Detailed information for compound 590319

Basic information

Technical information
  • TDR Targets ID: 590319
  • Name: 3',4'-dehydro-4'-deoxydothistromin
  • MW: 354.267 | Formula: C18H10O8
  • H donors: 4 H acceptors: 6 LogP: 2.06 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(c2c1C(=O)c1c(O)c3c(cc1C2=O)O[C@@H]1[C@@]3(O)C=CO1)O
  • InChi: 1S/C18H10O8/c19-7-1-2-8(20)12-11(7)14(21)6-5-9-13(16(23)10(6)15(12)22)18(24)3-4-25-17(18)26-9/h1-5,17,19-20,23-24H/t17-,18-/m1/s1
  • InChiKey: XXJIETBHRWEWQE-QZTJIDSGSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 98063-09-3
  • Anthra(2,3-b)furo(3,2-d)furan-5,10-dione, 3a,12a-dihydro-3a,4,6,9-tetrahydroxy-, (3aR-cis)-
  • DDDTT

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0403 0.4595 1
Echinococcus granulosus potassium large conductance calcium activated 0.0046 0.0344 0.0096
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0991 0.1436
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0991 0.1436
Onchocerca volvulus 0.0071 0.0642 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3508 0.7417
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0403 0.4595 0.4548
Echinococcus multilocularis calcium activated potassium channel 0.0047 0.0348 0.01
Treponema pallidum hypothetical protein 0.0025 0.0088 0.5
Brugia malayi hypothetical protein 0.0064 0.0556 0.0556
Trichomonas vaginalis glucosylceramidase, putative 0.0403 0.4595 1
Echinococcus multilocularis ceramide glucosyltransferase 0.0183 0.1968 0.1763
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0113 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0556 0.0403
Brugia malayi Ceramide glucosyltransferase 0.0183 0.1968 0.1968
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0991 1
Loa Loa (eye worm) alpha-L-fucosidase 0.0857 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0991 0.1436
Onchocerca volvulus 0.0071 0.0642 0.0292
Loa Loa (eye worm) hypothetical protein 0.0071 0.0642 0.0559
Brugia malayi hypothetical protein 0.0038 0.025 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0991 0.076
Echinococcus granulosus calcium activated potassium channel 0.0047 0.0348 0.01
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.0991 0.076
Schistosoma mansoni calcium-activated potassium channel 0.0043 0.0305 0.0057
Brugia malayi hypothetical protein 0.0025 0.0088 0.0088
Brugia malayi Trehalase family protein 0.0071 0.0642 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0556 0.0403
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0113 0.5
Echinococcus granulosus calcium activated potassium channel variant 0.0043 0.0305 0.0057
Loa Loa (eye worm) TRE-2 protein 0.0071 0.0642 0.0559
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0857 1 1
Echinococcus granulosus phosphorylase b kinase regulatory 0.0064 0.0556 0.0314
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0403 0.4595 0.4595
Trichomonas vaginalis glucosylceramidase, putative 0.0403 0.4595 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3508 0.7417
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0991 0.1436
Loa Loa (eye worm) ceramide glucosyltransferase 0.0183 0.1968 0.1897
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3508 0.7417
Brugia malayi phosphorylase B kinase beta regulatory chain 0.0064 0.0556 0.0556
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2849 0.585
Loa Loa (eye worm) trehalase 0.0071 0.0642 0.0559
Loa Loa (eye worm) myosin heavy chain 0.0064 0.0556 0.0472
Schistosoma mansoni phosphorylase B kinase alpha kpb1 0.0064 0.0556 0.0314
Brugia malayi Trehalase family protein 0.0071 0.0642 0.0642
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3508 0.7417
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0183 0.1968 0.4784
Trichomonas vaginalis trehalase, putative 0.0071 0.0642 0.0607
Brugia malayi Trehalase family protein 0.0025 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0071 0.0642 0.0559
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.0991 0.076
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.0991 1
Brugia malayi Trehalase protein 5 0.0025 0.0088 0.0088
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0376 0.4271 0.923
Brugia malayi trehalase I 0.0025 0.0088 0.0088
Loa Loa (eye worm) trehalase 0.0071 0.0642 0.0559
Mycobacterium tuberculosis Conserved protein 0.0064 0.0556 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0642 0.0559
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0113 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.0556 0.0472
Onchocerca volvulus Glucosylceramidase homolog 0.0312 0.3508 1
Schistosoma mansoni phosphorylase B kinase beta kpbb 0.0064 0.0556 0.0314
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0043 0.0305 0.022
Schistosoma mansoni ceramide glucosyltransferase 0.0183 0.1968 0.1763
Loa Loa (eye worm) hypothetical protein 0.0071 0.0642 0.0559
Trichomonas vaginalis glucosylceramidase, putative 0.0403 0.4595 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.0991 0.0991
Brugia malayi hypothetical protein 0.0025 0.0088 0.0088
Echinococcus multilocularis calcium activated potassium channel variant 0.0043 0.0305 0.0057
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.0991 0.0911
Schistosoma mansoni alpha-l-fucosidase 0.0857 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0348 0.0263
Schistosoma mansoni kinase 0.0051 0.0402 0.0156
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0113 0.5
Onchocerca volvulus 0.0071 0.0642 0.0292
Brugia malayi hypothetical protein 0.0025 0.0088 0.0088
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0857 1 1
Onchocerca volvulus 0.0071 0.0642 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.0403 0.4595 1
Brugia malayi phosphorylase B kinase alpha regulatory chain 0.0064 0.0556 0.0556
Onchocerca volvulus Trehalase homolog 0.0071 0.0642 0.0292
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0991 0.1436
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3508 0.7417
Schistosoma mansoni ceramide glucosyltransferase 0.0183 0.1968 0.1763
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.2849 0.585
Brugia malayi hypothetical protein 0.0071 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0027 0.0113 0.0026
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.0991 0.1474
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0031 0.0159 0.0159
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0991 1
Brugia malayi trehalase 0.0025 0.0088 0.0088
Echinococcus multilocularis phosphorylase b kinase regulatory 0.0064 0.0556 0.0314
Echinococcus multilocularis phosphorylase b kinase regulatory 0.0064 0.0556 0.0314
Loa Loa (eye worm) trehalase 0.0071 0.0642 0.0559
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3508 0.7417
Mycobacterium ulcerans alpha-L-fucosidase 0.0857 1 1
Echinococcus granulosus phosphorylase b kinase regulatory 0.0064 0.0556 0.0314
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3508 0.7417
Trichomonas vaginalis glucosylceramidase, putative 0.0403 0.4595 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0991 0.1436
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0556 0.0403
Giardia lamblia Kinase, PLK 0.0101 0.0991 1
Brugia malayi Trehalase family protein 0.0071 0.0642 0.0642
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.0991 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0556 0.0472
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0991 0.1436
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.0031 0.0159 0.0072
Echinococcus multilocularis potassium large conductance calcium activated 0.0046 0.0344 0.0096
Trypanosoma brucei polo-like protein kinase 0.0101 0.0991 1
Brugia malayi hypothetical protein 0.0064 0.0556 0.0556
Echinococcus granulosus ceramide glucosyltransferase 0.0183 0.1968 0.1763
Loa Loa (eye worm) hypothetical protein 0.0064 0.0556 0.0472
Schistosoma mansoni calcium-activated potassium channel 0.0046 0.0344 0.0096
Brugia malayi Trehalase family protein 0.0071 0.0642 0.0642
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0376 0.4271 0.923
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0642 0.0607
Brugia malayi Trehalase family protein 0.0025 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0071 0.0642 0.0559
Onchocerca volvulus 0.0071 0.0642 0.0292
Brugia malayi hypothetical protein 0.0027 0.0113 0.0113
Loa Loa (eye worm) TRE-1 protein 0.0071 0.0642 0.0559
Loa Loa (eye worm) hypothetical protein 0.0064 0.0556 0.0472

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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