Detailed information for compound 649366

Basic information

Technical information
  • TDR Targets ID: 649366
  • Name: (E)-1-(4-chlorophenyl)-3-(2-hydroxy-5-nitroph enyl)prop-2-en-1-one
  • MW: 303.697 | Formula: C15H10ClNO4
  • H donors: 1 H acceptors: 4 LogP: 3.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)/C=C/c1cc(ccc1O)[N+](=O)[O-]
  • InChi: 1S/C15H10ClNO4/c16-12-4-1-10(2-5-12)14(18)7-3-11-9-13(17(20)21)6-8-15(11)19/h1-9,19H/b7-3+
  • InChiKey: IULUHKWHSAQWFE-XVNBXDOJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-chlorophenyl)-3-(2-hydroxy-5-nitrophenyl)prop-2-en-1-one
  • (E)-1-(4-chlorophenyl)-3-(2-hydroxy-5-nitro-phenyl)prop-2-en-1-one
  • 1-(4-chlorophenyl)-3-(2-hydroxy-5-nitro-phenyl)prop-2-en-1-one
  • 1-(4-Chloro-phenyl)-3-(2-hydroxy-5-nitro-phenyl)-propenone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.038 0.038
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0288 0.072
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0169 0.0423
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0312 0.4 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0306 0.0931
Entamoeba histolytica hypothetical protein 0.0039 0.0303 0.0327
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0245 0.0611
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0393 0.0778
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.1455 0.3358
Loa Loa (eye worm) hypothetical protein 0.0043 0.0349 0.089
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0306 0.0779
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0072 0.0961
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0288 0.3848
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.038 0.098
Schistosoma mansoni intermediate filament proteins 0.0028 0.0149 0.0149
Echinococcus granulosus transcription factor btf3 0.0038 0.0288 0.0288
Echinococcus granulosus GPCR family 2 0.0017 0.0003 0.0003
Brugia malayi beta-NAC-like protein 0.0038 0.0288 0.0742
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0336 0.0336
Brugia malayi Muscleblind-like protein 0.0304 0.3881 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0289 0.311
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.1286 0.3215
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0393 0.1196
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.2185 0.563
Echinococcus multilocularis geminin 0.0185 0.2282 0.2282
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0072 0.0177
Echinococcus granulosus muscleblind protein 0.0304 0.3881 0.3881
Plasmodium falciparum thioredoxin reductase 0.0049 0.0434 0.1086
Echinococcus multilocularis GPCR, family 2 0.0017 0.0003 0.0003
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0434 0.1086
Loa Loa (eye worm) hypothetical protein 0.0035 0.0245 0.0622
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0288 0.0734
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0312 0.4 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.0929 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.003 0.018 0.0547
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0393 0.1196
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0289 0.0289
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0072 0.018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0212 0.0212
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0289 0.088
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0245 0.0611
Brugia malayi Inositol-1 0.0038 0.0289 0.0744
Brugia malayi intermediate filament protein 0.0028 0.0149 0.0383
Loa Loa (eye worm) hypothetical protein 0.0086 0.0929 0.2387
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0072 0.0961
Echinococcus multilocularis lamin dm0 0.0028 0.0149 0.0149
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0288 0.3848
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0288 0.0878
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0306 0.0931
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0245 0.0611
Toxoplasma gondii thioredoxin reductase 0.0049 0.0434 0.4676
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0748 0.1928
Brugia malayi Pre-SET motif family protein 0.0033 0.0212 0.0547
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.0929 0.1984
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0212 0.0212
Leishmania major basic transcription factor 3a, putative 0.0038 0.0288 0.3848
Echinococcus multilocularis chromobox protein 1 0.0076 0.0802 0.0802
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0929 0.2322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.038 0.038
Trypanosoma brucei trypanothione reductase 0.0049 0.0434 0.5806
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.2185 0.5626
Mycobacterium ulcerans lipase LipD 0.0035 0.0245 0.0611
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0289 0.3861
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0245 0.0745
Brugia malayi Thioredoxin reductase 0.0049 0.0434 0.1119
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0143 0.1915
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0434 0.0434
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0306 0.0787
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0748 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0245 0.0745
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0245 0.0245
Schistosoma mansoni alpha glucosidase 0.004 0.0306 0.0306
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.0929 0.0929
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0245 0.0611
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0245 0.063
Schistosoma mansoni inositol monophosphatase 0.0038 0.0289 0.0289
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0748 0.0748
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0306 0.0931
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0288 0.0878
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0245 0.0611
Echinococcus granulosus lamin 0.0028 0.0149 0.0149
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0802 0.2446
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2804 0.701
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.0929 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0212 0.0538
Echinococcus multilocularis microtubule associated protein 2 0.0755 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0303 0.0303
Echinococcus multilocularis lamin 0.0028 0.0149 0.0149
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0245 0.0611
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0003 0.0003
Brugia malayi Pre-SET motif family protein 0.0228 0.2855 0.7357
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0349 0.1062
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0306 0.0931
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0028 0.0149 0.0375
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0143 0.1915
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0289 0.088
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0802 0.2446
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0245 0.0622
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0245 0.0197
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0245 0.0745
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0748 1
Schistosoma mansoni chromobox protein 0.0076 0.0802 0.0802
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0303 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.038 0.038
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0306 0.329
Mycobacterium tuberculosis Conserved protein 0.0035 0.0245 0.0611
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0245 0.0245
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0143 0.0358
Onchocerca volvulus 0.0045 0.0381 0.0742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.038 0.038
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0245 0.0745
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.038 0.038
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.053 0.053
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.1286 0.3215
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0072 0.0177
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0275 0.0708
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0072 0.0177
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0748 0.0748
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0289 0.0021
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0802 0.2061
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0434 0.1111
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.0929 0.2322
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.053 0.053
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0289 0.088
Loa Loa (eye worm) hypothetical protein 0.0055 0.0509 0.1303
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0212 0.0212
Echinococcus multilocularis transcription factor btf3 0.0038 0.0288 0.0288
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0245 0.0245
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0003 0.0009
Brugia malayi Cytochrome P450 family protein 0.0022 0.0072 0.0185
Entamoeba histolytica hypothetical protein 0.0039 0.0303 0.0327
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.038 0.0972
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0381 0.0381
Echinococcus granulosus lamin dm0 0.0028 0.0149 0.0149
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0245 0.0745
Brugia malayi hypothetical protein 0.0028 0.0143 0.0369
Brugia malayi Cytochrome P450 family protein 0.0022 0.0072 0.0185
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0289 0.0722
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0289 0.3861
Brugia malayi beta-lactamase 0.0035 0.0245 0.063
Brugia malayi Probable ClpP-like protease 0.0086 0.0929 0.2394
Schistosoma mansoni transcription factor btf3 0.0038 0.0288 0.0288
Schistosoma mansoni hypothetical protein 0.0185 0.2282 0.2282
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0149 0.0375
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0434 0.1086
Loa Loa (eye worm) hypothetical protein 0.0035 0.0245 0.0622
Onchocerca volvulus 0.0035 0.0245 0.0306
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0289 0.311
Trichomonas vaginalis set domain proteins, putative 0.0259 0.3281 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0143 0.0361
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0306 0.0306
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.0929 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0245 0.0622
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0306 0.0931
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0312 0.4 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0245 0.0611
Echinococcus multilocularis muscleblind protein 0.0304 0.3881 0.3881
Mycobacterium ulcerans beta-lactamase 0.0035 0.0245 0.0611
Brugia malayi glutathione reductase 0.0049 0.0434 0.1119
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.038 0.038
Schistosoma mansoni hypothetical protein 0.0039 0.0303 0.0303
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0306 0.4084
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0245 0.0611
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.0929 0.0929
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.053 0.1324
Echinococcus granulosus geminin 0.0185 0.2282 0.2282
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0748 0.0748
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.053 0.1324
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0245 0.0611
Plasmodium vivax glutathione reductase, putative 0.0049 0.0434 0.1086
Toxoplasma gondii ABC1 family protein 0.0035 0.0245 0.2633
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0349 0.1062
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0003 0.0003
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0748 0.1921
Brugia malayi Cytochrome P450 family protein 0.0051 0.046 0.1185
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0509 0.1311
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0234 0.0586
Trypanosoma brucei glucosidase, putative 0.004 0.0306 0.4084
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0245 0.3269
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0288 0.3848
Toxoplasma gondii hypothetical protein 0.0029 0.0169 0.182
Brugia malayi beta-lactamase family protein 0.0035 0.0245 0.063
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0003
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0748 1
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0306 0.4084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0509 0.1303
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.1455 0.3638
Echinococcus granulosus chromobox protein 1 0.0076 0.0802 0.0802
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0336 0.0336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0212 0.0212
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0288 0.31
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0306 0.0931
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0306 0.4084
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0143 0.1543
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0306 0.0931
Loa Loa (eye worm) hypothetical protein 0.0304 0.3881 1
Schistosoma mansoni hypothetical protein 0.0037 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.0245 0.0622
Loa Loa (eye worm) hypothetical protein 0.0304 0.3881 1
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0312 0.4 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0245 0.0622
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0245 0.0611
Onchocerca volvulus 0.0035 0.0245 0.0306
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.0929 0.2322
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0288 0.0878
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0245 0.0611
Schistosoma mansoni alpha-glucosidase 0.0153 0.1849 0.1849
Leishmania major trypanothione reductase 0.0049 0.0434 0.5806
Leishmania major hypothetical protein, conserved 0.0028 0.0143 0.1915
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0306 0.0383
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.0929 1
Echinococcus multilocularis chromobox protein 1 0.0076 0.0802 0.0802
Mycobacterium tuberculosis Conserved protein 0.0035 0.0245 0.0611
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0003 0.0003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0169 0.0423
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.1286 0.3215
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.0357
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0434 0.0434
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0748 1
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0003
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0306 0.0306
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.046 0.1177
Brugia malayi Heterochromatin protein 1 0.0076 0.0802 0.2068
Entamoeba histolytica hypothetical protein 0.0039 0.0303 0.0327
Onchocerca volvulus 0.0259 0.3281 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0245 0.3269
Onchocerca volvulus 0.0103 0.1167 0.3249
Schistosoma mansoni lamin 0.0028 0.0149 0.0149
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0288 0.072
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0149 0.0383
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.0929 0.2322
Echinococcus granulosus chromobox protein 1 0.0076 0.0802 0.0802
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0 0.5
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.1286 0.3215
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0306 0.0931
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.1286 0.3215
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0245 0.0622
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.2855 0.7355
Schistosoma mansoni lamin 0.0028 0.0149 0.0149
Echinococcus granulosus neuropeptide receptor A26 0.0506 0.6625 0.6625
Mycobacterium leprae Probable lipase LipE 0.0035 0.0245 0.0197
Onchocerca volvulus 0.0034 0.0224 0.0239
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0306 0.0383
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0349 0.0638
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.0929 1
Schistosoma mansoni chromobox protein 0.0076 0.0802 0.0802
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.0929 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0245 0.0611
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0212 0.0212
Loa Loa (eye worm) glutathione reductase 0.0049 0.0434 0.1111
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0143 0.1915
Schistosoma mansoni alpha-glucosidase 0.0153 0.1849 0.1849
Trichomonas vaginalis conserved hypothetical protein 0.003 0.018 0.0547
Onchocerca volvulus 0.0035 0.0245 0.0306
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.2185 0.2185
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0289 0.3861
Plasmodium falciparum glutathione reductase 0.0049 0.0434 0.1086
Schistosoma mansoni inositol monophosphatase 0.0038 0.0289 0.0289
Echinococcus multilocularis neuropeptide receptor A26 0.0506 0.6625 0.6625
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.1286 0.2916
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.1455 0.3638
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.053 0.0941
Brugia malayi beta-lactamase family protein 0.0035 0.0245 0.063
Entamoeba histolytica hypothetical protein 0.0039 0.0303 0.0327
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.2185 0.2185
Schistosoma mansoni hypothetical protein 0.0185 0.2282 0.2282
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.1455 0.3638
Echinococcus multilocularis neuropeptide s receptor 0.0506 0.6625 0.6625
Mycobacterium tuberculosis Probable reductase 0.0112 0.1286 0.3215
Schistosoma mansoni microtubule-associated protein tau 0.0755 1 1
Treponema pallidum hypothetical protein 0.0312 0.4 1
Plasmodium vivax SET domain protein, putative 0.0033 0.0212 0.053
Echinococcus multilocularis musashi 0.0028 0.0149 0.0149
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0929 0.2322
Echinococcus granulosus neuropeptide s receptor 0.0506 0.6625 0.6625
Leishmania major hypothetical protein, conserved 0.0035 0.0245 0.3269
Echinococcus granulosus intermediate filament protein 0.0028 0.0149 0.0149
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0306 0.0931
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0072 0.0961
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0003 0.0009
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0312 0.4 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0212 0.0212
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0434 0.5806
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0568
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0289 0.3861
Echinococcus multilocularis muscleblind protein 1 0.0304 0.3881 0.3881
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0234 0.0171
Trichomonas vaginalis esterase, putative 0.0035 0.0245 0.0745
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0212 0.2284
Loa Loa (eye worm) hypothetical protein 0.0035 0.0245 0.0622
Loa Loa (eye worm) hypothetical protein 0.0037 0.0275 0.07
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0143 0.0358
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0149 0.0375
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0143 0.0358
Brugia malayi chromobox protein homolog 3 0.0043 0.0349 0.0898
Loa Loa (eye worm) inositol-1 0.0038 0.0289 0.0736
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.038 0.038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0245 0.0245
Brugia malayi hypothetical protein 0.0018 0.0011 0.0028
Leishmania major cytochrome p450-like protein 0.0022 0.0072 0.0961
Brugia malayi hypothetical protein 0.0039 0.0303 0.0781
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0509 0.1311
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0196 0.0196
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0748 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0169 0.0423
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.2185 0.2185
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0289 0.0289
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0245 0.3269

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Escherichia coli WF+ ChEMBL. 18584918

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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