Detailed information for compound 626725

Basic information

Technical information
  • TDR Targets ID: 626725
  • Name: N-(4-fluorophenyl)-2-[1-(4-fluorophenyl)-4-ox opyrazolo[5,4-d]pyrimidin-5-yl]acetamide
  • MW: 381.336 | Formula: C19H13F2N5O2
  • H donors: 1 H acceptors: 3 LogP: 2.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NC(=O)Cn1cnc2c(c1=O)cnn2c1ccc(cc1)F
  • InChi: 1S/C19H13F2N5O2/c20-12-1-5-14(6-2-12)24-17(27)10-25-11-22-18-16(19(25)28)9-23-26(18)15-7-3-13(21)4-8-15/h1-9,11H,10H2,(H,24,27)
  • InChiKey: UJYXNSMWULIYOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-fluorophenyl)-2-[1-(4-fluorophenyl)-4-oxo-pyrazolo[5,4-d]pyrimidin-5-yl]acetamide
  • N-(4-fluorophenyl)-2-[1-(4-fluorophenyl)-4-oxo-5-pyrazolo[5,4-d]pyrimidinyl]acetamide
  • N-(4-fluorophenyl)-2-[1-(4-fluorophenyl)-4-keto-pyrazolo[5,4-d]pyrimidin-5-yl]acetamide
  • N-(4-fluorophenyl)-2-[1-(4-fluorophenyl)-4-oxo-pyrazolo[5,4-d]pyrimidin-5-yl]ethanamide
  • ZINC04165989

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0023 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0095 0.0097
Echinococcus granulosus geminin 0.0853 0.6877 0.8451
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0087 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.1229 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0196 0.018
Schistosoma mansoni hypothetical protein 0.0853 0.6877 0.8438
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1406 0.166
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0458 0.3593 0.4405
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0095 0.0116
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0095 0.0116
Brugia malayi RNA recognition motif domain containing protein 0.0195 0.1406 0.1712
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0195 0.0221
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0116
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0228 0.028
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0226 0.0259
Loa Loa (eye worm) hypothetical protein 0.0053 0.0228 0.028
Schistosoma mansoni lamin 0.0053 0.0226 0.0197
Brugia malayi steroid hormone receptor 0.0037 0.0095 0.0097
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0095 0.0034
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0095 0.0034
Schistosoma mansoni hypothetical protein 0.0122 0.0802 0.0911
Brugia malayi nuclear hormone receptor 0.0037 0.0095 0.0097
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.1308 0.1607
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0195 0.0221
Echinococcus granulosus intermediate filament protein 0.0053 0.0226 0.0278
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0095 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0964 0.1167
Echinococcus multilocularis carbonic anhydrase 0.0458 0.3593 0.4416
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0272 0.0334
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.061 0.0596
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0272 0.0334
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0095 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.061 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0087 0.0071
Echinococcus multilocularis tar DNA binding protein 0.0195 0.1406 0.1728
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.061 0.075
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0175 0.0133
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0095 0.0116
Loa Loa (eye worm) TAR-binding protein 0.0195 0.1406 0.1728
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0335 0.0411
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0095 0.0034
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0228 0.0261
Loa Loa (eye worm) hypothetical protein 0.0053 0.0226 0.0278
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0195 0.024
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0095 0.0097
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0175 0.0215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0095 0.0116
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0095 0.0116
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0095 0.0116
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.061 0.0732
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0175 0.0133
Brugia malayi mbt repeat family protein 0.0046 0.0175 0.0196
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0095 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.2271 0.2777
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0627 0.4996 0.5979
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0116
Mycobacterium ulcerans carbonic anhydrase 0.0914 0.7377 0.7054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0095 0.0116
Schistosoma mansoni intermediate filament proteins 0.0053 0.0226 0.0197
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1005 0.8138 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0095 0.0116
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0226 0.0278
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.2271 0.2777
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0914 0.7377 0.5
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0016 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0205 0.0171
Onchocerca volvulus 0.0046 0.0175 0.1552
Echinococcus granulosus carbonic anhydrase 0.0458 0.3593 0.4416
Loa Loa (eye worm) carboxylesterase 0.0066 0.0335 0.0411
Loa Loa (eye worm) MBCTL1 0.0053 0.0228 0.028
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0087 0.0107
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1005 0.8138 1
Schistosoma mansoni lamin 0.0053 0.0226 0.0197
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0196 0.018
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0116
Schistosoma mansoni bromodomain containing protein 0.0062 0.03 0.0289
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0116
Brugia malayi mbt repeat family protein 0.0046 0.0175 0.0196
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0458 0.3593 0.4405
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0095 0.0116
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0164
Echinococcus granulosus lamin dm0 0.0053 0.0226 0.0278
Trypanosoma brucei carbonic anhydrase-like protein 0.1005 0.8138 1
Brugia malayi Carboxylesterase family protein 0.0066 0.0335 0.0393
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1406 0.166
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0087 0.1198
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0095 0.0116
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0138 0.0151
Loa Loa (eye worm) carbonic anhydrase 3 0.1005 0.8138 1
Schistosoma mansoni carbonic anhydrase-related 0.0458 0.3593 0.4369
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1005 0.8138 1
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.061 0.0673
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.061 0.0732
Schistosoma mansoni carbonic anhydrase-related 0.0458 0.3593 0.4369
Loa Loa (eye worm) hypothetical protein 0.0066 0.0335 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0095 0.0097
Loa Loa (eye worm) hypothetical protein 0.004 0.0118 0.0145
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0095 0.0097
Echinococcus granulosus tar DNA binding protein 0.0195 0.1406 0.1728
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0087 0.0025
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0335 0.0411
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0095 0.0116
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0095 0.0116
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0335 0.0411
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0964 0.1167
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0087 0.0107
Onchocerca volvulus 0.0053 0.0226 0.2549
Loa Loa (eye worm) hypothetical protein 0.0033 0.0067 0.0082
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0138 0.0151
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0175 0.0215
Echinococcus granulosus acetylcholinesterase 0.0066 0.0335 0.0411
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0458 0.3593 0.4416
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0175 0.1552
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0095 0.0034
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.2271 0.2777
Loa Loa (eye worm) hypothetical protein 0.0066 0.0335 0.0411
Loa Loa (eye worm) hypothetical protein 0.0036 0.0087 0.0107
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0138 0.0151
Schistosoma mansoni thyroid hormone receptor 0.0159 0.1108 0.129
Mycobacterium ulcerans short chain dehydrogenase 0.0275 0.207 0.1094
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.2271 0.2777
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0095 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0095 0.0097
Schistosoma mansoni coup transcription factor 0.0037 0.0095 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.061 0.0596
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0095 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0205 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0205 0.0252
Brugia malayi Bromodomain containing protein 0.0073 0.0395 0.0467
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0095 0.0097
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0023 0.0029
Loa Loa (eye worm) hypothetical protein 0.0069 0.0361 0.0443
Loa Loa (eye worm) hypothetical protein 0.0046 0.0175 0.0215
Loa Loa (eye worm) hypothetical protein 0.0052 0.0218 0.0268
Brugia malayi Bromodomain containing protein 0.0037 0.0099 0.0102
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.1108 0.1361
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1406 0.166
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0458 0.3593 0.4405
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0095 0.0116
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0458 0.3593 0.4405
Echinococcus multilocularis geminin 0.0853 0.6877 0.8451
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0214 0.0245
Brugia malayi TAR-binding protein 0.0195 0.1406 0.1712
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0095 0.0116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0205 0.0252
Leishmania major carbonic anhydrase family protein, putative 0.0914 0.7377 0.9063
Echinococcus multilocularis carbonic anhydrase 0.0458 0.3593 0.4416
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0175 0.0215
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0016 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1406 0.166
Loa Loa (eye worm) RNA binding protein 0.0195 0.1406 0.1728
Brugia malayi RNA binding protein 0.0195 0.1406 0.1712
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1406 0.166
Echinococcus multilocularis lamin dm0 0.0053 0.0226 0.0278
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0095 0.0116
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0228 0.028
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1005 0.8138 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0095 0.0097
Schistosoma mansoni carbonic anhydrase 0.0458 0.3593 0.4369
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0087 0.0107
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0335 0.0411
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0087 0.0088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0116
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.061 0.0732
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0095 0.0097
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0458 0.3593 0.4405
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0138 0.0151
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0116
Schistosoma mansoni carbonic anhydrase-related 0.0458 0.3593 0.4369
Schistosoma mansoni hypothetical protein 0.0853 0.6877 0.8438
Leishmania major carbonic anhydrase-like protein 0.1005 0.8138 1
Loa Loa (eye worm) hypothetical protein 0.0458 0.3593 0.4416
Toxoplasma gondii hypothetical protein 0.0048 0.0189 0.0486
Schistosoma mansoni hypothetical protein 0.0458 0.3593 0.4369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0095 0.0116
Echinococcus multilocularis carbonic anhydrase 0.0458 0.3593 0.4416
Echinococcus granulosus carbonic anhydrase 0.0458 0.3593 0.4416
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1005 0.8138 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.061 0.0596
Entamoeba histolytica carbonic anhydrase, putative 0.0914 0.7377 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0175 0.0133
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0228 0.02
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1005 0.8138 1
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0335 0.0411
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0087 0.0088
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0095 0.0034
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0095 0.0034
Echinococcus granulosus flap endonuclease 1 0.0027 0.0016 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.1229 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0087 0.0088
Echinococcus granulosus carbonic anhydrase II 0.1005 0.8138 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0195 0.1406 0.1728
Echinococcus multilocularis carbonic anhydrase II 0.1005 0.8138 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0067 0.0063
Echinococcus granulosus lamin 0.0053 0.0226 0.0278
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0228 0.028
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0175 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0095 0.0097
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.008 0.0098
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0016 0.0019
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0087 0.0025
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0095 0.0034
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0095 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0095 0.0097
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0087 0.0097
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0175 0.0215
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0095 0.0034
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0087 0.0088
Loa Loa (eye worm) hypothetical protein 0.0458 0.3593 0.4416
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0087 0.0107
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0802 0.0986
Loa Loa (eye worm) hypothetical protein 0.0049 0.0195 0.024
Giardia lamblia Kinase, PLK 0.0099 0.061 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0095 0.0097
Schistosoma mansoni hypothetical protein 0.0282 0.2132 0.2559
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.061 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0802 0.0986
Plasmodium falciparum carbonic anhydrase 0.0458 0.3593 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0205 0.0233
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0205 0.0252
Brugia malayi Carboxylesterase family protein 0.0066 0.0335 0.0393
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0228 0.028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0122
Trypanosoma brucei polo-like protein kinase 0.0099 0.061 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0095 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.061 0.0596
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.061 0.0596
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.061 0.0732
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0087 0.0088
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.061 0.075
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0226 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0095 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0205 0.0171
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0964 0.1167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0095 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0095 0.0097
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0087 0.0107
Schistosoma mansoni kinase 0.005 0.0207 0.0173
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0095 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0087 0.0071
Echinococcus multilocularis musashi 0.0053 0.0226 0.0278
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0116
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.1308 0.1607
Brugia malayi intermediate filament protein 0.0053 0.0226 0.0259
Echinococcus granulosus carbonic anhydrase 0.0458 0.3593 0.4416
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.061 0.0808
Brugia malayi ecdysteroid receptor 0.0037 0.0095 0.0097
Echinococcus multilocularis lamin 0.0053 0.0226 0.0278
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0943 0.762 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0205 0.0252
Mycobacterium tuberculosis Probable oxidoreductase 0.0275 0.207 0.1493
Schistosoma mansoni thyroid hormone receptor 0.0159 0.1108 0.129
Brugia malayi nuclear receptor NHR-88 0.0037 0.0095 0.0097
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0095 0.0116
Toxoplasma gondii hypothetical protein 0.0458 0.3593 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0335 0.0332
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.008 0.0098
Onchocerca volvulus 0.0053 0.0226 0.2549
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0095 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0095 0.0116
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0287 0.217 0.1645
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0095 0.0034
Schistosoma mansoni carbonic anhydrase 0.0914 0.7377 0.9057
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1005 0.8138 1
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0095 0.0097
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.061 0.075
Echinococcus granulosus acetylcholinesterase 0.0066 0.0335 0.0411
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0205 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.061 0.0596
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0087 0.0107
Loa Loa (eye worm) hypothetical protein 0.0458 0.3593 0.4416

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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