Detailed information for compound 561349

Basic information

Technical information
  • TDR Targets ID: 561349
  • Name: 3,6-bis(2-methylsulfanylethyl)piperazine-2,5- dione
  • MW: 262.392 | Formula: C10H18N2O2S2
  • H donors: 2 H acceptors: 2 LogP: 0.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCC1NC(=O)C(NC1=O)CCSC
  • InChi: 1S/C10H18N2O2S2/c1-15-5-3-7-9(13)12-8(4-6-16-2)10(14)11-7/h7-8H,3-6H2,1-2H3,(H,11,14)(H,12,13)
  • InChiKey: VSOISORJHNBTCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,6-bis[2-(methylthio)ethyl]piperazine-2,5-dione
  • 3,6-bis[2-(methylthio)ethyl]piperazine-2,5-quinone
  • cyclo-dimethionine
  • 36963-02-7
  • EINECS 253-290-8
  • NSC523126
  • NSC522234
  • 3,6-Bis(2-(methylthio)ethyl)piperazine-2,5-dione
  • Cyclo(dimethionine)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.002 0.0015
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0068 0.0811
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0364 0.0364
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.002 0.002
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0178 0.5835
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0015
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0093 0.1141
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0682 0.8757
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0063 0.0746
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0178 0.2276
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0071 0.0853
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0778 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0063
Schistosoma mansoni lamin 0.0027 0.0134 0.0134
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0054 0.0315 0.031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.002 0.0015
Toxoplasma gondii hypothetical protein 0.0054 0.0315 0.4011
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0054 0.0315 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.002 0.0015
Echinococcus granulosus carbonic anhydrase 0.0054 0.0315 0.0315
Echinococcus granulosus pyruvate kinase 0.0017 0.0068 0.0068
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0315 0.0315
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0778 1
Echinococcus multilocularis pyruvate kinase 0.0027 0.013 0.013
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0054 0.0315 1
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0015
Schistosoma mansoni nuclear hormone receptor 0.001 0.002 0.002
Echinococcus granulosus intermediate filament protein 0.0027 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0015
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0823 0.5443 0.5443
Brugia malayi Steroid receptor seven-up type 2 0.001 0.002 0.0015
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0315 0.0315
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0054 0.0315 0.031
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0315 0.0315
Leishmania major pyruvate kinase 0.0034 0.0178 0.2233
Brugia malayi steroid hormone receptor 0.001 0.002 0.0015
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.004 0.004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.0746
Echinococcus multilocularis FTZ F1 alpha 0.001 0.002 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0063 0.1861
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0178 0.5566
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0178 0.5835
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0093 0.121
Giardia lamblia Pyruvate kinase 0.0017 0.0068 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.002 0.0015
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.002 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.002 0.0015
Schistosoma mansoni thyroid hormone receptor 0.001 0.002 0.002
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0272 0.8607
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0109 0.157
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0195 0.0195
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0093 0.2845
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.002 0.002
Schistosoma mansoni thyroid hormone receptor 0.001 0.002 0.002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0682 0.8757
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0035
Echinococcus granulosus bifunctional protein NCOAT 0.1505 1 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0054 0.0315 0.031
Echinococcus granulosus carbonic anhydrase 0.0054 0.0315 0.0315
Brugia malayi glutathione reductase 0.0048 0.0272 0.0267
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.032 0.4076
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0764 0.9811
Schistosoma mansoni Hyaluronidase 0.1505 1 1
Schistosoma mansoni carbonic anhydrase 0.0054 0.0315 0.0315
Schistosoma mansoni ap endonuclease 0.0021 0.0093 0.0093
Mycobacterium tuberculosis Probable reductase 0.0109 0.0682 0.8757
Echinococcus multilocularis pyruvate kinase 0.0017 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0015
Echinococcus multilocularis bifunctional protein NCOAT 0.1505 1 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.002 0.0015
Schistosoma mansoni hypothetical protein 0.0415 0.2722 0.2722
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0315 0.0315
Loa Loa (eye worm) hyaluronidase 0.1505 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.002 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0778 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0093 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0149 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0015
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.002 0.002
Echinococcus granulosus dnaJ subfamily B 0.0415 0.2722 0.2722
Echinococcus multilocularis pyruvate kinase 0.0034 0.0178 0.0178
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.002 0.002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.002 0.002
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0178 0.0173
Echinococcus multilocularis pyruvate kinase 0.0017 0.0068 0.0068
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0272 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0036 0.0195 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0036 0.0195 0.0195
Leishmania major cytochrome p450-like protein 0.0018 0.0071 0.0853
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.002 0.002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.002 0.002
Echinococcus multilocularis musashi 0.0027 0.0134 0.0134
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0746
Schistosoma mansoni lamin 0.0027 0.0134 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.002 0.0015
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0272 0.0267
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0178 0.2233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.002 0.0015
Leishmania major pyruvate kinase 0.0034 0.0178 0.2233
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0063 0.1861
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0054 0.0315 0.031
Plasmodium falciparum thioredoxin reductase 0.0048 0.0272 0.8288
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0063 0.1861
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0272 0.0272
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0682 0.8926
Brugia malayi intermediate filament protein 0.0027 0.0134 0.0129
Echinococcus granulosus lamin 0.0027 0.0134 0.0134
Loa Loa (eye worm) glutathione reductase 0.0048 0.0272 0.0267
Entamoeba histolytica hypothetical protein 0.0036 0.0195 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0032
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0068 0.0238
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0063 0.0746
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0071 0.0066
Echinococcus granulosus carbonic anhydrase II 0.0054 0.0315 0.0315
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0063 0.0746
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0778 1
Loa Loa (eye worm) hypothetical protein 0.0639 0.422 0.4218
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0063 0.1861
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.0315 0.031
Onchocerca volvulus 0.0051 0.029 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.002 0.002
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.0005 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.002 0.002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0682 0.8757
Schistosoma mansoni pyruvate kinase 0.0034 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.002 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.002 0.0015
Schistosoma mansoni coup transcription factor 0.001 0.002 0.002
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.0315 0.0315
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0178 0.5835
Trypanosoma brucei trypanothione reductase 0.0048 0.0272 0.8607
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0012
Onchocerca volvulus 0.0027 0.0134 0.4231
Brugia malayi hypothetical protein 0.0036 0.0195 0.019
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0315 0.031
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0195 0.0195
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.002 0.002
Echinococcus granulosus lamin dm0 0.0027 0.0134 0.0134
Brugia malayi Cytochrome P450 family protein 0.0018 0.0071 0.0066
Loa Loa (eye worm) hypothetical protein 0.0051 0.029 0.0285
Echinococcus granulosus cpg binding protein 0.0031 0.0157 0.0157
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0134 0.0129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.1861
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.002 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0778 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0146 0.0141
Schistosoma mansoni cpg binding protein 0.0031 0.0157 0.0157
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.0746
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.005 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.002 0.0015
Loa Loa (eye worm) carbonic anhydrase 3 0.0054 0.0315 0.031
Leishmania major trypanothione reductase 0.0048 0.0272 0.3452
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0033 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0109 0.0104
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0178 0.5493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.002 0.0015
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0178 0.2233
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0178 0.5566
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0272 0.3452
Chlamydia trachomatis pyruvate kinase 0.0034 0.0178 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.005 0.0045
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0063 0.1861
Plasmodium vivax glutathione reductase, putative 0.0048 0.0272 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.002 0.002
Plasmodium falciparum carbonic anhydrase 0.0054 0.0315 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.002 0.0015
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0315 0.031
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0764 0.9811
Loa Loa (eye worm) hypothetical protein 0.0054 0.0315 0.031
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.002 0.0015
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.002 0.002
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0068 0.0198
Schistosoma mansoni hypothetical protein 0.0008 0.0005 0.0005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0778 0.0778
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.002 0.002
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.1505 1 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0109 0.0104
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0134 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.002 0.0015
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0071 0.2125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.002 0.0015
Plasmodium falciparum pyruvate kinase 0.0034 0.0178 0.4553
Onchocerca volvulus 0.0029 0.0146 0.4671
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.1861
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0054 0.0315 1
Schistosoma mansoni cytochrome P450 0.0008 0.0005 0.0005
Brugia malayi ecdysteroid receptor 0.001 0.002 0.0015
Entamoeba histolytica hypothetical protein 0.0036 0.0195 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0093 0.2658
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0093 0.2658
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0315 0.031
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0063
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0764 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.1861
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0071 0.2125
Echinococcus multilocularis pyruvate kinase 0.0017 0.0068 0.0068
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0063
Brugia malayi Cytochrome P450 family protein 0.0029 0.0149 0.0144
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0054 0.0315 0.0315
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0778 0.0778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.002 0.0015
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0778 0.0778
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0063 0.1861
Schistosoma mansoni cpg binding protein 0.0029 0.0146 0.0146
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0033 0.0028
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.2722 0.2722
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0071 0.0066
Leishmania major carbonic anhydrase-like protein 0.0054 0.0315 0.4011
Schistosoma mansoni pyruvate kinase 0.0034 0.0178 0.0178
Entamoeba histolytica hypothetical protein 0.0036 0.0195 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0054 0.0315 0.0315
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0272 0.0272
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0093 0.0088
Echinococcus multilocularis lamin dm0 0.0027 0.0134 0.0134
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0178 0.0173
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0093 0.1141
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0012 0.0007
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0063 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.002 0.0015
Brugia malayi nuclear hormone receptor 0.001 0.002 0.0015
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.002 0.0015
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0063 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.002 0.0015
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0178 0.0173
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0764 0.9811
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0778 0.0778
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.002 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0195 0.0195
Echinococcus multilocularis 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0178 0.0173
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0178 0.0173
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0682 0.8757
Echinococcus multilocularis carbonic anhydrase II 0.0054 0.0315 0.0315
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.002 0.002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0063 0.1861
Schistosoma mansoni ap endonuclease 0.0021 0.0093 0.0093
Echinococcus granulosus tumor protein p63 0.0346 0.2263 0.2263
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.002 0.002
Echinococcus granulosus pyruvate kinase 0.0034 0.0178 0.0178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.1861
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0093 0.146
Brugia malayi Cytochrome P450 family protein 0.0018 0.0071 0.0066
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0063 0.0746
Trypanosoma brucei carbonic anhydrase-like protein 0.0054 0.0315 1
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0015
Echinococcus granulosus FTZ F1 alpha 0.001 0.002 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.002 0.002
Schistosoma mansoni cpg binding protein 0.0031 0.0157 0.0157
Echinococcus multilocularis tumor protein p63 0.0346 0.2263 0.2263
Schistosoma mansoni intermediate filament proteins 0.0027 0.0134 0.0134
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.002 0.002
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0178 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0071 0.0066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0131 0.0126
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0093 0.2658
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.002 0.002
Echinococcus granulosus pyruvate kinase 0.0034 0.0178 0.0178
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.0315 0.031
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0178 0.5566
Giardia lamblia Pyruvate kinase 0.0034 0.0178 1
Brugia malayi nuclear receptor NHR-88 0.001 0.002 0.0015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0093 0.2845
Loa Loa (eye worm) hypothetical protein 0.0054 0.0315 0.031
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0071 0.2125
Toxoplasma gondii exonuclease III APE 0.0021 0.0093 0.1141
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0778 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0157 0.0157
Echinococcus multilocularis lamin 0.0027 0.0134 0.0134
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0178 0.0173
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0032
Loa Loa (eye worm) steroid hormone receptor 0.001 0.002 0.0015
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0178 0.2233
Echinococcus granulosus carbonic anhydrase 0.0054 0.0315 0.0315
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.1861
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.1861
Schistosoma mansoni pyruvate kinase 0.0017 0.0068 0.0068
Toxoplasma gondii thioredoxin reductase 0.0048 0.0272 0.3452
Echinococcus granulosus pyruvate kinase 0.0017 0.0068 0.0068
Onchocerca volvulus 0.0027 0.0134 0.4231
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0134 0.0129
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0063 0.0746
Brugia malayi Thioredoxin reductase 0.0048 0.0272 0.0267
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0093 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.002 0.002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0093 0.2845
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0093 0.0088
Echinococcus granulosus pyruvate kinase 0.0017 0.0068 0.0068
Echinococcus multilocularis pyruvate kinase 0.0034 0.0178 0.0178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.002 0.002
Plasmodium falciparum glutathione reductase 0.0048 0.0272 0.8288
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0146 0.0141
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0093 0.0093
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.002 0.002
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.029 0.029
Echinococcus multilocularis carbonic anhydrase 0.0054 0.0315 0.0315
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0178 0.5566
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0063 0.0746
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0682 0.8757
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0093 0.1141
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0011 0.0006
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0178 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.0315 0.031

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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