Detailed information for compound 583764

Basic information

Technical information
  • TDR Targets ID: 583764
  • Name: (4-chlorophenyl) 4-chlorobenzenesulfonate
  • MW: 303.161 | Formula: C12H8Cl2O3S
  • H donors: 0 H acceptors: 2 LogP: 4.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)OS(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C12H8Cl2O3S/c13-9-1-5-11(6-2-9)17-18(15,16)12-7-3-10(14)4-8-12/h1-8H
  • InChiKey: RZXLPPRPEOUENN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chlorobenzenesulfonic acid (4-chlorophenyl) ester
  • ovex
  • mitran
  • 80-33-1
  • (4-Chloor-fenyl)-4-chloor-benzeen-sulfonaat
  • (4-Chlor-phenyl)-4-chlor-benzol-sulfonate
  • (4-Cloro-fenil)-4-cloro-venzol-solfonato
  • 4-Chlorobenzenesulfonate de 4-chlorophenyle
  • 4-Chlorophenyl 4-chlorobenzenesulfonate
  • Acaricydol E 20
  • Benzenesulfonic acid, 4-chloro-, 4-chlorophenyl ester
  • Benzenesulfonic acid, p-chloro-, p-chlorophenyl ester
  • Benzolsulfonate
  • C 1,006
  • C-854
  • CCS
  • CPCBS
  • Chloorfenson
  • Chlorfensin
  • Chlorfenson
  • Chlorfensonchlorofensone
  • Chlorobenzolsulfonate
  • Chlorofenizon
  • Corotran
  • D 854
  • Difenson
  • ENT 16,358
  • Ephirsulphonate
  • Erysit
  • Ester sulfonate
  • Estonmite
  • Ethersulfonate
  • Genite 883
  • K 6451
  • Lethalaire G-58
  • Miticide K-101
  • Benzenesulfonic acid, p-chloro-, p-chlorophenylester
  • NSC5618
  • Niagaratran
  • ONEX
  • Orochlor
  • Orthotran
  • Otracid
  • Ovatran
  • Ovatron
  • Ovochlor
  • Ovotox
  • Ovotran
  • PCPCBS
  • Roztoczol fluid
  • Sappilan
  • Sappiran
  • Trichlorfenson
  • WLN: GR DSWOR DG
  • p-Chlorobenzenesulfonic acid, p-chlorophenyl ester
  • p-Chlorophenyl p-chlorobenzenesulfonate
  • p-Chlorophenyl-p-chlorobenzene sulfonate
  • AIDS-166716
  • AIDS166716
  • (4-Chloor-fenyl)-4-chloor-benzeen-sulfonaat [Dutch]
  • (4-Chlor-phenyl)-4-chlor-benzol-sulfonate [German]
  • (4-Cloro-fenil)-4-cloro-venzol-solfonato [Italian]
  • 4-11-00-00109 (Beilstein Handbook Reference)
  • 4-Chlorobenzenesulfonate de 4-chlorophenyle [French]
  • 4-Chlorobenzenesulfonate de 4-chlorphenyle [French]
  • 4-Chlorobenzenesulfonic acid, 4-chlorophenyl ester
  • 4-Chlorophenyl 4-chlorobenzenesulphonate
  • 4-Chlorphenyl-4'-chlorbenzolsulfonat [German]
  • AI3-16538
  • BRN 2944674
  • Benzenesulfonic acid, p-chloro-, p-chlorophenyl ester (8CI)
  • Benzolsulfonat
  • Caswell No. 624
  • Chloorfenson [Dutch]
  • Chlorbenzolsulfonat
  • Chlorefenizon [French]
  • Chlorfenson [BSI:ISO]
  • Chlorofenson
  • Chlorofensone
  • Danicut
  • Dow K-6,451
  • EINECS 201-270-4
  • EPA Pesticide Chemical Code 020201
  • HSDB 2055
  • K-101
  • NSC 5618
  • Ovex [ANSI]
  • Parachlorophenyl parachlorobenzene sulfonate
  • Parachlorophenyl-parachlorobenzene-sulfonate
  • Trichlorfenson (Obs.)
  • p-Chlorfenylester kyseliny p-chlorbenzensulfonove [Czech]
  • p-Chlorophenyl p-chlorobenzenesulphonate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0037 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.003
Echinococcus granulosus orexin receptor type 2 0.001 0.0037 0.003
Echinococcus multilocularis allatostatin A receptor 0.001 0.0037 0.003
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0037 0.0325 0.3553
Echinococcus granulosus g protein coupled receptor 0.001 0.0037 0.003
Onchocerca volvulus 0.001 0.0037 0.007
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.003
Trypanosoma cruzi cystathionine beta-synthase 0.0072 0.0692 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.003
Toxoplasma gondii CBS family protein 0.0072 0.0692 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0024 0.0018
Brugia malayi hypothetical protein 0.001 0.0037 0.0038
Entamoeba histolytica threonine dehydratase, putative 0.0018 0.0123 0.0099
Giardia lamblia Kinase, CMGC GSK 0.0047 0.0429 0.2222
Schistosoma mansoni hypothetical protein 0.001 0.0037 0.003
Echinococcus granulosus fmrfamide receptor 0.001 0.0037 0.003
Brugia malayi larval opioid receptor 0.001 0.0037 0.0038
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0037 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0523 0.747
Onchocerca volvulus 0.001 0.0037 0.007
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Echinococcus granulosus allatostatin A receptor 0.001 0.0037 0.003
Loa Loa (eye worm) ceramide kinase 0.0037 0.0325 0.0302
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0037 0.0325 0.0319
Entamoeba histolytica hypothetical protein, conserved 0.0955 1 1
Trypanosoma brucei diacylglycerol kinase, putative 0.0037 0.0325 0.4505
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0072 0.0692 0.0577
Echinococcus granulosus neuropeptide receptor 0.001 0.0037 0.003
Brugia malayi hypothetical protein 0.0009 0.0024 0.0002
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0018 0.0123 0.0664
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0072 0.0692 1
Echinococcus granulosus protein kinase shaggy 0.0047 0.0429 0.0423
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0429 0.0406
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0446 0.1209
Brugia malayi neuropeptide F receptor 0.001 0.0037 0.0038
Onchocerca volvulus Ceramide kinase 1 homolog 0.0037 0.0325 0.1651
Giardia lamblia Kinase, CMGC GSK 0.0047 0.0429 0.2222
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0404 0.0398
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0229 0.0205
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0095 0.0089
Schistosoma mansoni neuropeptide receptor 0.001 0.0037 0.003
Brugia malayi hypothetical protein 0.001 0.0037 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.003
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0182 0.1848 1
Entamoeba histolytica cysteine synthase A, putative 0.0072 0.0692 0.067
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0325 0.1759
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0037 0.003
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0009 0.0024 0.0018
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0037 0.003
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0037 0.0038
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0089
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0446 0.1209
Schistosoma mansoni biogenic amine receptor 0.001 0.0037 0.003
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0009 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.003
Echinococcus granulosus protein tyrosine phosphatase n9 0.0009 0.0024 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0558 0.0441
Brugia malayi sulfakinin receptor protein 0.001 0.0037 0.0038
Trichomonas vaginalis threonine synthase, putative 0.0072 0.0692 0.3747
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0037 0.003
Leishmania major sphingosine kinase A, B, putative 0.0037 0.0325 0.4505
Schistosoma mansoni hypothetical protein 0.001 0.0037 0.003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0037 0.003
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0341 0.3521 0.3517
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Trypanosoma cruzi threonine synthase, putative 0.0018 0.0123 0.1476
Schistosoma mansoni amine GPCR 0.001 0.0037 0.003
Echinococcus multilocularis Diacylglycerol kinase theta 0.0037 0.0325 0.0319
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0037 0.0038
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0037 0.003
Echinococcus granulosus dnaJ subfamily B 0.04 0.4145 0.4141
Leishmania major diacylglycerol kinase-like protein 0.0037 0.0325 0.4505
Loa Loa (eye worm) diacylglycerol kinase 2 0.0037 0.0325 0.0302
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0523 0.2832
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0037 0.003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0037 0.003
Entamoeba histolytica threonine dehydratase catabolic, putative 0.0018 0.0123 0.0099
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0037 0.003
Schistosoma mansoni amine GPCR 0.001 0.0037 0.003
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0523 0.2832
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Onchocerca volvulus 0.001 0.0037 0.007
Echinococcus granulosus somatostatin receptor 0.001 0.0037 0.003
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0341 0.3521 0.3517
Leishmania major serine-threonine dehydratase, putative 0.0018 0.0123 0.1476
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0037 0.003
Echinococcus multilocularis neuropeptide receptor A26 0.0459 0.4774 0.4771
Brugia malayi hypothetical protein 0.0009 0.0024 0.0002
Echinococcus multilocularis sex peptide receptor 0.001 0.0037 0.003
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0037 0.0013
Leishmania major diacylglycerol kinase, putative 0.0037 0.0325 0.4505
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0404 0.0398
Onchocerca volvulus 0.001 0.0037 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0325 0.0302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0404 0.0398
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0284 0.0745
Echinococcus multilocularis cpg binding protein 0.003 0.0246 0.0239
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0558 0.0441
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Trypanosoma cruzi serine sulfhydrylase 0.0072 0.0692 1
Trichomonas vaginalis diacylglycerol kinase, putative 0.0037 0.0325 0.1759
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0047 0.0429 0.0423
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0009 0.0024 0.0018
Schistosoma mansoni opsin-like receptor 0.001 0.0037 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.003
Entamoeba histolytica threonine dehydratase, putative 0.0018 0.0123 0.0099
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0047 0.0429 0.6063
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0037 0.003
Echinococcus multilocularis neuropeptide receptor 0.001 0.0037 0.003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Trypanosoma cruzi Sphingosine kinase 0.0037 0.0325 0.4505
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0095 0.0089
Onchocerca volvulus 0.001 0.0037 0.007
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0037 0.003
Echinococcus granulosus GPCR family 2 0.0015 0.0095 0.0089
Schistosoma mansoni adenoreceptor 0.001 0.0037 0.003
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0037 0.003
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0037 0.0325 0.0302
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0037 0.003
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0037 0.0013
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0325 0.0302
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0024 0.0018
Leishmania major cysteine synthase 0.0072 0.0692 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0325 0.4505
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0037 0.0013
Echinococcus multilocularis sphingosine kinase 1 0.0955 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Trypanosoma cruzi diacylglycerol kinase, putative 0.0037 0.0325 0.4505
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0037 0.003
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0037 0.0038
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0009 0.0024 0.0018
Entamoeba histolytica cysteine synthase A, putative 0.0072 0.0692 0.067
Brugia malayi Serotonin receptor 0.001 0.0037 0.0038
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0037 0.0013
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0037 0.003
Echinococcus multilocularis g protein coupled receptor 0.001 0.0037 0.003
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0037 0.0013
Loa Loa (eye worm) hypothetical protein 0.0955 1 1
Schistosoma mansoni protein tyrosine phosphatase 0.0009 0.0024 0.0018
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0024 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.003
Trypanosoma brucei cystathionine beta-synthase, putative 0.0072 0.0692 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Mycobacterium ulcerans cysteine synthase B 0.0072 0.0692 0.0577
Mycobacterium ulcerans diacylglycerol kinase 0.0037 0.0325 0.0205
Onchocerca volvulus 0.001 0.0037 0.007
Echinococcus granulosus ceramide kinase 0.0037 0.0325 0.0319
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0037 0.0325 0.0319
Leishmania major hypothetical protein, conserved 0.0037 0.0325 0.4505
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0558 0.0552
Echinococcus multilocularis hypothetical protein 0.0009 0.0024 0.0018
Brugia malayi Ceramide kinase 0.0037 0.0325 0.0863
Toxoplasma gondii pyridoxal-phosphate dependent superfamily protein 0.0072 0.0692 1
Brugia malayi follicle stimulating hormone receptor 0.001 0.0037 0.0038
Echinococcus granulosus cpg binding protein 0.003 0.0246 0.0239
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0558 0.0552
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Trichomonas vaginalis cysteine synthase, putative 0.0072 0.0692 0.3747
Brugia malayi hypothetical protein 0.0009 0.0024 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.0261
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0037 0.003
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0182 0.1848 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0325 0.0302
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0523 0.747
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0558 0.0552
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0037 0.0325 0.0319
Leishmania major threonine synthase, putative 0.0018 0.0123 0.1476
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Brugia malayi CXXC zinc finger family protein 0.0028 0.0229 0.0587
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0024 0.0018
Trypanosoma cruzi cysteine synthase, putative 0.0072 0.0692 1
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0037 0.003
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0024 0.0018
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0182 0.1848 0.1828
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0009 0.0024 0.0018
Brugia malayi GnHR receptor homolog 0.001 0.0037 0.0038
Trichomonas vaginalis cysteine synthase, putative 0.0072 0.0692 0.3747
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0009 0.0024 0.0002
Trichomonas vaginalis cysteine synthase, putative 0.0072 0.0692 0.3747
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0404 0.0398
Onchocerca volvulus 0.0037 0.0325 0.1651
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0404 0.0398
Echinococcus granulosus Diacylglycerol kinase zeta 0.0037 0.0325 0.0319
Echinococcus granulosus sex peptide receptor 0.001 0.0037 0.003
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0037 0.003
Trichomonas vaginalis cysteine synthase, putative 0.0018 0.0123 0.0664
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0037 0.003
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Entamoeba histolytica cysteine synthase A, putative 0.0072 0.0692 0.067
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Trichomonas vaginalis cysteine synthase, putative 0.0018 0.0123 0.0664
Schistosoma mansoni cpg binding protein 0.0028 0.0229 0.0222
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Brugia malayi Melatonin receptor type 1A 0.001 0.0037 0.0038
Echinococcus multilocularis orexin receptor type 2 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0009 0.0024 0.0018
Trypanosoma cruzi cystathionine beta-synthase, putative 0.0072 0.0692 1
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0009 0.0024 0.0018
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0037 0.003
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0089
Echinococcus granulosus serotonin receptor 0.001 0.0037 0.003
Trypanosoma cruzi diacylglycerol kinase, putative 0.0037 0.0325 0.4505
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Onchocerca volvulus 0.0182 0.1848 1
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0037 0.0013
Loa Loa (eye worm) pyridoxal-phosphate dependent enzyme family protein 0.0018 0.0123 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.003
Brugia malayi diacylglycerol kinase 0.0037 0.0325 0.0863
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0182 0.1848 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.003
Brugia malayi Dopamine receptor protein 1 0.001 0.0037 0.0038
Loa Loa (eye worm) hypothetical protein 0.0037 0.0325 0.0302
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.0325 0.0319
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0037 0.003
Schistosoma mansoni histamine h1 receptor 0.001 0.0037 0.003
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0126 0.1258 0.1149
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.0072 0.0692 0.1913
Schistosoma mansoni threonine dehydratase/deaminase 0.0018 0.0123 0.0116
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0018 0.0123 0.0664
Trichomonas vaginalis sphingosine kinase, putative 0.0037 0.0325 0.1759
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0009 0.0024 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0429 0.2323
Trypanosoma cruzi cystathionine beta-synthase, putative 0.0072 0.0692 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Onchocerca volvulus Neuropeptide F receptor homolog 0.001 0.0037 0.007
Trypanosoma cruzi cystathionine beta-synthase, putative 0.0072 0.0692 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Leishmania major hypothetical protein, conserved 0.0056 0.0523 0.747
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Echinococcus granulosus neuropeptide receptor A26 0.0459 0.4774 0.4771
Schistosoma mansoni neuropeptide receptor 0.001 0.0037 0.003
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0024 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.003
Trichomonas vaginalis sphingosine kinase, putative 0.0037 0.0325 0.1759
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0024 0.0018
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0182 0.1848 1
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0037 0.0325 0.1759
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0037 0.003
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0037 0.0013
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0037 0.003
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0018 0.0123 0.1476
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0404 0.1088
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Brugia malayi Protein-tyrosine phosphatase 1 0.0009 0.0024 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0404 0.0398
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0558 0.0441
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.003
Onchocerca volvulus 0.001 0.0037 0.007
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0325 0.0302
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0523 0.747
Echinococcus multilocularis ceramide kinase 0.0037 0.0325 0.0319
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0037 0.003
Brugia malayi hypothetical protein 0.0009 0.0024 0.0002
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0009 0.0024 0.0018
Brugia malayi Serotonin receptor 0.001 0.0037 0.0038
Loa Loa (eye worm) hypothetical protein 0.0049 0.0446 0.0423
Brugia malayi G-protein coupled receptor 0.001 0.0037 0.0038
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0037 0.003
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0024 0.0018
Onchocerca volvulus 0.001 0.0037 0.007
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0037 0.003
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0047 0.0429 0.0406
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0024 0.0001
Schistosoma mansoni pcd6 interacting protein-related 0.0009 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Trypanosoma cruzi serine sulfhydrylase 0.0072 0.0692 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus multilocularis serotonin receptor 0.001 0.0037 0.003
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0037 0.003
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Brugia malayi AKH receptor 0.001 0.0037 0.0038
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0018 0.0123 0.1476
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0047 0.0429 0.0423
Trypanosoma cruzi serine sulfhydrylase 0.0072 0.0692 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0047 0.0429 0.6063
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Trypanosoma brucei protein kinase, putative 0.0047 0.0429 0.6063
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0182 0.1848 0.1828
Loa Loa (eye worm) cbs-prov protein 0.0072 0.0692 0.067
Leishmania major cystathionine beta-synthase 0.0072 0.0692 1
Echinococcus multilocularis l serine dehydratase:l threonine deaminase 0.0018 0.0123 0.0116
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0182 0.1848 0.5217
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0037 0.0325 0.4505
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0037 0.003
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0341 0.3521 0.3506
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0009 0.0024 0.0018
Trichomonas vaginalis diacylglycerol kinase, putative 0.0037 0.0325 0.1759
Trypanosoma brucei threonine synthase, putative 0.0018 0.0123 0.1476
Echinococcus multilocularis serotonin receptor 0.001 0.0037 0.003
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0037 0.003
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0037 0.0325 0.0319
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0037 0.003
Brugia malayi Protein-tyrosine phosphatase 0.0009 0.0024 0.0002
Onchocerca volvulus 0.0047 0.0429 0.2222
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.003
Brugia malayi Diacylglycerol kinase protein 2 0.0037 0.0325 0.0863
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.0037 0.0325 0.0302
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0095 0.0089
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0047 0.0429 0.0423
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0009 0.0024 0.0018
Echinococcus granulosus Diacylglycerol kinase theta 0.0037 0.0325 0.0319
Mycobacterium ulcerans cysteine synthase a CysK1 0.0072 0.0692 0.0577
Brugia malayi diacylglycerol kinase 0.0037 0.0325 0.0863
Trypanosoma cruzi threonine synthase, putative 0.0018 0.0123 0.1476
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0009 0.0024 0.0018
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0024 0.0018
Onchocerca volvulus 0.001 0.0037 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.003
Trichomonas vaginalis threonine synthase, putative 0.0072 0.0692 0.3747
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0446 0.0423
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0037 0.003
Brugia malayi Eye-specific diacylglycerol kinase 0.0037 0.0325 0.0863
Schistosoma mansoni amine GPCR 0.001 0.0037 0.003
Onchocerca volvulus 0.001 0.0037 0.007
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0341 0.3521 0.3517
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Onchocerca volvulus Serine racemase homolog 0.0018 0.0123 0.0541
Loa Loa (eye worm) hypothetical protein 0.0015 0.0095 0.0072
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0558 0.7645
Plasmodium vivax glycogen synthase kinase 3, putative 0.0047 0.0429 1
Trichomonas vaginalis cysteine synthase, putative 0.0072 0.0692 0.3747
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0558 0.7992
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0024 0.0018
Mycobacterium ulcerans hypothetical protein 0.0955 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0037 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0558 0.0552
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Echinococcus multilocularis g protein coupled receptor 0.001 0.0037 0.003
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0037 0.0013
Trichomonas vaginalis bmru protein, putative 0.0037 0.0325 0.1759
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0037 0.003
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0037 0.003
Schistosoma mansoni protein tyrosine phosphatase 0.0009 0.0024 0.0018
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0037 0.003
Mycobacterium tuberculosis Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) 0.0072 0.0692 0.0577
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0095 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Schistosoma mansoni hypothetical protein 0.0037 0.0325 0.0319
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0404 0.0398
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0018 0.0123 0.0664
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0089
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.003
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0009 0.0024 0.0018
Trypanosoma cruzi serine sulfhydrylase 0.0072 0.0692 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.056 0.0554
Trichomonas vaginalis pten, drome, putative 0.0009 0.0024 0.013
Onchocerca volvulus 0.001 0.0037 0.007
Entamoeba histolytica protein kinase, putative 0.0047 0.0429 0.0406
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0037 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0037 0.003
Brugia malayi hypothetical protein 0.001 0.0037 0.0038
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0095 0.0206
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0037 0.003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0037 0.003
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Mycobacterium ulcerans cystathionine beta-synthase 0.0072 0.0692 0.0577
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0009 0.0024 0.0018
Brugia malayi cbs-prov protein 0.0072 0.0692 0.1913
Brugia malayi hypothetical protein 0.001 0.0037 0.0038
Trichomonas vaginalis cysteine synthase, putative 0.0072 0.0692 0.3747
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0037 0.0325 0.0319
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0182 0.1848 0.1828
Schistosoma mansoni biogenic amine receptor 0.001 0.0037 0.003
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0009 0.0024 0.0018
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0009 0.0024 0.0002
Brugia malayi RE15519p 0.001 0.0037 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Trypanosoma cruzi Sphingosine kinase 0.0037 0.0325 0.4505
Brugia malayi hypothetical protein 0.001 0.0037 0.0038
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0037 0.003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0037 0.003
Brugia malayi hypothetical protein 0.0009 0.0024 0.0002
Brugia malayi hypothetical protein 0.001 0.0037 0.0038
Entamoeba histolytica threonine dehydratase, putative 0.0018 0.0123 0.0099
Echinococcus multilocularis g protein coupled receptor 0.001 0.0037 0.003
Schistosoma mansoni neuropeptide receptor 0.001 0.0037 0.003
Echinococcus multilocularis dnaJ subfamily B 0.04 0.4145 0.4141
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Schistosoma mansoni hypothetical protein 0.001 0.0037 0.003
Echinococcus granulosus g-protein coupled receptor 0.001 0.0037 0.003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0037 0.003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Echinococcus multilocularis fmrfamide receptor 0.001 0.0037 0.003
Onchocerca volvulus 0.001 0.0037 0.007
Echinococcus multilocularis neuropeptide s receptor 0.0459 0.4774 0.4771
Brugia malayi hypothetical protein 0.001 0.0037 0.0038
Trichomonas vaginalis bmru protein, putative 0.0037 0.0325 0.1759
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Schistosoma mansoni threonine dehydratase 0.0018 0.0123 0.0116
Echinococcus multilocularis fmrfamide receptor 0.001 0.0037 0.003
Schistosoma mansoni cpg binding protein 0.003 0.0246 0.0239
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0037 0.003
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0037 0.0038
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0024 0.0018
Schistosoma mansoni amine GPCR 0.001 0.0037 0.003
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0037 0.003
Onchocerca volvulus 0.0018 0.0123 0.0541
Schistosoma mansoni myosin xvIII 0.001 0.0037 0.003
Schistosoma mansoni hypothetical protein 0.04 0.4145 0.4141
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Trypanosoma cruzi cysteine synthase, putative 0.0072 0.0692 1
Trypanosoma brucei Sphingosine kinase 0.0037 0.0325 0.4505
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0047 0.0429 0.5382
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0037 0.003
Schistosoma mansoni biogenic amine receptor 0.001 0.0037 0.003
Brugia malayi ORL1-like opioid receptor 0.001 0.0037 0.0038
Onchocerca volvulus 0.001 0.0037 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Trichomonas vaginalis cysteine synthase, putative 0.0072 0.0692 0.3747
Brugia malayi G protein-coupled receptor 0.001 0.0037 0.0038
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0037 0.0325 0.3553
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.003
Schistosoma mansoni sphingosine kinase A B 0.0955 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0404 0.0381
Echinococcus granulosus neuropeptide receptor 0.001 0.0037 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0037 0.003
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0037 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0037 0.003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0037 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0325 0.4505
Schistosoma mansoni hypothetical protein 0.001 0.0037 0.003
Onchocerca volvulus 0.0028 0.0229 0.1123
Schistosoma mansoni amine GPCR 0.001 0.0037 0.003
Onchocerca volvulus 0.001 0.0037 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0009 0.0024 0.0018
Brugia malayi hypothetical protein 0.0037 0.0325 0.0863
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0095 0.0089
Giardia lamblia Threonine dehydratase lateral transfer candidate 0.0018 0.0123 0.0541
Echinococcus granulosus g protein coupled receptor 0.001 0.0037 0.003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0037 0.003
Mycobacterium tuberculosis Conserved protein 0.0955 1 1
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0037 0.0325 0.1759
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0037 0.0325 0.4505
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Trypanosoma cruzi cystathionine beta-synthase 0.0072 0.0692 1
Brugia malayi hypothetical protein 0.001 0.0037 0.0038
Brugia malayi Dopamine receptor protein 2 0.001 0.0037 0.0038
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0037 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0037 0.003
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0047 0.0429 0.0406
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0325 0.0302
Echinococcus granulosus g protein coupled receptor 0.001 0.0037 0.003
Brugia malayi Protein-tyrosine phosphatase 0.0009 0.0024 0.0002
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0182 0.1848 1
Schistosoma mansoni opsin-like receptor 0.001 0.0037 0.003
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus granulosus l serine dehydratase:l threonine deaminase 0.0018 0.0123 0.0116
Onchocerca volvulus 0.001 0.0037 0.007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0037 0.0013
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.0325 0.0319
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0182 0.1848 0.1747
Leishmania major hypothetical protein, conserved 0.0037 0.0325 0.4505
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Plasmodium falciparum glycogen synthase kinase 3 0.0047 0.0429 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0024 0.0018
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0037 0.0325 0.4505
Echinococcus granulosus hypothetical protein 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0009 0.0024 0.0018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0024 0.0018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0095 0.0072
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0037 0.0013
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0037 0.003
Chlamydia trachomatis tryptophan synthase subunit beta 0.0018 0.0123 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Schistosoma mansoni sphingoid long chain base kinase 0.0955 1 1
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0009 0.0024 0.0018
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0089
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0429 0.0406
Brugia malayi G-protein coupled receptor 0.001 0.0037 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Brugia malayi Dopamine receptor 0.001 0.0037 0.0038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0024 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0341 0.3521 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0037 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.003
Schistosoma mansoni cysteine synthase 0.0072 0.0692 0.0686
Echinococcus multilocularis protein kinase shaggy 0.0047 0.0429 0.0423
Echinococcus multilocularis GPCR, family 2 0.0015 0.0095 0.0089
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0429 0.2323
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.003
Echinococcus multilocularis somatostatin receptor 0.001 0.0037 0.003
Echinococcus granulosus neuropeptide s receptor 0.0459 0.4774 0.4771
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0009 0.0024 0.0018
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0182 0.1848 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0024 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0024 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Toxoplasma gondii diacylglycerol kinase, putative 0.0037 0.0325 0.3553
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.001 0.0037 0.007
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.003
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0037 0.003
Schistosoma mansoni cpg binding protein 0.003 0.0246 0.0239
Echinococcus multilocularis 0.0009 0.0024 0.0018
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0037 0.0038
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0037 0.003
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0024 0.0018
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0037 0.0038
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0493 0.6504
Brugia malayi putative neuropeptide receptor 0.001 0.0037 0.0038
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0037 0.0325 0.1759
Schistosoma mansoni hypothetical protein 0.0033 0.0284 0.0278
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0037 0.003
Brugia malayi hypothetical protein 0.001 0.0037 0.0038
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0024 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0009 0.0024 0.0018
Onchocerca volvulus 0.001 0.0037 0.007
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0037 0.003
Trypanosoma cruzi serine-threonine dehydratase, putative 0.0018 0.0123 0.1476
Mycobacterium tuberculosis Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) 0.0072 0.0692 0.0577
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0558 0.0441
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.003
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0024 0.0018
Schistosoma mansoni cysteine synthase 0.0072 0.0692 0.0686
Mycobacterium tuberculosis Diacylglycerol kinase 0.0037 0.0325 0.0205
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Trichomonas vaginalis threonine dehydratase/deaminase, putative 0.0018 0.0123 0.0664
Mycobacterium leprae PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) 0.0072 0.0692 1
Echinococcus multilocularis neuropeptide receptor 0.001 0.0037 0.003
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0037 0.003
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0037 0.003
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Brugia malayi intracellular kinase 0.0047 0.0429 0.1161
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0182 0.1848 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0024 0.0018
Onchocerca volvulus 0.001 0.0037 0.007
Schistosoma mansoni neuropeptide receptor 0.001 0.0037 0.003
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0037 0.0013
Schistosoma mansoni opsin-like receptor 0.001 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0013
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.0018 0.0123 0.0284
Schistosoma mansoni protein tyrosine phosphatase 0.0009 0.0024 0.0018
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0037 0.003
Trypanosoma cruzi cystathionine beta-synthase 0.0072 0.0692 1
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.0018 0.0123 0.0284
Brugia malayi neuropeptide F receptor 0.001 0.0037 0.0038
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0024 0.0018
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0037 0.0325 0.4505
Brugia malayi hypothetical protein 0.001 0.0037 0.0038

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 26 % Inhibition of HSL in Wistar rat isolated fat cells at 10 uM by spectrophotometric assay ChEMBL. 18808096
Potency (functional) 34.6654 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 43.6412 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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