TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 339.455 | Formula: C19H21N3OS
H donors: 0 H acceptors: 1 LogP: 4.43 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(C)c2c(c1)s/c(=N/C(=O)c1ccc(cc1)N(C)C)/n2C
InChi: 1S/C19H21N3OS/c1-12-10-13(2)17-16(11-12)24-19(22(17)5)20-18(23)14-6-8-15(9-7-14)21(3)4/h6-11H,1-5H3/b20-19+
InChiKey: DPKXFDGWPMJZCL-FMQUCBEESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	phosphatidylinositol 3	0.0124	0.0086	0.1263
Echinococcus multilocularis	tar DNA binding protein	0.0131	0.0093	0.0093
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0086	0.1324
Echinococcus granulosus	7TM GPCR rhodopsin	0.0049	0.0005	0.0005
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0124	0.0086	0.0086
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0647	0.0652	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0647	0.0652	1
Entamoeba histolytica	hypothetical protein	0.0124	0.0086	0.1156
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0647	0.0652	0.181
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0124	0.0086	0.0249
Echinococcus multilocularis	fmrfamide receptor	0.0049	0.0005	0.0005
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0063	0.0905
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0124	0.0086	0.0086
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0124	0.0086	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0049	0.0005	0.0005
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0049	0.0005	0.0005
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0365	0.0346	0.5225
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0124	0.0086	0.0086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0124	0.0086	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0365	0.0346	0.5283
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0049	0.0005	0.0005
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0647	0.0652	0.0652
Trichomonas vaginalis	PIKK family atypical protein kinase	0.024	0.0212	0.3249
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0056	0.0012	0.0036
Brugia malayi	MH2 domain containing protein	0.0237	0.0208	0.3145
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0365	0.0346	0.5316
Trichomonas vaginalis	conserved hypothetical protein	0.0282	0.0257	0.3941
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0124	0.0086	0.1263
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0049	0.0005	0.0005
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.0093	0.1371
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0005	0.0005
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0406	0.0392	0.5931
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0124	0.0086	0.1156
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0049	0.0005	0.0005
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0049	0.0005	0.0005
Echinococcus granulosus	biogenic amine 5HT receptor	0.0049	0.0005	0.0005
Mycobacterium ulcerans	heat shock protein 90	0.0045	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0124	0.0086	0.1324
Echinococcus granulosus	serotonin receptor	0.0049	0.0005	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0365	0.0346	0.5316
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0049	0.0005	0.0005
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0028	0.036
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0647	0.0652	0.181
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0647	0.0652	1
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0365	0.0346	0.5316
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Loa Loa (eye worm)	heat shock protein 90	0.0056	0.0012	0.0121
Schistosoma mansoni	heat shock protein	0.0056	0.0012	0.0121
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0124	0.0086	0.0086
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0124	0.0086	0.0249
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0124	0.0086	0.1324
Schistosoma mansoni	endoplasmin	0.0056	0.0012	0.0121
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Echinococcus multilocularis	sex peptide receptor	0.0049	0.0005	0.0005
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0365	0.0346	0.5283
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.0005	0.0005
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0124	0.0086	0.1263
Schistosoma mansoni	hypothetical protein	0.0282	0.0257	0.3899
Echinococcus multilocularis	orexin receptor type 2	0.0049	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0056	0.0012	0.0036
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0365	0.0346	0.0346
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0124	0.0086	0.0086
Trypanosoma cruzi	target of rapamycin kinase 3	0.0647	0.0652	0.188
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0049	0.0005	0.0005
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0365	0.0346	0.5225
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0365	0.0346	0.5316
Loa Loa (eye worm)	MH2 domain-containing protein	0.0237	0.0208	0.3145
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0647	0.0652	1
Echinococcus granulosus	sex peptide receptor	0.0049	0.0005	0.0005
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0124	0.0086	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0056	0.0012	0.0036
Echinococcus granulosus	neuropeptide Y receptor	0.0049	0.0005	0.0005
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0647	0.0652	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0647	0.0652	0.188
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0124	0.0086	0.0249
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0124	0.0086	0.1156
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0131	0.0093	0.1371
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0056	0.0012	0.019
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0124	0.0086	0.1156
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0282	0.0257	0.0257
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Loa Loa (eye worm)	hypothetical protein	0.0282	0.0257	0.3899
Onchocerca volvulus		0.0124	0.0086	1
Echinococcus granulosus	neuropeptide receptor	0.0049	0.0005	0.0005
Echinococcus granulosus	orexin receptor type 2	0.0049	0.0005	0.0005
Loa Loa (eye worm)	RNA binding protein	0.0131	0.0093	0.1371
Entamoeba histolytica	hypothetical protein	0.0124	0.0086	0.1156
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0124	0.0086	0.1263
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0124	0.0086	0.0249
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0124	0.0086	0.1263
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.024	0.0212	0.0611
Brugia malayi	RNA binding protein	0.0131	0.0093	0.1371
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0063	0.0905
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Onchocerca volvulus		0.0124	0.0086	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0124	0.0086	0.1263
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0124	0.0086	0.0086
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0124	0.0086	0.1156
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0005	0.0005
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.0005	0.0005
Echinococcus multilocularis	allatostatin A receptor	0.0049	0.0005	0.0005
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0124	0.0086	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0647	0.0652	0.188
Echinococcus multilocularis	serotonin receptor	0.0049	0.0005	0.0005
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0049	0.0005	0.0005
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0124	0.0086	0.1156
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0124	0.0086	0.0086
Echinococcus granulosus	7tm_1 domain containing protein	0.0049	0.0005	0.0005
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Trichomonas vaginalis	heat shock protein, putative	0.0056	0.0012	0.019
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0365	0.0346	0.5283
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Plasmodium vivax	hypothetical protein, conserved	0.0124	0.0086	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0049	0.0005	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Loa Loa (eye worm)	phosphatidylinositol 3	0.0647	0.0652	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0124	0.0086	0.1324
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0124	0.0086	0.1324
Echinococcus multilocularis	g-protein coupled receptor	0.0049	0.0005	0.0005
Entamoeba histolytica	hypothetical protein	0.0365	0.0346	0.5225
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0647	0.0652	0.0652
Entamoeba histolytica	hypothetical protein	0.0124	0.0086	0.1156
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0124	0.0086	0.1324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0124	0.0086	0.1156
Trypanosoma cruzi	heat shock protein 85, putative	0.0056	0.0012	0.0036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0049	0.0005	0.0005
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0282	0.0257	0.0257
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0124	0.0086	0.1263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0365	0.0346	0.5316
Echinococcus granulosus	somatostatin receptor	0.0049	0.0005	0.0005
Entamoeba histolytica	hypothetical protein	0.0124	0.0086	0.1156
Leishmania major	hypothetical protein, conserved	0.3372	0.3601	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0124	0.0086	0.0086
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0008	0.0059
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0647	0.0652	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0086	0.1324
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0406	0.0392	0.5931
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0124	0.0086	0.0086
Echinococcus multilocularis	heat shock protein 90	0.0056	0.0012	0.0012
Echinococcus multilocularis	neuropeptide receptor	0.0049	0.0005	0.0005
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0049	0.0005	0.0005
Echinococcus multilocularis	neuropeptide Y receptor	0.0049	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.007	0.0028	0.036
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0049	0.0005	0.0005
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0124	0.0086	0.1324
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0005	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.024	0.0212	0.3249
Loa Loa (eye worm)	endoplasmin	0.0056	0.0012	0.0121
Trichomonas vaginalis	conserved hypothetical protein	0.0406	0.0392	0.6008
Echinococcus multilocularis	G protein coupled receptor 139	0.0049	0.0005	0.0005
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0647	0.0652	0.188
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0124	0.0086	0.1156
Echinococcus multilocularis	Zinc finger, PHD finger	0.0124	0.0086	0.0086
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.0005	0.0005
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0124	0.0086	0.024
Echinococcus granulosus	fmrfamide receptor	0.0049	0.0005	0.0005
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0049	0.0005	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0124	0.0086	0.024
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0124	0.0086	0.1263
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.0093	0.1371
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0124	0.0086	0.0249
Echinococcus multilocularis	neuropeptide receptor	0.0049	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Echinococcus granulosus	neuropeptides capa receptor	0.0049	0.0005	0.0005
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0124	0.0086	0.1324
Loa Loa (eye worm)	hypothetical protein	0.024	0.0212	0.3202
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0005	0.0005
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0049	0.0005	0.0005
Echinococcus granulosus	allatostatin A receptor	0.0049	0.0005	0.0005
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0124	0.0086	0.1156
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0049	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0406	0.0392	0.6008
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0124	0.0086	0.1263
Echinococcus granulosus	serine protein kinase ATM	0.0365	0.0346	0.0346
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0124	0.0086	0.0249
Loa Loa (eye worm)	phosphatidylinositol 3	0.0124	0.0086	0.1263
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0647	0.0652	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0647	0.0652	1
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Brugia malayi	Endoplasmin precursor	0.0056	0.0012	0.0121
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.0093	0.1371
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.0005	0.0005
Echinococcus multilocularis	neuropeptide s receptor	0.0049	0.0005	0.0005
Schistosoma mansoni	heat shock protein	0.0056	0.0012	0.0121
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0647	0.0652	0.0652
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0365	0.0346	0.5283
Echinococcus granulosus	neuropeptide receptor	0.0049	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0124	0.0086	0.1263
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0124	0.0086	0.1324
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0647	0.0652	0.181
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0124	0.0086	0.1156
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0124	0.0086	0.1324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0365	0.0346	0.5316
Echinococcus granulosus	neuropeptide Y receptor	0.0049	0.0005	0.0005
Loa Loa (eye worm)	phosphatidylinositol 3	0.0124	0.0086	0.1263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0124	0.0086	0.1324
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0124	0.0086	0.1156
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0124	0.0086	0.1156
Mycobacterium leprae	conserved hypothetical protein	0.0124	0.0086	1
Trypanosoma cruzi	Heat shock protein 83, putative	0.0056	0.0012	0.0036
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0124	0.0086	0.1324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0647	0.0652	0.181
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0008	0.0059
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.0005	0.0005
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0124	0.0086	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0124	0.0086	0.1156
Trypanosoma cruzi	hypothetical protein, conserved	0.3247	0.3466	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0049	0.0005	0.0005
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0647	0.0652	0.181
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0124	0.0086	0.1324
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0647	0.0652	1
Onchocerca volvulus		0.0052	0.0008	0.0464
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0124	0.0086	0.024
Loa Loa (eye worm)	phosphatidylinositol 3	0.0647	0.0652	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Echinococcus multilocularis	somatostatin receptor	0.0049	0.0005	0.0005
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0124	0.0086	0.1156
Echinococcus multilocularis	fmrfamide receptor	0.0049	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0124	0.0086	0.1156
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.0093	0.1371
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0049	0.0005	0.0005
Schistosoma mansoni	endoplasmin	0.0056	0.0012	0.0121
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Plasmodium vivax	hypothetical protein	0.0124	0.0086	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0049	0.0005	0.0005
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.9285	1	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0086	0.1263
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Giardia lamblia	Hypothetical protein	0.0124	0.0086	0.1324
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0647	0.0652	0.0652
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0049	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Loa Loa (eye worm)	hypothetical protein	0.0406	0.0392	0.598
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0086	0.1263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Echinococcus granulosus	heat shock protein	0.0056	0.0012	0.0012
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0124	0.0086	0.1263
Loa Loa (eye worm)	phosphatidylinositol 3	0.0124	0.0086	0.1263
Echinococcus granulosus	tar DNA binding protein	0.0131	0.0093	0.0093
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0124	0.0086	0.024
Entamoeba histolytica	protein kinase rad3, putative	0.0365	0.0346	0.5225
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0124	0.0086	0.1263
Echinococcus multilocularis	serine protein kinase ATM	0.0365	0.0346	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0124	0.0086	0.1263
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0124	0.0086	0.0086
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Echinococcus multilocularis	dro:myosuppressin receptor	0.0049	0.0005	0.0005
Echinococcus granulosus	neuropeptides capa receptor	0.0049	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0005	0.0005
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0124	0.0086	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0124	0.0086	0.1263
Echinococcus granulosus	neuropeptide receptor A26	0.0049	0.0005	0.0005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0124	0.0086	0.0086
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0049	0.0005	0.0005
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0647	0.0652	0.188
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0049	0.0005	0.0005
Echinococcus granulosus	G protein coupled receptor 139	0.0049	0.0005	0.0005
Echinococcus multilocularis	neuropeptides capa receptor	0.0049	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0365	0.0346	0.5316
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0124	0.0086	0.0249
Echinococcus granulosus	tumor protein p63	0.0358	0.0339	0.0339
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0124	0.0086	0.1324
Brugia malayi	TAR-binding protein	0.0131	0.0093	0.1371
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0124	0.0086	0.1263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0365	0.0346	0.5316
Echinococcus multilocularis	tumor protein p63	0.0358	0.0339	0.0339
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0124	0.0086	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Leishmania major	hypothetical protein, unknown function	0.0124	0.0086	0.024
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0049	0.0005	0.0005
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0124	0.0086	0.1263
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0124	0.0086	0.1263
Echinococcus granulosus	neuropeptide s receptor	0.0049	0.0005	0.0005
Echinococcus multilocularis		0.0124	0.0086	0.0086
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0049	0.0005	0.0005
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0124	0.0086	0.0249
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0124	0.0086	0.1324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0124	0.0086	0.1156
Echinococcus granulosus	heat shock protein 90	0.0056	0.0012	0.0012
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0124	0.0086	0.0249
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0647	0.0652	1
Schistosoma mansoni	hypothetical protein	0.007	0.0028	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0045	0	0.5
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0365	0.0346	0.0346
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Loa Loa (eye worm)	TAR-binding protein	0.0131	0.0093	0.1371
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0124	0.0086	0.1263
Brugia malayi	heat shock protein 90	0.0056	0.0012	0.0121
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Schistosoma mansoni	tar DNA-binding protein	0.0131	0.0093	0.1371
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0124	0.0086	1
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0086	0.1324
Echinococcus granulosus	hypothetical protein	0.0049	0.0005	0.0005
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Echinococcus multilocularis	serotonin receptor	0.0049	0.0005	0.0005
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0063	0.0905
Brugia malayi	RNA recognition motif domain containing protein	0.0131	0.0093	0.1371
Toxoplasma gondii	FATC domain-containing protein	0.0365	0.0346	0.5225
Treponema pallidum	heat shock protein 90	0.0045	0	0.5
Brugia malayi	FAT domain containing protein	0.0282	0.0257	0.3899
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0049	0.0005	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0063	0.0905
Echinococcus granulosus	g-protein coupled receptor	0.0049	0.0005	0.0005
Leishmania major	heat shock protein 83-1	0.0056	0.0012	0.0034
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0124	0.0086	0.1324
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0365	0.0346	0.0999
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0237	0.0208	0.3145
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0005	0.0005
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.0005	0.0005
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0124	0.0086	0.1324
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0365	0.0346	0.0999
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0124	0.0086	0.1156
Leishmania major	phosphatidylinositol kinase, putative	0.0124	0.0086	0.024
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0124	0.0086	0.1156
Echinococcus multilocularis	heat shock protein	0.0056	0.0012	0.0012
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0049	0.0005	0.0005
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0647	0.0652	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0124	0.0086	0.1263
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0124	0.0086	0.0249
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0124	0.0086	0.1156
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0647	0.0652	1
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0124	0.0086	0.0086
Giardia lamblia	GTOR	0.0647	0.0652	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0049	0.0005	0.0005
Echinococcus granulosus	neuropeptide FF receptor 2	0.0049	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0365	0.0346	0.5283
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0647	0.0652	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 622057