TDR Targets

Basic information

Technical information

TDR Targets ID: 659936
Name: N-(furan-2-ylmethyl)-2-[[2-[methylsulfonyl-(4 -propan-2-ylphenyl)amino]acetyl]amino]benzami de
MW: 469.553 | Formula: C24H27N3O5S
H donors: 2 H acceptors: 4 LogP: 3.52 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CN(S(=O)(=O)C)c1ccc(cc1)C(C)C)Nc1ccccc1C(=O)NCc1ccco1
InChi: 1S/C24H27N3O5S/c1-17(2)18-10-12-19(13-11-18)27(33(3,30)31)16-23(28)26-22-9-5-4-8-21(22)24(29)25-15-20-7-6-14-32-20/h4-14,17H,15-16H2,1-3H3,(H,25,29)(H,26,28)
InChiKey: FLPFKODTLYPYDA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-furylmethyl)-2-[[2-[(4-isopropylphenyl)-methylsulfonyl-amino]acetyl]amino]benzamide
N-(2-furylmethyl)-2-[[2-[(4-isopropylphenyl)-methylsulfonylamino]-1-oxoethyl]amino]benzamide
N-(2-furylmethyl)-2-[[2-[(4-isopropylphenyl)-mesyl-amino]acetyl]amino]benzamide
N-(furan-2-ylmethyl)-2-[2-[methylsulfonyl-(4-propan-2-ylphenyl)amino]ethanoylamino]benzamide
ZINC01119681

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0045	0.0522	0.541
Echinococcus multilocularis	glycyl tRNA synthetase	0.006	0.081	0.081
Schistosoma mansoni	methionyl-tRNA synthetase	0.0034	0.031	0.031
Plasmodium falciparum	methionine--tRNA ligase	0.0045	0.0522	1
Onchocerca volvulus	Huntingtin homolog	0.0139	0.2311	0.5578
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0209	0.3994
Onchocerca volvulus		0.003	0.0222	0.0535
Schistosoma mansoni	hypothetical protein	0.0041	0.0436	0.0436
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.5193	1
Brugia malayi	protein ZK524.3	0.0045	0.0522	0.0852
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0425	0.0425
Treponema pallidum	methionyl-tRNA synthetase	0.0319	0.5748	1
Leishmania major	hypothetical protein	0.0034	0.031	0.321
Schistosoma mansoni	leucyl-tRNA synthetase	0.0045	0.0522	0.0522
Chlamydia trachomatis	leucine--tRNA ligase	0.0045	0.0522	0.0444
Onchocerca volvulus		0.0029	0.0207	0.05
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0222	0.0222
Echinococcus granulosus	glycyl tRNA synthetase	0.006	0.081	0.081
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0209	0.0209
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.1564	0.1564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Schistosoma mansoni	methionine-tRNA synthetase	0.0284	0.5095	0.5095
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0325	0.0325
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.031	0.321
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0322	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0139	0.2311	0.3771
Wolbachia endosymbiont of Brugia malayi	leucyl-tRNA synthetase	0.0045	0.0522	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0325	0.0325
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0436	0.0436
Loa Loa (eye worm)	hypothetical protein	0.003	0.0222	0.0362
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0322	0.0525
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0045	0.0522	0.0852
Onchocerca volvulus	Alhambra homolog	0.0029	0.0209	0.0504
Schistosoma mansoni	lamin	0.0029	0.0207	0.0207
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0322	0.0322
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0209	0.1774
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0222	0.0222
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0222	0.0222
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0095	0.1465	0.1465
Leishmania major	cathepsin L-like protease	0.0068	0.0966	1
Loa Loa (eye worm)	hypothetical protein	0.0284	0.5095	0.8312
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.5193	1
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0045	0.0522	0.1006
Echinococcus granulosus	methionine tRNA synthetase	0.0045	0.0522	0.0522
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0436	0.0436
Toxoplasma gondii	tRNA ligases class I (M) protein	0.0045	0.0522	0.4442
Brugia malayi	Pre-SET motif family protein	0.0206	0.3599	0.5871
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0207	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1094	0.1785
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.0852	0.8824
Onchocerca volvulus		0.0029	0.0207	0.05
Brugia malayi	Pre-SET motif family protein	0.003	0.0222	0.0362
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0045	0.0522	0.1036
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.5193	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.006	0.081	0.1322
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.031	0.0597
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Brugia malayi	jmjC domain containing protein	0.0095	0.1465	0.239
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0325	0.053
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0522	0.0852
Echinococcus granulosus	peregrin	0.0029	0.0209	0.0209
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.031	0.0597
Loa Loa (eye worm)	multisynthetase complex auxiliary component p43	0.0273	0.4882	0.7965
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0209	0.1774
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.5193	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0322	0.0322
Echinococcus multilocularis	methionine tRNA synthetase	0.0045	0.0522	0.0522
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.1564	0.1564
Echinococcus multilocularis	aminoacyl tRNA synthase complex interacting	0.0034	0.031	0.031
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.031	0.0597
Onchocerca volvulus	Huntingtin homolog	0.0139	0.2311	0.5578
Loa Loa (eye worm)	hypothetical protein	0.005	0.0603	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0207	0.0338
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0045	0.0522	0.1036
Plasmodium vivax	SET domain protein, putative	0.003	0.0222	0.4247
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0322	0.0525
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0966	1
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0436	0.0436
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0322	0.0525
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0322	0.0322
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0209	0.0209
Leishmania major	cathepsin L-like protease	0.0068	0.0966	1
Brugia malayi	hypothetical protein	0.0139	0.2311	0.3771
Echinococcus multilocularis	leucyl tRNA synthetase	0.0045	0.0522	0.0522
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Echinococcus granulosus	GPCR family 2	0.0035	0.0322	0.0322
Trypanosoma cruzi	tyrosyl or methionyl-tRNA synthetase, putative	0.0034	0.031	0.321
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0045	0.0522	0.324
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0325	0.0325
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.1564	0.1564
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0222	0.0222
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0207	0.0338
Plasmodium falciparum	methionine--tRNA ligase, putative	0.0045	0.0522	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.5193	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0339	0.6129	1
Plasmodium vivax	methionine--tRNA ligase, putative	0.0045	0.0522	1
Schistosoma mansoni	lamin	0.0029	0.0207	0.0207
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.1564	0.1564
Echinococcus granulosus	intermediate filament protein	0.0029	0.0207	0.0207
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.01	0.1564	0.2552
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0209	0.3994
Brugia malayi	intermediate filament protein	0.0029	0.0207	0.0338
Brugia malayi	glycyl-tRNA synthetase	0.006	0.081	0.1322
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.3599	0.5871
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0322	0.0525
Mycobacterium ulcerans	leucyl-tRNA synthetase	0.0045	0.0522	0.1036
Schistosoma mansoni	hypothetical protein	0.0035	0.0322	0.0322
Leishmania major	hypothetical protein, conserved	0.0034	0.031	0.321
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0222	0.0222
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0325	0.0325
Brugia malayi	hypothetical protein	0.0041	0.0436	0.0711
Schistosoma mansoni	hypothetical protein	0.0035	0.0322	0.0322
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0339	0.6129	0.6129
Schistosoma mansoni	hypothetical protein	0.0029	0.0209	0.0209
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.1093	0.1093
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0095	0.1465	0.1465
Entamoeba histolytica	hypothetical protein	0.0041	0.0436	0.0759
Leishmania major	cathepsin L-like protease	0.0068	0.0966	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.5193	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0966	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.1564	0.1564
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0201	0.0201
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0322	0.0322
Treponema pallidum	fructose-bisphosphate aldolase	0.029	0.5193	0.8937
Echinococcus granulosus	tyrosyl tRNA synthetase	0.0034	0.031	0.031
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.01	0.1564	0.2552
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.2311	0.3771
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0207	0.0207
Schistosoma mansoni	hypothetical protein	0.0035	0.0322	0.0322
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.029	0.5193	0.9034
Giardia lamblia	Fructose-bisphosphate aldolase	0.029	0.5193	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.176	0.2871
Toxoplasma gondii	methionyl-tRNA synthetase	0.0079	0.1176	1
Schistosoma mansoni	hypothetical protein	0.0541	1	1
Plasmodium vivax	methionine-tRNA ligase, putative	0.0034	0.031	0.5933
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0045	0.0522	1
Giardia lamblia	Methionyl-tRNA synthetase	0.0034	0.031	0.0203
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.4144	0.7979
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0797	0.13
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0522	0.0852
Giardia lamblia	Leucyl-tRNA synthetase	0.0045	0.0522	0.0629
Echinococcus multilocularis	musashi	0.0029	0.0207	0.0207
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0222	0.0222
Trypanosoma cruzi	cysteine peptidase, putative	0.0068	0.0966	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.176	0.2871
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0425	0.0425
Echinococcus multilocularis	lamin dm0	0.0029	0.0207	0.0207
Trypanosoma cruzi	cruzipain precursor, putative	0.0068	0.0966	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Toxoplasma gondii	tRNA binding domain-containing protein	0.0034	0.031	0.2636
Entamoeba histolytica	hypothetical protein	0.0041	0.0436	0.0759
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0141	0.2361	1
Brugia malayi	methionyl-tRNA synthetase	0.0045	0.0522	0.0852
Entamoeba histolytica	hypothetical protein	0.0041	0.0436	0.0759
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0209	0.034
Leishmania major	leucyl-tRNA synthetase, putative	0.0045	0.0522	0.541
Plasmodium falciparum	tRNA import protein tRIP	0.0034	0.031	0.5933
Echinococcus multilocularis	geminin	0.0541	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0339	0.6129	1
Schistosoma mansoni	hypothetical protein	0.0075	0.1094	0.1094
Brugia malayi	PHD-finger family protein	0.0029	0.0209	0.034
Entamoeba histolytica	hypothetical protein	0.0034	0.031	0.0539
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0339	0.6129	0.6129
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.5193	1
Echinococcus multilocularis	tyrosyl tRNA synthetase	0.0034	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0197	0.0322
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0322	0.0322
Schistosoma mansoni	methionine-tRNA synthetase	0.0045	0.0522	0.0522
Plasmodium vivax	methionine--tRNA ligase, putative	0.0045	0.0522	1
Brugia malayi	methionyl-tRNA synthetase	0.0319	0.5748	0.9378
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0222	0.0222
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Plasmodium vivax	hypothetical protein, conserved	0.0045	0.0522	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.176	0.2871
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0141	0.2361	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0339	0.6129	0.6129
Schistosoma mansoni	glycyl-tRNA synthetase	0.006	0.081	0.081
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0141	0.2361	1
Chlamydia trachomatis	methionine--tRNA ligase	0.0284	0.5095	1
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.006	0.081	0.1322
Schistosoma mansoni	hypothetical protein	0.0541	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.176	0.2871
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.1094	0.1785
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.031	0.321
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.006	0.081	0.1322
Onchocerca volvulus		0.0235	0.4144	1
Trichomonas vaginalis	methionyl-tRNA synthetase, putative	0.0034	0.031	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0389	0.0749
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0068	0.0966	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.1564	0.1564
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.029	0.5193	0.9034
Schistosoma mansoni	tyrosyl-tRNA synthetase	0.0034	0.031	0.031
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0685	0.7098
Echinococcus granulosus	aminoacyl tRNA synthase complex interacting	0.0034	0.031	0.031
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.029	0.5193	1
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0207	0.0338
Brugia malayi	jmjC domain containing protein	0.0035	0.0325	0.053
Entamoeba histolytica	methionyl-tRNA synthetase, putative	0.0319	0.5748	1
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0284	0.5095	0.5095
Giardia lamblia	Methionyl-tRNA synthetase	0.0045	0.0522	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0209	0.034
Echinococcus multilocularis	lamin	0.0029	0.0207	0.0207
Leishmania major	tyrosyl or methionyl-tRNA synthetase-like protein	0.0034	0.031	0.321
Trypanosoma cruzi	tyrosyl or methionyl-tRNA synthetase, putative	0.0034	0.031	0.321
Echinococcus multilocularis	peregrin	0.0029	0.0209	0.0209
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.1564	0.1564
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0284	0.5095	0.5095
Echinococcus granulosus	lamin	0.0029	0.0207	0.0207
Entamoeba histolytica	hypothetical protein	0.0041	0.0436	0.0759
Entamoeba histolytica	hypothetical protein	0.0034	0.031	0.0539
Leishmania major	methionyl-tRNA synthetase, putative	0.0045	0.0522	0.541
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0209	0.0209
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0222	0.1887
Brugia malayi	Bromodomain containing protein	0.0029	0.0209	0.034
Echinococcus granulosus	lamin dm0	0.0029	0.0207	0.0207

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 659936