TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 696.784 | Formula: C37H48N2O11
H donors: 2 H acceptors: 6 LogP: 0.47 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: COC1CC[C@@]2(C3C41C1CC5C(C1[C@]([C@@](C4N(C2)CC)(C3O)O)(OC(=O)C)C[C@@H]5OC)OC)COC(=O)c1ccccc1N1C(=O)CCC1=O
InChi: 1S/C37H48N2O11/c1-6-38-17-34(18-49-32(44)20-9-7-8-10-23(20)39-26(41)11-12-27(39)42)14-13-25(47-4)36-22-15-21-24(46-3)16-35(50-19(2)40,28(22)29(21)48-5)37(45,33(36)38)31(43)30(34)36/h7-10,21-22,24-25,28-31,33,43,45H,6,11-18H2,1-5H3/t21?,22?,24-,25?,28?,29?,30?,31?,33?,34-,35+,36?,37-/m0/s1
InChiKey: IZUZVAYMMFNKMJ-VXCIEECRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0155	0.0119
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0126	0.0658	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0916	0.615
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0155	0.1767
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0421	0.288
Wolbachia endosymbiont of Brugia malayi	replicative DNA helicase	0.0625	0.3466	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0916	0.615
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0233	0.1261	0.1315
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0297	0.082
Brugia malayi	hypothetical protein	0.0126	0.0658	0.4506
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0127	0.0663	0.171
Plasmodium vivax	hypothetical protein, conserved	0.0126	0.0658	1
Mycobacterium ulcerans	replicative DNA helicase DnaB	0.0625	0.3466	0.3435
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0084	0.0421	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0155	0.106
Plasmodium falciparum	thioredoxin reductase	0.005	0.0231	0.3012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0051	0.0345
Onchocerca volvulus		0.0126	0.0658	0.6891
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0158	0.1811
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0203	0.0545
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0022	0.0148
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.0231	0.3012
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0014	0.021
Treponema pallidum	replicative DNA helicase (dnaB)	0.0625	0.3466	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.1422	0.9735
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0085	0.0038
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0155	0.5866
Mycobacterium tuberculosis	Probable replicative DNA helicase DnaB	0.0625	0.3466	0.3699
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.166	0.9292	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0155	0.1767
Chlamydia trachomatis	replicative DNA helicase	0.0625	0.3466	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0085	0.0618
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0126	0.0658	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0094	0.0758
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0203	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0155	0.106
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0085	0.0038
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0094	0.0746
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0203	0.3074
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0155	0.2353
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0158	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0085	0.0579
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0155	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0085	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0658	0.4503
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0155	0.2353
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0155	0.0119
Echinococcus multilocularis	cpg binding protein	0.0031	0.0123	0.1863
Trichomonas vaginalis	glucosylceramidase, putative	0.0181	0.0968	0.6518
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0022	0.0148
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0296	0.4076
Echinococcus granulosus	cpg binding protein	0.0031	0.0123	0.1863
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0094	0.0758
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0051	0.0004
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0158	0.1811
Leishmania major	hypothetical protein, conserved	0.0026	0.0094	0.0758
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0916	0.615
Loa Loa (eye worm)	glutaminase	0.0268	0.146	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0051	0.0345
Onchocerca volvulus		0.0036	0.0155	0.0844
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0047	0.0096
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.1422	0.9735
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0155	0.0119
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0296	0.0271
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.1422	0.9735
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0658	0.4503
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0114	0.0592	0.0591
Plasmodium vivax	basic transcription factor 3b, putative	0.0037	0.0158	0.1811
Toxoplasma gondii	histone lysine-specific demethylase	0.0126	0.0658	0.9839
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0155	0.0119
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.1785	1	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0127	0.0663	0.0668
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0085	0.0038
Mycobacterium ulcerans	oxidoreductase	0.0126	0.0658	0.0613
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0262	0.1422	0.9744
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.1422	0.9735
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0155	0.0108
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0126	0.0658	0.1694
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0085	0.0583
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0051	0.0006
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0126	0.0658	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.0126	0.0658	0.4506
Leishmania major	UDP-galactopyranose mutase	0.0126	0.0658	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.1422	0.9735
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0126	0.0658	1
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0155	0.0108
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0085	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0155	0.106
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0262	0.1422	0.9743
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0203	0.3074
Echinococcus multilocularis		0.0126	0.0658	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0126	0.0658	0.0662
Plasmodium vivax	hypothetical protein, conserved	0.0126	0.0658	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0085	0.0043
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0126	0.0658	0.1864
Schistosoma mansoni	transcription factor btf3	0.0037	0.0158	0.0416
Loa Loa (eye worm)	ICD-1 protein	0.0037	0.0158	0.1078
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0051	0.0058
Schistosoma mansoni	Replicative DNA helicase	0.0625	0.3466	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0155	0.0119
Brugia malayi	hypothetical protein	0.0016	0.0043	0.0293
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0155	0.0408
Entamoeba histolytica	transcription factor BTF3, putative	0.0037	0.0158	0.2168
Plasmodium vivax	glutathione reductase, putative	0.005	0.0231	0.3012
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0203	0.3074
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0916	0.615
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0051	0.0345
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0126	0.0658	0.0613
Mycobacterium ulcerans	monoamine oxidase	0.0126	0.0658	0.0613
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0085	0.0038
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0047	0.0712
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0203	0.1384
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0155	0.0119
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0094	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0051	0.0345
Brugia malayi	beta-NAC-like protein	0.0037	0.0158	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0658	0.4503
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0296	0.0816
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0126	0.0658	1
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0114	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0155	0.106
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0085	0.0579
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0203	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0051	0.0345
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0155	0.0763
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0916	0.615
Trypanosoma brucei	trypanothione reductase	0.005	0.0231	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0114	0.0592	0.0591
Mycobacterium ulcerans	dehydrogenase	0.0126	0.0658	0.0613
Echinococcus granulosus	transcription factor btf3	0.0037	0.0158	0.2394
Echinococcus multilocularis	transcription factor btf3	0.0037	0.0158	0.2394
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0085	0.0038
Schistosoma mansoni	amine oxidase	0.0126	0.0658	0.1864
Brugia malayi	Thioredoxin reductase	0.005	0.0231	0.1584
Entamoeba histolytica	hypothetical protein	0.0037	0.0158	0.2168
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0155	0.106
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0296	0.4498
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0155	0.0119
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0155	0.0207
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0127	0.0668	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.0231	0.3509
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0126	0.0658	1
Leishmania major	basic transcription factor 3a, putative	0.0037	0.0158	0.1811
Mycobacterium ulcerans	glutaminase	0.0268	0.146	0.1419
Schistosoma mansoni	cpg binding protein	0.0031	0.0123	0.0315
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.0231	0.3509
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0155	0.106
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0916	0.615
Brugia malayi	hypothetical protein	0.0026	0.0094	0.0642
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0155	0.1767
Mycobacterium tuberculosis	Possible oxidoreductase	0.0126	0.0658	0.0662
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0155	0.0207
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0126	0.0658	1
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0017	0.0047	0.0002
Onchocerca volvulus	Glucosylceramidase homolog	0.0172	0.0916	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0155	0.1064
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0114	0.0592	0.1498
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0085	0.0583
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0085	0.0038
Plasmodium falciparum	basic transcription factor 3b, putative	0.0037	0.0158	0.1811
Toxoplasma gondii	thioredoxin reductase	0.005	0.0231	0.2963
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0126	0.0658	1
Schistosoma mansoni	amine oxidase	0.0126	0.0658	0.1864
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0114	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0658	0.4503
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0047	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0094	0.0758
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.1422	0.9735
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0051	0.0058
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0296	0.025
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0094	0.2516
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0085	0.0618
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.026	0.343
Mycobacterium leprae	PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase	0.0625	0.3466	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0085	0.0038
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0126	0.0658	0.1785
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0155	0.0763
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0085	0.0038
Onchocerca volvulus		0.0036	0.0155	0.0844
Mycobacterium tuberculosis	Probable reductase	0.0114	0.0592	0.0591
Brugia malayi	glutathione reductase	0.005	0.0231	0.1584
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0296	0.0816
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0155	0.0119
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0155	0.0119
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0126	0.0658	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0123	0.0315
Mycobacterium tuberculosis	Probable oxidoreductase	0.0127	0.0663	0.0668
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0158	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0155	0.106
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0203	0.3074
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0155	0.0108
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.0231	0.0201
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0127	0.0663	0.0668
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0085	0.0043
Brugia malayi	SWIRM domain containing protein	0.0126	0.0658	0.4506
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0114	0.0592	0.0591
Plasmodium falciparum	protoporphyrinogen oxidase	0.0126	0.0658	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0155	0.0119
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0155	0.0108
Loa Loa (eye worm)	twinkle helicase	0.0178	0.0955	0.6537
Leishmania major	trypanothione reductase	0.005	0.0231	0.3012
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0155	0.0763
Onchocerca volvulus		0.0029	0.0114	0.0344
Toxoplasma gondii	NAC domain-containing protein	0.0037	0.0158	0.1782
Brugia malayi	glutaminase DH11.1	0.0268	0.146	1
Plasmodium falciparum	glutathione reductase	0.005	0.0231	0.3012
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0047	0.0712
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0203	0.1388
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0155	0.106
Brugia malayi	beta-lactamase family protein	0.0036	0.0155	0.1064
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0051	0.001
Schistosoma mansoni	glutaminase	0.0268	0.146	0.4188
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0158	0.0782
Toxoplasma gondii	ABC1 family protein	0.0036	0.0155	0.1738
Onchocerca volvulus		0.0036	0.0155	0.0844
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0296	0.025
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0658	0.4503
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.0231	0.3012
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0114	0.0592	0.0591
Trichomonas vaginalis	esterase, putative	0.0036	0.0155	0.0763
Mycobacterium tuberculosis	Probable dehydrogenase	0.0114	0.0592	0.0591
Schistosoma mansoni	cpg binding protein	0.0029	0.0114	0.0288
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0084	0.0421	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0014	0.021
Loa Loa (eye worm)	glutaminase 2	0.0268	0.146	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0296	0.4498
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0658	0.4503
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.0231	0.158
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0916	0.615
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0085	0.0618
Trichomonas vaginalis	glutaminase, putative	0.0268	0.146	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0296	0.025
Trichomonas vaginalis	glucosylceramidase, putative	0.0181	0.0968	0.6518
Trypanosoma brucei	transcription factor BTF3, putative	0.0037	0.0158	0.6012
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0296	0.401
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0126	0.0658	0.1864
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0094	0.0758
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0155	0.1767
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0155	0.0763
Brugia malayi	beta-lactamase	0.0036	0.0155	0.1064
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0126	0.0658	1
Loa Loa (eye worm)	glutathione reductase	0.005	0.0231	0.158
Mycobacterium ulcerans	lipase LipD	0.0036	0.0155	0.0108
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0155	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0094	0.0638
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0047	0.0325
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0155	0.0408

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 24883768
PubChem: 5320683

Bibliographic References

No literature references available for this target.

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Detailed information for compound 583965