Detailed information for compound 647204

Basic information

Technical information
  • TDR Targets ID: 647204
  • Name: 4-[5-(2-methylphenyl)-1,2,4-oxadiazol-3-yl]py ridine
  • MW: 237.257 | Formula: C14H11N3O
  • H donors: 0 H acceptors: 3 LogP: 2.76 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1c1onc(n1)c1ccncc1
  • InChi: 1S/C14H11N3O/c1-10-4-2-3-5-12(10)14-16-13(17-18-14)11-6-8-15-9-7-11/h2-9H,1H3
  • InChiKey: GJUVZJBNOGUNHT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • STK018636
  • 4-(5-o-Tolyl-[1,2,4]oxadiazol-3-yl)-pyridine
  • BAS 01416152
  • Oprea1_856234
  • ZINC00238192
  • Oprea1_651030

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.001 0.0002 0.0002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.109 0.1293
Echinococcus granulosus caspase 0.0382 0.7114 0.8454
Mycobacterium ulcerans hypothetical protein 0.0037 0.0514 0.1918
Echinococcus multilocularis caspase 3 0.0237 0.4354 0.5173
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.2576 1
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0147 0.0147
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0121 0.2123 0.2521
Onchocerca volvulus 0.0029 0.0366 0.0707
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.001 0.0002 0.0002
Brugia malayi CXXC zinc finger family protein 0.0032 0.042 0.0419
Brugia malayi bHLH-PAS transcription factor 0.0117 0.2063 0.2062
Schistosoma mansoni intermediate filament proteins 0.0029 0.0366 0.0432
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Plasmodium falciparum metacaspase-like protein 0.0144 0.2576 1
Onchocerca volvulus 0.0134 0.2387 0.4635
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Echinococcus multilocularis lamin 0.0029 0.0366 0.0432
Echinococcus granulosus caspase 8 0.0144 0.2576 0.306
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0121 0.2123 1
Onchocerca volvulus 0.0041 0.0605 0.1171
Trypanosoma brucei metacaspase 5, putative 0.0144 0.2576 1
Onchocerca volvulus 0.0117 0.2063 0.4005
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0605 0.2341
Echinococcus granulosus caspase 2 0.0279 0.5147 0.6116
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0366 0.0366
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0605 0.2341
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0081 0.0094
Brugia malayi Cytochrome P450 family protein 0.0017 0.0147 0.0146
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.021 0.5
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0121 0.2123 0.2521
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.2576 1
Mycobacterium ulcerans putative regulatory protein 0.0117 0.2063 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0144 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0514 0.0514
Echinococcus multilocularis musashi 0.0029 0.0366 0.0432
Loa Loa (eye worm) hypothetical protein 0.0013 0.0071 0.0071
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.109 0.4225
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0514 0.1989
Schistosoma mansoni cpg binding protein 0.0033 0.0454 0.0537
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0028 0.0356 0.0356
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0514 0.1989
Schistosoma mansoni ap endonuclease 0.0021 0.021 0.0247
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Onchocerca volvulus Cell death protein 3 homolog 0.0279 0.5147 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.096 0.372
Brugia malayi intermediate filament protein 0.0029 0.0366 0.0366
Brugia malayi beta-lactamase 0.0037 0.0514 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.2576 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0514 0.1989
Leishmania major protein kinase, putative 0.0041 0.0605 0.2341
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.001 0.0002 0.0002
Brugia malayi beta-lactamase family protein 0.0037 0.0514 0.0514
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0003 0.0001
Brugia malayi ubiquitin specific protease 14 0.001 0.0002 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.042 0.042
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0121 0.2123 0.2123
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.109 0.1293
Leishmania major protein kinase, putative 0.0041 0.0605 0.2341
Schistosoma mansoni hypothetical protein 0.045 0.8415 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0003 0.0001
Brugia malayi Cytochrome P450 family protein 0.0017 0.0147 0.0146
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0041 0.0605 0.2341
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0041 0.0605 0.2341
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0147 0.0561
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.2576 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0605 0.2341
Mycobacterium leprae Possible regulatory protein 0.0041 0.0605 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.021 0.0809
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0514 0.1989
Leishmania major cytochrome p450-like protein 0.0017 0.0147 0.0561
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0147 0.0561
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0121 0.2123 0.2521
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.4277 1
Echinococcus granulosus single minded 2 0.0117 0.2063 0.2449
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.2576 1
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.2576 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0041 0.0605 0.2341
Echinococcus granulosus lamin dm0 0.0029 0.0366 0.0432
Trypanosoma brucei metacaspase MCA2 0.0144 0.2576 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0121 0.2123 0.8241
Brugia malayi Cell death protein 3 precursor 0.0279 0.5147 0.5147
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0514 0.1989
Trypanosoma cruzi metacaspase, putative 0.0144 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.2387 0.2387
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0382 0.7114 0.8454
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0605 0.2341
Mycobacterium tuberculosis Conserved protein 0.0037 0.0514 0.0747
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0081
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0144 0.2576 1
Schistosoma mansoni caspase-7 (C14 family) 0.0382 0.7114 0.8454
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0514 0.1989
Echinococcus granulosus aryl hydrocarbon receptor 0.0041 0.0605 0.0716
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0041 0.0605 0.0716
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.021 0.0809
Brugia malayi PAS domain containing protein 0.0159 0.2851 0.2851
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0605 0.2341
Echinococcus granulosus ubiquitin specific protease 41 0.0121 0.2123 0.2521
Trypanosoma brucei Metacaspase-4 0.0144 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.001 0.0002 0.0002
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0605 0.2341
Echinococcus multilocularis transfer RNA-Lys 0.0117 0.2063 0.2449
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0121 0.2123 0.2521
Onchocerca volvulus 0.0037 0.0514 0.0995
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0514 0.0747
Echinococcus multilocularis caspase 0.0382 0.7114 0.8454
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0605 0.2341
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Trichomonas vaginalis esterase, putative 0.0037 0.0514 0.1989
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.109 0.1293
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0121 0.2123 0.2521
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0041 0.0605 0.0716
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0514 0.1918
Loa Loa (eye worm) hypothetical protein 0.0041 0.0605 0.0605
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0605 0.2341
Plasmodium falciparum metacaspase 1 0.0144 0.2576 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.2576 1
Onchocerca volvulus 0.0037 0.0514 0.0995
Brugia malayi beta-lactamase family protein 0.0037 0.0514 0.0514
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.021 0.0809
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2123 0.8241
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0514 0.0609
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.109 0.1293
Leishmania major hypothetical protein, conserved 0.0037 0.0514 0.1989
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0514 0.0609
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0147 0.0147
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Echinococcus granulosus apoptotic protease activating factor 1 0.0134 0.2387 0.2834
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.021 0.0247
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.2576 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0041 0.0605 0.0716
Loa Loa (eye worm) hypothetical protein 0.0029 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0279 0.5147 0.5147
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0121 0.2123 0.2521
Loa Loa (eye worm) hypothetical protein 0.0013 0.0071 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.109 0.4922
Schistosoma mansoni caspase-7 (C14 family) 0.0279 0.5147 0.6116
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.021 0.0809
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.001 0.0002 0.0002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.2576 1
Schistosoma mansoni cpg binding protein 0.0033 0.0454 0.0537
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0121 0.2123 0.8241
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.2576 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.109 0.4225
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0121 0.2123 0.2123
Plasmodium vivax metacaspase 1, putative 0.0144 0.2576 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0003 0.0003
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.001 0.0002 0.0002
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0514 0.1918
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0514 0.1989
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0514 0.0747
Trypanosoma brucei metacaspase MCA3 0.0144 0.2576 1
Onchocerca volvulus 0.0032 0.042 0.0811
Schistosoma mansoni lamin 0.0029 0.0366 0.0432
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.021 0.0333
Brugia malayi hypothetical protein 0.0134 0.2387 0.2386
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.021 0.0809
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.045 0.8415 1
Schistosoma mansoni hypothetical protein 0.0134 0.2387 0.2834
Loa Loa (eye worm) hypothetical protein 0.0037 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.0037 0.0514 0.0514
Loa Loa (eye worm) hypoxia-induced factor 1 0.0491 0.9211 0.9211
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0514 0.0514
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0144 0.2576 0.306
Loa Loa (eye worm) beta-lactamase 0.0037 0.0514 0.0514
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.021 0.0809
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0514 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.2576 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.021 0.0809
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0605 0.2341
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0121 0.2123 0.8241
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0514 0.0609
Echinococcus multilocularis apoptotic protease activating factor 1 0.0134 0.2387 0.2834
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0121 0.2123 0.8241
Echinococcus multilocularis ubiquitin specific protease 41 0.0121 0.2123 0.2521
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0366 0.0366
Trypanosoma cruzi metacaspase, putative 0.0144 0.2576 1
Echinococcus granulosus caspase 3 0.0237 0.4354 0.5173
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.2576 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0514 0.0609
Schistosoma mansoni lamin 0.0029 0.0366 0.0432
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0111 0.0111
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.021 0.0981
Trypanosoma cruzi metacaspase 5, putative 0.0144 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.2576 0.2576
Loa Loa (eye worm) hypothetical protein 0.0037 0.0514 0.0514
Mycobacterium ulcerans beta-lactamase 0.0037 0.0514 0.1918
Brugia malayi hypoxia-induced factor 1 0.0491 0.9211 0.9211
Schistosoma mansoni caspase-3 (C14 family) 0.0382 0.7114 0.8454
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0111 0.011
Trypanosoma brucei metacaspase 0.0144 0.2576 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0514 0.0514
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.1096 0.1301
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.021 0.021
Trypanosoma cruzi metacaspase, putative 0.0144 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.0533 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0514 0.0747
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0121 0.2123 0.8241
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0514 0.0747
Schistosoma mansoni aryl hydrocarbon receptor 0.0159 0.2851 0.3387
Schistosoma mansoni cpg binding protein 0.0032 0.042 0.0496
Echinococcus multilocularis lamin dm0 0.0029 0.0366 0.0432
Echinococcus multilocularis caspase 8 0.0144 0.2576 0.306
Leishmania major metacaspase, putative 0.0144 0.2576 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.109 0.2162
Echinococcus granulosus dnaJ subfamily B 0.045 0.8415 1
Toxoplasma gondii exonuclease III APE 0.0021 0.021 0.0809
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0041 0.0605 0.2341
Mycobacterium tuberculosis Conserved protein 0.0037 0.0514 0.0747
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Onchocerca volvulus 0.0037 0.0514 0.0995
Loa Loa (eye worm) hypothetical protein 0.0037 0.0514 0.0514
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0514 0.1989
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0605 0.2341
Echinococcus granulosus lamin 0.0029 0.0366 0.0432
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.021 0.021
Trypanosoma cruzi metacaspase 5, putative 0.0144 0.2576 1
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0605 0.2341
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0041 0.0605 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0041 0.0605 0.2341
Trypanosoma cruzi metacaspase, putative 0.0144 0.2576 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.001 0.0002 0.0002
Echinococcus granulosus cpg binding protein 0.0033 0.0454 0.0537
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0144 0.2576 0.2576
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Onchocerca volvulus 0.0029 0.0366 0.0707
Schistosoma mansoni ap endonuclease 0.0021 0.021 0.0247
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.021 0.0981
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0144 0.2576 1
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0041 0.0605 0.0605
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0144 0.2576 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0121 0.2123 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.021 0.0809
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0144 0.2576 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0514 0.0747
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.021 0.5
Mycobacterium tuberculosis Conserved protein 0.0037 0.0514 0.0747
Mycobacterium ulcerans lipase LipD 0.0037 0.0514 0.1918
Schistosoma mansoni single-minded 0.0159 0.2851 0.3387
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.109 0.4922
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0147 0.0561
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.001 0.0002 0.0002
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0382 0.7114 0.8454
Echinococcus multilocularis cpg binding protein 0.0033 0.0454 0.0537
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.001 0.0002 0.0002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.021 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Echinococcus multilocularis caspase 2 0.0279 0.5147 0.6116
Echinococcus granulosus intermediate filament protein 0.0029 0.0366 0.0432
Loa Loa (eye worm) hypothetical protein 0.0037 0.0514 0.0514
Toxoplasma gondii ABC1 family protein 0.0037 0.0514 0.1989
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0081 0.0094
Brugia malayi hypothetical protein 0.001 0.0002 0.0002
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0605 0.2341
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.109 0.4922
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0121 0.2123 0.8241
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0514 0.0747
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0041 0.0605 0.2341
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.001 0.0002 0.0002
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.001 0.0002 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0514 0.1989
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0147 0.0147

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.