0137 0.0631 0.0628
Schistosoma mansoni myosin xvIII 0.0142 0.0656 0.105
Brugia malayi hypothetical protein 0.0142 0.0656 0.0656
Leishmania major DNA polymerase eta, putative 0.0019 0.0013 0.0076
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Echinococcus multilocularis tumor protein p63 0.0344 0.1714 0.2756
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0142 0.0656 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0057 0.0211 0.0442
Brugia malayi hypothetical protein 0.0142 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0031 0.0075 0.0071
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0178 0.0281
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0045 0.0067
Plasmodium falciparum telomerase reverse transcriptase 0.0249 0.1218 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0047 0.0355
Schistosoma mansoni coup transcription factor 0.0025 0.0045 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0656 0.105
Loa Loa (eye worm) TYRA-2 protein 0.0142 0.0656 0.0652
Echinococcus multilocularis neuropeptide receptor A26 0.0142 0.0656 0.105
Echinococcus granulosus dro:myosuppressin receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Echinococcus granulosus neuropeptide receptor 0.0142 0.0656 0.105
Brugia malayi Telomerase reverse transcriptase 0.0664 0.3382 0.3382
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0186 0.0885 0.1419
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0045 0.0089
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.003 0.0042
Schistosoma mansoni biogenic amine receptor 0.0142 0.0656 0.105
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0013 0.0015
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0142 0.0656 0.105
Echinococcus multilocularis g protein coupled receptor 0.0142 0.0656 0.105
Echinococcus multilocularis GPCR, family 2 0.0063 0.0244 0.0386
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0254 0.2064
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0045 0.0045
Brugia malayi Peptidase family M13 containing protein 0.0186 0.0885 0.0885
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0045 0.0151 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0098
Echinococcus multilocularis neuropeptide receptor 0.0245 0.1192 0.1915
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.0151 0.0237
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Leishmania major telomerase reverse transcriptase, putative 0.0249 0.1218 1
Onchocerca volvulus 0.0025 0.0045 0.0089
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0142 0.0656 0.0652
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0045 0.0045
Brugia malayi CXXC zinc finger family protein 0.0085 0.0357 0.0357
Schistosoma mansoni neuropeptide f receptor 76f 0.0142 0.0656 0.105
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0045 0.0067
Loa Loa (eye worm) G-protein coupled receptor 0.0142 0.0656 0.0652
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0045 0.0067
Toxoplasma gondii histone lysine methyltransferase SET1 0.0161 0.0758 0.621
Brugia malayi Dopamine receptor 0.0142 0.0656 0.0656
Brugia malayi hypothetical protein 0.0105 0.0463 0.0463
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0045 0.0067
Schistosoma mansoni growth hormone secretagogue receptor 0.0142 0.0656 0.105
Schistosoma mansoni biogenic amine (5HT) receptor 0.0142 0.0656 0.105
Schistosoma mansoni opsin-like receptor 0.0142 0.0656 0.105
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0047 0.0355
Onchocerca volvulus 0.0142 0.0656 0.1392
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0047 0.0355
Brugia malayi G protein-coupled receptor 0.0142 0.0656 0.0656
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0045 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0045 0.0042
Echinococcus multilocularis dro:myosuppressin receptor 0.0142 0.0656 0.105
Echinococcus multilocularis neuropeptide FF receptor 2 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0105 0.0463 0.0459
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.014 0.0648 0.0645
Schistosoma mansoni hypothetical protein 0.0063 0.0244 0.0386
Echinococcus multilocularis g protein coupled receptor 0.0142 0.0656 0.105
Brugia malayi putative neuropeptide receptor 0.0142 0.0656 0.0656
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0045 0.0067
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0225 0.1821
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0045 0.0067
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0013 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Echinococcus multilocularis neuropeptide receptor 0.0142 0.0656 0.105
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0142 0.0656 0.105
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0142 0.0656 0.105
Brugia malayi hypothetical protein 0.0025 0.0047 0.0047
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0045 0.0067
Loa Loa (eye worm) hypothetical protein 0.014 0.0648 0.0645
Onchocerca volvulus 0.0142 0.0656 0.1392
Echinococcus granulosus biogenic amine 5HT receptor 0.0142 0.0656 0.105
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0076
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Schistosoma mansoni amine GPCR 0.0142 0.0656 0.105
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0142 0.0656 0.105
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0142 0.0656 0.105
Schistosoma mansoni biogenic amine receptor 0.0142 0.0656 0.105
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0105 0.0463 0.0459
Brugia malayi hypothetical protein 0.0142 0.0656 0.0656
Schistosoma mansoni hypothetical protein 0.0329 0.1633 0.2626
Brugia malayi hypothetical protein 0.0142 0.0656 0.0656
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0142 0.0656 0.105
Brugia malayi steroid hormone receptor 0.0025 0.0045 0.0045
Schistosoma mansoni neuropeptide receptor 0.0142 0.0656 0.105
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0244 0.0386
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0009
Schistosoma mansoni biogenic amine receptor 0.0142 0.0656 0.105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0045 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0015 0.0098
Echinococcus granulosus 7tm_1 domain containing protein 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0186 0.0885 0.0881
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0057 0.0086
Schistosoma mansoni neuropeptide F-like receptor 0.0142 0.0656 0.105
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0094 0.0404 0.0645
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0094 0.0404 0.0645
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0142 0.0656 0.105
Onchocerca volvulus 0.0142 0.0656 0.1392
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0075 0.0115
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0013 0.0076
Brugia malayi hypothetical protein 0.0142 0.0656 0.0656
Schistosoma mansoni cpg binding protein 0.0089 0.0382 0.0609
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0076
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0045 0.0042
Echinococcus granulosus neuropeptide FF receptor 2 0.0142 0.0656 0.105
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0647 0.1037
Leishmania major cathepsin L-like protease 0.0065 0.0254 0.2064
Onchocerca volvulus 0.0142 0.0656 0.1392
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0045 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0045 0.0045
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0045 0.0067
Echinococcus granulosus somatostatin receptor 0.0142 0.0656 0.105
Echinococcus multilocularis geminin 0.0329 0.1633 0.2626
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0075 0.0115
Brugia malayi GnHR receptor homolog 0.0597 0.3036 0.3036
Echinococcus granulosus adenylate cyclase 9 0.0057 0.0211 0.0333
Leishmania major hypothetical protein, conserved 0.0025 0.0047 0.0355
Echinococcus multilocularis neuropeptides capa receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0045 0.0042
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0142 0.0656 0.105
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0254 0.2064
Echinococcus multilocularis dna polymerase eta 0.0019 0.0013 0.0015
Leishmania major cathepsin L-like protease 0.0065 0.0254 0.2064
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0057 0.0211 0.0207
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0004
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0013 0.0076
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0013 0.0082
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Echinococcus granulosus 7TM GPCR rhodopsin 0.0142 0.0656 0.105
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0048 0.0168 0.0264
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0142 0.0656 0.105
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0244 0.0386
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.0954 0.0954
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0045 0.0067
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0045 0.0067
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0142 0.0656 0.0652
Echinococcus granulosus dna polymerase eta 0.0019 0.0013 0.0015
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0055 0.0055
Brugia malayi Dopamine receptor protein 2 0.0142 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0045 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0045 0.0045
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0136 0.0625 0.0622
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Brugia malayi hypothetical protein 0.0142 0.0656 0.0656
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0045 0.0045
Echinococcus granulosus tm gpcr rhodopsin 0.0142 0.0656 0.105
Schistosoma mansoni hypothetical protein 0.0048 0.0168 0.0264
Loa Loa (eye worm) hypothetical protein 0.0063 0.0244 0.024
Onchocerca volvulus 0.0031 0.0075 0.0152
Loa Loa (eye worm) hypothetical protein 0.005 0.0178 0.0174
Brugia malayi Adenylyl cyclase protein 0.0057 0.0211 0.0211
Schistosoma mansoni neuropeptide receptor 0.0245 0.1192 0.1915
Schistosoma mansoni cpg binding protein 0.0085 0.0357 0.0569
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0045 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0075 0.0115
Schistosoma mansoni hypothetical protein 0.0063 0.0244 0.0386
Echinococcus granulosus tm gpcr rhodopsin 0.0142 0.0656 0.105
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0045 0.0067
Schistosoma mansoni hypothetical protein 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0186 0.0885 0.0881
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0004
Echinococcus multilocularis serotonin receptor 0.0142 0.0656 0.105
Echinococcus granulosus g protein coupled receptor 0.0142 0.0656 0.105
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0004
Schistosoma mansoni opsin-like receptor 0.0142 0.0656 0.105
Echinococcus multilocularis G-protein coupled receptor, putative 0.0142 0.0656 0.105
Schistosoma mansoni hypothetical protein 0.0063 0.0244 0.0386
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0647 0.1037
Schistosoma mansoni opsin-like receptor 0.0142 0.0656 0.105
Onchocerca volvulus 0.0142 0.0656 0.1392
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0042
Brugia malayi hypothetical protein 0.0142 0.0656 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0015 0.0098
Echinococcus multilocularis neuropeptide Y receptor 0.0142 0.0656 0.105
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.003 0.0042
Onchocerca volvulus Neuropeptide F receptor homolog 0.0142 0.0656 0.1392
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0057 0.0053
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Brugia malayi POT family protein 0.0123 0.056 0.056
Brugia malayi hypothetical protein 0.0142 0.0656 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0098
Echinococcus multilocularis neuropeptide s receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.0151 0.0237
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0647 0.1037
Brugia malayi ORL1-like opioid receptor 0.0142 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Schistosoma mansoni amine GPCR 0.0142 0.0656 0.105
Echinococcus granulosus cpg binding protein 0.0089 0.0382 0.0609
Echinococcus granulosus g-protein coupled receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.0647 0.0644
Schistosoma mansoni hypothetical protein 0.0329 0.1633 0.2626
Schistosoma mansoni hypothetical protein 0.1205 0.6211 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0137 0.0631 0.0628
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0186 0.0885 0.0881
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.003 0.0042
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0075 0.0586
Trypanosoma brucei telomerase reverse transcriptase 0.0249 0.1218 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0098
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0142 0.0656 0.105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0015 0.0098
Loa Loa (eye worm) adenylyl cyclase 3 0.0134 0.0614 0.061
Schistosoma mansoni amine GPCR 0.0142 0.0656 0.105
Onchocerca volvulus 0.005 0.0178 0.0372
Schistosoma mansoni hypothetical protein 0.0048 0.0168 0.0264
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0142 0.0656 0.105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0155 0.0722 0.0719
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Echinococcus granulosus neuropeptides capa receptor 0.0142 0.0656 0.105
Brugia malayi Melatonin receptor type 1A 0.0142 0.0656 0.0656
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0137 0.0631 0.0628
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0045 0.0089
Onchocerca volvulus 0.0142 0.0656 0.1392
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0249 0.1218 1
Brugia malayi RE15519p 0.0142 0.0656 0.0656
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0004
Brugia malayi Tachykinin-like peptides receptor 99D 0.0142 0.0656 0.0656
Brugia malayi hypothetical protein 0.0142 0.0656 0.0656
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Echinococcus granulosus g protein coupled receptor 0.0142 0.0656 0.105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0045 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0656 0.105
Echinococcus multilocularis endothelin converting enzyme 1 0.0186 0.0885 0.1419
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0045 0.0045
Onchocerca volvulus 0.0142 0.0656 0.1392
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0045 0.0151 0.0237
Onchocerca volvulus 0.0142 0.0656 0.1392
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0656 0.105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0656 0.105
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0045 0.0067
Schistosoma mansoni endothelin-converting enzyme-related 0.0045 0.0151 0.0237
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0975 0.0971
Brugia malayi Dopamine receptor protein 1 0.0142 0.0656 0.0656
Loa Loa (eye worm) POT family protein 0.0123 0.056 0.0556
Toxoplasma gondii RNA-directed DNA polymerase 0.0249 0.1218 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0013 0.0015
Echinococcus multilocularis G protein coupled receptor 139 0.0245 0.1192 0.1915
Schistosoma mansoni hypothetical protein 0.0048 0.0168 0.0264
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0913 0.4685 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0045 0.0067
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0045 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0656 0.105
Echinococcus granulosus adenylate cyclase type IX 0.008 0.033 0.0526
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0045 0.0045
Onchocerca volvulus 0.0231 0.112 0.2384
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0656 0.105
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0142 0.0656 0.0656
Brugia malayi sulfakinin receptor protein 0.1004 0.516 0.516
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0142 0.0656 0.105
Echinococcus granulosus alpha 1A adrenergic receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.014 0.0648 0.0645
Schistosoma mansoni hypothetical protein 0.0048 0.0168 0.0264
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0047 0.0355
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1931 1 1
Echinococcus multilocularis adenylate cyclase 9 0.0057 0.0211 0.0333
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0656 0.105
Onchocerca volvulus 0.0085 0.0357 0.0754
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Mycobacterium leprae probable zinc metalloprotease 0.0186 0.0885 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0656 0.105
Schistosoma mansoni amine GPCR 0.0142 0.0656 0.105
Plasmodium vivax SET domain protein, putative 0.0031 0.0075 0.0586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0045 0.0042
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0142 0.0656 0.105
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0142 0.0656 0.105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0075 0.0115
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0013 1
Echinococcus granulosus fmrfamide receptor 0.0142 0.0656 0.105
Echinococcus granulosus peptide allatostatin:somatostatin 0.0142 0.0656 0.105
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0244 0.0244
Echinococcus multilocularis orexin receptor type 2 0.0142 0.0656 0.105
Giardia lamblia Telomerase catalytic subunit 0.0249 0.1218 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0013 0.0009
Loa Loa (eye worm) zinc metallopeptidase 4 0.0045 0.0151 0.0147
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0157 0.0735 0.1561
Onchocerca volvulus 0.0142 0.0656 0.1392
Onchocerca volvulus 0.0142 0.0656 0.1392
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Leishmania major DNA polymerase kappa, putative 0.0019 0.0013 0.0076
Echinococcus granulosus protection of telomeres protein 1 0.0531 0.2691 0.4329
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0045 0.0045
Echinococcus granulosus neuropeptide Y receptor 0.0142 0.0656 0.105
Brugia malayi Pre-SET motif family protein 0.0031 0.0075 0.0075
Brugia malayi neuropeptide F receptor 0.0142 0.0656 0.0656
Schistosoma mansoni hypothetical protein 0.0048 0.0168 0.0264
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0045 0.0151 0.0237
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0656 0.105
Onchocerca volvulus 0.0142 0.0656 0.1392
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0042
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0142 0.0656 0.105
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0142 0.0656 0.0652
Echinococcus granulosus neuropeptide receptor 0.0245 0.1192 0.1915
Echinococcus multilocularis cpg binding protein 0.0089 0.0382 0.0609
Echinococcus multilocularis fmrfamide receptor 0.0142 0.0656 0.105
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0142 0.0656 0.105
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0142 0.0656 0.105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0045 0.0067
Schistosoma mansoni cpg binding protein 0.0089 0.0382 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0045 0.0045
Onchocerca volvulus 0.0142 0.0656 0.1392
Brugia malayi Serotonin receptor 0.0142 0.0656 0.0656
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0004
Echinococcus granulosus GPCR family 2 0.0063 0.0244 0.0386
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0045 0.0045
Onchocerca volvulus 0.0142 0.0656 0.1392
Echinococcus multilocularis serotonin receptor 0.0142 0.0656 0.105
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0182 0.1465
Brugia malayi nuclear hormone receptor 0.0025 0.0045 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.0954 0.0954
Echinococcus multilocularis neuropeptide Y receptor 0.0142 0.0656 0.105
Schistosoma mansoni hypothetical protein 0.0142 0.0656 0.105
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0015 0.0098
Plasmodium vivax telomerase reverse transcriptase, putative 0.0249 0.1218 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0648 0.0645
Echinococcus granulosus tachykinin peptides receptor 99D 0.0142 0.0656 0.105
Echinococcus granulosus g protein coupled receptor 0.0142 0.0656 0.105
Echinococcus multilocularis somatostatin receptor 0.0142 0.0656 0.105
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0098
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Loa Loa (eye worm) hypothetical protein 0.0137 0.0631 0.0628
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0142 0.0656 0.105
Brugia malayi putative neuropeptide receptor NPR1 0.0142 0.0656 0.0656
Schistosoma mansoni alpha-1 adrenergic receptor 0.0142 0.0656 0.105
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.0647 0.0647
Echinococcus granulosus allatostatin A receptor 0.0142 0.0656 0.105
Schistosoma mansoni histamine h1 receptor 0.0142 0.0656 0.105
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0142 0.0656 0.105
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0015 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Brugia malayi Serotonin receptor 0.0142 0.0656 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0254 0.2004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0045 0.0089
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0047 0.0355
Schistosoma mansoni DNA polymerase eta 0.0019 0.0013 0.0015
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0142 0.0656 0.105
Echinococcus multilocularis g-protein coupled receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.014 0.0648 0.0645
Echinococcus granulosus sex peptide receptor 0.0142 0.0656 0.105
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0047 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0015 0.0098
Leishmania major cathepsin L-like protease 0.0065 0.0254 0.2064
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.003 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0656 0.105
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0186 0.0885 1
Brugia malayi hypothetical protein 0.1004 0.516 0.516
Echinococcus multilocularis fmrfamide receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0042
Echinococcus multilocularis protection of telomeres protein 1 0.0531 0.2691 0.4329
Brugia malayi G-protein coupled receptor 0.0142 0.0656 0.0656
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0249 0.1218 1
Echinococcus granulosus neuropeptide Y receptor 0.0142 0.0656 0.105
Loa Loa (eye worm) G-protein coupled receptor 0.0142 0.0656 0.0652
Mycobacterium ulcerans zinc metalloprotease 0.0186 0.0885 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0142 0.0656 0.105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0181 0.0858 0.1376
Brugia malayi follicle stimulating hormone receptor 0.0142 0.0656 0.0656
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0244 0.0386
Schistosoma mansoni hypothetical protein 0.0142 0.0656 0.105
Loa Loa (eye worm) hypothetical protein 0.0142 0.0656 0.0652
Onchocerca volvulus 0.0057 0.0211 0.0442
Toxoplasma gondii peptidase family M13 protein 0.0186 0.0885 0.7256
Loa Loa (eye worm) melatonin receptor type 1A 0.0142 0.0656 0.0652
Trichomonas vaginalis helicase, putative 0.0019 0.0015 0.0098
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0142 0.0656 0.0656
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0045 0.0067
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0045 0.0067
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0142 0.0656 0.105
Echinococcus multilocularis rhodopsin orphan GPCR 0.0142 0.0656 0.105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0647 0.1037
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0045 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0045 0.0042
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0045 0.0067
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0015
Schistosoma mansoni hypothetical protein 0.0105 0.0463 0.0739

Activities

Activity type Activity value Assay description Source Reference
logP (ADMET) = 6.78 Partition coefficient (logP) ChEMBL. 6492079
pI50 (functional) = 5.89 mM Juvenile hormone mimetic activity in Aedes aegypti (yellow-fever mosquito) ChEMBL. 6492079
pI50 (functional) = 3.49 uM pupa-1 Juvenile hormone mimetic activity in Tenebrio molitor (yellow mealworm) ChEMBL. 6492079

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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