Detailed information for compound 561229

Basic information

Technical information
  • TDR Targets ID: 561229
  • Name: (1-$l^{1}-oxidanyl-2,2,6,6-tetramethyl-4-pipe ridyl) 2-iodoacetate
  • MW: 340.178 | Formula: C11H19INO3
  • H donors: 1 H acceptors: 2 LogP: 2.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ICC(=O)OC1CC(C)(C)N(C(C1)(C)C)[O]
  • InChi: 1S/C11H19INO3/c1-10(2)5-8(16-9(14)7-12)6-11(3,4)13(10)15/h8H,5-7H2,1-4H3
  • InChiKey: PRTDQECVEWLPKM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-iodoacetic acid (1-$l^{1}-oxidanyl-2,2,6,6-tetramethyl-4-piperidinyl) ester
  • (1-$l^{1}-oxidanyl-2,2,6,6-tetramethyl-piperidin-4-yl) 2-iodoethanoate
  • 2-iodoacetic acid (1-$l^{1}-oxidanyl-2,2,6,6-tetramethyl-4-piperidyl) ester
  • (1-$l^{1}-oxidanyl-2,2,6,6-tetramethylpiperidin-4-yl) 2-iodoacetate
  • 2,2,6,6-tetramethylpiperidine N-oxyl 4-iodoacetate
  • 36775-20-9
  • 1-Piperidinyloxy, 4-((iodoacetyl)oxy)-2,2,6,6-tetramethyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0435 0.868
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0435 0.868
Plasmodium vivax calcium-dependent protein kinase, putative 0.0038 0.0429 0.0597
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.1568 0.1552
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0519 0.0501
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0163 0.021
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0429 0.0411
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0435 0.868
Schistosoma mansoni DNA helicase recq5 0.0011 0.0071 0.0071
Trypanosoma cruzi hexose transporter 0.0039 0.0435 0.868
Schistosoma mansoni glucose transport protein 0.0125 0.1568 0.1568
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0071 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.05 0.612
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0064 0.1132
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0441 0.0441
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0064 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0435 0.868
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0007 0.0019 0.0262
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0268 0.3228
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Loa Loa (eye worm) sugar transporter 0.0125 0.1568 0.5259
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0071 0.0052
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0037 0.0419 0.0401
Echinococcus multilocularis peregrin 0.0032 0.0352 0.0334
Brugia malayi Sugar transporter family protein 0.0018 0.0157 0.047
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0429 0.0411
Entamoeba histolytica protein kinase, putative 0.0038 0.0429 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0352 0.0485
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0065 0.0143
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.001 0.0064 0.1132
Echinococcus multilocularis solute carrier family 22 0.0018 0.0157 0.0139
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0007 0.0019 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Loa Loa (eye worm) hypothetical protein 0.0166 0.2107 0.7089
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Plasmodium vivax hexose transporter 0.0125 0.1568 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Brugia malayi major facilitator superfamily protein 0.0018 0.0157 0.047
Echinococcus granulosus solute carrier family 22 0.0018 0.0157 0.0139
Schistosoma mansoni sugar transporter 0.0018 0.0157 0.0157
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0038 0.0429 0.0597
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0362 0.0344
Loa Loa (eye worm) hypothetical protein 0.0092 0.114 0.3807
Onchocerca volvulus 0.0092 0.114 0.3046
Trichomonas vaginalis set domain proteins, putative 0.0263 0.3384 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0435 0.5312
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0081 0.0081
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.01 0.2978
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.0064 0.0139
Brugia malayi PHD-finger family protein 0.0032 0.0352 0.1131
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Brugia malayi Sugar transporter family protein 0.0018 0.0157 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0435 0.1266
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0064 0.0045
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0268 0.3228
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0398 0.038
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0157 0.047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Onchocerca volvulus 0.0033 0.0362 0.0635
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0038 0.0429 0.0597
Plasmodium falciparum proline--tRNA ligase 0.0044 0.05 0.0701
Echinococcus multilocularis muscleblind protein 0.0166 0.2107 0.2092
Trypanosoma brucei glucose transporter 1E 0.0039 0.0435 0.868
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0007 0.0019 0.0434
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0157 0.047
Loa Loa (eye worm) hypothetical protein 0.0055 0.0656 0.2163
Echinococcus multilocularis phd:f box containing protein 0.001 0.0064 0.0045
Leishmania major glucose transporter, lmgt1 0.0039 0.0435 0.5312
Schistosoma mansoni phd/f-box containing protein 0.001 0.0064 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0362 0.0362
Brugia malayi jmjC domain containing protein 0.001 0.0064 0.0153
Echinococcus granulosus muscleblind protein 0.0166 0.2107 0.2092
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0419 0.0419
Leishmania major threonyl-tRNA synthetase, putative 0.0007 0.0019 0.0134
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0064 0.0045
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.05 0.612
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0157 0.047
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0293 0.3539
Plasmodium falciparum calcium-dependent protein kinase 2 0.0038 0.0429 0.0597
Loa Loa (eye worm) hypothetical protein 0.003 0.0326 0.1045
Schistosoma mansoni glucose transporter 0.0018 0.0157 0.0157
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0157 0.303
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0071 0.0076
Brugia malayi Sugar transporter family protein 0.0125 0.1568 0.5259
Schistosoma mansoni protein kinase 0.0038 0.0429 0.0429
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0157 0.1854
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0234 0.0313
Brugia malayi jmjC domain containing protein 0.001 0.0064 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.01 0.3278
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0519 0.0501
Plasmodium falciparum mitogen-activated protein kinase 2 0.0202 0.2579 0.3724
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0429 0.0429
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0293 0.0641
Loa Loa (eye worm) RecQ helicase 0.0027 0.0277 0.0876
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0157 0.0442
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.114 0.114
Onchocerca volvulus 0.0263 0.3384 1
Schistosoma mansoni microtubule-associated protein tau 0.0766 1 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.114 0.3807
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0007 0.0019 0.0134
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0813 1
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0113 0.0313
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0157 0.303
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Loa Loa (eye worm) hypothetical protein 0.0134 0.169 0.5675
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.2964 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.05 1
Schistosoma mansoni sugar transporter 0.0018 0.0157 0.0157
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.132 0.1304
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0293 0.0275
Brugia malayi hypothetical protein 0.0018 0.0157 0.047
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.1568 0.1552
Toxoplasma gondii sugar transporter ST2 0.0018 0.0157 0.0344
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0268 0.9085
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0293 0.5783
Plasmodium falciparum JmjC domain-containing protein, putative 0.001 0.0064 0.0065
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0007 0.0019 0.0032
Trypanosoma brucei glucose transporter, putative 0.0039 0.0435 0.868
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0157 0.0139
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.05 0.0701
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0064 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0037 0.0419 0.1358
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0157 0.0442
Giardia lamblia Sugar-proton symporter 0.0018 0.0157 0.346
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.114 0.1123
Loa Loa (eye worm) hypothetical protein 0.0032 0.0352 0.1131
Brugia malayi Pre-SET motif family protein 0.0033 0.0362 0.1166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Echinococcus multilocularis muscleblind protein 1 0.0166 0.2107 0.2092
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0435 0.1266
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0435 0.1266
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0157 0.0442
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0064 0.1132
Leishmania major glucose transporter, lmgt3 0.0039 0.0435 0.5312
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Entamoeba histolytica hypothetical protein 0.0028 0.0293 0.6823
Toxoplasma gondii glycyl-tRNA synthetase 0.0007 0.0019 0.0041
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0293 0.093
Loa Loa (eye worm) hypothetical protein 0.0037 0.0419 0.1358
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0037 0.0419 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0237 0.5587
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0435 0.1266
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0352 0.0771
Echinococcus granulosus phd:f box containing protein 0.001 0.0064 0.0045
Leishmania major protein kinase, putative 0.0038 0.0429 0.5232
Loa Loa (eye worm) sugar transporter 0.0018 0.0157 0.047
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0064 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0419 0.1358
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0429 0.0411
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0064 0.0045
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0429 0.0411
Toxoplasma gondii sugar transporter ST3 0.0018 0.0157 0.0344
Echinococcus granulosus solute carrier family 22 0.0018 0.0157 0.0139
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0007 0.0019 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0237 0.2853
Leishmania major glucose transporter, lmgt2 0.0039 0.0435 0.5312
Schistosoma mansoni protein phosphatase 2C 0.001 0.0064 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0071 0.0178
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0006 0.0008 0.0017
Plasmodium falciparum calcium-dependent protein kinase 5 0.0038 0.0429 0.0597
Entamoeba histolytica protein kinase, putative 0.0038 0.0429 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0429 0.1393
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0352 0.0334
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0157 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0805 0.267
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0346 0.0328
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0064 0.0064
Echinococcus multilocularis solute carrier family 22 0.0018 0.0157 0.0139
Brugia malayi hypothetical protein 0.0018 0.0157 0.047
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0268 0.0362
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Brugia malayi jmjC domain containing protein 0.0106 0.132 0.4418
Schistosoma mansoni glucose transport protein 0.0125 0.1568 0.1568
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0071 0.0052
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0813 0.0796
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0293 1
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0813 0.178
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0038 0.0429 0.855
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0157 0.0157
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0268 0.6321
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0157 0.1854
Loa Loa (eye worm) hypothetical protein 0.0033 0.0362 0.1166
Plasmodium vivax SET domain protein, putative 0.0033 0.0362 0.0499
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Trypanosoma brucei glucose transporter 2A 0.0039 0.0435 0.868
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0205 0.3994
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0037 0.0419 0.1217
Plasmodium falciparum calcium-dependent protein kinase 1 0.0038 0.0429 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0038 0.0429 0.0411
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0813 0.0796
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.05 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0293 0.0293
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0157 0.303
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0293 0.0399
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0293 0.3539
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.132 0.1304
Schistosoma mansoni protein kinase 0.0038 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0157 0.047
Loa Loa (eye worm) hypothetical protein 0.001 0.0064 0.0153
Leishmania major hypothetical protein, conserved 0.0018 0.0157 0.1854
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0268 0.5274
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0125 0.1568 0.1552
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0157 0.0139
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0071 0.0178
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0429 0.1247
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0157 0.303
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Plasmodium falciparum calcium-dependent protein kinase 4 0.0038 0.0429 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0007 0.0019 0.0218
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0065 0.0143
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0038 0.0429 0.0597
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0038 0.0429 0.1393
Schistosoma mansoni sugar transporter 0.0018 0.0157 0.0157
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0813 0.0813
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.1568 0.1552
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0157 0.5561
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.1568 0.1552
Schistosoma mansoni protein kinase 0.0038 0.0429 0.0429
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0065 0.1167
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0352 0.1131
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0268 0.0586
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0362 0.0793
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0441 0.1435
Schistosoma mansoni hypothetical protein 0.0011 0.0065 0.0065
Schistosoma mansoni jumonji domain containing protein 0.001 0.0064 0.0064
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0157 0.1854
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Schistosoma mansoni hypothetical protein 0.0125 0.1568 0.1568
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0429 0.0411
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0157 0.0442
Loa Loa (eye worm) hypothetical protein 0.001 0.0064 0.0153
Trypanosoma brucei glucose transporter, putative 0.0039 0.0435 0.868
Giardia lamblia PHD finger protein 15 0.0032 0.0352 0.8327
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Plasmodium falciparum protein kinase 6 0.053 0.6894 1
Entamoeba histolytica hypothetical protein 0.0026 0.0268 0.6239
Trypanosoma brucei glucose transporter, putative 0.0039 0.0435 0.868
Schistosoma mansoni jumonji domain containing protein 0.0084 0.1034 0.1034
Echinococcus multilocularis General substrate transporter 0.0107 0.1337 0.1321
Brugia malayi Muscleblind-like protein 0.0166 0.2107 0.7089
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0065 0.1167
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Giardia lamblia Prolyl-tRNA synthetase 0.0037 0.0419 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0113 0.2144
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0157 0.0442
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0157 0.1854
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0268 0.3228
Trypanosoma brucei glucose transporter, putative 0.0039 0.0435 0.868
Echinococcus granulosus General substrate transporter 0.0107 0.1337 0.1321
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0037 0.0419 0.1358
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0293 0.0275
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0128 0.0373
Plasmodium vivax CDK-related protein kinase 6, putative 0.053 0.6894 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.016 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0435 0.1266
Toxoplasma gondii sugar transporter ST1 0.0018 0.0157 0.0344
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0113 0.1312
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.001 0.0064 0.0045
Schistosoma mansoni hypothetical protein 0.0032 0.0352 0.0352
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0157 0.1854
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Trypanosoma brucei glucose transporter, putative 0.0039 0.0435 0.868
Plasmodium falciparum calcium-dependent protein kinase 3 0.0038 0.0429 0.0597
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0362 0.0362
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0157 0.0139
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0064 0.0045
Schistosoma mansoni glycyl-tRNA synthetase 0.0007 0.0019 0.0019
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0277 0.0259
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0038 0.0429 0.1393
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0159
Brugia malayi AF-10 protein 0.0011 0.0065 0.0159
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0037 0.0419 0.9763
Echinococcus granulosus bloom syndrome protein 0.0027 0.0277 0.0259
Brugia malayi PHD-finger family protein 0.0011 0.0065 0.0159
Schistosoma mansoni glucose transport protein 0.0125 0.1568 0.1568
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0071 0.0155
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Leishmania major hypothetical protein, conserved 0.001 0.0064 0.0693
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0268 0.3228
Toxoplasma gondii protein kinase, putative 0.0353 0.4565 1
Echinococcus granulosus solute carrier family 22 0.0018 0.0157 0.0139
Plasmodium falciparum hexose transporter 0.0125 0.1568 0.2253
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.05 0.1096
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0435 0.868
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0157 0.0139
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0293 0.6849
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0157 0.0442
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0398 0.038
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0362 0.0362
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.1568 0.1552
Brugia malayi Pre-SET motif family protein 0.0231 0.2964 1
Plasmodium falciparum phd finger protein, putative 0.0032 0.0352 0.0485
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0813 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0028 0.0293 0.093
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0071 0.1307
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0293 0.3539
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Echinococcus granulosus solute carrier family 22 0.0018 0.0157 0.0139
Brugia malayi Bromodomain containing protein 0.0032 0.0352 0.1131
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.114 0.1123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0813 1
Brugia malayi Cam kinase protein 1 0.0038 0.0429 0.1393
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.001 0.0064 0.0045
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.01 0.1148
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0157 0.0442
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0429 0.0411
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0293 0.5783
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0038 0.0429 0.094
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0435 0.1266
Brugia malayi jmjC domain containing protein 0.001 0.0064 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0019 0.0218
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0293 0.0399
Onchocerca volvulus Alhambra homolog 0.0032 0.0352 0.0604
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0248 0.071
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0019 0.0218
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0038 0.0429 0.1393
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.05 1
Brugia malayi jmjC domain containing protein 0.0039 0.0441 0.1435
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0268 0.0586
Echinococcus multilocularis solute carrier family 22 0.0018 0.0157 0.0139
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0352 0.0352
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.0064 0.0139
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0429 0.0411
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0435 0.1266
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0441 0.0424
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.1568 0.1552
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0268 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0293 0.6932
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0441 0.0424
Schistosoma mansoni DNA helicase recq1 0.0011 0.0071 0.0071
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0293 0.0844
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0441 0.0441
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0352 0.0771
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0157 0.1854
Toxoplasma gondii facilitative glucose transporter GT1 0.0125 0.1568 0.3435
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0007 0.0019 0.0134
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0038 0.0429 0.094
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0007 0.0019 0.0434
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0362 0.0362
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0362 0.0344
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0157 0.0344
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0293 0.0293
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0064 0.0045
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0203 0.0203
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0065 0.0068
Schistosoma mansoni sugar transporter 0.0018 0.0157 0.0157
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0268 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0065 0.0068
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0037 0.0419 0.0401
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0071 0.0052
Plasmodium falciparum protein kinase 7 0.0353 0.4565 0.6612
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0237 0.2853
Trypanosoma brucei glucose transporter, putative 0.0039 0.0435 0.868
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0113 0.2144
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0435 0.868
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0157 0.047
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0071 0.0155
Trypanosoma brucei sugar transporter, putative 0.0018 0.0157 0.303
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0813 1
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0064 0.0153
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0362 0.0344
Trypanosoma brucei glucose transporter, putative 0.0039 0.0435 0.868
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.047
Giardia lamblia Hexose transporter 0.0018 0.0157 0.346
Echinococcus granulosus peregrin 0.0032 0.0352 0.0334
Plasmodium vivax sugar transporter, putative 0.0018 0.0157 0.0201
Loa Loa (eye worm) hypothetical protein 0.0166 0.2107 0.7089
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0268 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.1568 0.4621
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0277 0.0796
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0064 0.0153
Echinococcus multilocularis microtubule associated protein 2 0.0766 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0352 0.0334
Brugia malayi major facilitator superfamily protein 0.0018 0.0157 0.047
Brugia malayi hypothetical protein 0.0018 0.0157 0.047
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0202 0.2579 0.3724
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0007 0.0019 0.0134
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.1568 0.1552
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0813 1
Plasmodium vivax JmjC domain containing protein 0.001 0.0064 0.0065
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0277 0.0876
Mycobacterium ulcerans sugar transporter 0.0018 0.0157 0.1854
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0157 0.0442
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0081 0.0213
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0442
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0277 0.0796
Echinococcus multilocularis solute carrier family 22 0.0018 0.0157 0.0139
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0113 0.2645
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0071 0.0178
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0202 0.2579 0.565
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0038 0.0429 0.094
Trypanosoma brucei glucose transporter, putative 0.0039 0.0435 0.868
Brugia malayi jmjC domain containing protein 0.001 0.0064 0.0153

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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