Detailed information for compound 650762

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 304.364 | Formula: C15H16N2O3S
  • H donors: 1 H acceptors: 1 LogP: 3.15 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1OC)C=NNC(=O)c1cccs1
  • InChi: 1S/C15H16N2O3S/c1-3-20-12-7-6-11(9-13(12)19-2)10-16-17-15(18)14-5-4-8-21-14/h4-10H,3H2,1-2H3,(H,17,18)/b16-10+
  • InChiKey: IUSKYNFEGASGOY-MHWRWJLKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0522 0.0508
Schistosoma mansoni glucose transport protein 0.0114 0.1865 0.1854
Echinococcus granulosus General substrate transporter 0.0098 0.1562 0.155
Schistosoma mansoni protein kinase 0.0035 0.0371 0.0357
Echinococcus granulosus intermediate filament protein 0.0029 0.025 0.0236
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0371 0.0404
Schistosoma mansoni ap endonuclease 0.0042 0.0512 0.0498
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.2067 0.2056
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0431 0.0883
Trypanosoma brucei glucose transporter, putative 0.0035 0.0379 0.7365
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Trypanosoma brucei glucose transporter, putative 0.0035 0.0379 0.7365
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0351 0.0338
Schistosoma mansoni rab6-interacting 0.0021 0.0105 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.2669
Brugia malayi Sugar transporter family protein 0.0016 0.0014 0.003
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0358 0.7651
Loa Loa (eye worm) hypothetical protein 0.0166 0.2847 0.6019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0371 0.0784
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0192 0.0377
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0294 0.0483
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0223
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0512 0.1082
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0358 0.0344
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0512 0.0498
Brugia malayi Pre-SET motif family protein 0.0032 0.0308 0.0651
Echinococcus granulosus lamin dm0 0.0029 0.025 0.0236
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0379 0.7339
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0512 0.0498
Brugia malayi major facilitator superfamily protein 0.0016 0.0014 0.003
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0431 0.097
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0358 0.0344
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.1865 0.1854
Schistosoma mansoni protein kinase 0.0035 0.0371 0.0357
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0351 0.0382
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1865 0.1854
Brugia malayi beta-lactamase family protein 0.0038 0.0431 0.091
Schistosoma mansoni loxhd1 0.0021 0.0105 0.0091
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0371 0.0784
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0351 0.0382
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0143 0.2669
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0379 0.0774
Onchocerca volvulus 0.0032 0.0308 0.0663
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0351 0.0338
Schistosoma mansoni lipoxygenase 0.0125 0.2067 0.2056
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0213 0.0199
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.3432 0.3423
Loa Loa (eye worm) hypothetical protein 0.0038 0.0431 0.091
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1865 0.3925
Loa Loa (eye worm) hypothetical protein 0.0031 0.0294 0.0621
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0704 0.069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1865 0.1854
Brugia malayi Doublecortin family protein 0.0021 0.0105 0.0223
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0379 0.0774
Brugia malayi hypothetical protein 0.0016 0.0014 0.003
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0431 0.8384
Echinococcus multilocularis lamin dm0 0.0029 0.025 0.0236
Onchocerca volvulus 0.0038 0.0431 0.094
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0351 0.0583
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0512 1
Onchocerca volvulus 0.0038 0.0431 0.094
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0371 0.0617
Echinococcus granulosus tar DNA binding protein 0.0067 0.0977 0.0964
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0914 0.1932
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0431 0.0417
Giardia lamblia DINP protein human, muc B family 0.0023 0.0143 0.2596
Loa Loa (eye worm) hypothetical protein 0.0032 0.0308 0.0651
Schistosoma mansoni polycystin 1-related 0.0021 0.0105 0.0091
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0704 0.069
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0192 0.3576
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.0465 0.051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0704 0.069
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0143 0.0274
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0512 0.0563
Brugia malayi Bromodomain containing protein 0.0031 0.0294 0.0621
Onchocerca volvulus Alhambra homolog 0.0031 0.0294 0.0631
Echinococcus granulosus dna polymerase kappa 0.0023 0.0143 0.0129
Trypanosoma cruzi hexose transporter 0.0035 0.0379 0.7339
Schistosoma mansoni hypothetical protein 0.0053 0.0704 0.069
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0371 0.0357
Trypanosoma brucei unspecified product 0.0023 0.0143 0.2669
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0143 0.0129
Schistosoma mansoni lamin 0.0029 0.025 0.0236
Brugia malayi jmjC domain containing protein 0.0027 0.0213 0.045
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0512 0.1159
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0512 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0143 0.0129
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0371 0.0357
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0192 0.2331
Trypanosoma brucei glucose transporter 1E 0.0035 0.0379 0.7365
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0704 0.069
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0143 0.2596
Echinococcus granulosus dna polymerase eta 0.0023 0.0143 0.0129
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0358 0.0756
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0351 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.2669
Loa Loa (eye worm) jmjC domain-containing protein 0.01 0.1591 0.3364
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0286 0.0272
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.025 0.0529
Leishmania major hypothetical protein, conserved 0.0038 0.0431 0.4575
Leishmania major glucose transporter, lmgt3 0.0035 0.0379 0.4012
Schistosoma mansoni glucose transport protein 0.0114 0.1865 0.1854
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0431 0.097
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0371 0.0404
Mycobacterium tuberculosis Conserved protein 0.0038 0.0431 0.097
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0977 0.2065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Trichomonas vaginalis set domain proteins, putative 0.0251 0.4443 0.9391
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0977 0.0964
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.2669
Plasmodium vivax SET domain protein, putative 0.0032 0.0308 0.0332
Schistosoma mansoni hypothetical protein 0.0053 0.0704 0.069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0308 0.0294
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0303
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0105 0.0091
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0431 0.091
Mycobacterium ulcerans lipase LipD 0.0038 0.0431 0.0883
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0431 0.0883
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0379 0.4012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Trypanosoma brucei glucose transporter, putative 0.0035 0.0379 0.7365
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Schistosoma mansoni lamin 0.0029 0.025 0.0236
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0351 0.0338
Onchocerca volvulus 0.0021 0.0105 0.0205
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0431 0.8368
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0465 0.4949
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0077 0.1252
Brugia malayi Calcitonin receptor-like protein seb-1 0.0166 0.2847 0.6019
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0213 0.0199
Leishmania major protein kinase, putative 0.0035 0.0371 0.3919
Loa Loa (eye worm) hypothetical protein 0.0034 0.0358 0.0756
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0143 0.0303
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0371 0.0617
Leishmania major hypothetical protein, conserved 0.0027 0.0213 0.218
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0114 0.1865 0.1854
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0014 0.0098
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0704 0.1487
Trichomonas vaginalis glutaminase, putative 0.0266 0.473 1
Entamoeba histolytica protein kinase, putative 0.0035 0.0371 0.6176
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0379 0.0774
Echinococcus multilocularis lamin 0.0029 0.025 0.0236
Toxoplasma gondii protein kinase, putative 0.0323 0.5796 1
Schistosoma mansoni hypothetical protein 0.0545 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0105 0.0091
Plasmodium vivax hexose transporter 0.0114 0.1865 0.2094
Leishmania major DNA polymerase eta, putative 0.0023 0.0143 0.1419
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1865 0.1854
Echinococcus multilocularis musashi 0.0029 0.025 0.0236
Loa Loa (eye worm) sugar transporter 0.0114 0.1865 0.3943
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0105 0.0223
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0358 0.6901
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0213 0.0199
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0213 0.3988
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0294 0.0316
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.2067 0.2056
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.1591 0.1579
Plasmodium falciparum protein kinase 7 0.0323 0.5796 0.6542
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.3868 0.8179
Schistosoma mansoni hypothetical protein 0.0031 0.0294 0.028
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0014 0.003
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0358 0.5814
Loa Loa (eye worm) hypothetical protein 0.0038 0.0431 0.091
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0163 0.2793 0.2783
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0977 0.0964
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.033 0.0316
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0371 0.0784
Mycobacterium ulcerans hypothetical protein 0.0038 0.0431 0.0883
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0143 0.2669
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0431 0.0471
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0371 0.0357
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0371 0.0404
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0512 0.0563
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.1591 0.1579
Schistosoma mansoni lipoxygenase 0.0087 0.1358 0.1346
Mycobacterium ulcerans glutaminase 0.0266 0.473 1
Echinococcus multilocularis RUN 0.0021 0.0105 0.0091
Onchocerca volvulus 0.0029 0.025 0.0533
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0143 0.1419
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0192 0.0308
Schistosoma mansoni hypothetical protein 0.0114 0.1855 0.1843
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0727 0.0714
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0143 0.2596
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.2669
Leishmania major glucose transporter, lmgt1 0.0035 0.0379 0.4012
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0143 0.0303
Onchocerca volvulus 0.0038 0.0431 0.094
Brugia malayi glutaminase DH11.1 0.0266 0.473 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0143 0.0301
Plasmodium falciparum proline--tRNA ligase 0.004 0.0465 0.051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.2669
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0512 0.1055
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0431 0.097
Echinococcus multilocularis lysine specific demethylase 5A 0.01 0.1591 0.1579
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0371 0.0404
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0704 0.1487
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0512 0.1055
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0358 0.0756
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0192 0.0178
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0192 0.0377
Loa Loa (eye worm) hypothetical protein 0.0028 0.0236 0.05
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0431 0.097
Schistosoma mansoni DNA polymerase eta 0.0023 0.0143 0.0129
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0371 0.0404
Onchocerca volvulus 0.0029 0.025 0.0533
Brugia malayi Pre-SET motif family protein 0.022 0.3868 0.8179
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0294 0.028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0308 0.0294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.3432 0.3423
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0351 0.6778
Giardia lamblia PHD finger protein 15 0.0031 0.0294 0.5618
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1865 0.1854
Loa Loa (eye worm) beta-lactamase 0.0038 0.0431 0.091
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0512 0.5
Echinococcus multilocularis tumor protein p63 0.0368 0.6651 0.6646
Toxoplasma gondii facilitative glucose transporter GT1 0.0114 0.1865 0.3201
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0213 0.0199
Echinococcus granulosus phd:f box containing protein 0.0027 0.0213 0.0199
Schistosoma mansoni hypothetical protein 0.0053 0.0704 0.069
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0358 0.0728
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.2669
Mycobacterium tuberculosis Conserved protein 0.0038 0.0431 0.097
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0371 0.0404
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0351 0.681
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0522 0.0508
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0105 0.0103
Onchocerca volvulus 0.0054 0.0727 0.161
Loa Loa (eye worm) RNA binding protein 0.0067 0.0977 0.2065
Schistosoma mansoni glucose transport protein 0.0114 0.1865 0.1854
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0185 0.3192 0.5495
Schistosoma mansoni hypothetical protein 0.0021 0.0105 0.0091
Plasmodium falciparum phd finger protein, putative 0.0031 0.0294 0.0316
Schistosoma mansoni hypothetical protein 0.0053 0.0704 0.069
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0924 0.0911
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0192 0.0377
Loa Loa (eye worm) hypothetical protein 0.0054 0.0727 0.1537
Loa Loa (eye worm) intermediate filament protein 0.0029 0.025 0.0529
Brugia malayi jmjC domain containing protein 0.01 0.1591 0.3364
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0213 0.0199
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0197 0.3432 0.7256
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0143 0.0129
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0977 0.2065
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0192 0.0178
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0143 0.0274
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0924 0.193
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0213 0.045
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0351 0.0338
Brugia malayi jmjC domain containing protein 0.0027 0.0213 0.045
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0185 0.3192 0.3595
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0371 0.0357
Brugia malayi hypothetical protein 0.0016 0.0014 0.003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0105 0.0091
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0465 0.9053
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0213 0.0343
Brugia malayi Cam kinase protein 1 0.0035 0.0371 0.0784
Loa Loa (eye worm) hypothetical protein 0.0038 0.0431 0.091
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0143 0.0129
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.3432 0.3423
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0379 0.0774
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0371 0.0357
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0431 0.8368
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0014 0.003
Schistosoma mansoni hypothetical protein 0.0545 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.033 0.0316
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0371 0.0404
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0143 0.0301
Schistosoma mansoni glutaminase 0.0266 0.473 0.4722
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0371 0.0404
Entamoeba histolytica protein kinase, putative 0.0035 0.0371 0.6176
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0192 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.3432 0.3423
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.1865 0.1854
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0213 0.0199
Leishmania major glucose transporter, lmgt2 0.0035 0.0379 0.4012
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0105 0.0091
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0351 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0379 0.0774
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0351 0.0743
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0379 0.7339
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0192 0.1955
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0213 0.045
Loa Loa (eye worm) glutaminase 2 0.0266 0.473 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0512 1
Brugia malayi hypothetical protein 0.0021 0.0105 0.0223
Echinococcus granulosus GPCR family 2 0.0053 0.0704 0.069
Trypanosoma brucei sugar transporter, putative 0.0016 0.0014 0.0098
Brugia malayi major facilitator superfamily protein 0.0016 0.0014 0.003
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0192 0.0201
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0294 0.028
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0431 0.0417
Loa Loa (eye worm) hypothetical protein 0.0038 0.0431 0.091
Trypanosoma brucei glucose transporter, putative 0.0035 0.0379 0.7365
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.012 0.0246
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0371 0.7197
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.2669
Brugia malayi jmjC domain containing protein 0.0027 0.0213 0.045
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0371 0.0357
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0213 0.0343
Loa Loa (eye worm) hypothetical protein 0.0028 0.024 0.0508
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Schistosoma mansoni rab6-interacting 0.0021 0.0105 0.0091
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0465 0.4949
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0223
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0213 0.4047
Echinococcus granulosus tumor protein p63 0.0368 0.6651 0.6646
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0371 0.0404
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0924 0.1574
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0358 0.0344
Brugia malayi jmjC domain containing protein 0.0027 0.0213 0.045
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0977 0.0964
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0192 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.2669
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0371 0.0617
Schistosoma mansoni hypothetical protein 0.0114 0.1865 0.1854
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0431 0.097
Echinococcus granulosus peregrin 0.0031 0.0294 0.028
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0977 0.0964
Echinococcus multilocularis peregrin 0.0031 0.0294 0.028
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0379 0.7365
Mycobacterium leprae Probable lipase LipE 0.0038 0.0431 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0294 0.028
Onchocerca volvulus 0.0251 0.4443 1
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0294 0.0621
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0924 0.0911
Trypanosoma brucei glucose transporter, putative 0.0035 0.0379 0.7365
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0431 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0308 0.0294
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0143 0.2669
Loa Loa (eye worm) hypothetical protein 0.0053 0.0704 0.1487
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0924 0.193
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0924 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.3432 0.3423
Trypanosoma brucei glucose transporter 2A 0.0035 0.0379 0.7365
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0351 0.0786
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0213 0.0199
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0431 0.0883
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0924 0.0911
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0431 0.0417
Echinococcus granulosus RUN 0.0021 0.0105 0.0091
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0431 0.097
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0977 0.2065
Trypanosoma brucei glucose transporter, putative 0.0035 0.0379 0.7365
Brugia malayi isocitrate dehydrogenase 0.0034 0.0351 0.0743
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0197 0.3432 0.7256
Leishmania major DNA polymerase kappa, putative 0.0023 0.0143 0.1419
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0512 0.5467
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0143 0.2596
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0133 0.0252
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0192 0.3639
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0431 0.0883
Mycobacterium tuberculosis Conserved protein 0.0038 0.0431 0.097
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.1865 0.1854
Trypanosoma brucei glucose transporter, putative 0.0035 0.0379 0.7365
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0351 0.0338
Brugia malayi Sugar transporter family protein 0.0114 0.1865 0.3943
Loa Loa (eye worm) hypothetical protein 0.0038 0.0431 0.091
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0308 0.0294
Loa Loa (eye worm) hypothetical protein 0.0114 0.1855 0.3922
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0465 0.9062
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0143 0.0274
Onchocerca volvulus 0.0021 0.0105 0.0205
Brugia malayi hypothetical protein 0.0021 0.0105 0.0223
Loa Loa (eye worm) hypothetical protein 0.0027 0.0213 0.045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0213 0.045
Loa Loa (eye worm) hypothetical protein 0.0029 0.025 0.0529
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0704 0.1487
Trypanosoma brucei glucose transporter, putative 0.0035 0.0379 0.7365
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0379 0.7339
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0213 0.0199
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0924 0.212
Echinococcus multilocularis GPCR, family 2 0.0053 0.0704 0.069
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0143 0.2669
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0308 0.0294
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0143 0.0274
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0371 0.0784
Loa Loa (eye worm) sugar transporter 0.0016 0.0014 0.003
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0379 0.7365
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0431 0.0883
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0143 0.2596
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.2669
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0512 1
Echinococcus granulosus lysine specific demethylase 5A 0.01 0.1591 0.1579
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0512 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0014 0.003
Mycobacterium ulcerans beta-lactamase 0.0038 0.0431 0.0883
Brugia malayi PHD-finger family protein 0.0031 0.0294 0.0621
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0379 0.0774
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0512 0.1082
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0143 0.0129
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0143 0.0303
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.0465 0.0779
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0213 0.0199
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0192 0.0201
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0213 0.0199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.3432 0.3423
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0371 0.0756
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0308 0.0294
Entamoeba histolytica hypothetical protein 0.0025 0.0192 0.1323
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0371 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.2669
Echinococcus multilocularis General substrate transporter 0.0098 0.1562 0.155
Plasmodium vivax CDK-related protein kinase 6, putative 0.0485 0.8852 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0185 0.3192 0.3595
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0308 0.0507
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0924 0.0911
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0351 0.681
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0431 0.0883
Brugia malayi intermediate filament protein 0.0029 0.025 0.0529
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0431 0.097
Brugia malayi beta-lactamase 0.0038 0.0431 0.091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.3432 0.3423
Loa Loa (eye worm) glutaminase 0.0266 0.473 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0431 0.091
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0105 0.0091
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0105 0.0091
Brugia malayi jmjC domain containing protein 0.0163 0.2793 0.5906
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0465 0.9053
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0379 0.7365
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0014 0.003
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.012 0.0246
Toxoplasma gondii ABC1 family protein 0.0038 0.0431 0.072
Echinococcus multilocularis geminin 0.0545 1 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0213 0.0224
Brugia malayi RNA binding protein 0.0067 0.0977 0.2065
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0213 0.045
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0294 0.0483
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0213 0.3988
Loa Loa (eye worm) hypothetical protein 0.0025 0.0192 0.0406
Loa Loa (eye worm) hypothetical protein 0.0034 0.0358 0.0756
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0431 0.091
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0977 0.0964
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0213 0.0199
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0512 0.1055
Schistosoma mansoni protein kinase 0.0035 0.0371 0.0357
Loa Loa (eye worm) hypothetical protein 0.007 0.1023 0.2163
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0192 0.3576
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0431 0.0883
Schistosoma mansoni intermediate filament proteins 0.0029 0.025 0.0236
Plasmodium falciparum protein kinase 6 0.0485 0.8852 1
Brugia malayi TAR-binding protein 0.0067 0.0977 0.2065
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.1855 0.3922
Schistosoma mansoni jumonji domain containing protein 0.0143 0.2401 0.2391
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0379 0.0774
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0351 0.6778
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0213 0.0199
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.4306 1
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0213 0.0199
Brugia malayi beta-lactamase family protein 0.0038 0.0431 0.091
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0351 0.3706
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0014 0.003
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0105 0.0103
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.025 0.0529
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0351 0.0743
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0371 0.0357
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0977 0.0964
Brugia malayi hypothetical protein 0.0016 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.003
Plasmodium vivax JmjC domain containing protein 0.0027 0.0213 0.0224
Echinococcus multilocularis dna polymerase eta 0.0023 0.0143 0.0129
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0512 1
Toxoplasma gondii exonuclease III APE 0.0042 0.0512 0.086
Echinococcus granulosus lamin 0.0029 0.025 0.0236
Brugia malayi Sugar transporter family protein 0.0016 0.0014 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0166 0.2847 0.6019
Plasmodium falciparum hexose transporter 0.0114 0.1865 0.2094
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0308 0.0294
Schistosoma mansoni ap endonuclease 0.0042 0.0512 0.0498
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0163 0.2793 0.2783
Trichomonas vaginalis esterase, putative 0.0038 0.0431 0.0883
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0371 0.0357
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0192 0.0178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0143 0.2596
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0431 0.0417
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0213 0.0199
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0924 0.193
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0192 0.0406
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0351 0.0583
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0166 0.2847 0.6019
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0358 0.0344

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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