Detailed information for compound 562566

Basic information

Technical information
  • TDR Targets ID: 562566
  • Name: [7-[(E)-2-methylbut-2-enoyl]oxy-5,6,7,8-tetra hydro-3H-pyrrolizin-1-yl]methyl 2,3-dihydroxy -2-(1-hydroxyethyl)-3-methyl-butanoate; 3,4,5 -trihydroxybenzoic acid
  • MW: 567.582 | Formula: C27H37NO12
  • H donors: 7 H acceptors: 10 LogP: -1.96 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC(=O)c1cc(O)c(c(c1)O)O.C/C=C(/C(=O)OC1CCN2C1C(=CC2)COC(=O)C(C(O)(C)C)(C(O)C)O)\C
  • InChi: 1S/C20H31NO7.C7H6O5/c1-6-12(2)17(23)28-15-8-10-21-9-7-14(16(15)21)11-27-18(24)20(26,13(3)22)19(4,5)25;8-4-1-3(7(11)12)2-5(9)6(4)10/h6-7,13,15-16,22,25-26H,8-11H2,1-5H3;1-2,8-10H,(H,11,12)/b12-6+;
  • InChiKey: VGANGUGHQNNIFW-WXIWBVQFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,3-dihydroxy-2-(1-hydroxyethyl)-3-methylbutanoic acid [7-[(E)-2-methyl-1-oxobut-2-enoxy]-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl ester; 3,4,5-trihydroxybenzoic acid
  • gallic acid; (E)-2-methylbut-2-enoic acid [7-[[2,3-dihydroxy-2-(1-hydroxyethyl)-3-methyl-butanoyl]oxymethyl]-2,3,5,8-tetrahydro-1H-pyrrolizin-1-yl] ester
  • [7-[(E)-2-methylbut-2-enoyl]oxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl 2,3-dihydroxy-2-(1-hydroxyethyl)-3-methylbutanoate; 3,4,5-trihydroxybenzoic acid
  • cyngal
  • 39456-87-6
  • 50894-36-5
  • Benzoic acid, 3,4,5-trihydroxy-, compd. with 7-((2,3-dihydroxy-2-(1-hydroxyethyl)-3-methyl-1-oxobutoxy)methyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl 2-methyl-2-butenoate (1:1)
  • Cynoglossophine gallate
  • Heliosupine gallate
  • Tsingal

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sugar transporter 0.0063 0.0201 0.0199
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0063 0.0201 0.0201
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.014 0.2109
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trypanosoma brucei glucose transporter, putative 0.014 0.0576 0.868
Brugia malayi hypothetical protein 0.0063 0.0201 0.084
Mycobacterium ulcerans sugar transporter 0.0063 0.0201 0.5239
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trichomonas vaginalis sugar transporter, putative 0.014 0.0576 0.274
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trypanosoma cruzi sugar transporter, putative 0.0063 0.0201 0.303
Schistosoma mansoni lysyl-tRNA synthetase 0.0101 0.0383 0.0381
Schistosoma mansoni sugar transporter 0.0063 0.0201 0.0199
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Entamoeba histolytica hypothetical protein 0.0071 0.024 0.4078
Entamoeba histolytica hypothetical protein 0.0071 0.024 0.4078
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0121 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0201 0.0956
Onchocerca volvulus 0.01 0.038 1
Brugia malayi lysyl-tRNA synthetase 0.0101 0.0383 0.1664
Plasmodium falciparum calcium-dependent protein kinase 2 0.0138 0.0567 0.0597
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Echinococcus multilocularis solute carrier family 22 0.0063 0.0201 0.0199
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Trichomonas vaginalis glucose transporter, putative 0.014 0.0576 0.274
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.014 0.2109
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0135 0.0553 0.2429
Trichomonas vaginalis glucose transporter, putative 0.014 0.0576 0.274
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.0663 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0052 0.1688
Brugia malayi Sugar transporter family protein 0.0451 0.21 0.9404
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Echinococcus multilocularis solute carrier family 22 0.0063 0.0201 0.0199
Schistosoma mansoni hypothetical protein 0.0047 0.0121 0.0119
Giardia lamblia Sugar-proton symporter 0.0063 0.0201 0.346
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0135 0.0553 0.9752
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.0663 1
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0576 0.274
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trypanosoma brucei glucose transporter, putative 0.014 0.0576 0.868
Giardia lamblia Prolyl-tRNA synthetase 0.0135 0.0553 1
Schistosoma mansoni glucose transporter 0.0063 0.0201 0.0199
Echinococcus multilocularis calcium dependent protein kinase 0.013 0.0525 0.0523
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0201 0.0956
Loa Loa (eye worm) hypothetical protein 0.0047 0.012 0.0474
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0025 0.0014 0.0262
Treponema pallidum prolyl-tRNA synthetase 0.0048 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0429 0.1868
Schistosoma mansoni sugar transporter 0.0063 0.0201 0.0199
Echinococcus multilocularis General substrate transporter 0.0388 0.179 0.1788
Onchocerca volvulus 0.0063 0.0201 0.3123
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.0663 1
Schistosoma mansoni hypothetical protein 0.0071 0.024 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0201 0.0956
Trypanosoma cruzi hexose transporter, putative 0.014 0.0576 0.868
Echinococcus granulosus GPCR family 2 0.0047 0.0121 0.0119
Schistosoma mansoni hypothetical protein 0.0047 0.0121 0.0119
Loa Loa (eye worm) hypothetical protein 0.01 0.038 0.1648
Schistosoma mansoni protein kinase 0.0138 0.0567 0.0565
Echinococcus granulosus synaptic vesicle 2 protein 0.0063 0.0201 0.0199
Onchocerca volvulus 0.0063 0.0201 0.3123
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0201 0.084
Schistosoma mansoni cellular tumor antigen P53 0.01 0.038 0.0378
Echinococcus multilocularis solute carrier family 22 0.0063 0.0201 0.0199
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0101 0.0383 0.6932
Brugia malayi hypothetical protein 0.0063 0.0201 0.084
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.014 0.0135
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0567 0.0565
Leishmania major hypothetical protein, conserved 0.0051 0.014 0.2109
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0063 0.0201 0.5239
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.024 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.21 1
Entamoeba histolytica protein kinase, putative 0.0138 0.0567 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0138 0.0567 0.0597
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0567 0.0565
Leishmania major lysyl-tRNA synthetase, putative 0.0101 0.0383 0.5783
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0201 0.084
Leishmania major protein kinase, putative 0.0138 0.0567 0.855
Echinococcus multilocularis glycyl tRNA synthetase 0.0025 0.0014 0.0012
Onchocerca volvulus 0.0063 0.0201 0.3123
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0138 0.0567 0.0925
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0025 0.0014 0.0024
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0135 0.0553 0.0551
Loa Loa (eye worm) hypothetical protein 0.0101 0.0383 0.1664
Schistosoma mansoni hypothetical protein 0.0047 0.0121 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0138 0.0567 0.0925
Onchocerca volvulus 0.0063 0.0201 0.3123
Toxoplasma gondii lysine-tRNA ligase 0.0101 0.0383 0.0625
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.012 0.3868
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.014 0.0135
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.012 0.1803
Trypanosoma brucei THT1 - hexose transporter, putative 0.014 0.0576 0.868
Trypanosoma brucei THT1 - hexose transporter, putative 0.014 0.0576 0.868
Brugia malayi hypothetical protein 0.0478 0.2233 1
Onchocerca volvulus 0.0097 0.0368 0.9534
Leishmania major hypothetical protein, conserved 0.0063 0.0201 0.303
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0135 0.0553 0.0551
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.014 0.0576 0.868
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0368 0.1593
Onchocerca volvulus Putative transporter 0.0063 0.0201 0.3123
Schistosoma mansoni lysyl-tRNA synthetase 0.0101 0.0383 0.0381
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trypanosoma brucei glucose transporter, putative 0.014 0.0576 0.868
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Loa Loa (eye worm) hypothetical protein 0.0478 0.2233 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0101 0.0383 0.5783
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0201 0.0956
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0088 0.0323 0.1536
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0025 0.0014 0.0218
Trypanosoma brucei glucose transporter, putative 0.014 0.0576 0.868
Loa Loa (eye worm) hypothetical protein 0.0138 0.0567 0.2491
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.012 0.2161
Leishmania major glucose transporter, lmgt2 0.014 0.0576 0.868
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0567 0.0565
Echinococcus multilocularis survival motor neuron protein 1 0.0478 0.2233 0.2231
Toxoplasma gondii sugar transporter ST3 0.0063 0.0201 0.0327
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0101 0.0383 1
Echinococcus granulosus General substrate transporter 0.0388 0.179 0.1788
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0052 0.1688
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0063 0.0201 0.6499
Toxoplasma gondii sugar transporter ST1 0.0063 0.0201 0.0327
Echinococcus multilocularis GPCR, family 2 0.0047 0.0121 0.0119
Toxoplasma gondii sugar transporter ST2 0.0063 0.0201 0.0327
Brugia malayi major facilitator superfamily protein 0.0063 0.0201 0.084
Brugia malayi hypothetical protein 0.0051 0.014 0.0565
Plasmodium vivax proline--tRNA ligase, putative 0.0158 0.0663 0.0701
Trypanosoma cruzi hexose transporter, putative 0.014 0.0576 0.868
Toxoplasma gondii facilitative glucose transporter GT1 0.0451 0.21 0.3424
Plasmodium falciparum mitogen-activated protein kinase 2 0.0729 0.3462 0.3724
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0048 0.0124 0.3243
Brugia malayi MH2 domain containing protein 0.0241 0.1073 0.4771
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0201 0.0956
Giardia lamblia Hexose transporter 0.0063 0.0201 0.346
Schistosoma mansoni hypothetical protein 0.0047 0.0121 0.0119
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.012 0.3118
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0729 0.3462 0.3724
Schistosoma mansoni microtubule-associated protein tau 0.2063 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.062 0.2732
Trypanosoma cruzi hexose transporter, putative 0.014 0.0576 0.868
Plasmodium falciparum proline--tRNA ligase 0.0158 0.0663 0.0701
Loa Loa (eye worm) hypothetical protein 0.0047 0.012 0.0474
Trypanosoma brucei sugar transporter, putative 0.0063 0.0201 0.303
Brugia malayi Sugar transporter family protein 0.0063 0.0201 0.084
Brugia malayi AMP-binding enzyme family protein 0.0047 0.012 0.0474
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0138 0.0567 0.2491
Schistosoma mansoni protein kinase 0.0138 0.0567 0.0565
Toxoplasma gondii glycyl-tRNA synthetase 0.0025 0.0014 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.0567 0.2699
Chlamydia trachomatis proline--tRNA ligase 0.0048 0.0124 0.2978
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0135 0.0553 0.2634
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0138 0.0567 0.855
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0567 0.0565
Trypanosoma brucei glucose transporter, putative 0.014 0.0576 0.868
Plasmodium falciparum hexose transporter 0.0451 0.21 0.2253
Plasmodium falciparum lysine--tRNA ligase 0.0101 0.0383 0.0399
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0062 0.1605
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0201 0.303
Brugia malayi hypothetical protein 0.0063 0.0201 0.084
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.21 0.2099
Mycobacterium ulcerans hypothetical protein 0.0047 0.012 0.3118
Onchocerca volvulus 0.0063 0.0201 0.3123
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0138 0.0567 0.0597
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0025 0.0014 0.0069
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0138 0.0567 0.0597
Loa Loa (eye worm) hypothetical protein 0.0047 0.0121 0.0481
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.012 0.1803
Leishmania major glucose transporter/membrane transporter D2, putative 0.014 0.0576 0.868
Schistosoma mansoni hypothetical protein 0.0451 0.21 0.2099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0052 0.1688
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.012 0.3868
Loa Loa (eye worm) hypothetical protein 0.0149 0.062 0.2732
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0085 0.0309 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0553 0.2429
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.012 0.1902
Schistosoma mansoni glucose transport protein 0.0451 0.21 0.2099
Loa Loa (eye worm) hypothetical protein 0.0051 0.014 0.0565
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Plasmodium vivax hexose transporter 0.0451 0.21 0.2253
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0063 0.0201 0.0199
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.0014 0.0218
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0121 0.0481
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0025 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Echinococcus multilocularis synaptic vesicle 2 protein 0.0063 0.0201 0.0199
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0138 0.0567 0.2491
Loa Loa (eye worm) hypothetical protein 0.0135 0.0553 0.2429
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trichomonas vaginalis sugar transport protein, putative 0.0063 0.0201 0.0956
Brugia malayi Sugar transporter family protein 0.0063 0.0201 0.084
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0729 0.3462 0.5643
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0158 0.0663 0.1081
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0062 0.1991
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0062 0.0051
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0138 0.0567 0.2491
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0062 0.1276
Plasmodium falciparum protein kinase 7 0.1274 0.6135 0.6612
Onchocerca volvulus 0.0063 0.0201 0.3123
Chlamydia trachomatis lysine--tRNA ligase 0.0101 0.0383 1
Loa Loa (eye worm) sugar transporter 0.0063 0.0201 0.084
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0212
Onchocerca volvulus 0.0063 0.0201 0.3123
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0121 0.0119
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0212
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.012 0.3118
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0085 0.0309 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0085 0.0309 0.5587
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Brugia malayi major facilitator superfamily protein 0.0063 0.0201 0.084
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.012 0.1902
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0451 0.21 0.2099
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0121 0.0481
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0063 0.0201 0.0199
Entamoeba histolytica hypothetical protein 0.0071 0.024 0.4078
Trypanosoma brucei glucose transporter 1E 0.014 0.0576 0.868
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.014 0.2109
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.014 0.0135
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0201 0.084
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0567 0.0565
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.012 0.3118
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0567 0.0565
Trichomonas vaginalis sugar transporter, putative 0.014 0.0576 0.274
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0025 0.0014 0.0218
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0063 0.0201 0.6499
Loa Loa (eye worm) major facilitator superfamily transporter 0.0063 0.0201 0.084
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0576 0.274
Schistosoma mansoni glucose transport protein 0.0451 0.21 0.2099
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0063 0.0201 0.5239
Echinococcus granulosus survival motor neuron protein 1 0.0478 0.2233 0.2231
Echinococcus multilocularis solute carrier family 22 0.0063 0.0201 0.0199
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0451 0.21 0.2099
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0063 0.0201 1
Onchocerca volvulus 0.0063 0.0201 0.3123
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Echinococcus multilocularis microtubule associated protein 2 0.2063 1 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0567 0.0565
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0389 0.169
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.012 0.1902
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0025 0.0014 0.0468
Echinococcus multilocularis tumor protein p63 0.0683 0.3237 0.3236
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0212
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0063 0.0201 0.303
Toxoplasma gondii transporter, major facilitator family protein 0.0063 0.0201 0.0327
Onchocerca volvulus 0.0063 0.0201 0.3123
Trypanosoma cruzi glucose transporter, putative 0.0063 0.0201 0.303
Schistosoma mansoni sugar transporter 0.0063 0.0201 0.0199
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.012 0.1803
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0135 0.0553 1
Mycobacterium ulcerans integral membrane transport protein 0.0063 0.0201 0.5239
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0121 0.0119
Echinococcus multilocularis lysyl tRNA synthetase 0.0101 0.0383 0.0381
Schistosoma mansoni hypothetical protein 0.0033 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0212
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.024 0.0238
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.062 0.2732
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trypanosoma brucei glucose transporter, putative 0.014 0.0576 0.868
Echinococcus granulosus Threonyl tRNA synthetase C 0.0025 0.0014 0.0012
Plasmodium vivax lysine--tRNA ligase, putative 0.0101 0.0383 0.0399
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Trypanosoma brucei glucose transporter 2A 0.014 0.0576 0.868
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0201 0.0956
Echinococcus granulosus calcium dependent protein kinase 0.013 0.0525 0.0523
Leishmania major glucose transporter, lmgt1 0.014 0.0576 0.868
Onchocerca volvulus 0.0063 0.0201 0.3123
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Plasmodium falciparum calcium-dependent protein kinase 3 0.0138 0.0567 0.0597
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0135 0.0553 0.0551
Brugia malayi Cam kinase protein 1 0.0138 0.0567 0.2491
Schistosoma mansoni protein kinase 0.0138 0.0567 0.0565
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0138 0.0567 0.0597
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0138 0.0567 0.0925
Onchocerca volvulus 0.0063 0.0201 0.3123
Schistosoma mansoni glucose transport protein 0.0451 0.21 0.2099
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0101 0.0383 0.5783
Brugia malayi hypothetical protein 0.0071 0.024 0.1016
Loa Loa (eye worm) major facilitator superfamily transporter 0.0063 0.0201 0.084
Plasmodium falciparum calcium-dependent protein kinase 5 0.0138 0.0567 0.0597
Leishmania major myo-inositol/proton symporter (MIT) 0.0063 0.0201 0.303
Echinococcus granulosus solute carrier family 22 0.0063 0.0201 0.0199
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.21 0.2099
Onchocerca volvulus 0.0063 0.0201 0.3123
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trypanosoma brucei RNA helicase, putative 0.0033 0.005 0.0759
Plasmodium vivax calcium-dependent protein kinase, putative 0.0138 0.0567 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.012 0.3118
Plasmodium falciparum protein kinase 6 0.1914 0.9271 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0138 0.0567 0.0597
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.012 0.2161
Echinococcus granulosus solute carrier family 22 0.0063 0.0201 0.0199
Entamoeba histolytica hypothetical protein 0.0101 0.0383 0.6679
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0158 0.0663 1
Leishmania major glucose transporter, lmgt3 0.014 0.0576 0.868
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0121 0.0481
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0025 0.0014 0.0377
Echinococcus granulosus solute carrier family 22 0.0063 0.0201 0.0199
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.012 0.3118
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0121 0.0119
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0056 0.0162 0.0667
Leishmania major threonyl-tRNA synthetase, putative 0.0025 0.0014 0.0218
Onchocerca volvulus 0.0063 0.0201 0.3123
Brugia malayi hypothetical protein 0.0033 0.0051 0.0166
Giardia lamblia Lysyl-tRNA synthetase 0.0101 0.0383 0.6849
Echinococcus granulosus glycyl tRNA synthetase 0.0025 0.0014 0.0012
Loa Loa (eye worm) sugar transporter 0.0451 0.21 0.9404
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.0014 0.0218
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.014 0.0228
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0135 0.0553 0.0551
Loa Loa (eye worm) hypothetical protein 0.0102 0.0389 0.169
Schistosoma mansoni survival motor neuron protein 0.0097 0.0368 0.0366
Echinococcus granulosus tumor protein p63 0.0683 0.3237 0.3236
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Brugia malayi AMP-binding enzyme family protein 0.0047 0.012 0.0474
Entamoeba histolytica hypothetical protein 0.0071 0.024 0.4078
Schistosoma mansoni hypothetical protein 0.0097 0.0368 0.0366
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.21 0.2099
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Echinococcus granulosus Sugar transporter ERD6 protein 0.0063 0.0201 0.0199
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0451 0.21 0.2099
Trypanosoma cruzi hexose transporter 0.014 0.0576 0.868
Toxoplasma gondii protein kinase, putative 0.1274 0.6135 1
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0567 0.0565
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Echinococcus granulosus lysyl tRNA synthetase 0.0101 0.0383 0.0381
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.1073 0.4771
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.1073 0.4771
Trichomonas vaginalis sugar transporter, putative 0.014 0.0576 0.274
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.012 0.3118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0052 0.1688
Schistosoma mansoni hypothetical protein 0.0102 0.0389 0.0387
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0135 0.0553 0.2429
Echinococcus granulosus solute carrier family 22 0.0063 0.0201 0.0199
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0451 0.21 0.2099
Trichomonas vaginalis myo-inositol transporter, putative 0.0063 0.0201 0.0956
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0212
Entamoeba histolytica protein kinase, putative 0.0138 0.0567 1
Trypanosoma cruzi hexose transporter, putative 0.0076 0.0265 0.3994
Onchocerca volvulus 0.0063 0.0201 0.3123
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0025 0.0014 0.0377
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.024 0.0238
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.062 0.2732
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0158 0.0663 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0138 0.0567 0.0565
Onchocerca volvulus 0.0063 0.0201 0.3123
Loa Loa (eye worm) hypothetical protein 0.0047 0.012 0.0474
Plasmodium vivax CDK-related protein kinase 6, putative 0.1914 0.9271 1
Trypanosoma brucei glucose transporter, putative 0.014 0.0576 0.868
Schistosoma mansoni glycyl-tRNA synthetase 0.0025 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.084
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0101 0.0383 1
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Onchocerca volvulus 0.0063 0.0201 0.3123
Trypanosoma brucei glucose transporter, putative 0.014 0.0576 0.868
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Brugia malayi AMP-binding enzyme family protein 0.0047 0.012 0.0474
Plasmodium vivax sugar transporter, putative 0.0063 0.0201 0.0201
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.012 0.3118
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0101 0.0383 0.1826
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0062 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0201 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.21 0.2099

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.