Detailed information for compound 672579

Basic information

Technical information
  • TDR Targets ID: 672579
  • Name: 2-[(3-methoxyphenyl)-methylsulfonylamino]-N-[ 2-(pyrrolidine-1-carbonyl)phenyl]acetamide
  • MW: 431.505 | Formula: C21H25N3O5S
  • H donors: 1 H acceptors: 4 LogP: 2.44 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)N(S(=O)(=O)C)CC(=O)Nc1ccccc1C(=O)N1CCCC1
  • InChi: 1S/C21H25N3O5S/c1-29-17-9-7-8-16(14-17)24(30(2,27)28)15-20(25)22-19-11-4-3-10-18(19)21(26)23-12-5-6-13-23/h3-4,7-11,14H,5-6,12-13,15H2,1-2H3,(H,22,25)
  • InChiKey: LEEMXUNECJKDKT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(3-methoxyphenyl)-methylsulfonyl-amino]-N-[2-(pyrrolidine-1-carbonyl)phenyl]acetamide
  • 2-[(3-methoxyphenyl)-methylsulfonylamino]-N-[2-(oxo-1-pyrrolidinylmethyl)phenyl]acetamide
  • 2-[mesyl-(3-methoxyphenyl)amino]-N-[2-(pyrrolidine-1-carbonyl)phenyl]acetamide
  • 2-[(3-methoxyphenyl)-methylsulfonyl-amino]-N-(2-pyrrolidin-1-ylcarbonylphenyl)ethanamide
  • Oprea1_633092
  • BAS 04924487
  • ZINC00785498

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GPCR, family 2 0.0016 0.0013 0.0013
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0058 0.561
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0008 0.0093
Onchocerca volvulus 0.0094 0.0186 0.3444
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Echinococcus multilocularis gamma secretase subunit aph 1 0.4533 1 1
Echinococcus granulosus GPCR family 2 0.0016 0.0013 0.0013
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0292 0.4528
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0058 0.0058
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0013 0.0013
Brugia malayi hypothetical protein 0.0146 0.0301 0.0301
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0058 0.1034
Brugia malayi MH2 domain containing protein 0.0144 0.0297 0.0297
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.4533 1 1
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0003 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0013 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0101 0.1843
Schistosoma mansoni hypothetical protein 0.0164 0.0342 0.0339
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.0642 0.1647
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.0003 0.0003
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.0055 0.534
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0182 0.0181
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.001
Brugia malayi Pre-SET motif family protein 0.0032 0.0049 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0182 0.0181
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0008 0.0093
Echinococcus granulosus cpg binding protein 0.003 0.0045 0.0045
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0058 0.1034
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0013 0.0013
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0101 0.3017
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0164 0.0342 0.0339
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0328 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0058 0.0058
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0101 0.1534
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0058 0.561
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0297 0.0297
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0008 0.0093
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0003 0.0003
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0008 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0058 0.1034
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0003 0.0003
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0101 0.1843
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0003 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0252 0.0535 1
Schistosoma mansoni ap endonuclease 0.0056 0.0101 0.0098
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0182 0.0179
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.0003 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0055 0.0055
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0058 0.1034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0088 0.0088
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.0003 0.0003
Toxoplasma gondii exonuclease III APE 0.0056 0.0101 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0297 0.0297
Trypanosoma brucei Aph-1 protein, putative 0.1766 0.3883 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0008 0.0093
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.0003 0.0003
Brugia malayi CXXC zinc finger family protein 0.0029 0.0041 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0049 0.0047
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.0003 0.0003
Echinococcus multilocularis geminin 0.0164 0.0342 0.0341
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0071 0.0177
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.0003 0.0003
Schistosoma mansoni alpha glucosidase 0.0036 0.0058 0.0055
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0008 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0092 0.0229
Onchocerca volvulus 0.0146 0.0301 0.5611
Echinococcus granulosus synaptojanin 1 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0252 0.0535 1
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0182 0.0179
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0008 0.0093
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.001
Trypanosoma cruzi Aph-1 protein, putative 0.1766 0.3883 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0101 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0049 0.0047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.0467 0.0467
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0058 0.0861
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0088 0.0088
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0003 0.0003
Toxoplasma gondii hypothetical protein 0.0048 0.0085 0.8393
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0101 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0101 1
Schistosoma mansoni alpha-glucosidase 0.014 0.0288 0.0285
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0071 0.0177
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0292 0.0746
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0049 0.0049
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0058 0.1034
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0146 0.0301 0.0301
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0115 0.0112
Schistosoma mansoni hypothetical protein 0.0035 0.0055 0.0052
Trypanosoma brucei glucosidase, putative 0.0036 0.0058 0.0142
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0101 0.0253
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0049 0.0049
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0008 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0058 0.0142
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0338 0.0338
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0809 0.1768 0.1768
Leishmania major mitochondrial DNA polymerase beta 0.03 0.0642 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0292 0.0746
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.0055 0.534
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0182 0.0181
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0101 0.0101
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0008 0.0093
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0101 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0003 0.0003
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0003 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0642 0.1647
Schistosoma mansoni hypothetical protein 0.0034 0.0053 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0008 0.0093
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0058 0.1034
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0035 0.0055 0.534
Loa Loa (eye worm) hypothetical protein 0.0034 0.0053 0.0053
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0058 0.561
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0045 0.0045
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0642 0.1647
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0042
Brugia malayi hypothetical protein 0.0035 0.0055 0.0055
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0011 0.0003 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0013 0.0013
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0338 0.0337
Echinococcus granulosus geminin 0.0164 0.0342 0.0341
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0101 0.9968
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0008 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0049 0.0047
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0011 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0182 0.0179
Schistosoma mansoni cpg binding protein 0.0029 0.0041 0.0039
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0008 0.0502
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0049 0.0049
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0053 0.0053
Onchocerca volvulus 0.0029 0.0041 0.0724
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0101 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0013 0.0013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0013 0.0013
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0008 0.0077
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0049 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0101 0.0253
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0049 0.475
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0003 0.0003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0338 0.0337
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0003 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0008 0.0093
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0058 0.1034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0101 1
Echinococcus granulosus gamma secretase subunit aph 1 0.4533 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0055 0.534
Echinococcus multilocularis synaptojanin 1 0.0011 0.0003 0.0003
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0058 0.1034
Schistosoma mansoni gamma-secretase subunit aph-1 0.4533 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0058 0.0142
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0182 0.0182
Plasmodium vivax SET domain protein, putative 0.0032 0.0049 0.475
Trypanosoma cruzi Aph-1 protein, putative 0.1766 0.3883 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0101 0.0101
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0058 0.0058
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0338 0.0337
Schistosoma mansoni ap endonuclease 0.0056 0.0101 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0058 0.1034
Schistosoma mansoni alpha-glucosidase 0.014 0.0288 0.0285
Brugia malayi CCR4 0.0011 0.0003 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0055 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0182 0.0181
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0049 0.0047
Mycobacterium ulcerans hypothetical protein 0.0158 0.0328 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0338 0.0337
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.001
Brugia malayi Pre-SET motif family protein 0.0221 0.0467 0.0467
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0071 0.0177
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0071 0.0177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0182 0.0181
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0003 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0101 0.0253
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0013 0.0013
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.0003 0.0003
Echinococcus multilocularis cpg binding protein 0.003 0.0045 0.0045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0055 0.0055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0101 0.0101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0041 0.0041
Onchocerca volvulus 0.0032 0.0049 0.0875

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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