Detailed information for compound 677205

Basic information

Technical information
  • TDR Targets ID: 677205
  • Name: N-(3-dimethylamino-3-oxo-1-phenylprop-1-en-2- yl)benzamide
  • MW: 294.348 | Formula: C18H18N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.85 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)/C(=C/c1ccccc1)/NC(=O)c1ccccc1)C
  • InChi: 1S/C18H18N2O2/c1-20(2)18(22)16(13-14-9-5-3-6-10-14)19-17(21)15-11-7-4-8-12-15/h3-13H,1-2H3,(H,19,21)/b16-13+
  • InChiKey: YDXFVSDNPMKYPC-DTQAZKPQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(E)-3-dimethylamino-3-oxo-1-phenylprop-1-en-2-yl]benzamide
  • N-[(E)-1-(dimethylcarbamoyl)-2-phenyl-vinyl]benzamide
  • N-[1-(dimethylcarbamoyl)-2-phenyl-vinyl]benzamide
  • N-[1-(dimethylamino-oxomethyl)-2-phenylvinyl]benzamide
  • N-[(E)-1-(dimethylamino-oxomethyl)-2-phenylvinyl]benzamide
  • N-(3-dimethylamino-3-oxo-1-phenyl-prop-1-en-2-yl)benzamide
  • N-[(E)-3-dimethylamino-3-oxo-1-phenyl-prop-1-en-2-yl]benzamide
  • ChemDiv3_002777
  • 2-Benzoylamino-3-phenyl-N,N-dimethylpropenamide
  • ZINC04756049

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0172 0.0418
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0191 0.2618 0.8903
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0024
Schistosoma mansoni hypothetical protein 0.0082 0.096 0.096
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Brugia malayi PAN domain containing protein 0.0019 0.001 0.0037
Trypanosoma brucei phosphoglycerate kinase 0.0168 0.2261 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0157 0.0694
Echinococcus granulosus dna polymerase eta 0.0044 0.0394 0.0394
Leishmania major hypothetical protein, conserved 0.0029 0.0162 0.0717
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0043 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0399
Brugia malayi PAN domain containing protein 0.0019 0.001 0.0037
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0213 0.294 1
Onchocerca volvulus 0.0234 0.3254 1
Toxoplasma gondii microneme protein MIC4 0.0019 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.0066
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0191 0.2618 0.5251
Leishmania major trypanothione reductase 0.0084 0.0995 0.4399
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0167 0.0405
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0658 0.2909
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0031 0.02 0.0884
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.1134 0.3464
Schistosoma mansoni hypothetical protein 0.0082 0.096 0.096
Mycobacterium tuberculosis Probable oxidoreductase 0.0213 0.294 1
Toxoplasma gondii ThiF family protein 0.0031 0.02 0.0485
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0167 0.0738
Plasmodium falciparum phosphoglycerate kinase 0.0168 0.2261 1
Schistosoma mansoni phosphoglycerate kinase 0.0168 0.2261 0.2261
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0172 0.0172
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0167 0.0469
Toxoplasma gondii PAN/Apple domain-containing protein 0.0019 0.001 0.0025
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0658 0.2909
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0031 0.02 0.0884
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0213 0.294 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.0066
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.1134 0.1134
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0031 0.02 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0167 0.0738
Echinococcus multilocularis microtubule associated protein 2 0.0681 1 1
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.001 0.0024
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0167 0.0738
Giardia lamblia Kinase, PLK 0.0093 0.1134 0.4981
Brugia malayi hypothetical protein 0.0019 0.0008 0.0029
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0167 0.0738
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1134 0.3454
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0167 0.0676
Toxoplasma gondii PAN domain-containing protein 0.0291 0.4119 1
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.001 0.0024
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0658 0.2909
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1134 0.3454
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0167 0.0738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0167 0.0738
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0167 0.0167
Brugia malayi glutathione reductase 0.0084 0.0995 0.352
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0015 0.0066
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0167 0.0676
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0076 0.0188
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0048 0.0445 0.1969
Echinococcus granulosus importin subunit beta 1 0.0028 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0024
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0157 0.0694
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0162 0.0717
Mycobacterium tuberculosis Probable reductase 0.0191 0.2618 0.8903
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.096 0.2228
Plasmodium falciparum glutathione reductase 0.0084 0.0995 0.4399
Brugia malayi Phosphoglycerate kinase 0.0062 0.0658 0.2328
Echinococcus granulosus phosphoglycerate kinase 1 0.0168 0.2261 0.2261
Leishmania major phosphoglycerate kinase B, cytosolic 0.0168 0.2261 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0167 0.0676
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0167 0.0738
Brugia malayi ThiF family protein 0.0048 0.0445 0.1576
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0196 0.0476
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1134 0.3454
Loa Loa (eye worm) ThiF family protein 0.0031 0.02 0.0464
Echinococcus granulosus snurportin 1 0.0304 0.431 0.431
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0167 0.0738
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0162 0.0717
Brugia malayi Pre-SET motif family protein 0.0029 0.0172 0.0609
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0191 0.2618 0.8903
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0031 0.02 0.02
Loa Loa (eye worm) glutathione reductase 0.0084 0.0995 0.2308
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0015 0.0015
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0658 0.2909
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0658 0.2909
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.1002 0.1002
Leishmania major DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0424 0.1262
Entamoeba histolytica hypothetical protein 0.0023 0.0076 0.0271
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0168 0.2261 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.1134 0.5014
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0024
Onchocerca volvulus 0.0029 0.0172 0.0499
Brugia malayi RNA, U transporter 1 0.0081 0.0948 0.3356
Toxoplasma gondii thioredoxin reductase 0.0084 0.0995 0.2415
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0015 0.0051
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.431 1
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0995 0.4399
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1134 0.5014
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0167 0.059
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1134 0.3454
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.1134 0.4013
Brugia malayi PAN domain containing protein 0.0019 0.001 0.0037
Brugia malayi Thioredoxin reductase 0.0084 0.0995 0.352
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0167 0.0567
Leishmania major DNA polymerase eta, putative 0.0044 0.0394 0.1743
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0076 0.0188
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0019 0.001 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0015 0.0053
Trypanosoma brucei trypanothione reductase 0.0084 0.0995 0.4399
Toxoplasma gondii PAN domain-containing protein 0.0019 0.001 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0167 0.0738
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0658 0.2909
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.096 0.096
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0168 0.2261 1
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0048 0.0445 0.0445
Toxoplasma gondii PAN domain-containing protein 0.0019 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0376
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0168 0.2261 1
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0031 0.02 0.0884
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0015 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0424 0.1262
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.0658 0.2909
Leishmania major importin beta-1 subunit, putative 0.0023 0.0076 0.0335
Loa Loa (eye worm) hypothetical protein 0.0168 0.2261 0.5247
Loa Loa (eye worm) hypothetical protein 0.0048 0.0445 0.1033
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0168 0.2261 0.5489
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.096 0.096
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2826 0.6557
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0168 0.2261 0.6935
Loa Loa (eye worm) hypothetical protein 0.0028 0.0157 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0172 0.0172
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0156 0.0156
Toxoplasma gondii hypothetical protein 0.0019 0.001 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0015 0.0015
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0048 0.0445 0.0445
Leishmania major DNA polymerase eta, putative 0.0031 0.0196 0.0867
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.096 0.096
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.005 0.0178
Schistosoma mansoni phosphoglycerate kinase 0.0168 0.2261 0.2261
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0168 0.2261 0.5489
Brugia malayi Importin beta-1 subunit 0.0028 0.0157 0.0556
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0172 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Trichomonas vaginalis set domain proteins, putative 0.0234 0.3254 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.096 0.2228
Brugia malayi hypothetical protein 0.0029 0.0162 0.0574
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0995 0.3383
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.001 0.0024
Plasmodium falciparum thioredoxin reductase 0.0084 0.0995 0.4399
Plasmodium vivax SET domain protein, putative 0.0029 0.0172 0.0761
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0167 0.0738
Plasmodium vivax ubiquitin activating enzyme, putative 0.0048 0.0445 0.1969
Brugia malayi PAN domain containing protein 0.0019 0.001 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1134 0.3454
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0213 0.294 1
Brugia malayi PAN domain containing protein 0.0019 0.001 0.0037
Toxoplasma gondii hypothetical protein 0.0048 0.0445 0.1081
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0157 0.0157
Brugia malayi PAN domain containing protein 0.0019 0.001 0.0037
Toxoplasma gondii microneme protein, putative 0.0019 0.001 0.0025
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0027 0.0134 0.0593
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0048 0.0445 0.0445
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0162 0.0394
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0167 0.0738
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0162 0.0717
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0167 0.0738
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0168 0.2261 0.6935
Schistosoma mansoni importin beta-1 0.0028 0.0157 0.0157
Toxoplasma gondii microneme protein MIC17A 0.0019 0.001 0.0025
Treponema pallidum phosphoglycerate kinase 0.0168 0.2261 1
Entamoeba histolytica phosphoglycerate kinase, putative 0.0168 0.2261 1
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0162 0.0717
Toxoplasma gondii microneme protein MIC17B 0.0019 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0162 0.0717
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0167 0.0738
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0015 0.0015
Schistosoma mansoni DNA polymerase eta 0.0044 0.0394 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.096 0.096
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.1002 0.1002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0167 0.0738
Echinococcus multilocularis phosphoglycerate kinase 1 0.0168 0.2261 0.2261
Giardia lamblia Phosphoglycerate kinase 0.0168 0.2261 1
Mycobacterium ulcerans phosphoglycerate kinase 0.0168 0.2261 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0167 0.0167
Echinococcus granulosus dna polymerase kappa 0.0019 0.0015 0.0015
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0167 0.0738
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1134 0.3454
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.096 0.3399
Chlamydia trachomatis phosphoglycerate kinase 0.0168 0.2261 1
Schistosoma mansoni apoptosis regulator bax 0.0082 0.096 0.096
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0167 0.0738
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.0658 0.2909
Plasmodium vivax glutathione reductase, putative 0.0084 0.0995 0.4399
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0015 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0394 0.1395
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.001 0.0024
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0394 0.1743
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0167 0.0738
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0995 0.4399
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.1134 0.1134
Brugia malayi PAN domain containing protein 0.0019 0.001 0.0037
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0031 0.02 0.02
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0168 0.2261 0.769
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0995 0.2308
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0172 0.0172
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0162 0.0717
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0196 0.0867
Echinococcus multilocularis snurportin 1 0.0304 0.431 0.431
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0167 0.0738
Plasmodium falciparum glutathione reductase 0.0029 0.0167 0.0738
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0191 0.2618 0.8903
Trypanosoma brucei phosphoglycerate kinase 0.0168 0.2261 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0167 0.0738
Echinococcus multilocularis dna polymerase eta 0.0044 0.0394 0.0394
Toxoplasma gondii hypothetical protein 0.0019 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0024
Trypanosoma brucei unspecified product 0.0019 0.0015 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Schistosoma mansoni hypothetical protein 0.0304 0.431 0.431
Brugia malayi PAN domain containing protein 0.0019 0.001 0.0037
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0031 0.02 0.0884
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.1134 0.2631
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.001 0.0024
Toxoplasma gondii PAN domain-containing protein 0.0291 0.4119 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0168 0.2261 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0167 0.0167
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0167 0.0676
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0076 0.0335
Toxoplasma gondii PAN domain-containing protein 0.0019 0.001 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Trypanosoma brucei polo-like protein kinase 0.0093 0.1134 0.5014
Plasmodium vivax importin-beta 2, putative 0.0028 0.0157 0.0694
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0172 0.0172
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0394 0.1743
Toxoplasma gondii subtilisin SUB12 0.0019 0.001 0.0025
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.1134 0.4981
Brugia malayi PAN domain containing protein 0.0019 0.001 0.0037
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0167 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1134 0.1134
Leishmania major phosphoglycerate kinase C, glycosomal 0.0168 0.2261 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0167 0.0738
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1134 0.3454
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1134 0.5014
Brugia malayi Phosphoglycerate kinase 0.0168 0.2261 0.8002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0076 0.0188
Brugia malayi ThiF family protein 0.0031 0.02 0.0707
Brugia malayi Pre-SET motif family protein 0.0205 0.2826 1
Leishmania major ubiquitin-activating enzyme-like protein 0.0031 0.02 0.0884
Loa Loa (eye worm) hypothetical protein 0.0044 0.0394 0.0915
Schistosoma mansoni microtubule-associated protein tau 0.0681 1 1
Plasmodium falciparum importin beta, putative 0.0028 0.0157 0.0694
Toxoplasma gondii PAN domain-containing protein 0.0019 0.001 0.0025
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0015 0.0035
Brugia malayi PAN domain containing protein 0.0019 0.001 0.0037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0167 0.0738
Mycobacterium tuberculosis Probable dehydrogenase 0.0191 0.2618 0.8903
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0172 0.0172
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.005 0.0178
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0024
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0157 0.0381
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.0066
Toxoplasma gondii microneme protein MIC17C 0.0019 0.001 0.0025
Schistosoma mansoni kinase 0.0047 0.0442 0.0442
Plasmodium falciparum thioredoxin reductase 0.0029 0.0167 0.0738
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0167 0.0405
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.096 0.096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0172 0.0172
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0191 0.2618 0.8903
Schistosoma mansoni hypothetical protein 0.0082 0.096 0.096

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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