Detailed information for compound 580622

Basic information

Technical information
  • TDR Targets ID: 580622
  • Name: berkelium
  • MW: 247.07 | Formula: Bk
  • H donors: 0 H acceptors: 0 LogP: 0 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: [Bk]
  • InChi: 1S/Bk
  • InChiKey: PWVKJRSRVJTHTR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7440-40-6
  • CHEBI:33391
  • berkelio
  • 97Bk

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0429 0.3415
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1785 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0208 0.0181
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0429 0.3415
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0227 0.1704 0.1682
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0204 0.0855
Brugia malayi jmjC domain containing protein 0.0098 0.0603 0.0577
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0227 0.1704 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0227 0.1704 0.2635
Brugia malayi MH2 domain containing protein 0.0119 0.0788 0.0763
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0204 0.0855
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1205 1 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0429 0.5
Loa Loa (eye worm) hypothetical protein 0.0616 0.5001 0.4987
Echinococcus granulosus peregrin 0.003 0.0027 0.0052
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0429 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0296 0.027
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0204 0.0277
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0204 0.4744
Giardia lamblia PHD finger protein 15 0.003 0.0027 0.5
Plasmodium vivax hypothetical protein, conserved 0.003 0.0027 0.0635
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0028 0.0003
Toxoplasma gondii hypothetical protein 0.0049 0.0188 0.4383
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0135 0.0067
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0988 0.0926
Brugia malayi Pre-SET motif family protein 0.003 0.0028 0.0001
Brugia malayi beta-lactamase family protein 0.0035 0.0068 0.0041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.008 0.0317
Plasmodium falciparum phd finger protein, putative 0.003 0.0027 0.0635
Schistosoma mansoni hypothetical protein 0.0163 0.1157 0.6737
Onchocerca volvulus 0.003 0.0028 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0135 0.0067
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0068 0.0295
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0603 0.3465
Mycobacterium leprae Probable lipase LipE 0.0035 0.0068 0.1589
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0204 0.1098
Toxoplasma gondii ABC1 family protein 0.0035 0.0068 0.1589
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0988 0.0926
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.078 0.6391 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0429 1
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0432 0.2415
Trypanosoma brucei C-8 sterol isomerase, putative 0.1205 1 1
Echinococcus granulosus leukotriene A 4 hydrolase 0.0227 0.1704 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0988 0.0926
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0068 0.1589
Schistosoma mansoni hypothetical protein 0.0163 0.1157 0.6737
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0041
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0429 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0028 0.0003
Loa Loa (eye worm) hypothetical protein 0.1205 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0214 0.0147
Trypanosoma cruzi Emopamil binding protein, putative 0.045 0.3594 0.355
Leishmania major C-8 sterol isomerase-like protein 0.1205 1 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.2339 0.2287
Trypanosoma cruzi Emopamil binding protein, putative 0.045 0.3594 0.355
Loa Loa (eye worm) beta-lactamase 0.0035 0.0068 0.0041
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0027 0.0635
Brugia malayi beta-lactamase 0.0035 0.0068 0.0041
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0221 0.1651 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0429 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0028 0.0001
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0027 0.0052
Loa Loa (eye worm) hypothetical protein 0.0077 0.0429 0.0403
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0126 0.0156
Onchocerca volvulus 0.0035 0.0068 0.0115
Onchocerca volvulus 0.0237 0.1785 0.4928
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.2339 0.2287
Echinococcus granulosus geminin 0.0163 0.1157 0.6754
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.045 0.3594 0.355
Loa Loa (eye worm) hypothetical protein 0.003 0.0028 0.0001
Leishmania major hypothetical protein, conserved 0.045 0.3594 0.355
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0028 0.0003
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0126 0.064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1541 0.1518
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0429 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.008 0.0084
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0028 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0788 0.0763
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.006 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.008 0.0053
Plasmodium vivax SET domain protein, putative 0.003 0.0028 0.0648
Brugia malayi beta-lactamase family protein 0.0035 0.0068 0.0041
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0603 0.0904
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.045 0.3594 0.355
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0027 0.0635
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0068 0.0244
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0028 0.0648
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0041
Onchocerca volvulus 0.045 0.3594 1
Brugia malayi Pre-SET motif family protein 0.0208 0.1541 0.1518
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1125 0.6678
Schistosoma mansoni hypothetical protein 0.0034 0.006 0.0194
Brugia malayi Probable ClpP-like protease 0.0077 0.0429 0.0403
Onchocerca volvulus 0.0035 0.0068 0.0115
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.045 0.3594 0.355
Onchocerca volvulus 0.0035 0.0068 0.0115
Brugia malayi jmjC domain containing protein 0.0036 0.008 0.0053
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0033
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0429 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0135 0.0067
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0788 0.0763
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0068 0.0064
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0135 0.0067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0041
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0028 0.0055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0192 0.0165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0192 0.0165
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0429 1
Echinococcus multilocularis geminin 0.0163 0.1157 0.1775
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0068 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0028 0.0003
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0429 0.0632
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.2339 0.2287
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0429 0.2436
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0068 0.1589
Trypanosoma brucei Emopamil binding protein, putative 0.045 0.3594 0.355
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.2339 0.2287
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0068 0.0244
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0429 0.2397
Loa Loa (eye worm) hypothetical protein 0.0049 0.0192 0.0165
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0429 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0041
Mycobacterium ulcerans hypothetical protein 0.0159 0.1125 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.008 0.0317
Brugia malayi hypothetical protein 0.0105 0.0662 0.0636
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0192 0.0165
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0068 0.0041
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0041
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.008 0.0368

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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