Detailed information for compound 561644

Basic information

Technical information
  • TDR Targets ID: 561644
  • Name: ammonium 5,6-diphenyl-1,2,4-triazine-3-thiola te
  • MW: 284.379 | Formula: C15H16N4S
  • H donors: 1 H acceptors: 3 LogP: 2.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [SH2-]c1nnc(c(n1)c1ccccc1)c1ccccc1.[NH4+]
  • InChi: 1S/C15H11N3S.H3N/c19-15-16-13(11-7-3-1-4-8-11)14(17-18-15)12-9-5-2-6-10-12;/h1-10H,(H,16,18,19);1H3
  • InChiKey: OVHSVTYEKDVHQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • azanium 5,6-diphenyl-1,2,4-triazine-3-thiolate
  • azanium 5,6-di(phenyl)-1,2,4-triazine-3-thiolate
  • ammonium 5,6-di(phenyl)-1,2,4-triazine-3-thiolate
  • 56223-64-4
  • 5,6-Diphenyl-as-triazine-3-thione ammonium salt
  • as-Triazine-3-thione, 5,6-diphenyl-, ammonium salt

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0027 0.0201
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.1107
Echinococcus granulosus expressed protein 0.0451 0.2135 0.246
Brugia malayi PXA domain containing protein 0.0023 0.008 0.0618
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0037 0.0042
Schistosoma mansoni inositol monophosphatase 0.0037 0.0146 0.0146
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.008 0.0327
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0135 0.0156
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0027 0.0027
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0146 0.0146
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0275 0.1288 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0146 0.0839
Schistosoma mansoni inositol monophosphatase 0.0037 0.0146 0.0146
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0027 0.0031
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.008 0.0618
Plasmodium falciparum protoporphyrinogen oxidase 0.0275 0.1288 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.008 0.008
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.008 0.0618
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0027 0.021
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1343 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0143 0.0106
Loa Loa (eye worm) hypothetical protein 0.0275 0.1288 1
Leishmania major hypothetical protein, conserved 0.0041 0.0167 0.1044
Echinococcus multilocularis 0.0275 0.1288 0.1288
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0027 0.0031
Brugia malayi nuclear hormone receptor 0.0012 0.0027 0.021
Brugia malayi Augmenter of liver regeneration 0.0041 0.0167 0.13
Leishmania major UDP-galactopyranose mutase 0.0275 0.1288 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0146 0.0169
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0321 0.0285
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0027 0.021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.021
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.008 0.0092
Brugia malayi hypothetical protein 0.0023 0.008 0.0618
Onchocerca volvulus 0.0286 0.1343 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0027 0.0027
Brugia malayi Inositol-1 0.0037 0.0146 0.1136
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.008 0.0618
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.008 0.0092
Loa Loa (eye worm) RGS-3 protein 0.0023 0.008 0.0618
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.008 0.0618
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0027 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0027 0.0027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0321 0.0321
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0037 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0027 0.021
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0027 0.0201
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.008 0.008
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.021
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.008 0.008
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0167 0.13
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0202 0.0165
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0037 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.1107
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0618
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0037 0.0011
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0202 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0321 0.0321
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.0167 0.0193
Schistosoma mansoni regulator of G protein signaling 0.0023 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0027 0.021
Brugia malayi PXA domain containing protein 0.0023 0.008 0.0618
Brugia malayi SWIRM domain containing protein 0.0275 0.1288 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0146 0.011
Brugia malayi Pre-SET motif family protein 0.0251 0.1176 0.9131
Plasmodium vivax SET domain protein, putative 0.0036 0.0142 0.1099
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0037 0.2199
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.0167 0.13
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0027 0.0027
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.0167 0.0167
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0275 0.1288 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.008 0.0092
Echinococcus granulosus axis inhibition protein axin 0.0023 0.008 0.0092
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.008 0.0092
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0202 0.0201
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0133 0.0122
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0142 0.1099
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.008 0.008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0202 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.008 0.0327
Loa Loa (eye worm) hypothetical protein 0.0275 0.1288 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0275 0.1288 0.1288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0234 0.0269
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0037 0.0286
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0027 0.0031
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0027 0.0201
Onchocerca volvulus 0.0014 0.0037 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0027 0.021
Mycobacterium ulcerans monoamine oxidase 0.0275 0.1288 0.1256
Onchocerca volvulus 0.0014 0.0037 0.0274
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.2087 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0618
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.008 0.008
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.008 0.0618
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.1099
Schistosoma mansoni regulator of G protein signaling 0.0023 0.008 0.008
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0027 0.021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0234 0.1815
Onchocerca volvulus 0.0036 0.0142 0.1054
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.008 0.008
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0037 0.0286
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0037 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0234 0.0234
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0037 0.0286
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0202 0.1317
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.008 0.008
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.0876
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.021
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0146 0.1136
Loa Loa (eye worm) inositol-1 0.0037 0.0146 0.1136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0202 0.0201
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.1136
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0037 0.0286
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.008 0.008
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0202 0.1565
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0027 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0027 0.021
Plasmodium vivax hypothetical protein, conserved 0.0275 0.1288 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0618
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0234 0.0234
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0167 0.13
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0202 0.0165
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0037 0.0286
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0321 0.0285
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0202 0.0165
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.008 0.008
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0146 0.5
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0128 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0027 0.021
Schistosoma mansoni axis inhibition protein axin 0.0023 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.008 0.0327
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0027 0.0027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0027 0.0031
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0027 0.0031
Onchocerca volvulus 0.0014 0.0037 0.0274
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0027 0.0027
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.1136
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0202 0.0165
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0027 0.0027
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.008 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.008 0.0327
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1176 0.9131
Entamoeba histolytica hypothetical protein 0.0023 0.008 0.2597
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.008 0.008
Mycobacterium ulcerans oxidoreductase 0.0275 0.1288 0.1256
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.008 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.008 0.008
Schistosoma mansoni regulator of G protein signaling 0.0023 0.008 0.008
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0142 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0027 0.021
Plasmodium vivax hypothetical protein, conserved 0.0275 0.1288 1
Loa Loa (eye worm) hypothetical protein 0.0275 0.1288 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0027 0.0027
Echinococcus granulosus lysine specific histone demethylase 1A 0.0275 0.1288 0.1484
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.008 0.0092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.1107
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0037 0.0286
Echinococcus multilocularis expressed protein 0.0451 0.2135 0.2135
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0167 0.13
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0027 0.021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0146 0.0839
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.008 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.008 0.008
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0321 0.037
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0202 0.1565
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0275 0.1288 0.1256
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0202 0.1317
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0133 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0142 0.0142
Onchocerca volvulus 0.0049 0.0202 0.1501
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0202 0.0165
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0037 0.0286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.1107
Schistosoma mansoni regulator of G protein signaling 0.0023 0.008 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0027 0.021
Brugia malayi nuclear receptor NHR-88 0.0012 0.0027 0.021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0202 0.1565
Loa Loa (eye worm) hypothetical protein 0.0049 0.0202 0.1565
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0202 0.0165
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.008 0.0618
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0037 0.0286
Onchocerca volvulus 0.0012 0.0027 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0027 0.021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0142 0.0142
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.008 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0133 0.0122
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0202 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0027 0.021
Onchocerca volvulus 0.0275 0.1288 0.959
Loa Loa (eye worm) hypothetical protein 0.0049 0.0202 0.1565
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0011
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0143 0.1107
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.008 0.0618
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0234 0.0234
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0142 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0027 0.021
Brugia malayi Pre-SET motif family protein 0.0036 0.0142 0.1099
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.008 0.0618
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0027 0.021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0275 0.1288 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0037 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0037 0.0286
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0321 0.249
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0618
Schistosoma mansoni regulator of G protein signaling 0.0023 0.008 0.008
Trypanosoma cruzi UDP-galactopyranose mutase 0.0275 0.1288 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3974 0.3974
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.008 0.008
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0202 0.1317
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0321 0.0321
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0037 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0027 0.021
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0037 0.0011
Schistosoma mansoni amine oxidase 0.0275 0.1288 0.1288
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0167 0.13
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0142 0.0142
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0027 0.0027
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0027 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0027 0.0027
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0275 0.1288 0.1288
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0202 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0167 0.13
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0027 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0133 0.0122
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0202 0.0165
Brugia malayi hypothetical protein 0.0275 0.1288 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0037 0.0286
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0128 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.008 0.0327
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0027 0.0027
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0275 0.1288 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0234 0.0269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.021
Schistosoma mansoni amine oxidase 0.0275 0.1288 0.1288
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0275 0.1288 1
Echinococcus granulosus axis inhibition protein axin 0.0023 0.008 0.0092
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0143 0.1107
Loa Loa (eye worm) hypothetical protein 0.0275 0.1288 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0027 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0321 0.0285
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0037 0.0286
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0143 0.0133
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0027 0.0031
Brugia malayi steroid hormone receptor 0.0012 0.0027 0.021
Echinococcus granulosus protoporphyrinogen oxidase 0.1812 0.868 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0037 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0234 0.0234
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0321 0.0339
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0321 0.2269
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0146 0.8742
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0037 0.0286
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0286
Echinococcus granulosus lysine specific histone demethylase 1A 0.0275 0.1288 0.1484
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0027 0.0031
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0167 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0027 0.021
Loa Loa (eye worm) hypothetical protein 0.0275 0.1288 1
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.008 0.0618
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.021
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0037 0.0286
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0167 0.13
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.008 0.0618
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0037 0.0286
Toxoplasma gondii histone lysine-specific demethylase 0.0275 0.1288 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0275 0.1288 0.1457
Mycobacterium tuberculosis Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) 0.1812 0.868 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0202 0.1565
Mycobacterium ulcerans dehydrogenase 0.0275 0.1288 0.1256
Mycobacterium tuberculosis Conserved hypothetical protein 0.0275 0.1288 0.1457
Mycobacterium ulcerans protoporphyrinogen oxidase 0.2087 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0027 0.021
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0275 0.1288 1
Entamoeba histolytica hypothetical protein 0.0023 0.008 0.2597
Trypanosoma cruzi UDP-galactopyranose mutase 0.0275 0.1288 1
Entamoeba histolytica hypothetical protein 0.0023 0.008 0.2597
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0027 0.021
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.2087 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3974 0.3974
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0011
Echinococcus multilocularis protoporphyrinogen oxidase 0.2087 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0234 0.1815
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.008 0.0327
Brugia malayi amine oxidase, flavin-containing family protein 0.0275 0.1288 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.1107
Schistosoma mansoni coup transcription factor 0.0012 0.0027 0.0027
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0027 0.021
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3974 0.4578
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0037 0.0286
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0167 0.13
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0286
Loa Loa (eye worm) oxidoreductase 0.0014 0.0037 0.0286
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0037 0.2199
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0037 0.0011
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.008 0.0092
Schistosoma mansoni axis inhibition protein axin 0.0023 0.008 0.008
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0027 0.021
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0146 0.665
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0618
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0146 0.0839
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0027 0.021
Onchocerca volvulus 0.0018 0.0056 0.0418
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0027 0.0027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.021
Brugia malayi ecdysteroid receptor 0.0012 0.0027 0.021
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0037 0.0286
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0202 1
Mycobacterium ulcerans hypothetical protein 0.0049 0.0202 0.0165
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0618
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0037 0.0286
Brugia malayi hypothetical protein 0.0023 0.008 0.0618
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0027 0.021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0027 0.0027
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0275 0.1288 0.1256

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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