Detailed information for compound 557226

Basic information

Technical information
  • TDR Targets ID: 557226
  • Name: 7-methoxy-11a-methyl-1,9b,10,11-tetrahydronap htho[1,2-g]indole
  • MW: 265.35 | Formula: C18H19NO
  • H donors: 0 H acceptors: 0 LogP: 2.95 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)C=CC1=C3C(CCC21)(C)CC=N3
  • InChi: 1S/C18H19NO/c1-18-8-7-15-14-6-4-13(20-2)11-12(14)3-5-16(15)17(18)19-10-9-18/h3-6,10-11,15H,7-9H2,1-2H3
  • InChiKey: TVSCFMXJYNZEER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methoxyimine
  • 28901-18-0
  • 1,10,11,11a-Tetrahydro-7-methoxy-11a-methyl-1H-naphth(1,2-g)indole
  • 1H-Naphth(1,2-g)indole, 2,10,11,11a-tetrahydro-7-methoxy-11a-methyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Serotonin/octopamine receptor family protein 7 0.022 0.2505 0.8003
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.0315 0.0725
Echinococcus multilocularis g protein coupled receptor 0.004 0.0315 0.0222
Brugia malayi hypothetical protein 0.004 0.0315 0.1005
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0153 0.0488
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0488
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.0315 0.1005
Brugia malayi hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni hypothetical protein 0.0139 0.1514 0.4677
Echinococcus granulosus G protein coupled receptor 139 0.004 0.0315 0.0222
Loa Loa (eye worm) glutaminase 2 0.0271 0.3131 1
Brugia malayi beta-lactamase 0.0036 0.0263 0.084
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0037 0.028 0.0187
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.0315 0.0222
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.0315 0.0725
Echinococcus multilocularis serotonin receptor 0.0117 0.1245 0.1162
Brugia malayi beta-lactamase family protein 0.0036 0.0263 0.084
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.0032 0.021 0.0669
Loa Loa (eye worm) hypothetical protein 0.0037 0.028 0.0893
Schistosoma mansoni amine GPCR 0.004 0.0315 0.0725
Schistosoma mansoni neuropeptide receptor 0.004 0.0315 0.0725
Loa Loa (eye worm) serotonin transporter b 0.022 0.2508 0.8013
Plasmodium vivax hypothetical protein, conserved 0.0037 0.028 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.0117 0.1245 0.3978
Echinococcus multilocularis allatostatin A receptor 0.004 0.0315 0.0222
Trichomonas vaginalis glutaminase, putative 0.0271 0.3131 1
Echinococcus granulosus g protein coupled receptor 0.004 0.0315 0.0222
Echinococcus multilocularis orexin receptor type 2 0.004 0.0315 0.0222
Schistosoma mansoni amine GPCR 0.004 0.0315 0.0725
Loa Loa (eye worm) beta-lactamase 0.0036 0.0263 0.084
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.028 0.061
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.0315 0.0222
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0263 0.017
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.0315 0.0912
Brugia malayi hypothetical protein 0.004 0.0315 0.1005
Brugia malayi hypothetical protein 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Loa Loa (eye worm) norepinephrine transporter 0.022 0.2508 0.8013
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0037 0.028 0.061
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.0315 0.1005
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0263 0.5
Brugia malayi beta-lactamase family protein 0.0036 0.0263 0.084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0147 0.0469
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.021 0.0116
Echinococcus granulosus g protein coupled receptor 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0263 0.084
Echinococcus multilocularis fmrfamide receptor 0.004 0.0315 0.0222
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0315 0.0222
Plasmodium vivax amine transporter, putative 0.0037 0.028 1
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0315 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0315 0.0725
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0315 0.0725
Onchocerca volvulus 0.004 0.0315 0.0912
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0315 0.0222
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0315 0.0725
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0022 0.0094 0.0301
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.0315 0.0222
Echinococcus multilocularis lamin 0.0027 0.0153 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.0315 0.0912
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0835 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.022 0.2505 0.7941
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0315 0.0222
Echinococcus granulosus neuropeptide receptor A26 0.0501 0.5926 0.5887
Plasmodium falciparum amino acid transporter, putative 0.0037 0.028 0.5
Onchocerca volvulus 0.0027 0.0153 0.0242
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.028 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.0315 0.0222
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.084
Schistosoma mansoni biogenic amine receptor 0.004 0.0315 0.0725
Echinococcus granulosus allatostatin A receptor 0.004 0.0315 0.0222
Brugia malayi Dopamine receptor 0.004 0.0315 0.1005
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.028 0.0893
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus granulosus sodium and chloride dependent glycine 0.0037 0.028 0.0187
Onchocerca volvulus 0.004 0.0315 0.0912
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus multilocularis lamin dm0 0.0027 0.0153 0.0059
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0037 0.028 0.0187
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.0315 0.0725
Brugia malayi Uncoordinated protein 44 0.0022 0.0094 0.0301
Onchocerca volvulus 0.0037 0.028 0.0767
Brugia malayi glutaminase DH11.1 0.0271 0.3131 1
Echinococcus granulosus neuropeptide s receptor 0.0501 0.5926 0.5887
Loa Loa (eye worm) hypothetical protein 0.0037 0.028 0.0893
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.084
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.0037 0.028 0.0893
Schistosoma mansoni biogenic amine receptor 0.004 0.0315 0.0725
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Mycobacterium ulcerans glutaminase 0.0271 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.022 0.2505 0.8003
Echinococcus multilocularis g protein coupled receptor 0.004 0.0315 0.0222
Brugia malayi hypothetical protein 0.0037 0.028 0.0893
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.028 0.061
Echinococcus granulosus biogenic amine 5HT receptor 0.0117 0.1245 0.1162
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0263 0.5
Brugia malayi RE15519p 0.004 0.0315 0.1005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0315 0.0725
Loa Loa (eye worm) hypothetical protein 0.01 0.1043 0.3332
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.028 0.0893
Brugia malayi follicle stimulating hormone receptor 0.027 0.312 0.9968
Echinococcus granulosus geminin 0.0139 0.1514 0.1434
Brugia malayi GnHR receptor homolog 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0315 0.0222
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1043 0.3332
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0094 0.0301
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus granulosus neuropeptide receptor 0.004 0.0315 0.0222
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0037 0.028 0.0187
Brugia malayi larval opioid receptor 0.004 0.0315 0.1005
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.0315 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0315 0.0725
Brugia malayi sulfakinin receptor protein 0.004 0.0315 0.1005
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.0315 0.0725
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0379
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.0315 0.0725
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.084
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0315 0.0222
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.0315 0.0222
Brugia malayi Serotonin receptor 0.004 0.0315 0.1005
Echinococcus multilocularis neuropeptide receptor A26 0.0501 0.5926 0.5887
Loa Loa (eye worm) TYRA-2 protein 0.004 0.0315 0.1005
Brugia malayi neuropeptide F receptor 0.004 0.0315 0.1005
Brugia malayi G protein-coupled receptor 0.004 0.0315 0.1005
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0379
Echinococcus multilocularis serotonin receptor 0.0117 0.1245 0.1162
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0315 0.0725
Echinococcus granulosus g-protein coupled receptor 0.004 0.0315 0.0222
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.0315 0.0725
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.021 0.0116
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.0315 0.0222
Echinococcus granulosus orexin receptor type 2 0.004 0.0315 0.0222
Echinococcus granulosus neuropeptide receptor 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Brugia malayi Dopamine receptor protein 2 0.004 0.0315 0.1005
Onchocerca volvulus 0.004 0.0315 0.0912
Onchocerca volvulus 0.022 0.2508 1
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0315 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0315 0.0222
Echinococcus multilocularis somatostatin receptor 0.004 0.0315 0.0222
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.021 0.0669
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.0315 0.0222
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.0315 0.1005
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus granulosus somatostatin receptor 0.004 0.0315 0.0222
Brugia malayi hypothetical protein 0.004 0.0315 0.1005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.021 0.0116
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0037 0.028 0.0187
Echinococcus granulosus lamin 0.0027 0.0153 0.0059
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.0315 0.0222
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.0315 0.0222
Loa Loa (eye worm) follicle stimulating hormone receptor 0.027 0.312 0.9968
Plasmodium falciparum transporter, putative 0.0037 0.028 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.0315 0.0725
Toxoplasma gondii hypothetical protein 0.0037 0.028 1
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0315 0.0222
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0315 0.0725
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0315 0.0222
Schistosoma mansoni opsin-like receptor 0.004 0.0315 0.0725
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0037 0.028 0.0893
Schistosoma mansoni opsin-like receptor 0.004 0.0315 0.0725
Brugia malayi G-protein coupled receptor 0.004 0.0315 0.1005
Onchocerca volvulus 0.004 0.0315 0.0912
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.0315 0.1005
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.0315 0.1005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0263 0.084
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.022 0.2508 0.8013
Brugia malayi ORL1-like opioid receptor 0.004 0.0315 0.1005
Brugia malayi G-protein coupled receptor 0.004 0.0315 0.1005
Brugia malayi Death domain containing protein 0.0022 0.0094 0.0301
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni opsin-like receptor 0.004 0.0315 0.0725
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.0315 0.1005
Echinococcus granulosus sodium and chloride dependent glycine 0.0037 0.028 0.0187
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0263 0.0555
Loa Loa (eye worm) solute carrier family 6 member 4 0.022 0.2508 0.8013
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.0315 0.0222
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.0315 0.1005
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.0725
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.084
Echinococcus granulosus GPCR family 2 0.0032 0.021 0.0116
Schistosoma mansoni hypothetical protein 0.0139 0.1514 0.4677
Echinococcus multilocularis g protein coupled receptor 0.004 0.0315 0.0222
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.0315 0.0222
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.0315 0.0222
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0153 0.0488
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0037 0.028 0.5
Brugia malayi Latrophilin receptor protein 2 0.0032 0.021 0.0669
Schistosoma mansoni lamin 0.0027 0.0153 0.0192
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.263 1
Treponema pallidum sodium- and chloride- dependent transporter 0.022 0.2508 0.5
Onchocerca volvulus 0.004 0.0315 0.0912
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0315 0.0222
Onchocerca volvulus 0.004 0.0315 0.0912
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0315 0.1005
Toxoplasma gondii hypothetical protein 0.0037 0.028 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0037 0.028 0.0187
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni glutaminase 0.0271 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Brugia malayi hypothetical protein 0.004 0.0315 0.1005
Brugia malayi putative neuropeptide receptor 0.004 0.0315 0.1005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0315 0.0725
Echinococcus granulosus fmrfamide receptor 0.004 0.0315 0.0222
Onchocerca volvulus 0.004 0.0315 0.0912
Echinococcus granulosus sex peptide receptor 0.004 0.0315 0.0222
Onchocerca volvulus 0.004 0.0315 0.0912
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0037 0.028 0.0187
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0315 0.0222
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0315 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0315 0.0222
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.028 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus multilocularis g-protein coupled receptor 0.004 0.0315 0.0222
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0263 0.0555
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0315 0.0222
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.0315 0.0222
Schistosoma mansoni sodium/chloride dependent transporter 0.022 0.2508 0.7951
Onchocerca volvulus 0.004 0.0315 0.0912
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0315 0.0222
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0037 0.028 0.0187
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.028 0.0893
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0315 0.0222
Echinococcus granulosus hypothetical protein 0.004 0.0315 0.0222
Onchocerca volvulus 0.004 0.0315 0.0912
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.0068 0.0657 0.2099
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0315 0.0222
Schistosoma mansoni amine GPCR 0.004 0.0315 0.0725
Onchocerca volvulus 0.0037 0.028 0.0767
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.084
Schistosoma mansoni histamine h1 receptor 0.004 0.0315 0.0725
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus multilocularis neuropeptide receptor 0.004 0.0315 0.0222
Onchocerca volvulus 0.0037 0.028 0.0767
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.028 0.061
Schistosoma mansoni hypothetical protein 0.0068 0.0657 0.1854
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0315 0.0725
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.028 0.061
Brugia malayi intermediate filament protein 0.0027 0.0153 0.0488
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.084
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0153 0.0488
Loa Loa (eye worm) hypothetical protein 0.0022 0.0094 0.0301
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0315 0.0222
Echinococcus multilocularis GPCR, family 2 0.0032 0.021 0.0116
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.0315 0.1005
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0379
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.0315 0.1005
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Leishmania major hypothetical protein, conserved 0.0036 0.0263 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.028 0.0893
Onchocerca volvulus 0.0027 0.0153 0.0242
Brugia malayi Serotonin receptor 0.004 0.0315 0.1005
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0315 0.0222
Onchocerca volvulus 0.004 0.0315 0.0912
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.028 0.061
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0315 0.1005
Brugia malayi Dopamine receptor protein 1 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.022 0.2505 0.8003
Mycobacterium leprae Probable lipase LipE 0.0036 0.0263 0.5
Loa Loa (eye worm) hypothetical protein 0.022 0.2508 0.8013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0315 0.0725
Echinococcus multilocularis serotonin transporter 0.022 0.2508 0.2437
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.0315 0.0725
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0037 0.028 0.0893
Brugia malayi hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.028 0.061
Echinococcus multilocularis neuropeptide s receptor 0.0501 0.5926 0.5887
Schistosoma mansoni amine GPCR 0.004 0.0315 0.0725
Echinococcus multilocularis geminin 0.0139 0.1514 0.1434
Echinococcus granulosus lamin dm0 0.0027 0.0153 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0094 0.0301
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0315 0.0725
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.028 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.0315 0.1005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.021 0.0116
Echinococcus multilocularis fmrfamide receptor 0.004 0.0315 0.0222
Schistosoma mansoni sodium/chloride dependent transporter 0.0037 0.028 0.061
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.0315 0.0222
Echinococcus multilocularis neuropeptide receptor 0.004 0.0315 0.0222
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0315 0.0222
Loa Loa (eye worm) glutaminase 0.0271 0.3131 1
Schistosoma mansoni neuropeptide receptor 0.004 0.0315 0.0725
Echinococcus multilocularis musashi 0.0027 0.0153 0.0059
Onchocerca volvulus 0.0036 0.0263 0.0698
Echinococcus multilocularis sodium and chloride dependent glycine 0.0037 0.028 0.0187
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.021 0.0669
Schistosoma mansoni biogenic amine (5HT) receptor 0.0117 0.1245 0.379
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus granulosus intermediate filament protein 0.0027 0.0153 0.0059
Echinococcus granulosus serotonin transporter 0.022 0.2508 0.2437
Onchocerca volvulus 0.0036 0.0263 0.0698
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0315 0.0222
Echinococcus granulosus serotonin receptor 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.0198 0.2232 0.7128
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0315 0.1005
Schistosoma mansoni sodium/chloride dependent transporter 0.0037 0.028 0.061
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0037 0.028 0.061
Onchocerca volvulus 0.004 0.0315 0.0912
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.0725
Loa Loa (eye worm) hypothetical protein 0.0037 0.028 0.0893
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0657 0.2099
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Onchocerca volvulus 0.004 0.0315 0.0912
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1043 0.3332
Onchocerca volvulus 0.004 0.0315 0.0912
Onchocerca volvulus 0.004 0.0315 0.0912
Schistosoma mansoni myosin xvIII 0.004 0.0315 0.0725
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.0117 0.1245 0.3978
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0315 0.0222
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0037 0.028 0.0893
Brugia malayi hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni intermediate filament proteins 0.0027 0.0153 0.0192
Brugia malayi hypothetical protein 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.9715 0.9713
Schistosoma mansoni sodium-dependent amino acid transporter 0.0037 0.028 0.061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0315 0.0725
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0315 0.0725
Brugia malayi hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni hypothetical protein 0.0032 0.021 0.0379
Onchocerca volvulus 0.004 0.0315 0.0912
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0315 0.0222
Onchocerca volvulus 0.004 0.0315 0.0912
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0315 0.0222
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.0315 0.0222
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.0725
Echinococcus granulosus g protein coupled receptor 0.004 0.0315 0.0222
Schistosoma mansoni adenoreceptor 0.004 0.0315 0.0725
Schistosoma mansoni neuropeptide receptor 0.004 0.0315 0.0725
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni amine GPCR 0.004 0.0315 0.0725
Schistosoma mansoni biogenic amine receptor 0.004 0.0315 0.0725
Brugia malayi Melatonin receptor type 1A 0.004 0.0315 0.1005
Loa Loa (eye worm) hypothetical protein 0.022 0.2508 0.8013
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.0315 0.0222
Brugia malayi Protein kinase domain containing protein 0.0022 0.0094 0.0301
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.0315 0.0725
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.022 0.2508 0.7951
Brugia malayi AKH receptor 0.004 0.0315 0.1005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0315 0.0725
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0263 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0315 0.0222
Loa Loa (eye worm) hypothetical protein 0.0037 0.028 0.0893
Brugia malayi Sodium:neurotransmitter symporter family protein 0.022 0.2508 0.8013
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0263 0.5
Onchocerca volvulus 0.0036 0.0263 0.0698
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.0315 0.0725
Schistosoma mansoni hypothetical protein 0.004 0.0315 0.0725
Schistosoma mansoni neuropeptide receptor 0.004 0.0315 0.0725
Echinococcus multilocularis sodium and chloride dependent glycine 0.0037 0.028 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0315 0.0725
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1043 0.3332
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0315 0.0725
Brugia malayi neuropeptide F receptor 0.004 0.0315 0.1005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0263 0.017
Echinococcus multilocularis sex peptide receptor 0.004 0.0315 0.0222
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0315 0.0725
Loa Loa (eye worm) hypothetical protein 0.0037 0.028 0.0893
Loa Loa (eye worm) hypothetical protein 0.004 0.0315 0.1005
Schistosoma mansoni lamin 0.0027 0.0153 0.0192
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0315 0.0222

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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