Detailed information for compound 649269

Basic information

Technical information
  • TDR Targets ID: 649269
  • Name: 4-methyl-3-morpholin-4-ylsulfonyl-N-(phenylme thyl)benzamide
  • MW: 374.454 | Formula: C19H22N2O4S
  • H donors: 1 H acceptors: 3 LogP: 1.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)S(=O)(=O)N1CCOCC1)C)NCc1ccccc1
  • InChi: 1S/C19H22N2O4S/c1-15-7-8-17(19(22)20-14-16-5-3-2-4-6-16)13-18(15)26(23,24)21-9-11-25-12-10-21/h2-8,13H,9-12,14H2,1H3,(H,20,22)
  • InChiKey: GMZGMBJOOWXBTE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methyl-3-morpholinosulfonyl-N-(phenylmethyl)benzamide
  • N-(benzyl)-4-methyl-3-morpholinosulfonyl-benzamide
  • ZINC00832277
  • Oprea1_137443
  • BAS 00154288
  • N-Benzyl-4-methyl-3-(morpholine-4-sulfonyl)-benzamide
  • Oprea1_525653
  • BIM-0037248.P001
  • CBMicro_037324

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ctsf protein 0.0028 0.0173 0.0646
Leishmania major cathepsin L-like protease 0.0028 0.0173 0.104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0173 0.1679
Echinococcus multilocularis cysteine protease 0.0028 0.0173 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Toxoplasma gondii cathepsin CPL 0.0028 0.0173 0.2555
Schistosoma mansoni hypothetical protein 0.0062 0.0471 0.0468
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0003 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Brugia malayi Cathepsin L-like cysteine proteinase 0.0019 0.0089 0.0321
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0232 0.0228
Schistosoma mansoni hypothetical protein 0.0415 0.3631 0.3629
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Schistosoma mansoni cpg binding protein 0.0031 0.0195 0.0192
Schistosoma mansoni hypothetical protein 0.0172 0.1457 0.1454
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0108 0.0884 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.009 0.0326
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0011 0.0008
Brugia malayi mothers against decapentaplegic homolog 3 0.0009 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0035 0.0231 1
Brugia malayi latrophilin 2 splice variant baaae 0.0062 0.0471 0.1751
Trichomonas vaginalis esterase, putative 0.0035 0.0232 0.2484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0041
Onchocerca volvulus 0.0028 0.0173 0.2416
Echinococcus granulosus tar DNA binding protein 0.006 0.0455 0.0455
Echinococcus granulosus Smad4 0.0021 0.0107 0.0107
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0011 0.0011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0232 0.0855
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.003
Loa Loa (eye worm) RNA binding protein 0.006 0.0455 0.1703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0232 0.2593
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0173 0.1679
Mycobacterium ulcerans beta-lactamase 0.0035 0.0232 1
Schistosoma mansoni ap endonuclease 0.0019 0.009 0.0087
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0011 0.003
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.009 0.009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.009 0.0337
Brugia malayi Cathepsin L-like precursor 0.0028 0.0173 0.0635
Echinococcus granulosus cathepsin l cysteine peptidase 0.0028 0.0173 0.0173
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.005 0.0047
Echinococcus granulosus cathepsin l1 0.0028 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0011 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0232 0.2484
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0175 0.0642
Mycobacterium ulcerans lipase LipD 0.0035 0.0232 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0089 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0232 0.2484
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0148 0.1797
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0334 0.0331
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0232 0.2484
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0148 0.1178
Brugia malayi beta-lactamase 0.0035 0.0232 0.0855
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0173 0.017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.009 0.0726 0.2707
Echinococcus multilocularis cathepsin L 0.0015 0.005 0.005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0011 0.0011
Loa Loa (eye worm) cysteine protease 0.0028 0.0173 0.0646
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0334 0.0334
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.005 0.0175
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0028 0.0173 0.0635
Entamoeba histolytica hypothetical protein 0.0035 0.0231 1
Brugia malayi beta-lactamase family protein 0.0035 0.0232 0.0855
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0232 0.0232
Schistosoma mansoni microtubule-associated protein tau 0.1127 1 1
Echinococcus multilocularis cysteine protease 0.0028 0.0173 0.0173
Echinococcus granulosus TGF beta signal transducer SmadC 0.0021 0.0107 0.0107
Brugia malayi MH1 domain containing protein 0.0012 0.0023 0.0075
Trypanosoma cruzi cysteine peptidase, putative 0.0108 0.0884 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0089 0.0321
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0173 0.0635
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0089 0.0086
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0028 0.0173 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0334 0.0331
Onchocerca volvulus 0.0088 0.0704 1
Trypanosoma cruzi cysteine peptidase, putative 0.0108 0.0884 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0011 0.0008
Brugia malayi MH1 domain containing protein 0.0012 0.0023 0.0075
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0413 1
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0173 0.1924
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0041
Entamoeba histolytica hypothetical protein 0.0035 0.0231 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0195 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0089 0.0534
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0173 0.0173
Schistosoma mansoni ap endonuclease 0.0019 0.009 0.0087
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0173 0.6766
Echinococcus multilocularis mothers against decapentaplegic 2 0.0009 0.0003 0.0003
Plasmodium falciparum cysteine proteinase falcipain 3 0.0028 0.0173 1
Plasmodium vivax vivapain-2 0.0028 0.0173 0.742
Toxoplasma gondii ABC1 family protein 0.0035 0.0232 0.4379
Brugia malayi CXXC zinc finger family protein 0.0029 0.018 0.0662
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0028 0.0173 0.0646
Trypanosoma cruzi major cysteine proteinase, putative 0.0085 0.0678 0.7656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0173 0.1679
Echinococcus granulosus cathepsin l1 0.0019 0.0089 0.0089
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0232 0.0776
Echinococcus granulosus FTZ F1 alpha 0.001 0.0011 0.0011
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0232 0.0776
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0148 0.1646
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.018 0.0673
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0011 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0011 0.0112
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0173 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0334 0.0331
Schistosoma mansoni cpg binding protein 0.0029 0.018 0.0177
Schistosoma mansoni hypothetical protein 0.0029 0.0175 0.0172
Leishmania major hypothetical protein, conserved 0.0035 0.0232 0.1782
Brugia malayi MH2 domain containing protein 0.0021 0.0107 0.0389
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.0866
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0012
Plasmodium vivax vivapain-2 0.0028 0.0173 0.742
Brugia malayi ecdysteroid receptor 0.001 0.0011 0.003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.009 0.0482
Onchocerca volvulus 0.0028 0.0173 0.2416
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0011 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Loa Loa (eye worm) hypothetical protein 0.0062 0.0471 0.1761
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0232 0.0776
Loa Loa (eye worm) hypothetical protein 0.0028 0.0173 0.0646
Plasmodium vivax unspecified product 0.0015 0.005 0.2046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0012
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0173 0.6766
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0232 0.2178
Brugia malayi TAR-binding protein 0.006 0.0455 0.1693
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0334 0.0334
Onchocerca volvulus 0.001 0.0011 0.0112
Onchocerca volvulus 0.0028 0.0173 0.2416
Echinococcus multilocularis Smad4 0.0021 0.0107 0.0107
Loa Loa (eye worm) MH2 domain-containing protein 0.0308 0.2673 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Onchocerca volvulus 0.0028 0.0173 0.2416
Schistosoma mansoni smad1 5 8 and 0.0021 0.0107 0.0104
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0011 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Echinococcus multilocularis tar DNA binding protein 0.006 0.0455 0.0455
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0232 0.0776
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Echinococcus granulosus cathepsin L cysteine protease 0.0015 0.005 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0232 0.2593
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0011 0.003
Trypanosoma cruzi cruzipain precursor, putative 0.0108 0.0884 1
Onchocerca volvulus 0.0035 0.0232 0.3256
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1914 1
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.005 0.053
Echinococcus multilocularis smad 0.0021 0.0107 0.0107
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.005 0.053
Schistosoma mansoni tar DNA-binding protein 0.006 0.0455 0.0452
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.009 0.3807
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0173 0.1679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0173 0.1679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0173 0.1679
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0041
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0232 0.0776
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0015 0.005 0.053
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0012
Mycobacterium tuberculosis Conserved protein 0.0035 0.0232 0.0776
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0098 0.08 0.905
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0232 0.0866
Onchocerca volvulus Cathepsin F homolog 0.0028 0.0173 0.2416
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0175 0.0175
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.005 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0029 0.0175 0.0653
Brugia malayi MH1 domain containing protein 0.0021 0.0107 0.0389
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.009 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0232 0.2484
Brugia malayi MH2 domain containing protein 0.0308 0.2673 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0173 0.0173
Echinococcus granulosus cathepsin L 0.0015 0.005 0.005
Entamoeba histolytica hypothetical protein 0.0035 0.0231 1
Loa Loa (eye worm) transcription factor SMAD2 0.0308 0.2673 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0173 0.1679
Brugia malayi Calcitonin receptor-like protein seb-1 0.009 0.0726 0.2707
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0173 0.2416
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0003 0.0012
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0019 0.0089 0.0321
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0232 0.0776
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0041
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.009 0.3276
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.009 0.055
Brugia malayi cathepsin L-like precursor 0.0019 0.0089 0.0321
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0022 0.0022
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.005 0.0175
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0173 0.017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.009 0.2217
Brugia malayi beta-lactamase family protein 0.0035 0.0232 0.0855
Mycobacterium ulcerans hypothetical protein 0.0035 0.0232 1
Onchocerca volvulus 0.0028 0.0173 0.2416
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0148 0.8006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0173 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0011 0.0041
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0021 0.0107 0.0104
Schistosoma mansoni Smad4 0.0021 0.0107 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0041
Echinococcus granulosus smad 0.0021 0.0107 0.0107
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0022 0.0022
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0173 0.2416
Brugia malayi MH1 domain containing protein 0.0021 0.0107 0.0389
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0232 0.0228
Onchocerca volvulus 0.0028 0.0173 0.2416
Schistosoma mansoni hypothetical protein 0.0035 0.0231 0.0228
Schistosoma mansoni smad1 5 8 and 0.0021 0.0107 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0011 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0011 0.003
Loa Loa (eye worm) hypothetical protein 0.009 0.0726 0.2715
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Leishmania major cathepsin L-like protease 0.0108 0.0884 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0823 0.7278 0.7278
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0232 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Echinococcus multilocularis tumor protein p63 0.0599 0.5282 0.5282
Loa Loa (eye worm) hypothetical protein 0.0088 0.0704 0.2634
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0148 0.6349
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.003
Echinococcus granulosus dnaJ subfamily B 0.0415 0.3631 0.3631
Mycobacterium tuberculosis Conserved protein 0.0035 0.0232 0.0776
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0011 0.0008
Loa Loa (eye worm) MH1 domain-containing protein 0.0021 0.0107 0.04
Brugia malayi Smad1 0.0021 0.0107 0.0389
Echinococcus granulosus cpg binding protein 0.0031 0.0195 0.0195
Brugia malayi hypothetical protein 0.0017 0.0067 0.024
Trypanosoma cruzi cysteine protease, putative 0.0015 0.005 0.053
Onchocerca volvulus 0.0028 0.0173 0.2416
Echinococcus granulosus geminin 0.0172 0.1457 0.1457
Schistosoma mansoni tar DNA-binding protein 0.006 0.0455 0.0452
Echinococcus granulosus tumor protein p63 0.0599 0.5282 0.5282
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0332
Echinococcus multilocularis microtubule associated protein 2 0.1127 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.3631 0.3631
Brugia malayi MH2 domain containing protein 0.0021 0.0107 0.0389
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0011 0.0011
Onchocerca volvulus 0.0019 0.0089 0.1222
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0041
Leishmania major cathepsin L-like protease 0.0028 0.0173 0.104
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.009 0.0987
Echinococcus granulosus mothers against decapentaplegic 6 0.0009 0.0003 0.0003
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0011 0.003
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0232 0.0776
Echinococcus granulosus mothers against decapentaplegic 5 0.0021 0.0107 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Brugia malayi MH2 domain containing protein 0.0009 0.0003 0.0001
Brugia malayi Cathepsin L-like precursor 0.0028 0.0173 0.0635
Loa Loa (eye worm) MH2 domain-containing protein 0.0021 0.0107 0.04
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0173 0.1679
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0011 0.0112
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0231 0.0231
Brugia malayi Cathepsin L-like precursor 0.0028 0.0173 0.0635
Schistosoma mansoni hypothetical protein 0.0011 0.0022 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Entamoeba histolytica cysteine protease, putative 0.0028 0.0173 0.6766
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.0455 0.1703
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.009 0.009
Leishmania major cathepsin L-like protease 0.0108 0.0884 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.009 0.0726 0.2715
Leishmania major cathepsin L-like protease 0.0028 0.0173 0.104
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0175 0.0175
Plasmodium vivax vivapain-1 0.0015 0.005 0.2046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0334 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0781 1
Schistosoma mansoni tar DNA-binding protein 0.006 0.0455 0.0452
Brugia malayi Cathepsin L-like precursor 0.0028 0.0173 0.0635
Leishmania major cathepsin L-like protease 0.0108 0.0884 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0175 0.0653
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.009 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0028 0.0173 0.0173
Schistosoma mansoni cellular tumor antigen P53 0.0088 0.0704 0.0701
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0232 1
Loa Loa (eye worm) TAR-binding protein 0.006 0.0455 0.1703
Brugia malayi RNA binding protein 0.006 0.0455 0.1693
Schistosoma mansoni tar DNA-binding protein 0.006 0.0455 0.0452
Echinococcus multilocularis Zinc finger, DBF type 0.0443 0.3881 0.3881
Leishmania major hypothetical protein, conserved 0.0026 0.0148 0.0731
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.009 0.055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0011 0.0008
Schistosoma mansoni hypothetical protein 0.0029 0.0175 0.0172
Schistosoma mansoni smad1 5 8 and 0.0021 0.0107 0.0104
Mycobacterium tuberculosis Conserved protein 0.0035 0.0232 0.0776
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0089 0.2153
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0175 0.0175
Loa Loa (eye worm) Smad1 0.0021 0.0107 0.04
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0148 0.1646
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0087
Schistosoma mansoni tar DNA-binding protein 0.006 0.0455 0.0452
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0334 0.0334
Schistosoma mansoni hypothetical protein 0.0441 0.3867 0.3865
Leishmania major cathepsin L-like protease 0.0028 0.0173 0.104
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0011 0.003
Loa Loa (eye worm) fibroinase 0.0028 0.0173 0.0646
Schistosoma mansoni hypothetical protein 0.0172 0.1457 0.1454
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0028 0.0173 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0173 0.1679
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0472 0.0469
Brugia malayi Cathepsin L-like precursor 0.0028 0.0173 0.0635
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0012
Brugia malayi steroid hormone receptor 0.001 0.0011 0.003
Schistosoma mansoni coup transcription factor 0.001 0.0011 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0175 0.0175
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0231 0.0228
Onchocerca volvulus 0.0035 0.0232 0.3256
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0232 0.2484
Plasmodium vivax vivapain-3 0.0015 0.005 0.2046
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0011 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0781 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0011 0.003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.009 0.5
Brugia malayi hypothetical protein 0.0035 0.0231 0.0855
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0334 0.1241
Echinococcus granulosus GPCR family 2 0.0029 0.0175 0.0175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.003
Schistosoma mansoni smad 0.0021 0.0107 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.003
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.003
Loa Loa (eye worm) beta-lactamase 0.0035 0.0232 0.0866
Echinococcus granulosus Zinc finger DBF type 0.0098 0.0796 0.0796
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.0031 0.0195 0.0192
Echinococcus multilocularis geminin 0.0172 0.1457 0.1457
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.009 0.0987
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0173 0.1679
Echinococcus multilocularis mothers against decapentaplegic 6 0.0009 0.0003 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0175 0.0642
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0011 0.0008
Echinococcus granulosus mothers against decapentaplegic 2 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.0866
Echinococcus multilocularis mothers against decapentaplegic 5 0.0021 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.0866
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0232 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.005 0.0047
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0011 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0011 0.0008
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0011
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0009 0.0003 0.0012
Leishmania major cathepsin L-like protease 0.0028 0.0173 0.104
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0231 0.0231
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0334 0.1251
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.005 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0011 0.003
Schistosoma mansoni hypothetical protein 0.0029 0.0175 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0173 0.1679
Echinococcus multilocularis GPCR, family 2 0.0029 0.0175 0.0175
Loa Loa (eye worm) nuclear factor I 0.0012 0.0023 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0173 0.1679
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0148 0.8006
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0021 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0029 0.0175 0.0172
Onchocerca volvulus 0.0029 0.018 0.2521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0108 0.0884 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.0866
Leishmania major cysteine peptidase A (CPA) 0.0028 0.0173 0.104
Brugia malayi RNA recognition motif domain containing protein 0.006 0.0455 0.1693
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.0866
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0011
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0173 0.0173
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0232 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0041
Onchocerca volvulus 0.0035 0.0232 0.3256
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0011 0.0008
Echinococcus granulosus cysteine protease 0.0015 0.005 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Brugia malayi hypothetical protein 0.0026 0.0148 0.0543
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0011 0.0041
Mycobacterium leprae Probable lipase LipE 0.0035 0.0232 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.0866

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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