Detailed information for compound 580473

Basic information

Technical information
  • TDR Targets ID: 580473
  • Name: methyl 2-[(4-methoxy-6-methyl-1,3,5-triazin-2 -yl)carbamoylsulfamoyl]benzoate
  • MW: 381.364 | Formula: C14H15N5O6S
  • H donors: 2 H acceptors: 7 LogP: 1.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1nc(nc(n1)C)NC(=O)NS(=O)(=O)c1ccccc1C(=O)OC
  • InChi: 1S/C14H15N5O6S/c1-8-15-12(18-14(16-8)25-3)17-13(21)19-26(22,23)10-7-5-4-6-9(10)11(20)24-2/h4-7H,1-3H3,(H2,15,16,17,18,19,21)
  • InChiKey: RSMUVYRMZCOLBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]-oxomethyl]sulfamoyl]benzoic acid methyl ester
  • 2-[(4-methoxy-6-methyl-s-triazin-2-yl)carbamoylsulfamoyl]benzoic acid methyl ester
  • metsulfuron methyl
  • 82197-07-7
  • 74223-64-6
  • CBDivE_002527
  • 1MM
  • METHYL 2-[({[(4-METHOXY-6-METHYL-1,3,5-TRIAZIN-2-YL)AMINO]CARBONYL}AMINO)SULFONYL]BENZOATE
  • AIDS-040011
  • AIDS040011
  • Methyl-2[[[[(4-methoxy-6-Methyl-1.3.5triazin-2-yl)-amino]carbonyl]amino]sulfonyl]benzoate
  • Metsulphuron methyl
  • C10946
  • PS1078_SUPELCO
  • 46432_RIEDEL
  • 2-(((((4-Methoxy-6-methyl-1,3,5-triazin-2yl)amino)carbonyl)amino)sulfonyl)benzoic acid methyl ester
  • 5-26-09-00406 (Beilstein Handbook Reference)
  • ALLY
  • ALLY 20DF
  • Allie
  • BRN 0587472
  • Benzoic acid, 2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)-, methyl ester
  • Brush-off
  • Caswell No. 419H
  • DPD 63760H
  • DPX 6376
  • DPX-T 6376
  • EPA Pesticide Chemical Code 122010
  • Escort
  • Escort (pesticide)
  • Granstar
  • Gropper
  • HCHA 92HA
  • HSDB 6849
  • METSULFURON-METHYL
  • Methyl 2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)benzoate
  • Methyl 2-(3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)ureidosulfonyl)benzoate
  • Methyl 2-(3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)ureidosulphonyl)benzoate
  • Metsulfuron methyl ester [ANSI]
  • N-((2-Methylcarbonyl)phenyl)sulfonyl-N'-(6-methoxy-4-methyl-2-triazinyl)urea
  • N-((4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl)-2-methoxycarbonylbenzenesulfonamide
  • T 6376
  • Metsulfuron-Me

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens androgen receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0086 0.0946 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0096 0.0228
Brugia malayi hypothetical protein 0.0028 0.0044 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4013 1
Brugia malayi nuclear hormone receptor 0.0059 0.0526 0.125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0059 0.0526 0.125
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0044 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0096 0.0228
Mycobacterium ulcerans hypothetical protein 0.0266 0.3735 1
Entamoeba histolytica hypothetical protein 0.0073 0.0741 0.1847
Onchocerca volvulus Bile acid receptor homolog 0.0059 0.0526 1
Mycobacterium ulcerans putative oxalyl-CoA decarboxylase 0.0266 0.3735 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0044 0.0024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0031 0.0096 0.0076
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0031 0.0096 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4013 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0059 0.0526 0.0507
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0602 0.1612
Echinococcus multilocularis FTZ F1 alpha 0.0059 0.0526 0.0507
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0059 0.0526 0.125
Loa Loa (eye worm) hypothetical protein 0.0059 0.0526 0.125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0059 0.0526 0.125
Loa Loa (eye worm) hypothetical protein 0.0044 0.0302 0.0717
Loa Loa (eye worm) hypothetical protein 0.0031 0.0096 0.0228
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0365 0.0867
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0031 0.0096 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4013 1
Loa Loa (eye worm) steroid hormone receptor 0.0059 0.0526 0.125
Brugia malayi CHE-14 protein 0.0044 0.0302 0.0717
Brugia malayi nuclear receptor RXR 0.0031 0.0096 0.0228
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0608 0.1445
Onchocerca volvulus 0.0028 0.0044 0.0841
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0059 0.0526 0.0507
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0059 0.0526 0.125
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0059 0.0526 0.0507
Leishmania major putative pyruvate/indole-pyruvate carboxylase, putative 0.0152 0.1972 1
Entamoeba histolytica hypothetical protein 0.0073 0.0741 0.1847
Loa Loa (eye worm) hypothetical protein 0.0059 0.0526 0.125
Mycobacterium leprae PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SH 0.0047 0.0347 0.0929
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.4013 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0027 0.0064
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0028 0.0044 0.0024
Echinococcus multilocularis muscleblind protein 0.0296 0.4205 0.4193
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0059 0.0526 0.125
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0602 0.0583
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0741 0.0722
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.1216 0.303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4013 1
Echinococcus multilocularis muscleblind protein 1 0.0296 0.4205 0.4193
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0044 0.0024
Brugia malayi Cytochrome P450 family protein 0.0027 0.0027 0.0064
Loa Loa (eye worm) ILVBL protein 0.0161 0.211 0.5017
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0028 0.0044 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0059 0.0526 0.125
Mycobacterium ulcerans 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase 0.0047 0.0347 0.0929
Echinococcus multilocularis expressed conserved protein 0.0097 0.1119 0.1101
Schistosoma mansoni hypothetical protein 0.0043 0.0277 0.0257
Brugia malayi Cytochrome P450 family protein 0.0056 0.0486 0.1155
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0741 0.0722
Schistosoma mansoni nuclear receptor 0.0028 0.0044 0.0024
Loa Loa (eye worm) hypothetical protein 0.0048 0.0359 0.0853
Schistosoma mansoni nuclear receptor nhr-48 0.0028 0.0044 0.0024
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0608 0.0589
Mycobacterium leprae PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) 0.0266 0.3735 1
Brugia malayi intermediate filament protein 0.0026 0.002 0.0048
Brugia malayi hypothetical protein 0.0031 0.0096 0.0228
Schistosoma mansoni zinc finger protein 0.0028 0.0044 0.0024
Brugia malayi nuclear hormone receptor family member odr-7 0.0028 0.0044 0.0105
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0028 0.0044 0.0024
Brugia malayi hypothetical protein 0.0031 0.0096 0.0228
Loa Loa (eye worm) nuclear receptor NHR-67 0.0028 0.0044 0.0105
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0044 0.0105
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0189 0.017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0059 0.0526 0.125
Loa Loa (eye worm) hypothetical protein 0.0296 0.4205 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1763 0.472
Loa Loa (eye worm) hypothetical protein 0.0031 0.0096 0.0228
Brugia malayi ecdysteroid receptor 0.0059 0.0526 0.125
Leishmania major phosphonopyruvate decarboxylase-like protein 0.0086 0.0946 0.4797
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0189 0.017
Mycobacterium tuberculosis Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) 0.0114 0.1377 0.3687
Onchocerca volvulus 0.0059 0.0526 1
Schistosoma mansoni hypothetical protein 0.0073 0.0741 0.0722
Loa Loa (eye worm) hypothetical protein 0.0059 0.0526 0.125
Loa Loa (eye worm) DR-78 0.0028 0.0044 0.0105
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Mycobacterium ulcerans acetolactate synthase 1 catalytic subunit 0.0266 0.3735 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0608 0.0589
Brugia malayi orphan nuclear receptor NR2E1 0.0028 0.0044 0.0105
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1763 0.472
Mycobacterium tuberculosis Probable oxalyl-CoA decarboxylase OxcA 0.0266 0.3735 1
Entamoeba histolytica pyruvate:ferredoxin oxidoreductase 0.0039 0.0214 0.0533
Brugia malayi Thiamine pyrophosphate enzyme, central domain containing protein 0.0266 0.3735 0.8882
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0059 0.0526 0.0507
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0059 0.0526 0.0507
Loa Loa (eye worm) intermediate filament protein 0.0026 0.002 0.0048
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0608 0.1515
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0302 0.0231
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0028 0.0044 0.0024
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0086 0.0946 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.1241 0.1223
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0059 0.0526 0.0507
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0096 0.0228
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0359 0.0339
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.4013 1
Brugia malayi nuclear receptor NHR-88 0.0028 0.0044 0.0105
Loa Loa (eye worm) hypothetical protein 0.0296 0.4205 1
Mycobacterium tuberculosis Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) 0.0266 0.3735 1
Loa Loa (eye worm) thiamine pyrophosphate enzyme 0.0152 0.1976 0.47
Echinococcus granulosus nuclear receptor nhr 48 0.0028 0.0044 0.0024
Echinococcus granulosus thyroid hormone receptor alpha 0.0028 0.0044 0.0024
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.4013 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.3228 0.7676
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0602 0.0583
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4013 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.1216 0.2891
Schistosoma mansoni coup transcription factor 0.0059 0.0526 0.0507
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0608 0.0589
Brugia malayi Muscleblind-like protein 0.0296 0.4205 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0096 0.0228
Schistosoma mansoni retinoic acid receptor RXR 0.0059 0.0526 0.0507
Brugia malayi follicle stimulating hormone receptor 0.0233 0.3228 0.7676
Onchocerca volvulus 0.0026 0.002 0.0384
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0044 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0059 0.0526 0.125
Loa Loa (eye worm) hypothetical protein 0.0054 0.0456 0.1085
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0059 0.0526 0.0507
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.002 0.0048
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0028 0.0044 0.0105
Entamoeba histolytica hypothetical protein 0.0073 0.0741 0.1847
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0602 0.0583
Schistosoma mansoni microtubule-associated protein tau 0.067 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0602 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0602 0.1612
Brugia malayi steroid hormone receptor 0.0059 0.0526 0.125
Echinococcus granulosus muscleblind protein 0.0296 0.4205 0.4193
Brugia malayi tailless protein 0.0028 0.0044 0.0105
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0086 0.0946 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0059 0.0526 0.0507
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0059 0.0526 0.125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0602 0.1612
Echinococcus granulosus ecdysone induced protein 78C 0.0059 0.0526 0.0507
Schistosoma mansoni hypothetical protein 0.0043 0.0277 0.0257
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4013 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0526 0.125
Schistosoma mansoni acetolactate synthase 0.0227 0.3136 0.3122
Brugia malayi nuclear hormone receptor 0.0028 0.0044 0.0105
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4013 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0044 0.0024
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0044 0.0841
Mycobacterium ulcerans acetolactate synthase large subunit IlvB 0.0152 0.1972 0.5281
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0608 0.6318
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1458 0.3468
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.1216 0.1198
Brugia malayi nuclear receptor NHR-88 0.0059 0.0526 0.125
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0048
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0044 0.0105
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0602 0.1612
Loa Loa (eye worm) hypothetical protein 0.0059 0.0526 0.125
Brugia malayi Steroid receptor seven-up type 2 0.0059 0.0526 0.125
Echinococcus multilocularis thyroid hormone receptor alpha 0.0059 0.0526 0.0507
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0602 0.0583
Loa Loa (eye worm) hypothetical protein 0.0048 0.0365 0.0867
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0127 0.0302
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0608 0.6318
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0027 0.0064
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0059 0.0526 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0059 0.0526 0.125
Brugia malayi nuclear receptor NHR-67 0.0028 0.0044 0.0105
Loa Loa (eye worm) nuclear hormone receptor 0.0028 0.0044 0.0105
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0059 0.0526 0.0507
Echinococcus granulosus expressed conserved protein 0.0097 0.1119 0.1101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0044 0.0024
Schistosoma mansoni acetolactate synthase 0.0227 0.3136 0.3122
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0059 0.0526 0.125
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0608 0.3081
Loa Loa (eye worm) hypothetical protein 0.0059 0.0526 0.125
Schistosoma mansoni hypothetical protein 0.0043 0.0277 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0059 0.0526 0.125
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0059 0.0526 0.0507
Loa Loa (eye worm) hypothetical protein 0.0033 0.0127 0.0302
Brugia malayi MH2 domain containing protein 0.0119 0.1458 0.3468
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0027 0.0073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0059 0.0526 0.0507
Onchocerca volvulus 0.0048 0.0359 0.6823
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0608 0.6318
Mycobacterium ulcerans acetolactate synthase 0.0152 0.1972 0.5281
Schistosoma mansoni hypothetical protein 0.0043 0.0277 0.0257
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0044 0.0841
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0044 0.0024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0059 0.0526 0.0507
Schistosoma mansoni patched 1 0.0044 0.0302 0.0282
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0302 0.0282
Onchocerca volvulus 0.0028 0.0044 0.0841
Schistosoma mansoni nuclear hormone receptor 0.0059 0.0526 0.0507
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Leishmania major cytochrome p450-like protein 0.0027 0.0027 0.0137
Schistosoma mansoni thyroid hormone receptor 0.0059 0.0526 0.0507
Mycobacterium ulcerans 2-oxoglutarate ferredoxin oxidoreductase subunit beta 0.0039 0.0214 0.0572
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0059 0.0526 0.125
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.4013 1
Mycobacterium ulcerans hypothetical protein 0.0086 0.0946 0.2533
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0059 0.0526 0.125
Mycobacterium leprae Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) 0.0266 0.3735 1
Onchocerca volvulus 0.0026 0.002 0.0384
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0059 0.0526 0.0507
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Brugia malayi ecdysone receptor 0.0028 0.0044 0.0105
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0086 0.0946 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.1216 0.1198
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0059 0.0526 0.0507
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0096 0.0076
Schistosoma mansoni RAR-like nuclear receptor 0.0059 0.0526 0.0507
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1763 0.472
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0059 0.0526 0.0507
Loa Loa (eye worm) hypothetical protein 0.0059 0.0526 0.125
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0365 0.0867
Brugia malayi conserved hypotetical protein 0.0028 0.0044 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0059 0.0526 0.0507
Brugia malayi Nuclear hormone receptor-like 1 0.0059 0.0526 0.125
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.002 0.0048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0096 0.0228
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1458 0.3468
Plasmodium vivax acyl-CoA synthetase, putative 0.0171 0.2261 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Echinococcus multilocularis protein patched 0.0044 0.0302 0.0282
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0602 0.3052
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Brugia malayi hypothetical protein 0.0073 0.0741 0.1762
Echinococcus multilocularis microtubule associated protein 2 0.067 1 1
Brugia malayi nuclear receptor RXR 0.0028 0.0044 0.0105
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0608 0.1445
Loa Loa (eye worm) hypothetical protein 0.0059 0.0526 0.125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0059 0.0526 0.125
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0059 0.0526 0.0507
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0059 0.0526 0.0507
Echinococcus granulosus FTZ F1 alpha 0.0059 0.0526 0.0507
Brugia malayi Cytochrome P450 family protein 0.0027 0.0027 0.0064
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0027 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4013 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0059 0.0526 0.125
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0302 0.0282
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0028 0.0044 0.0024
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0028 0.0044 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0059 0.0526 0.125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0044 0.0024
Brugia malayi nuclear hormone receptor family member nhr-6 0.0028 0.0044 0.0105
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Plasmodium falciparum acyl-CoA synthetase 0.0171 0.2261 0.5
Brugia malayi hypothetical protein 0.0028 0.0044 0.0105
Echinococcus granulosus Niemann Pick C1 protein 0.0148 0.1903 0.1887
Onchocerca volvulus Protein ultraspiracle homolog 0.0059 0.0526 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0059 0.0526 0.125
Schistosoma mansoni hypothetical protein 0.0033 0.0127 0.0107
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0365 0.0867
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0031 0.0096 0.0076
Echinococcus multilocularis protein dispatched 1 0.0051 0.0399 0.0379
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0059 0.0526 0.125
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0302 0.0282
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0059 0.0526 1
Schistosoma mansoni thyroid hormone receptor 0.0059 0.0526 0.0507
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0486 0.1155
Mycobacterium tuberculosis Probable oxidoreductase (beta subunit) 0.0039 0.0214 0.0572
Echinococcus multilocularis Niemann Pick C1 protein 0.0148 0.1903 0.1887
Mycobacterium ulcerans pyruvate or indole-3-pyruvate decarboxylase Pdc 0.0152 0.1972 0.5281
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0302 0.0717
Brugia malayi photoreceptor-specific nuclear receptor 0.0059 0.0526 0.125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Entamoeba histolytica hypothetical protein 0.0073 0.0741 0.1847
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0059 0.0526 0.0507
Echinococcus granulosus tumor protein p63 0.0328 0.47 0.4689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0059 0.0526 0.125
Schistosoma mansoni nuclear receptor 0.0028 0.0044 0.0024
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.1216 0.2891
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0105
Echinococcus multilocularis tumor protein p63 0.0328 0.47 0.4689
Echinococcus multilocularis nuclear receptor nhr 48 0.0028 0.0044 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0741 0.0722
Schistosoma mansoni steroid hormone receptor ad4bp 0.0059 0.0526 0.0507

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 90 % Inhibition of Stellaria media protoporphyinogen oxidase assessed as herbicidal activity at 0.3 g/ha measured after 14 days after treatment under greenhouse by time-course analysis ChEMBL. No reference
Potency (functional) 0.0071 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of androgen receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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