Detailed information for compound 59463

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 443.624 | Formula: C29H37N3O
  • H donors: 0 H acceptors: 0 LogP: 5.67 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N(Cc1ccccc1)CCN1CCN(CC1)CCCc1ccccc1
  • InChi: 1S/C29H37N3O/c1-33-29-16-14-28(15-17-29)32(25-27-11-6-3-7-12-27)24-23-31-21-19-30(20-22-31)18-8-13-26-9-4-2-5-10-26/h2-7,9-12,14-17H,8,13,18-25H2,1H3
  • InChiKey: HDPHOPOIGUJUKC-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0933 0.2008
Echinococcus multilocularis casein kinase ii subunit alpha 0.0137 0.1959 0.2761
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1214 0.2612
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0336 0.1241
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.014 0.2006 0.2826
Schistosoma mansoni nAChR subunit 0.0303 0.4647 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0163 0.2385 0.3188
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0336 0.1716
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0355 0.05
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0354 0.1808
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0075 0.0075
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0151 0.0201
Echinococcus multilocularis neuropeptide receptor A26 0.0455 0.7097 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0046 0.0099
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0303 0.4647 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0347 0.104
Loa Loa (eye worm) hypothetical protein 0.0028 0.0188 0.0188
Leishmania major trypanothione reductase 0.0037 0.0347 0.1771
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0046 0.0065
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0046 0.0099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1214 0.1623
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0306 0.0431
Plasmodium falciparum glutathione reductase 0.0037 0.0347 0.0462
Echinococcus multilocularis nAChR subunit 0.0163 0.2385 0.3361
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0306 0.1561
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0075 0.0105
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0303 0.4647 0.6212
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0075 0.0075
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0046 0.0099
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0046 0.0065
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0322 0.0429
Onchocerca volvulus 0.0303 0.4647 1
Brugia malayi nuclear hormone receptor 0.002 0.0075 0.01
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0303 0.4647 0.6549
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0336 0.0448
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0303 0.4647 0.6549
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0303 0.4647 0.6549
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Echinococcus multilocularis casein kinase ii subunit beta 0.0037 0.0336 0.0474
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0306 0.0917
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1284 0.2763
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0303 0.4647 0.6212
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0075 0.01
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0284 0.04
Plasmodium falciparum thioredoxin reductase 0.0037 0.0347 0.0462
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0303 0.4647 0.6212
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0291 0.0626
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0184 0.2711 0.5513
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0046 0.0062
Plasmodium vivax CDK-related protein kinase 6, putative 0.048 0.7504 1
Echinococcus granulosus neuropeptide s receptor 0.0455 0.7097 1
Schistosoma mansoni nAChR subunit 0.0303 0.4647 1
Schistosoma mansoni nAChR subunit 0.0303 0.4647 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0303 0.4647 1
Trypanosoma brucei glucose transporter, putative 0.0035 0.0309 0.1578
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0113 0.1567 0.2209
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0303 0.4647 0.6212
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.1959 1
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0948 0.4836
Echinococcus granulosus tar DNA binding protein 0.0074 0.0933 0.1315
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0347 0.0347
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.014 0.2006 0.2006
Giardia lamblia Kinase, PLK 0.0095 0.1284 0.6554
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0025 0.0151 0.0151
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0113 0.1567 0.2209
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0101 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0309 0.1578
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0075 0.0105
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0309 0.1578
Echinococcus multilocularis glycine receptor subunit beta 0.0303 0.4647 0.6549
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.014 0.2006 0.2826
Mycobacterium tuberculosis Conserved protein 0.0035 0.0306 0.0917
Brugia malayi Cytochrome P450 family protein 0.003 0.0235 0.0314
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0163 0.2385 0.3188
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0137 0.1959 0.1959
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1284 0.6554
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0303 0.4647 0.6212
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0075 0.0161
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0151 0.0212
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0309 0.1578
Trypanosoma brucei glucose transporter, putative 0.0035 0.0309 0.1578
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0381 0.0508
Trypanosoma brucei glucose transporter, putative 0.0035 0.0309 0.1578
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.3611 0.3611
Entamoeba histolytica casein kinase, putative 0.0137 0.1959 0.8179
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0101 0.0217
Onchocerca volvulus 0.0035 0.0306 0.0658
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0151 0.0324
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0046 0.0065
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.112 0.3358
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1284 0.1284
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0099
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0355 0.05
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0046 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0306 0.1561
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0075 0.0161
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0322 0.0453
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0099
Onchocerca volvulus 0.0303 0.4647 1
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0948 0.1927
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0151 0.0201
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0075
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0089 0.0268
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1284 0.6554
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0113 0.1567 0.2209
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.112 0.8703
Brugia malayi hypothetical protein 0.014 0.2006 0.2681
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0948 0.4836
Echinococcus granulosus glycine receptor subunit beta 0.0303 0.4647 0.6549
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0347 0.1771
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.014 0.2006 0.2826
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0306 0.1561
Schistosoma mansoni inositol monophosphatase 0.0038 0.0354 0.0762
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0303 0.4647 0.6212
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0303 0.4647 0.6549
Loa Loa (eye worm) hypothetical protein 0.0034 0.0291 0.0291
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0291 0.041
Toxoplasma gondii facilitative glucose transporter GT1 0.0113 0.1567 0.3188
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0151 0.0212
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0163 0.2385 0.3188
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.1274 0.3818
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1214 0.2612
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0303 0.4647 0.6212
Echinococcus granulosus casein kinase ii subunit alpha 0.0137 0.1959 0.2761
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0075 0.0105
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0303 0.4647 0.4647
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0037 0.0336 0.0684
Loa Loa (eye worm) GABA receptor subunit 0.0163 0.2385 0.2385
Brugia malayi Inositol-1 0.0038 0.0354 0.0473
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0306 0.1561
Loa Loa (eye worm) hypothetical protein 0.0163 0.2385 0.2385
Entamoeba histolytica hypothetical protein 0.0025 0.0151 0.0447
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.112 0.3358
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0303 0.4647 0.6212
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0075 0.0161
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0101 0.0217
Trypanosoma cruzi casein kinase II, putative 0.0137 0.1959 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0933 0.2008
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0291 0.1701
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0046 0.0062
Brugia malayi RNA binding protein 0.0074 0.0933 0.1247
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0151 0.0306
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1284 0.6554
Giardia lamblia Kinase, CMGC CK2 0.0137 0.1959 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0303 0.4647 0.6212
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0306 0.0658
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0303 0.4647 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0322 0.1642
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0046 0.0065
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0303 0.4647 0.6212
Toxoplasma gondii thioredoxin reductase 0.0037 0.0347 0.0706
Brugia malayi hypothetical protein 0.014 0.2006 0.2681
Onchocerca volvulus 0.014 0.2006 0.4316
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0948 0.4836
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1284 0.2763
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0303 0.4647 0.6549
Trichomonas vaginalis esterase, putative 0.0035 0.0306 0.1561
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0075 0.0075
Echinococcus granulosus nAChR subunit 0.0303 0.4647 0.6549
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0303 0.4647 0.6549
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Loa Loa (eye worm) hypothetical protein 0.0074 0.0948 0.0948
Loa Loa (eye worm) LGC-31 protein 0.0303 0.4647 0.4647
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0046 0.0099
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.1274 0.3818
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0053 0.0269
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0291 0.0626
Mycobacterium leprae Probable lipase LipE 0.0035 0.0306 0.1828
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0046 0.0065
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0336 0.0448
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0163 0.2385 0.2385
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0151 0.4253
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0354 0.0499
Schistosoma mansoni acetylcholine receptor subunit beta 0.014 0.2006 0.4316
Loa Loa (eye worm) hypothetical protein 0.0034 0.0291 0.0291
Loa Loa (eye worm) ACC-1 protein 0.0303 0.4647 0.4647
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0101 0.0217
Loa Loa (eye worm) sugar transporter 0.0113 0.1567 0.1567
Schistosoma mansoni coup transcription factor 0.002 0.0075 0.0161
Brugia malayi hypothetical protein 0.0048 0.0521 0.0696
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0322 0.0453
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0046 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0075 0.0105
Loa Loa (eye worm) hypothetical protein 0.0163 0.2385 0.2385
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0306 0.0917
Trypanosoma brucei glucose transporter 1E 0.0035 0.0309 0.1578
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0046 0.0065
Schistosoma mansoni neurotransmitter gated ion channel 0.014 0.2006 0.4316
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0322 0.0453
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1284 0.6554
Schistosoma mansoni nAChR subunit 0.014 0.2006 0.4316
Echinococcus granulosus glycine receptor subunit beta 0.0303 0.4647 0.6549
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0933 0.1315
Brugia malayi excitatory GABA receptor EXP-1A 0.0303 0.4647 0.6212
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.1959 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0075 0.01
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0336 0.0724
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0151 0.0769
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0075 0.01
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0303 0.4647 0.4647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1214 0.1711
Trypanosoma cruzi hexose transporter 0.0035 0.0309 0.1578
Leishmania major casein kinase II, putative 0.0137 0.1959 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0306 0.1561
Brugia malayi Cation transporter family protein 0.0303 0.4647 0.6212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0075 0.0075
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.01 0.0513
Loa Loa (eye worm) hypothetical protein 0.0479 0.7481 0.7481
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0336 0.0448
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0075 0.0161
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0151 0.0324
Brugia malayi hypothetical protein 0.0019 0.0046 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0046 0.0065
Schistosoma mansoni thyroid hormone receptor 0.002 0.0075 0.0161
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0284 0.04
Brugia malayi PXA domain containing protein 0.0019 0.0046 0.0062
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.014 0.2006 0.2681
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0933 0.2008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0151 0.0518
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0075
Plasmodium falciparum mitogen-activated protein kinase 2 0.0184 0.2711 0.3612
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0303 0.4647 0.6549
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0075 0.0105
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0306 0.8632
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0309 0.1578
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0303 0.4647 0.6549
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1214 0.1214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0075 0.0075
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0303 0.4647 0.4647
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0381 0.1947
Plasmodium vivax unspecified product 0.0137 0.1959 0.2611
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0303 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0354 0.0499
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0046 0.0099
Schistosoma mansoni nAChR subunit 0.0303 0.4647 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0303 0.4647 0.6549
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0381 0.1947
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0075 0.0161
Trypanosoma brucei Casein kinase II 0.0137 0.1959 1
Onchocerca volvulus 0.0163 0.2385 0.5133
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0099
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0309 0.1578
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0322 0.0453
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0037 0.0336 0.1716
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0322 0.0429
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0354 0.1808
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0303 0.4647 0.4647
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0163 0.2385 0.3188
Loa Loa (eye worm) hypothetical protein 0.0163 0.2385 0.2385
Leishmania major glucose transporter, lmgt3 0.0035 0.0309 0.1578
Mycobacterium tuberculosis Conserved protein 0.0035 0.0306 0.0917
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0101 0.0142
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0306
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0075 0.0105
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.1959 1
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0267 0.0377
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1214 0.1711
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0113 0.1567 0.2209
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.1274 1
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0046 0.0065
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.029 0.1697
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0322 0.0453
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0303 0.4647 0.6549
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0322 0.043
Loa Loa (eye worm) hypothetical protein 0.0339 0.5219 0.5219
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0933 0.1247
Schistosoma mansoni glucose transport protein 0.0113 0.1567 0.3373
Brugia malayi ecdysteroid receptor 0.002 0.0075 0.01
Trypanosoma brucei glucose transporter 2A 0.0035 0.0309 0.1578
Schistosoma mansoni protein kinase 0.0036 0.0322 0.0692
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0046 0.0065
Brugia malayi follicle stimulating hormone receptor 0.0239 0.3611 0.4826
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0291 0.041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0075 0.0105
Onchocerca volvulus 0.0035 0.0306 0.0658
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0322 0.0655
Brugia malayi Csnk2b protein 0.0037 0.0336 0.0449
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0046 0.0062
Schistosoma mansoni nAChR subunit 0.014 0.2006 0.4316
Plasmodium falciparum hexose transporter 0.0113 0.1567 0.2089
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0306 0.1561
Loa Loa (eye worm) glutathione reductase 0.0037 0.0347 0.0347
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0101 0.0142
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1284 0.1716
Echinococcus granulosus neuropeptide receptor A26 0.0455 0.7097 1
Brugia malayi hypothetical protein 0.014 0.2006 0.2681
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0354 0.1317
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0354 1
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Echinococcus multilocularis nAChR subunit 0.0303 0.4647 0.6549
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0046 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1214 0.1711
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0303 0.4647 0.6549
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0322 0.0655
Mycobacterium ulcerans lipase LipD 0.0035 0.0306 0.8632
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0075 0.0105
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0336 0.1241
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0075 0.0161
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0046 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0322 0.0692
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0322 0.0453
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0336 0.0724
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0075 0.01
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0184 0.2711 0.3612
Echinococcus granulosus nAChR subunit 0.0163 0.2385 0.3361
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0303 0.4647 0.6212
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0381 0.1947
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0948 0.1263
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0075 0.0161
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0531 0.2712
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0046 0.0099
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0306 0.0306
Brugia malayi hypothetical protein 0.014 0.2006 0.2681
Onchocerca volvulus Putative nachr subunit 0.0303 0.4647 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0303 0.4647 0.6549
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0089 0.0268
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0046 0.0062
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0046 0.0065
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.3335 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0075 0.0105
Loa Loa (eye worm) hypothetical protein 0.0036 0.0322 0.0322
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0075 0.0161
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Leishmania major glucose transporter, lmgt1 0.0035 0.0309 0.1578
Schistosoma mansoni protein kinase 0.0036 0.0322 0.0692
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0046 0.0235
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0306
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0291 0.1484
Entamoeba histolytica protein kinase domain containing protein 0.0137 0.1959 0.8179
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0381 0.1947
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0113 0.1567 0.2209
Trypanosoma brucei glucose transporter, putative 0.0035 0.0309 0.1578
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0075
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0322 0.0429
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0303 0.4647 0.6212
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1284 0.6554
Leishmania major hypothetical protein, conserved 0.0074 0.0948 0.4836
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0267 0.0377
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0933 0.2008
Leishmania major glucose transporter, lmgt2 0.0035 0.0309 0.1578
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.1959 1
Brugia malayi Thioredoxin reductase 0.0037 0.0347 0.0464
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0075 0.01
Plasmodium falciparum protein kinase 7 0.032 0.4916 0.6551
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0306 0.1561
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.112 0.3358
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0309 0.1578
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0309 0.1578
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0113 0.1567 0.2209
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0303 0.4647 0.6212
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0354 0.1808
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0303 0.4647 0.6549
Echinococcus granulosus expressed protein 0.0364 0.5634 0.7939
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0303 0.4647 0.6549
Trypanosoma brucei glucose transporter, putative 0.0035 0.0309 0.1578
Echinococcus granulosus casein kinase ii subunit beta 0.0037 0.0336 0.0474
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1284 0.6554
Loa Loa (eye worm) hypothetical protein 0.0163 0.2385 0.2385
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0381 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0075 0.01
Schistosoma mansoni acetylcholine receptor-related 0.014 0.2006 0.4316
Mycobacterium ulcerans beta-lactamase 0.0035 0.0306 0.8632
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0075 0.0161
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0336 0.1716
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0303 0.4647 0.6549
Echinococcus granulosus glycine receptor subunit alpha 1 0.0303 0.4647 0.6549
Mycobacterium tuberculosis Probable reductase 0.0085 0.112 0.3358
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0322 0.0429
Mycobacterium ulcerans hypothetical protein 0.0035 0.0306 0.8632
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0075 0.0105
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0322 0.0322
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0303 0.4647 0.6212
Onchocerca volvulus 0.0303 0.4647 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0075 0.01
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0322 0.0429
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0303 0.4647 0.6549
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0322 0.0429
Brugia malayi nuclear receptor NHR-88 0.002 0.0075 0.01
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0309 0.1578
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0151 0.0769
Loa Loa (eye worm) acetylcholine receptor protein 0.014 0.2006 0.2006
Schistosoma mansoni neurotransmitter gated ion channel 0.0163 0.2385 0.5133
Onchocerca volvulus 0.0303 0.4647 1
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Entamoeba histolytica hypothetical protein 0.0163 0.2385 1
Onchocerca volvulus 0.0035 0.0306 0.0658
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0306
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0306 0.0917
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0235 0.0235
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0306 0.0917
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0075 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0075 0.01
Entamoeba histolytica protein kinase, putative 0.0036 0.0322 0.1179
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0151 0.0769
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0075 0.0105
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0303 0.4647 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0306 0.0306
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0075 0.01
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0075 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0075 0.01
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1284 0.1809
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0151 0.0769
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0309 0.1578
Mycobacterium tuberculosis Conserved protein 0.0035 0.0306 0.0917
Brugia malayi Casein kinase II, alpha chain 0.0137 0.1959 0.2619
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1284 0.6554
Loa Loa (eye worm) ACC-1 protein 0.0303 0.4647 0.4647
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0354 0.1808
Brugia malayi Cation transporter family protein 0.0303 0.4647 0.6212
Schistosoma mansoni glucose transport protein 0.0113 0.1567 0.3373
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0291 0.0389
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0933 0.0933
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0322 0.0453
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0075 0.0075
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0309 0.1578
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0075 0.01
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0163 0.2385 0.5133
Brugia malayi Sugar transporter family protein 0.0113 0.1567 0.2095
Brugia malayi TAR-binding protein 0.0074 0.0933 0.1247
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1284 0.5292
Schistosoma mansoni hypothetical protein 0.0033 0.0284 0.061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0075 0.01
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0948 0.1263
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0046 0.0065
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0354 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0322 0.0429
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0948 0.1263
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.112 0.3358
Loa Loa (eye worm) hypothetical protein 0.0163 0.2385 0.2385
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.029 0.087
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0306 0.1828
Trypanosoma brucei glucose transporter, putative 0.0035 0.0309 0.1578
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0113 0.1567 0.2209
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0354 0.072
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0381 0.1947
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0101 0.0101
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0046 0.0065
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0075
Schistosoma mansoni protein kinase 0.0137 0.1959 0.4216
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0163 0.2385 0.5133
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0354 0.1808
Schistosoma mansoni nAChR subunit 0.0303 0.4647 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0303 0.4647 1
Brugia malayi steroid hormone receptor 0.002 0.0075 0.01
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0309 0.1578
Onchocerca volvulus 0.014 0.2006 0.4316
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.014 0.2006 0.2826
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0113 0.1567 0.2209
Entamoeba histolytica protein kinase, putative 0.0036 0.0322 0.1179
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0303 0.4647 0.4647
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0151 0.0201
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.014 0.2006 0.2681
Brugia malayi PXA domain containing protein 0.0019 0.0046 0.0062
Schistosoma mansoni neurotransmitter gated ion channel 0.014 0.2006 0.4316
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0075 0.0161
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.112 0.3358
Schistosoma mansoni nAChR subunit 0.0303 0.4647 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0075 0.0161
Plasmodium vivax hexose transporter 0.0113 0.1567 0.2089
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0479 0.7481 1
Plasmodium vivax glutathione reductase, putative 0.0037 0.0347 0.0462
Brugia malayi glutathione reductase 0.0037 0.0347 0.0464
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0075 0.0105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0531 0.2712
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0291 0.1046
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0933 0.2008
Trypanosoma brucei glucose transporter, putative 0.0035 0.0309 0.1578
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0151 0.5
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0309 0.1578
Onchocerca volvulus 0.0163 0.2385 0.5133
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0075 0.01
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Echinococcus granulosus glycine receptor subunit alpha 1 0.0303 0.4647 0.6549
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.014 0.2006 0.2826
Leishmania major protein kinase, putative 0.0036 0.0322 0.1642
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.014 0.2006 0.2681
Leishmania major hypothetical protein, conserved 0.0035 0.0306 0.1561
Brugia malayi hypothetical protein 0.0074 0.0948 0.1267
Brugia malayi Cation transporter family protein 0.0303 0.4647 0.6212
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0037 0.0336 0.1716
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0046 0.0065
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0075 0.0105
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0354 0.1808
Schistosoma mansoni hypothetical protein 0.0113 0.1567 0.3373
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0322 0.1642
Loa Loa (eye worm) hypothetical protein 0.0163 0.2385 0.2385
Loa Loa (eye worm) inositol-1 0.0038 0.0354 0.0354
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0075 0.0161
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0306 0.8632
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0322 0.0429
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0101 0.0101
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0322 0.0453
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0075
Schistosoma mansoni protein kinase 0.0036 0.0322 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1567 0.8
Toxoplasma gondii CMGC kinase, CK2 family 0.0137 0.1959 0.3985
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0354 0.1808
Echinococcus multilocularis neuropeptide s receptor 0.0455 0.7097 1
Loa Loa (eye worm) hypothetical protein 0.0303 0.4647 0.4647
Echinococcus multilocularis expressed protein 0.0364 0.5634 0.7939
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0075 0.0105
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Onchocerca volvulus 0.014 0.2006 0.4316
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0291 0.1484
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0075 0.0161
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0151 0.0769
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0306 0.0407
Toxoplasma gondii ABC1 family protein 0.0035 0.0306 0.0622
Brugia malayi hypothetical protein 0.0019 0.0046 0.0062
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0336 0.0448
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0303 0.4647 0.6549
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Onchocerca volvulus 0.002 0.0075 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0075 0.01
Brugia malayi beta-lactamase 0.0035 0.0306 0.0409
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0303 0.4647 0.6549
Toxoplasma gondii ck2 beta subunit 0.0037 0.0336 0.0684
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0099
Brugia malayi Cam kinase protein 1 0.0036 0.0322 0.043
Echinococcus granulosus General substrate transporter 0.0097 0.1311 0.1847
Onchocerca volvulus 0.0303 0.4647 1
Echinococcus multilocularis glycine receptor subunit beta 0.0303 0.4647 0.6549
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0075 0.01
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0137 0.1959 0.2611
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0075 0.0105
Schistosoma mansoni inositol monophosphatase 0.0038 0.0354 0.0762
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.1959 1
Brugia malayi hypothetical protein 0.014 0.2006 0.2681
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Loa Loa (eye worm) RNA binding protein 0.0074 0.0933 0.0933
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Echinococcus multilocularis General substrate transporter 0.0097 0.1311 0.1847
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0046 0.0065
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0322 0.0655
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0306 0.0917
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0306 0.0917
Echinococcus granulosus FTZ F1 alpha 0.002 0.0075 0.0105
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0306 0.0431
Schistosoma mansoni nAChR subunit 0.0303 0.4647 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.014 0.2006 0.2681
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0046 0.0099
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0322 0.0429
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.1959 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.014 0.2006 0.2006
Plasmodium falciparum casein kinase 2, alpha subunit 0.0137 0.1959 0.2611
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0336 0.1241
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1284 0.6554
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0306 0.0306
Trypanosoma brucei glucose transporter, putative 0.0035 0.0309 0.1578
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0075
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0303 0.4647 1
Brugia malayi beta-lactamase family protein 0.0035 0.0306 0.0409
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1284 0.1809
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.014 0.2006 0.2681
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0381 0.0508
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0306 0.0917
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1284 0.6554
Toxoplasma gondii protein kinase, putative 0.032 0.4916 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0306 0.0658
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.014 0.2006 0.2681
Plasmodium falciparum protein kinase 6 0.048 0.7504 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0291 0.0389
Schistosoma mansoni glucose transport protein 0.0113 0.1567 0.3373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0075 0.01
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0303 0.4647 0.6212
Giardia lamblia Casein kinase II beta chain 0.0037 0.0336 0.1716
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0046 0.0065
Trypanosoma brucei trypanothione reductase 0.0037 0.0347 0.1771
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1214 0.1711
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0309 0.1578
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0933 0.0933
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1214 0.2612
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0163 0.2385 0.2385
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0306 0.1561
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1284 0.6554
Loa Loa (eye worm) Csnk2b protein 0.0037 0.0336 0.0336
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.1274 0.3818
Schistosoma mansoni casein kinase II beta subunit 0.0037 0.0336 0.0724
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0309 0.1578
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0306 0.0409
Loa Loa (eye worm) hypothetical protein 0.014 0.2006 0.2006
Brugia malayi beta-lactamase family protein 0.0035 0.0306 0.0409
Onchocerca volvulus 0.0303 0.4647 1
Schistosoma mansoni kinase 0.005 0.0551 0.1185
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0347 0.0462
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.1959 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.0235
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0303 0.4647 0.6549
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0336 0.1716
Schistosoma mansoni thyroid hormone receptor 0.002 0.0075 0.0161
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0151 0.4253
Trypanosoma brucei polo-like protein kinase 0.0095 0.1284 0.6554

Activities

Activity type Activity value Assay description Source Reference
Log 1/C (binding) = 6.67 Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter ChEMBL. 11931612
Log 1/C (binding) = 6.67 Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter ChEMBL. 11931612
pKD (binding) = 6.04 Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells ChEMBL. 11931612
pKD (binding) = 6.59 Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells ChEMBL. 11931612
pKD (binding) = 6.04 Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells ChEMBL. 11931612
pKD (binding) = 6.59 Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells ChEMBL. 11931612

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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