TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 337.224 | Formula: C15H10Cl2N2OS
H donors: 0 H acceptors: 1 LogP: 4.84 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)C(=O)N=c1sc2c(n1C)c(Cl)ccc2
InChi: 1S/C15H10Cl2N2OS/c1-19-13-11(17)6-3-7-12(13)21-15(19)18-14(20)9-4-2-5-10(16)8-9/h2-8H,1H3/b18-15+
InChiKey: SZFICXRJAXKZJS-OBGWFSINSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0213	0.0794	0.0794
Echinococcus multilocularis	zinc finger protein	0.2264	0.9132	0.9132
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0071	0.0832
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0071	0.5
Loa Loa (eye worm)	CYP4Cod1	0.0022	0.0016	0.0016
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0094	0.1182
Entamoeba histolytica	hypothetical protein	0.0035	0.007	0.0876
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0213	0.0794	0.0794
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0027	0.0345
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0072	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0213	0.0794	1
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0213	0.0794	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0016	0.0016
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0004	0.0004
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0072	0.0072
Trypanosoma cruzi	cytochrome P450, putative	0.0022	0.0016	0.0204
Schistosoma mansoni	loxhd1	0.0019	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0035	0.007	0.007
Leishmania major	glycerol uptake protein, putative	0.0213	0.0794	1
Brugia malayi	Doublecortin family protein	0.0019	0.0004	0.0004
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0004	0.0004
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0094	0.1182
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0027	0.0345
Brugia malayi	hypothetical protein	0.0025	0.0027	0.0027
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.007	0.007
Entamoeba histolytica	hypothetical protein	0.0213	0.0794	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0072	0.0072
Trypanosoma brucei	glycerol uptake protein, putative	0.0213	0.0794	1
Trypanosoma cruzi	cytochrome P450, putative	0.0022	0.0016	0.0204
Brugia malayi	MBOAT family protein	0.0213	0.0794	0.0794
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0213	0.0794	0.0794
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0071	0.0832
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0071	0.0893
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0114	0.0391	0.0391
Brugia malayi	hypothetical protein	0.0035	0.007	0.007
Entamoeba histolytica	hypothetical protein, conserved	0.0213	0.0794	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0071	0.0893
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0213	0.0794	0.0794
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0094	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0004	0.0004
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0071	0.0071
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0094	0.0094
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0027	0.0345
Trichomonas vaginalis	conserved hypothetical protein	0.0213	0.0794	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0794	0.0794
Echinococcus granulosus	sterol O acyltransferase 1	0.0213	0.0794	0.0794
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0004	0.0004
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0004	0.0004
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.0852	1
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0213	0.0794	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0071	0.0893
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0213	0.0794	0.0794
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.008	0.1006
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0072	0.0902
Trichomonas vaginalis	esterase, putative	0.0036	0.0071	0.0893
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0027	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0071	0.0071
Entamoeba histolytica	vacuolar protein sorting 26	0.0213	0.0794	1
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0213	0.0794	0.0794
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0016	0.0016
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0071	0.0832
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.007	0.007
Loa Loa (eye worm)	MBOAT family protein	0.2477	1	1
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0004	0.0004
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0071	0.0832
Onchocerca volvulus		0.0036	0.0071	0.0851
Leishmania major	hypothetical protein, conserved	0.0213	0.0794	1
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.2477	1	1
Brugia malayi	MBOAT family protein	0.0213	0.0794	0.0794
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0071	0.0832
Onchocerca volvulus		0.0213	0.0794	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0	0.5
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0094	0.1182
Leishmania major	hypothetical protein, conserved	0.0036	0.0071	0.0893
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0071	0.0832
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0072	0.0902
Treponema pallidum	alginate O-acetylation protein (algI)	0.0213	0.0794	1
Loa Loa (eye worm)	MBOAT family protein	0.0213	0.0794	0.0794
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0016	0.0016
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0072	0.0902
Schistosoma mansoni	sterol O-acyltransferase 1	0.0213	0.0794	0.0794
Leishmania major	glycerol uptake protein, putative	0.0213	0.0794	1
Loa Loa (eye worm)	MBOAT family protein	0.0213	0.0794	0.0794
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0213	0.0794	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0071	0.0893
Trichomonas vaginalis	conserved hypothetical protein	0.0213	0.0794	1
Brugia malayi	Hhat protein	0.0213	0.0794	0.0794
Brugia malayi	MBOAT family protein	0.0213	0.0794	0.0794
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0071	0.0071
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0071	0.0832
Onchocerca volvulus		0.0036	0.0071	0.0851
Trypanosoma cruzi	glycerol uptake protein, putative	0.0213	0.0794	1
Entamoeba histolytica	hypothetical protein	0.0035	0.007	0.0876
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0022	0.0016	0.2286
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0072	0.8968
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0213	0.0794	0.0794
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0027	0.0345
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0071	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0071	0.0893
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.0497	0.0497
Schistosoma mansoni	lipoxygenase	0.0114	0.0391	0.0391
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0071	0.0832
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0213	0.0794	0.0794
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0071	1
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0213	0.0794	0.0794
Leishmania major	cytochrome p450-like protein	0.0022	0.0016	0.0204
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0071	0.0893
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0114	0.0391	0.0391
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.008	0.1006
Echinococcus granulosus	zinc finger protein	0.2264	0.9132	0.9132
Brugia malayi	beta-lactamase family protein	0.0036	0.0071	0.0071
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0094	0.1182
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0071	0.0832
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0213	0.0794	0.0794
Brugia malayi	beta-lactamase	0.0036	0.0071	0.0071
Trypanosoma cruzi	glycerol uptake protein, putative	0.0213	0.0794	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0072	0.0072
Leishmania major	glycerol uptake protein, putative	0.0213	0.0794	1
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.0497	0.0497
Schistosoma mansoni	lipoxygenase	0.008	0.0251	0.0251
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0071	0.5
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0213	0.0794	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0213	0.0794	0.0794
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.2477	1	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0071	0.0071
Leishmania major	hypothetical protein, conserved	0.0025	0.0027	0.0345
Loa Loa (eye worm)	hhat protein	0.0213	0.0794	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0004	0.0004
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0213	0.0794	0.0794
Entamoeba histolytica	hypothetical protein	0.0035	0.007	0.0876
Echinococcus granulosus	RUN	0.0019	0.0004	0.0004
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0213	0.0794	0.0794
Toxoplasma gondii	hypothetical protein	0.0213	0.0794	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.0071	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0071	0.0071
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0072	0.0072
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0072	0.0072
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0071	0.0893
Trypanosoma brucei	glycerol uptake protein, putative	0.0213	0.0794	1
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0016	0.0016
Brugia malayi	Cytochrome P450 family protein	0.0051	0.0132	0.0132
Brugia malayi	beta-lactamase family protein	0.0036	0.0071	0.0071
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.008	1
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0004	0.0045
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0794	0.0794
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.0497	0.0497
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0213	0.0794	0.0794
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0071	0.0893
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0072	0.0072
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0213	0.0794	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0004	0.0045
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0213	0.0794	0.0794
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0071	0.0071
Schistosoma mansoni	hypothetical protein	0.0019	0.0004	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0072	0.0902
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0027	0.0345
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0072	0.0902
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0213	0.0794	1
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0213	0.0794	0.0794
Loa Loa (eye worm)	hhat protein	0.0213	0.0794	0.0794
Schistosoma mansoni	polycystin 1-related	0.0019	0.0004	0.0004
Leishmania major	glycerol uptake protein, putative	0.0213	0.0794	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0071	0.0071
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0071	0.0893
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0071	0.0071
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.0481	0.0481
Loa Loa (eye worm)	acetyltransferase	0.014	0.0497	0.0497
Loa Loa (eye worm)	cytochrome P450 family protein	0.0051	0.0132	0.0132
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0027	0.0345
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0072	0.0902
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0071	1
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0213	0.0794	0.0794
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0071	0.0071
Toxoplasma gondii	ABC1 family protein	0.0036	0.0071	0.0893
Trypanosoma cruzi	glycerol uptake protein, putative	0.0213	0.0794	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0004	0.0004
Entamoeba histolytica	hypothetical protein	0.0035	0.007	0.0876
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0072	0.0072
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0072	0.0072
Brugia malayi	diacylglycerol acyltransferase	0.0213	0.0794	0.0794
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0213	0.0794	0.0794
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0213	0.0794	0.0794
Brugia malayi	hypothetical protein	0.0019	0.0004	0.0004
Schistosoma mansoni	zinc finger protein	0.2477	1	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0071	0.0832
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0213	0.0794	0.0794
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0213	0.0794	0.0794
Schistosoma mansoni	hypothetical protein	0.0213	0.0794	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0794	0.0794
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0072	0.0902
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0071	0.0071
Trypanosoma brucei	cytochrome P450, putative	0.0022	0.0016	0.0204
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0213	0.0794	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0794	0.0794
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0213	0.0794	1
Trypanosoma cruzi	GUP1, putative	0.0213	0.0794	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0072	0.0902
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0004	0.0004
Trypanosoma cruzi	GUP1, putative	0.0213	0.0794	1
Leishmania major	glycerol uptake protein, putative	0.0213	0.0794	1
Schistosoma mansoni	rab6-interacting	0.0019	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0071	0.0071
Trichomonas vaginalis	porcupine, putative	0.0213	0.0794	1
Onchocerca volvulus		0.0036	0.0071	0.0851
Echinococcus multilocularis	sterol O acyltransferase 1	0.0213	0.0794	0.0794
Echinococcus multilocularis	RUN	0.0019	0.0004	0.0004
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0213	0.0794	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.007	0.007
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0071	1
Brugia malayi	hypothetical protein	0.0019	0.0004	0.0004
Brugia malayi	MBOAT family protein	0.0213	0.0794	0.0794
Schistosoma mansoni	rab6-interacting	0.0019	0.0004	0.0004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 619648