Detailed information for compound 551410

Basic information

Technical information
  • TDR Targets ID: 551410
  • Name: 1,2-diamino-9-[(2R,4S,5R)-4-hydroxy-5-(hydrox ymethyl)tetrahydrofuran-2-yl]purin-6-one
  • MW: 282.256 | Formula: C10H14N6O4
  • H donors: 4 H acceptors: 4 LogP: -2.32 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c1nc(N)n(c2=O)N
  • InChi: 1S/C10H14N6O4/c11-10-14-8-7(9(19)16(10)12)13-3-15(8)6-1-4(18)5(2-17)20-6/h3-6,17-18H,1-2,12H2,(H2,11,14)/t4-,5+,6+/m0/s1
  • InChiKey: RRIXSWKTPPFTLI-KVQBGUIXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,2-diamino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-6-purinone
  • 1,2-bis(azanyl)-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-one
  • 1,2-diamino-9-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]purin-6-one
  • 1,2-diamino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-one
  • 5'-amino-5'-deoxyguanosine
  • Guanosine, 1-amino-2'-deoxy-
  • NSC 119850
  • 5'-Deoxy-5'-aminoquanosine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0201 0.0894
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.4095 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0006 0.0003 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Loa Loa (eye worm) AGC/PKG protein kinase 0.0006 0.0003 0.0006
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0201 0.0305
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0007 0.003
Toxoplasma gondii sugar transporter ST3 0.0015 0.0201 0.0305
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0201 0.0894
Trypanosoma cruzi hypothetical protein 0.0007 0.0014 0.02
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Schistosoma mansoni glucose transport protein 0.0107 0.2253 1
Onchocerca volvulus 0.0015 0.0201 0.0459
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0201 0.2874
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0606 0.8651
Brugia malayi RasGEF domain containing protein 0.0007 0.0014 0.0034
Echinococcus multilocularis son of sevenless 1 0.0007 0.0014 0.0062
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0201 0.0894
Brugia malayi major facilitator superfamily protein 0.0015 0.0201 0.0492
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0597 0.2648
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0003 0.0012
Leishmania major glucose transporter, lmgt1 0.0033 0.0606 0.8651
Brugia malayi Cam kinase protein 1 0.0033 0.0597 0.1458
Toxoplasma gondii hypothetical protein 0.0009 0.0074 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0606 0.269
Brugia malayi Sugar transporter family protein 0.0107 0.2253 0.5503
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0201 0.0492
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0201 0.2874
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2253 1
Brugia malayi hypothetical protein 0.0015 0.0201 0.0492
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0074 0.0328
Plasmodium vivax CDK-related protein kinase 6, putative 0.0456 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Toxoplasma gondii sugar transporter ST2 0.0015 0.0201 0.0305
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0201 0.5052
Echinococcus granulosus General substrate transporter 0.0092 0.1918 0.851
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0582 0.2583
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0399 0.1769
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.2253 1
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0014 0.0062
Onchocerca volvulus 0.0015 0.0201 0.0459
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0119 0.2978
Brugia malayi Sugar transporter family protein 0.0015 0.0201 0.0492
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Leishmania major protein kinase, putative 0.0006 0.0003 0.0037
Brugia malayi hypothetical protein 0.0015 0.0201 0.0492
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0492
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0399 0.1769
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Echinococcus multilocularis expressed conserved protein 0.0006 0.0003 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0606 0.269
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0074 0.0328
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Schistosoma mansoni protein kinase 0.0033 0.0597 0.2648
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0074 0.0328
Trypanosoma brucei sugar transporter, putative 0.0015 0.0201 0.2874
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0606 0.269
Trypanosoma brucei glucose transporter 1E 0.0033 0.0606 0.8651
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0399 0.0974
Onchocerca volvulus 0.0015 0.0201 0.0459
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Brugia malayi major facilitator superfamily protein 0.0015 0.0201 0.0492
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0074 0.018
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0552 0.2448
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0597 0.0597
Leishmania major protein kinase, putative 0.0033 0.0597 0.8517
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0606 0.8651
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0582 0.1421
Schistosoma mansoni dep domain containing protein 0.0009 0.0074 0.0328
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0894
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0597 0.8517
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0318 0.5469
Echinococcus multilocularis General substrate transporter 0.0092 0.1918 0.851
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0074 0.0328
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0201 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.2648
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0201 0.0894
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0597 0.0597
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0003 0.0012
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0074 0.018
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0201 0.0201
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.2253 0.3408
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0014 0.0062
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.2648
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Plasmodium falciparum protein kinase 7 0.0303 0.6612 0.6612
Onchocerca volvulus Putative transporter 0.0015 0.0201 0.0459
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0492
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0597 0.0597
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0014 0.0062
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0606 0.269
Schistosoma mansoni dishevelled 0.0009 0.0074 0.0328
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0006 0.0003 0.0012
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0014 0.0034
Toxoplasma gondii sugar transporter ST1 0.0015 0.0201 0.0305
Loa Loa (eye worm) hypothetical protein 0.0009 0.0074 0.018
Onchocerca volvulus 0.0015 0.0201 0.0459
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0399 1
Onchocerca volvulus 0.0015 0.0201 0.0459
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.0014 0.02
Onchocerca volvulus 0.0015 0.0201 0.0459
Loa Loa (eye worm) hypothetical protein 0.0024 0.0399 0.0974
Schistosoma mansoni glucose transport protein 0.0107 0.2253 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0201 0.0492
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2253 1
Onchocerca volvulus 0.0015 0.0201 0.0459
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0014 0.0062
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0074 0.018
Onchocerca volvulus 0.0015 0.0201 0.0459
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0009 0.0074 0.018
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0701 1
Brugia malayi N-terminal motif family protein 0.019 0.4095 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0597 0.0903
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0399 0.5689
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0074 0.0328
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0606 0.269
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0701 1
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0014 0.0062
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0399 0.0399
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0399 0.0399
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0074 0.018
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0701 0.0701
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.016 0.039
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0597 0.1458
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0006 0.0003 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0597 0.2648
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.2648
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.019 0.4095 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0018 0.027 0.386
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0606 0.8651
Plasmodium vivax sugar transporter, putative 0.0015 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0034
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0074 0.0328
Brugia malayi DIX domain containing protein 0.0009 0.0074 0.018
Mycobacterium ulcerans sugar transporter 0.0015 0.0201 0.5052
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0014 0.0034
Schistosoma mansoni hypothetical protein 0.0107 0.2253 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0074 0.0328
Brugia malayi Egg laying defective protein 4 0.0006 0.0003 0.0006
Schistosoma mansoni dishevelled 0.0009 0.0074 0.0328
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Brugia malayi N-terminal motif family protein 0.0007 0.0014 0.0034
Brugia malayi hypothetical protein 0.0009 0.0074 0.018
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0201 0.6328
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0606 0.269
Giardia lamblia Sugar-proton symporter 0.0015 0.0201 0.346
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0074 0.018
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0399 0.5689
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0894
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0606 0.8651
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0318 1
Loa Loa (eye worm) sugar transporter 0.0015 0.0201 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Onchocerca volvulus 0.0015 0.0201 0.0459
Entamoeba histolytica protein kinase, putative 0.0033 0.0597 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0448 0.1093
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0062
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.2648
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2253 1
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0003 0.0012
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0597 0.0597
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0074 0.0328
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0201 0.2874
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0399 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0597 0.0597
Brugia malayi Sugar transporter family protein 0.0015 0.0201 0.0492
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0014 0.0062
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.2648
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0399 0.5689
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0399 0.6849
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0014 0.0062
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0074 0.0328
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0119 0.2978
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0399 0.1769
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0014 0.0062
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0701 0.106
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0597 0.0903
Onchocerca volvulus 0.0015 0.0201 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0034
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0014 0.0062
Schistosoma mansoni protein kinase 0.0033 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0032 0.0582 0.1421
Onchocerca volvulus 0.0015 0.0201 0.0459
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0492
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Schistosoma mansoni glucose transporter 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0074 0.0146
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0582 0.2583
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0014 0.0062
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.2648
Leishmania major glucose transporter, lmgt3 0.0033 0.0606 0.8651
Schistosoma mansoni glucose transport protein 0.0107 0.2253 1
Onchocerca volvulus 0.0015 0.0201 0.0459
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0201 0.6328
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0552 0.2448
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0582 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0074 0.0328
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0606 0.8651
Onchocerca volvulus 0.0015 0.0201 0.0459
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0333 0.1477
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0399 0.1769
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0014 0.0062
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0894
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0582 0.9752
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0894
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Trypanosoma cruzi hypothetical protein 0.0007 0.0014 0.02
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0318 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0014 0.0034
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2253 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0606 0.8651
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0399 0.6849
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0894
Leishmania major hypothetical protein, conserved 0.0015 0.0201 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Onchocerca volvulus 0.0009 0.0074 0.0146
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0201 0.0894
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0399 0.0603
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Plasmodium vivax hexose transporter 0.0107 0.2253 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0201 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0606 0.8651
Trypanosoma brucei glucose transporter 2A 0.0033 0.0606 0.8651
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2253 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0582 0.2583
Echinococcus granulosus cGMP dependent protein kinase 0.0006 0.0003 0.0012
Schistosoma mansoni protein kinase 0.0033 0.0597 0.2648
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0009 0.0074 0.018
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0894
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0701 1
Onchocerca volvulus 0.0015 0.0201 0.0459
Onchocerca volvulus 0.0015 0.0201 0.0459
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0014 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Giardia lamblia Hexose transporter 0.0015 0.0201 0.346
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0894
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0701 1
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0014 0.0062
Plasmodium falciparum mitogen-activated protein kinase 2 0.0174 0.3724 0.3724
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2253 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0597 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0597 0.1458
Brugia malayi N-terminal motif family protein 0.0007 0.0014 0.0034
Echinococcus granulosus cGMP dependent protein kinase 1 0.0006 0.0003 0.0012
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0014 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0597 0.0903
Echinococcus granulosus son of sevenless 1 0.0007 0.0014 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0606 0.269
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0597 0.2648
Toxoplasma gondii protein kinase, putative 0.0303 0.6612 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0174 0.3724 0.3724
Echinococcus granulosus Protein son of sevenless 0.0007 0.0014 0.0062
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0201 0.5052
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0582 0.2583
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0032 0.0582 0.1421
Brugia malayi RasGEF domain containing protein 0.0007 0.0014 0.0034
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0701 0.0701
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0597 0.1458
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0582 0.2583
Leishmania major glucose transporter, lmgt2 0.0033 0.0606 0.8651
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0399 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0201 0.2874
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Echinococcus granulosus cGMP dependent protein kinase 1 0.0006 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0492
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0014 0.0062
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0701 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0074 0.0328
Brugia malayi RasGEF domain containing protein 0.0007 0.0014 0.0034
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0597 0.0597
Trypanosoma cruzi hexose transporter 0.0033 0.0606 0.8651
Plasmodium falciparum hexose transporter 0.0107 0.2253 0.2253
Entamoeba histolytica hypothetical protein 0.0007 0.0014 0.0235
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.8651
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0399 0.1769
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0033 0.0597 0.1458
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0074 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.2253 1
Brugia malayi hypothetical protein 0.0009 0.0074 0.018
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Loa Loa (eye worm) sugar transporter 0.0107 0.2253 0.5503
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0201 0.2874
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0014 0.0235
Onchocerca volvulus 0.0015 0.0201 0.0459
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0119 1
Entamoeba histolytica hypothetical protein 0.0024 0.0399 0.6679
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0582 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0074 0.0328
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0201 0.5052
Brugia malayi hypothetical protein 0.0015 0.0201 0.0492
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0582 0.1421
Leishmania major protein kinase, putative 0.0006 0.0003 0.0037
Plasmodium falciparum cGMP-dependent protein kinase 0.0006 0.0003 0.0003
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0597 0.0597
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0174 0.3724 0.5632

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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