Detailed information for compound 656141

Basic information

Technical information
  • TDR Targets ID: 656141
  • Name: 2-chloro-N-(2-hydroxyphenyl)-5-morpholin-4-yl sulfonylbenzamide
  • MW: 396.845 | Formula: C17H17ClN2O5S
  • H donors: 2 H acceptors: 4 LogP: 1.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(ccc1Cl)S(=O)(=O)N1CCOCC1)Nc1ccccc1O
  • InChi: 1S/C17H17ClN2O5S/c18-14-6-5-12(26(23,24)20-7-9-25-10-8-20)11-13(14)17(22)19-15-3-1-2-4-16(15)21/h1-6,11,21H,7-10H2,(H,19,22)
  • InChiKey: LTSXMFGJMKMIFI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-chloro-N-(2-hydroxyphenyl)-5-morpholinosulfonyl-benzamide
  • 2-chloro-N-(2-hydroxyphenyl)-5-morpholinosulfonylbenzamide
  • 2-chloro-N-(2-hydroxyphenyl)-5-morpholin-4-ylsulfonyl-benzamide
  • 2-Chloro-N-(2-hydroxy-phenyl)-5-(morpholine-4-sulfonyl)-benzamide
  • MLS000071696
  • SMR000009588
  • EU-0034684
  • Oprea1_509730
  • ZINC00837317
  • BAS 00822779
  • Oprea1_159621

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens CREB binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) CBP-B Get druggable targets OG5_129174 All targets in OG5_129174
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129174 All targets in OG5_129174
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) Get druggable targets OG5_129174 All targets in OG5_129174
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum CREB-binding protein, putative Get druggable targets OG5_129174 All targets in OG5_129174
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum IPR011071,Polysaccharide lyase family 8-like, C-terminal,domain-containing Get druggable targets OG5_129174 All targets in OG5_129174
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Protein cbp-1, putative Get druggable targets OG5_129174 All targets in OG5_129174
Echinococcus granulosus CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04498 E1A/CREB-binding protein, putative Get druggable targets OG5_129174 All targets in OG5_129174
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi TAZ zinc finger family protein Get druggable targets OG5_129174 All targets in OG5_129174
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni CREB-binding protein 2 Get druggable targets OG5_129174 All targets in OG5_129174
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis CREB binding protein Get druggable targets OG5_129174 All targets in OG5_129174
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis CREB binding protein 0.0084 0.1853 0.1853
Schistosoma mansoni cpg binding protein 0.0031 0.0596 0.0596
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0912 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0362 0.4094
Echinococcus multilocularis cpg binding protein 0.0031 0.0596 0.0596
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0456 0.0521
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0912 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0884 0.9691
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0884 0.0851
Brugia malayi Importin beta-1 subunit 0.0035 0.0676 0.2438
Plasmodium vivax importin-beta 2, putative 0.0035 0.0676 0.7653
Brugia malayi RNA, U transporter 1 0.0099 0.2214 0.7981
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0456 0.6744
Echinococcus multilocularis CREB binding protein 0.002 0.0323 0.0323
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0063 0.0063
Loa Loa (eye worm) beta-lactamase 0.0043 0.0884 0.101
Brugia malayi beta-lactamase 0.0043 0.0884 0.3185
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0362 0.5
Brugia malayi TAZ zinc finger family protein 0.0122 0.2774 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0519 0.5687
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0042
Entamoeba histolytica Ran family GTPase 0.0026 0.0456 0.5002
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0043 0.0884 0.101
Mycobacterium tuberculosis Conserved protein 0.0043 0.0884 0.0851
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0063 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0912 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0884 0.9487
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0019 0.0019
Schistosoma mansoni ran 0.0026 0.0456 0.0456
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0456 0.3664
Loa Loa (eye worm) hypothetical protein 0.0043 0.0884 0.101
Echinococcus granulosus CREB binding protein 0.002 0.0323 0.0323
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0456 0.1644
Mycobacterium leprae Probable lipase LipE 0.0043 0.0884 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0042
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0676 0.7416
Loa Loa (eye worm) hypothetical protein 0.0043 0.0884 0.101
Loa Loa (eye worm) CBP-B 0.0085 0.1878 0.2148
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0362 0.3968
Loa Loa (eye worm) hypothetical protein 0.0043 0.0884 0.101
Echinococcus granulosus CREB binding protein 0.002 0.0323 0.0323
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1245 1
Echinococcus granulosus cpg binding protein 0.0031 0.0596 0.0596
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0555 0.0635
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.6496 1
Leishmania major hypothetical protein, conserved 0.0043 0.0884 0.9691
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0884 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0884 0.0851
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0912 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.006 0.0217
Mycobacterium tuberculosis Conserved protein 0.0043 0.0884 0.0851
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0362 0.3968
Entamoeba histolytica hypothetical protein 0.0028 0.0519 0.5687
Echinococcus multilocularis CREB binding protein 0.002 0.0323 0.0323
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0884 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0884 0.101
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0884 0.0851
Leishmania major importin beta-1 subunit, putative 0.0028 0.0519 0.5687
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0042
Plasmodium falciparum importin beta, putative 0.0035 0.0676 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0063 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0042
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0912 0.0912
Schistosoma mansoni importin beta-1 0.0035 0.0676 0.0676
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0884 0.9691
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0519 0.5687
Toxoplasma gondii exonuclease III APE 0.0022 0.0362 0.2906
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0884 0.9487
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0362 0.1304
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0362 0.3968
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0042
Brugia malayi beta-lactamase family protein 0.0043 0.0884 0.3185
Loa Loa (eye worm) hypothetical protein 0.0043 0.0884 0.101
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.0109
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0519 0.285
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0004 0.0042
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0912 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0456 0.1714
Mycobacterium ulcerans beta-lactamase 0.0043 0.0884 1
Schistosoma mansoni ap endonuclease 0.0022 0.0362 0.0362
Echinococcus granulosus CREB binding protein 0.0075 0.165 0.165
Schistosoma mansoni ap endonuclease 0.0022 0.0362 0.0362
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0884 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0884 0.3185
Trichomonas vaginalis ran, putative 0.0026 0.0456 0.5002
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0019 0.0019
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0912 0.0912
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0519 0.5687
Schistosoma mansoni ran 0.0026 0.0456 0.0456
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0912 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0456 0.5002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0884 0.0851
Leishmania major GTP-binding protein, putative 0.0026 0.0456 0.5002
Schistosoma mansoni cpg binding protein 0.0031 0.0596 0.0596
Toxoplasma gondii ABC1 family protein 0.0043 0.0884 0.7099
Mycobacterium tuberculosis Conserved protein 0.0043 0.0884 0.0851
Onchocerca volvulus 0.0043 0.0884 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0912 0.0912
Brugia malayi beta-lactamase family protein 0.0043 0.0884 0.3185
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0019 0.0019
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0884 0.0884
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0042
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0912 0.3287
Onchocerca volvulus 0.0043 0.0884 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0884 0.0884
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0884 0.0884
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0912 0.0912
Echinococcus multilocularis CREB binding protein 0.002 0.0323 0.0323
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0884 0.0851
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0912 0.0912
Trichomonas vaginalis esterase, putative 0.0043 0.0884 0.9691
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0042
Schistosoma mansoni hypothetical protein 0.0424 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0042
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0362 0.0414
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0362 0.0362
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0362 0.3968
Schistosoma mansoni hypothetical protein 0.0372 0.8746 0.8746
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0884 0.9691
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0884 0.9691
Mycobacterium ulcerans lipase LipD 0.0043 0.0884 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0456 0.5161
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0884 0.0884
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0676 0.0676
Loa Loa (eye worm) hypothetical protein 0.0043 0.0884 0.101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0045 0.0912 0.1043
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0456 0.1714
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0019 0.0019
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0362 0.5
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0884 0.0851
Mycobacterium ulcerans hypothetical protein 0.0043 0.0884 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0362 0.3968
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0676 0.5433
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0019 0.0019
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0912 0.0912
Loa Loa (eye worm) hypothetical protein 0.0057 0.1219 0.1393
Trichomonas vaginalis helicase, putative 0.0007 0.0004 0.0042
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0362 0.535
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0912 1
Echinococcus granulosus CREB binding protein 0.0122 0.2774 0.2774
Schistosoma mansoni cpg binding protein 0.003 0.0555 0.0555
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0884 0.9691
Echinococcus granulosus snurportin 1 0.0372 0.8746 0.8746
Onchocerca volvulus 0.0043 0.0884 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0912 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0676 0.0676
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.8746 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0676 0.0773
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0912 0.0912
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0912 0.0912
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0884 0.0851
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0004 0.0042
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0884 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0042
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0912 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0676 0.7416
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0042
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0456 0.1714
Schistosoma mansoni CREB-binding protein 2 0.0122 0.2774 0.2774
Echinococcus multilocularis dnaJ subfamily B 0.0424 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0004 0.0042
Echinococcus multilocularis snurportin 1 0.0372 0.8746 0.8746
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0884 0.9691
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0004 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1355 0.1355
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0456 0.0456
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0362 0.0362
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0122 0.2774 0.2774
Brugia malayi CXXC zinc finger family protein 0.003 0.0555 0.2002

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Cell signaling CRE-BLA (Fsk stim) - HEK293 CREB Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 662 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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