TDR Targets

Basic information

Technical information

TDR Targets ID: 622196
Name: [6,7-dimethoxy-1-[(2-methoxyphenoxy)methyl]-3 ,4-dihydro-1H-isoquinolin-2-yl]-(2-nitropheny l)methanone
MW: 478.494 | Formula: C26H26N2O7
H donors: 0 H acceptors: 3 LogP: 4.35 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(cc1OC)CCN(C2COc1ccccc1OC)C(=O)c1ccccc1[N+](=O)[O-]
InChi: 1S/C26H26N2O7/c1-32-22-10-6-7-11-23(22)35-16-21-19-15-25(34-3)24(33-2)14-17(19)12-13-27(21)26(29)18-8-4-5-9-20(18)28(30)31/h4-11,14-15,21H,12-13,16H2,1-3H3
InChiKey: QMCKDBPAOHQAMM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

Oprea1_428747

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0127	0.008	0.008
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0373	0.034	0.527
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0127	0.008	0.008
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0127	0.008	0.02
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0373	0.034	0.521
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0127	0.008	0.0208
Schistosoma mansoni	heat shock protein	0.0059	0.0008	0.0126
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0127	0.008	0.124
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0127	0.008	0.1128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0373	0.034	0.0962
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0127	0.008	0.0208
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0127	0.008	0.1128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Echinococcus multilocularis		0.0127	0.008	0.008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Echinococcus multilocularis	heat shock protein 90	0.0059	0.0008	0.0008
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0127	0.008	0.124
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.0057	0.0057
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0127	0.008	0.0208
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0127	0.008	0.1128
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.0057	0.0057
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0127	0.008	0.124
Plasmodium vivax	hypothetical protein, conserved	0.0127	0.008	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0662	0.0646	0.1777
Schistosoma mansoni	hypothetical protein	0.0106	0.0057	0.0885
Schistosoma mansoni	hypothetical protein	0.0127	0.008	0.124
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0662	0.0646	0.1777
Loa Loa (eye worm)	heat shock protein 90	0.0059	0.0008	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0127	0.008	0.1128
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0127	0.008	0.0208
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0289	0.0251	0.0251
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0662	0.0646	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0127	0.008	0.008
Brugia malayi	FAT domain containing protein	0.0289	0.0251	0.3882
Loa Loa (eye worm)	phosphatidylinositol 3	0.0127	0.008	0.124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0127	0.008	0.1128
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0127	0.008	0.124
Echinococcus multilocularis	heat shock protein	0.0059	0.0008	0.0008
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0127	0.008	0.1128
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0127	0.008	0.124
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.0057	0.0057
Plasmodium vivax	hypothetical protein	0.0127	0.008	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.9498	1	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0373	0.034	0.527
Schistosoma mansoni	endoplasmin	0.0059	0.0008	0.0126
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0662	0.0646	0.1846
Schistosoma mansoni	glucose transport protein	0.0106	0.0057	0.0885
Loa Loa (eye worm)	endoplasmin	0.0059	0.0008	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0662	0.0646	0.1846
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0373	0.034	0.521
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0127	0.008	0.1128
Leishmania major	hypothetical protein, unknown function	0.0127	0.008	0.02
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trichomonas vaginalis	conserved hypothetical protein	0.0416	0.0385	0.5918
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0662	0.0646	0.0646
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0373	0.034	0.0962
Brugia malayi	heat shock protein 90	0.0059	0.0008	0.0126
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0127	0.008	0.124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0127	0.008	0.008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0373	0.034	0.521
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0662	0.0646	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0127	0.008	0.008
Echinococcus granulosus	heat shock protein	0.0059	0.0008	0.0008
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0127	0.008	0.124
Onchocerca volvulus		0.0127	0.008	1
Schistosoma mansoni	hypothetical protein	0.0289	0.0251	0.3882
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0127	0.008	0.124
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0416	0.0385	0.5918
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0127	0.008	0.1128
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0662	0.0646	0.0646
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0057	0.0769
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Echinococcus multilocularis	serine protein kinase ATM	0.0373	0.034	0.034
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0127	0.008	0.1128
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0127	0.008	0.1128
Loa Loa (eye worm)	phosphatidylinositol 3	0.0127	0.008	0.124
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.0057	0.0057
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0246	0.0206	0.0572
Trypanosoma cruzi	target of rapamycin kinase 3	0.0662	0.0646	0.1846
Loa Loa (eye worm)	sugar transporter	0.0106	0.0057	0.0885
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0127	0.008	0.1128
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0662	0.0646	0.1846
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0127	0.008	0.0208
Entamoeba histolytica	protein kinase rad3, putative	0.0373	0.034	0.521
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trypanosoma cruzi	hypothetical protein, conserved	0.3322	0.3462	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0127	0.008	0.1128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0127	0.008	0.008
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0127	0.008	0.0208
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0662	0.0646	0.0646
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0127	0.008	0.008
Loa Loa (eye worm)	phosphatidylinositol 3	0.0127	0.008	0.124
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0127	0.008	0.1128
Echinococcus granulosus	General substrate transporter	0.0091	0.0041	0.0041
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0662	0.0646	0.1777
Mycobacterium leprae	conserved hypothetical protein	0.0127	0.008	0.5
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0662	0.0646	0.0646
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0127	0.008	0.1128
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0127	0.008	0.0208
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0127	0.008	0.1128
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0127	0.008	0.1128
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0127	0.008	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0373	0.034	0.527
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0127	0.008	0.1128
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0373	0.034	0.527
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0662	0.0646	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0662	0.0646	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0127	0.008	0.0208
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0127	0.008	0.02
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0127	0.008	0.1128
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0127	0.008	0.008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0127	0.008	0.1128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0373	0.034	0.521
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0127	0.008	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0662	0.0646	1
Loa Loa (eye worm)	hypothetical protein	0.0127	0.008	0.124
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0127	0.008	0.02
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0662	0.0646	1
Toxoplasma gondii	FATC domain-containing protein	0.0373	0.034	0.521
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0373	0.034	0.521
Brugia malayi	Sugar transporter family protein	0.0106	0.0057	0.0885
Plasmodium vivax	hexose transporter	0.0106	0.0057	0.6815
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0127	0.008	0.124
Schistosoma mansoni	glucose transport protein	0.0106	0.0057	0.0885
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0127	0.008	0.0208
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0127	0.008	0.1128
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0127	0.008	0.1128
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.0057	0.0057
Leishmania major	phosphatidylinositol kinase, putative	0.0127	0.008	0.02
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0373	0.034	0.521
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0127	0.008	0.0208
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0127	0.008	0.008
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0416	0.0385	0.5918
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0127	0.008	0.008
Entamoeba histolytica	hypothetical protein	0.0127	0.008	0.1128
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0127	0.008	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0373	0.034	0.521
Loa Loa (eye worm)	phosphatidylinositol 3	0.0662	0.0646	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0373	0.034	0.527
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0127	0.008	0.008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0662	0.0646	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0127	0.008	0.1128
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0127	0.008	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0246	0.0206	0.3184
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0662	0.0646	1
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0127	0.008	0.1128
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0662	0.0646	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.0057	0.0057
Schistosoma mansoni	endoplasmin	0.0059	0.0008	0.0126
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0127	0.008	0.1128
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0662	0.0646	0.1777
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0127	0.008	0.124
Trichomonas vaginalis	conserved hypothetical protein	0.0289	0.0251	0.3805
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0127	0.008	0.1128
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0373	0.034	0.034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0416	0.0385	0.5918
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0127	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0127	0.008	0.124
Leishmania major	hypothetical protein, conserved	0.3449	0.3597	1
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0127	0.008	0.02
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0246	0.0206	0.3097
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Loa Loa (eye worm)	hypothetical protein	0.0416	0.0385	0.5969
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0127	0.008	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0127	0.008	0.124
Echinococcus multilocularis	General substrate transporter	0.0091	0.0041	0.0041
Brugia malayi	Endoplasmin precursor	0.0059	0.0008	0.0126
Entamoeba histolytica	hypothetical protein	0.0127	0.008	0.1128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0127	0.008	0.1128
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0662	0.0646	0.1846
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0662	0.0646	0.1777
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0127	0.008	0.1128
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0127	0.008	0.124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0127	0.008	0.1128
Loa Loa (eye worm)	phosphatidylinositol 3	0.0127	0.008	0.124
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0127	0.008	0.5
Entamoeba histolytica	hypothetical protein	0.0127	0.008	0.1128
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0127	0.008	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0662	0.0646	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0662	0.0646	1
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0127	0.008	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0662	0.0646	1
Onchocerca volvulus		0.0127	0.008	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0373	0.034	0.521
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0127	0.008	0.1128
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0127	0.008	0.1128
Echinococcus granulosus	serine protein kinase ATM	0.0373	0.034	0.034
Trichomonas vaginalis	conserved hypothetical protein	0.0246	0.0206	0.3097
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0127	0.008	0.1128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0127	0.008	0.1128
Schistosoma mansoni	heat shock protein	0.0059	0.0008	0.0126
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0127	0.008	1
Echinococcus granulosus	heat shock protein 90	0.0059	0.0008	0.0008
Plasmodium falciparum	hexose transporter	0.0106	0.0057	0.6815
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0662	0.0646	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0373	0.034	0.521
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Entamoeba histolytica	hypothetical protein	0.0373	0.034	0.521
Schistosoma mansoni	glucose transport protein	0.0106	0.0057	0.0885
Loa Loa (eye worm)	hypothetical protein	0.0289	0.0251	0.3882
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0127	0.008	1
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0127	0.008	0.008
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0127	0.008	0.1128
Entamoeba histolytica	hypothetical protein	0.0127	0.008	0.1128
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0373	0.034	0.521
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0127	0.008	0.124
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0127	0.008	0.124
Loa Loa (eye worm)	phosphatidylinositol 3	0.0127	0.008	0.124
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0127	0.008	0.124
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.0057	0.0057
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Giardia lamblia	GTOR	0.0662	0.0646	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0127	0.008	0.1128
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0127	0.008	0.1128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0289	0.0251	0.0251
Toxoplasma gondii	facilitative glucose transporter GT1	0.0106	0.0057	0.0769
Giardia lamblia	Hypothetical protein	0.0127	0.008	0.1128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0127	0.008	0.124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0662	0.0646	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0106	0.0057	0.0057
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0373	0.034	0.034

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 622196