Detailed information for compound 542924

Basic information

Technical information
  • TDR Targets ID: 542924
  • Name: 4-(3-methyl-1-piperidyl)-1-(2,4,6-trimethoxyp henyl)butan-1-one; succinic acid
  • MW: 453.526 | Formula: C23H35NO8
  • H donors: 2 H acceptors: 5 LogP: 0.07 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCC(=O)O.COc1cc(OC)cc(c1C(=O)CCCN1CCCC(C1)C)OC
  • InChi: 1S/C19H29NO4.C4H6O4/c1-14-7-5-9-20(13-14)10-6-8-16(21)19-17(23-3)11-15(22-2)12-18(19)24-4;5-3(6)1-2-4(7)8/h11-12,14H,5-10,13H2,1-4H3;1-2H2,(H,5,6)(H,7,8)
  • InChiKey: DNEQGHONGAQMLP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(3-methyl-1-piperidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone; succinic acid
  • butanedioic acid; 4-(3-methylpiperidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one
  • 4-(3-methylpiperidino)-1-(2,4,6-trimethoxyphenyl)butan-1-one; succinic acid
  • CRL 41034
  • 4-(3-methyl-1-piperidinyl)-1-(2,4,6-trimethoxyphenyl)butan-1-one; succinic acid
  • 138230-22-5
  • Butanedioic acid, compd. with 4-(3-methyl-1-piperidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone (1:1)
  • Crl 41 034
  • 1-Butanone, 4-(3-methyl-1-piperidinyl)-1-(2,4,6-trimethoxyphenyl)-, butanedioate (1:1)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.0405 0.035
Loa Loa (eye worm) hypothetical protein 0.0033 0.033 0.0275
Onchocerca volvulus 0.0036 0.0405 0.0374
Schistosoma mansoni protein kinase 0.0032 0.0312 0.0452
Plasmodium falciparum mitogen-activated protein kinase 2 0.017 0.3303 0.3546
Loa Loa (eye worm) hypothetical protein 0.0031 0.0298 0.0242
Echinococcus multilocularis Protein lozenge 0.0056 0.0835 0.1223
Schistosoma mansoni polycystin 1-related 0.002 0.0057 0.0076
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0628 0.0917
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0662 0.0657
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0123 0.0117
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0628 0.0614
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.2642 0.4394
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.2642 0.4389
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.1897 0.2788
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.042 0.0611
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0298 0.0432
Schistosoma mansoni hypothetical protein 0.0283 0.5782 0.8513
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0321 0.0534
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.1283 0.1374
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0298 0.1548
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0298 0.0432
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.1283 0.1374
Mycobacterium tuberculosis Conserved protein 0.0036 0.0405 0.0856
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0513 0.0845
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0313 0.0507
Plasmodium vivax hexose transporter 0.0105 0.1897 0.2034
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0875 0.1281
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.2484 0.5311
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0321 0.0534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.0009
Onchocerca volvulus 0.0448 0.9355 1
Schistosoma mansoni loxhd1 0.002 0.0057 0.0076
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.1283 0.2134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0405 0.035
Entamoeba histolytica protein kinase, putative 0.0032 0.0312 0.6384
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0412 0.0676
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0312 0.0452
Brugia malayi beta-lactamase 0.0036 0.0405 0.04
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.2484 1
Loa Loa (eye worm) hypothetical protein 0.0448 0.9355 0.9352
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0875 0.2918
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0005 0.0009
Schistosoma mansoni protein kinase 0.0032 0.0312 0.0452
Mycobacterium tuberculosis Conserved protein 0.0036 0.0405 0.0856
Loa Loa (eye worm) hypothetical protein 0.0077 0.1283 0.1233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.3576 0.5263
Loa Loa (eye worm) hypothetical protein 0.0448 0.9355 0.9352
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0066
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0768 0.1124
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0405 0.0856
Echinococcus granulosus geminin 0.033 0.6791 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0412 0.067
Schistosoma mansoni rab6-interacting 0.002 0.0057 0.0076
Onchocerca volvulus 0.0036 0.0405 0.0374
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.3576 0.354
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0123 0.0394
Toxoplasma gondii hypothetical protein 0.0047 0.0645 0.1056
Schistosoma mansoni hypothetical protein 0.0034 0.0362 0.0526
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0628 0.0917
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0412 0.0676
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0123 0.4009
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0321 0.167
Entamoeba histolytica hypothetical protein 0.0037 0.042 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.3612 0.5315
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0405 0.0856
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0123 0.0173
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0856 0.1254
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0745 0.0692
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0628 0.0917
Echinococcus multilocularis General substrate transporter 0.009 0.1576 0.2314
Schistosoma mansoni hypothetical protein 0.0033 0.033 0.0479
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0405 0.0589
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0405 0.0673
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.2196 0.4694
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0405 0.0856
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0123 0.0195
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.1897 0.3121
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0412 0.0684
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1897 0.2788
Mycobacterium tuberculosis Conserved protein 0.0036 0.0405 0.0856
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0269 0.0389
Leishmania major hypothetical protein, conserved 0.0036 0.0405 0.0665
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0057 0.0076
Brugia malayi glutathione reductase 0.0052 0.0745 0.074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0405 0.0589
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0321 0.0526
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0513 0.0853
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0875 0.1281
Onchocerca volvulus 0.0036 0.0405 0.0374
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0405 0.0589
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0312 0.0452
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0313 0.033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.3576 0.5263
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0321 0.167
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0298 0.0293
Schistosoma mansoni lozenge 0.0056 0.0835 0.1223
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0405 0.0673
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.3576 0.5263
Brugia malayi mbt repeat family protein 0.0047 0.0628 0.0623
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0768 0.0763
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0321 0.167
Plasmodium falciparum glutathione reductase 0.0052 0.0745 0.0796
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0856 0.1254
Schistosoma mansoni lipoxygenase 0.0057 0.0856 0.1254
Loa Loa (eye worm) hypothetical protein 0.0036 0.0405 0.035
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0123 0.0194
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0405 0.2112
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0123 0.0173
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0123 0.0173
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.1283 0.2109
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0298 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.079 0.0737
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0875 0.087
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1897 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0313 0.033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0405 0.035
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0057 0.0076
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.6014 1
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0057 0.0076
Trypanosoma brucei glucose transporter, putative 0.0033 0.0321 0.0526
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0321 0.0526
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.033 0.0325
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0005 0.0009
Echinococcus multilocularis RUN 0.002 0.0057 0.0076
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0405 0.1341
Entamoeba histolytica hypothetical protein 0.0037 0.042 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0405 0.04
Plasmodium falciparum protein kinase 6 0.0445 0.9306 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0321 0.0526
Brugia malayi hypothetical protein 0.0037 0.042 0.0415
Schistosoma mansoni hypothetical protein 0.033 0.6791 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0312 0.0307
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0313 0.033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0312 0.0257
Brugia malayi Cam kinase protein 1 0.0032 0.0312 0.0307
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0362 0.0526
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0628 0.0917
Toxoplasma gondii thioredoxin reductase 0.0052 0.0745 0.1221
Loa Loa (eye worm) hypothetical protein 0.0026 0.017 0.0113
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0321 0.0534
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0312 0.0257
Toxoplasma gondii protein kinase, putative 0.0297 0.6066 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0362 0.0526
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.3576 0.5263
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0321 0.167
Loa Loa (eye worm) hypothetical protein 0.0036 0.0405 0.035
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0477 1 1
Brugia malayi beta-lactamase family protein 0.0036 0.0405 0.04
Brugia malayi Sugar transporter family protein 0.0105 0.1897 0.1893
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.3576 0.5263
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0875 0.1447
Loa Loa (eye worm) runx1 0.0056 0.0835 0.0782
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0005 0.0009
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.1283 0.2127
Brugia malayi Doublecortin family protein 0.002 0.0057 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.3576 0.5263
Entamoeba histolytica hypothetical protein 0.0037 0.042 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0321 0.0526
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0405 0.2112
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0298 0.1035
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.017 0.3303 0.5442
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0321 0.167
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0046 0.0087
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0745 0.1239
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0768 0.1124
Leishmania major hypothetical protein, conserved 0.0077 0.1283 0.2127
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1897 0.2788
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.017 0.3303 0.3546
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0768 0.1124
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0745 0.109
Loa Loa (eye worm) MBCTL1 0.0053 0.0768 0.0715
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0313 0.033
Plasmodium vivax CDK-related protein kinase 6, putative 0.0445 0.9306 1
Mycobacterium tuberculosis Probable reductase 0.0119 0.2196 0.4694
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0768 0.1124
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0298 0.0293
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0405 0.2112
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0312 0.0452
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0313 0.0507
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.0009
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0405 0.0856
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0313 0.0507
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0745 0.1585
Loa Loa (eye worm) hypothetical protein 0.0048 0.0662 0.0609
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0057 0.0056
Mycobacterium ulcerans lipase LipD 0.0036 0.0405 0.1341
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.2196 0.4694
Brugia malayi hypothetical protein 0.005 0.0691 0.0686
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0057 0.0056
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.4672 1
Echinococcus granulosus RUN 0.002 0.0057 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.0298 0.0242
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0123 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.3576 0.5263
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0312 0.0511
Entamoeba histolytica hypothetical protein 0.0037 0.042 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1897 0.2788
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0768 0.1124
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0628 0.0917
Trypanosoma brucei glucose transporter, putative 0.0033 0.0321 0.0526
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0405 0.043
Echinococcus granulosus General substrate transporter 0.009 0.1576 0.2314
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.6014 1
Schistosoma mansoni hypothetical protein 0.0037 0.042 0.0611
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.042 0.0611
Trypanosoma brucei glucose transporter 1E 0.0033 0.0321 0.0526
Trypanosoma brucei glucose transporter, putative 0.0033 0.0321 0.0526
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.071 0.118
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.1283 0.1374
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0123 0.0126
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0412 0.0676
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0321 0.167
Schistosoma mansoni rab6-interacting 0.002 0.0057 0.0076
Schistosoma mansoni glucose transport protein 0.0105 0.1897 0.2788
Brugia malayi hypothetical protein 0.0077 0.1283 0.1279
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.6014 1
Schistosoma mansoni hypothetical protein 0.033 0.6791 1
Brugia malayi hypothetical protein 0.0448 0.9355 0.9355
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.2196 0.4694
Loa Loa (eye worm) sugar transporter 0.0105 0.1897 0.185
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.2196 0.4694
Treponema pallidum NADH oxidase 0.0018 0.0005 0.5
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0405 0.0856
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0005 0.5
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0405 0.0856
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.006 0.0288
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.2484 0.5311
Schistosoma mansoni glucose transport protein 0.0105 0.1897 0.2788
Echinococcus multilocularis geminin 0.033 0.6791 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.3612 0.5315
Schistosoma mansoni hypothetical protein 0.002 0.0057 0.0076
Loa Loa (eye worm) beta-lactamase 0.0036 0.0405 0.035
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0312 0.0452
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.2642 0.4389
Entamoeba histolytica protein kinase, putative 0.0032 0.0312 0.6384
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0513 0.0853
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.2984 0.6383
Trypanosoma brucei glucose transporter 2A 0.0033 0.0321 0.0526
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0298 0.0432
Brugia malayi hypothetical protein 0.002 0.0057 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0312 0.1623
Mycobacterium ulcerans beta-lactamase 0.0036 0.0405 0.1341
Schistosoma mansoni glucose transport protein 0.0105 0.1897 0.2788
Loa Loa (eye worm) glutathione reductase 0.0052 0.0745 0.0692
Plasmodium falciparum protein kinase 7 0.0297 0.6066 0.6516
Schistosoma mansoni protein kinase 0.0032 0.0312 0.0452
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0123 0.0394
Leishmania major glucose transporter, lmgt2 0.0033 0.0321 0.0526
Mycobacterium ulcerans hypothetical protein 0.0036 0.0405 0.1341
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0875 0.2918
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0875 0.1281
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.6014 1
Brugia malayi beta-lactamase family protein 0.0036 0.0405 0.04
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0412 0.0437
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0321 0.0526
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.042 0.0611
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0405 0.1472
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0123 0.0315
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0745 0.109
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0745 0.0796
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0313 0.033
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0321 0.167
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0405 0.0856
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0313 0.033
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.2196 0.8818
Trichomonas vaginalis esterase, putative 0.0036 0.0405 0.2112
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0313 0.033
Schistosoma mansoni hypothetical protein 0.0105 0.1897 0.2788
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0046 0.0087
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0057 0.0076
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0412 0.0437
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0312 0.0452
Leishmania major trypanothione reductase 0.0052 0.0745 0.1232
Leishmania major glucose transporter, lmgt3 0.0033 0.0321 0.0526
Schistosoma mansoni lipoxygenase 0.002 0.0057 0.0076
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0628 0.0574
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0123 0.0204
Loa Loa (eye worm) hypothetical protein 0.0047 0.0628 0.0574
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0662 0.0657
Brugia malayi hypothetical protein 0.002 0.0057 0.0052
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0123 0.0126
Plasmodium vivax glutathione reductase, putative 0.0052 0.0745 0.0796
Loa Loa (eye worm) hypothetical protein 0.0053 0.0768 0.0715
Loa Loa (eye worm) hypothetical protein 0.0036 0.0405 0.035
Brugia malayi Thioredoxin reductase 0.0052 0.0745 0.074
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0513 0.0853
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0405 0.0589
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1897 0.2788
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0123 0.0173
Plasmodium falciparum thioredoxin reductase 0.0052 0.0745 0.0796
Plasmodium falciparum hexose transporter 0.0105 0.1897 0.2034
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.2196 0.4694
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.3576 0.3573
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0405 0.1341
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0005 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0405 0.035
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0312 0.0452
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0412 0.0684
Brugia malayi mbt repeat family protein 0.0047 0.0628 0.0623
Trypanosoma brucei glucose transporter, putative 0.0033 0.0321 0.0526
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0875 0.1863
Trypanosoma cruzi hexose transporter 0.0033 0.0321 0.0534
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0313 0.033
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1897 0.2788
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0312 0.0257
Leishmania major protein kinase, putative 0.0032 0.0312 0.0511
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0628 0.0917
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0313 0.033
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0405 0.2112
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0298 0.5907
Trypanosoma brucei glucose transporter, putative 0.0033 0.0321 0.0526
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0123 0.0621
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0269 0.0389
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1897 0.2788
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0405 0.2112
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0321 0.0526
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0312 0.0452
Mycobacterium ulcerans hypothetical protein 0.0155 0.2984 1
Leishmania major glucose transporter, lmgt1 0.0033 0.0321 0.0526
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0312 0.0452
Onchocerca volvulus 0.0047 0.0628 0.0614
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.0009
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0123 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0057 0.0076
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0628 0.0917
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1897 0.2788
Toxoplasma gondii ABC1 family protein 0.0036 0.0405 0.0659
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.1283 0.2134
Trypanosoma brucei trypanothione reductase 0.0052 0.0745 0.1232
Trypanosoma brucei glucose transporter, putative 0.0033 0.0321 0.0526
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0298 0.0432
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0057 0.0076
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0312 0.0452
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0662 0.0609
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.2484 0.5311
Mycobacterium leprae Probable lipase LipE 0.0036 0.0405 0.1472
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0405 0.0665

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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