TDR Targets

Basic information

Technical information

TDR Targets ID: 678642
Name: 4-fluoro-N-(thiophen-2-ylmethyl)benzamide
MW: 235.277 | Formula: C12H10FNOS
H donors: 1 H acceptors: 1 LogP: 2.51 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)C(=O)NCc1cccs1
InChi: 1S/C12H10FNOS/c13-10-5-3-9(4-6-10)12(15)14-8-11-2-1-7-16-11/h1-7H,8H2,(H,14,15)
InChiKey: QFRIFIILJSMAKU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-fluoro-N-(2-thienylmethyl)benzamide
AO-081/15043062
ST5170610
ZINC00155363
4-Fluoro-N-thiophen-2-ylmethyl-benzamide
BAS 07320666

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0031	0.0026	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0031	0.0026	0.0016
Brugia malayi	hypothetical protein	0.0125	0.0335	0.2105
Echinococcus multilocularis	microtubule associated protein 2	0.0702	0.223	0.2222
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0148	0.0838
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0104	0.0266	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0104	0.0266	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0104	0.0266	0.0266
Trypanosoma cruzi	ion transport protein, putative	0.0104	0.0266	1
Onchocerca volvulus		0.0104	0.0266	0.1746
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0025	0.0015
Giardia lamblia	Hypothetical protein	0.0104	0.0266	1
Loa Loa (eye worm)	beta-lactamase	0.0074	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0104	0.0266	0.1623
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0032	0.0022
Schistosoma mansoni	lozenge	0.0057	0.0111	0.0086
Onchocerca volvulus		0.0074	0.0169	0.1039
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0031	0.0026	0.0001
Echinococcus multilocularis	Protein lozenge	0.0057	0.0111	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0032	0.0006
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0044	0.0765
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0104	0.0266	0.3418
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0335	0.0335
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.0169	0.0975
Echinococcus multilocularis	small conductance calcium activated potassium	0.3071	1	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0044	0.0489
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0029	0.0024
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0052	0.0096	0.0096
Echinococcus granulosus	potassium channel subfamily K	0.0104	0.0266	0.0245
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0033	0.0032	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0044	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus granulosus	jumonji domain containing protein	0.0043	0.0065	0.0044
Leishmania major	hypothetical protein, conserved	0.0104	0.0266	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0473	0.1478	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0026	0.0026
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.0169	0.0949
Schistosoma mansoni	calcium-activated potassium channel	0.0104	0.0266	0.0241
Echinococcus granulosus	potassium channel subfamily K 8	0.0104	0.0266	0.0245
Loa Loa (eye worm)	inositol-1	0.0036	0.0044	0.0044
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0104	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0451	0.1405	0.1405
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0104	0.0266	0.1639
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0104	0.0266	0.3418
Brugia malayi	Bromodomain containing protein	0.0031	0.0026	0.0004
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.0252	0.0252
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0032	0.029
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0104	0.0266	0.1639
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0104	0.0266	0.1639
Loa Loa (eye worm)	hypothetical protein	0.3071	1	1
Echinococcus granulosus	twik family of potassium channels	0.0104	0.0266	0.0245
Brugia malayi	beta-lactamase family protein	0.0074	0.0169	0.0975
Onchocerca volvulus		0.0074	0.0169	0.1039
Echinococcus multilocularis	twik family of potassium channels	0.0104	0.0266	0.0257
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0104	0.0266	0.0257
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0044	0.0167
Plasmodium falciparum	pyruvate kinase	0.0033	0.0032	0.0269
Echinococcus multilocularis	jumonji domain containing protein	0.0043	0.0065	0.0055
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0478	0.1495	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0097	0.0097
Brugia malayi	beta-lactamase	0.0074	0.0169	0.0975
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0032	0.0051
Loa Loa (eye worm)	runx1	0.0057	0.0111	0.0111
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0169	0.5827
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0052	0.0096	0.2714
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0029	0.0007
Loa Loa (eye worm)	hypothetical protein	0.1067	0.3427	0.3427
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0169	0.0169
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.0169	0.0159
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0104	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.089	0.2846	0.2846
Loa Loa (eye worm)	hypothetical protein	0.0451	0.1405	0.1405
Onchocerca volvulus		0.0104	0.0266	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0104	0.0266	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus multilocularis	muscleblind protein	0.03	0.091	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.003	0.0025	0.0025
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.0169	0.0949
Onchocerca volvulus		0.0074	0.0169	0.1039
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0104	0.0266	0.1639
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0032	0.0051
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0169	0.0949
Schistosoma mansoni	hypothetical protein	0.0031	0.0029	0.0003
Toxoplasma gondii	ABC1 family protein	0.0074	0.0169	0.5948
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0032	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0052	0.0096	0.2714
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0169	0.0169
Loa Loa (eye worm)	TWK-28 protein	0.0104	0.0266	0.0266
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0096	0.2714
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0052	0.0096	0.2926
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0252	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0026	0.0022
Plasmodium vivax	potassium channel, putative	0.0104	0.0266	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0025	0.0015
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0052	0.0096	0.2714
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0079	0.0069
Mycobacterium leprae	Probable lipase LipE	0.0074	0.0169	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.0169	0.0949
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0079	0.0069
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0169	0.1991
Echinococcus granulosus	muscleblind protein	0.03	0.091	0.0891
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.0169	0.0949
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0104	0.0266	0.3418
Trypanosoma cruzi	hypothetical protein, conserved	0.0104	0.0266	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus granulosus	mitogen activated protein kinase	0.0052	0.0096	0.0074
Echinococcus multilocularis	twik family of potassium channels	0.0104	0.0266	0.0257
Mycobacterium ulcerans	lipase LipD	0.0074	0.0169	0.5827
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0096	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0029	0.0029
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0044	0.0489
Mycobacterium ulcerans	esterase/lipase LipP	0.0074	0.0169	0.5827
Schistosoma mansoni	pyruvate kinase	0.0033	0.0032	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Toxoplasma gondii	ion channel protein	0.0104	0.0266	1
Schistosoma mansoni	hypothetical protein	0.0068	0.0148	0.0124
Schistosoma mansoni	hypothetical protein	0.0031	0.0029	0.0003
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0032	0.0032
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0212	0.0621	0.0621
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0104	0.0266	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0133	0.0133
Onchocerca volvulus		0.0104	0.0266	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.101	0.3238	0.3238
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0044	0.0034
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0044	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Trichomonas vaginalis	esterase, putative	0.0074	0.0169	0.1991
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0148	0.0148
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.01	0.0254	0.0233
Schistosoma mansoni	calcium-activated potassium channel	0.3071	1	1
Echinococcus granulosus	potassium channel subfamily K 8	0.0104	0.0266	0.0245
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0169	0.0949
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0169	0.0949
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0104	0.0266	0.1639
Plasmodium vivax	potassium channel, putative	0.0104	0.0266	1
Mycobacterium ulcerans	transmembrane cation transporter	0.0104	0.0266	1
Leishmania major	ion transport protein-like protein	0.0104	0.0266	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0079	0.0079
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0096	0.0071
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0096	0.2714
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0104	0.0266	1
Leishmania major	hypothetical protein, conserved	0.0074	0.0169	0.5827
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0029	0.0019
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0044	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0079	0.0057
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0104	0.0266	0.1639
Brugia malayi	Muscleblind-like protein	0.03	0.091	0.6023
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0047	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Schistosoma mansoni	hypothetical protein	0.0104	0.0266	0.0241
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0104	0.0266	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0104	0.0266	0.3418
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.0186	0.0161
Brugia malayi	PHD-finger family protein	0.0031	0.0026	0.0004
Schistosoma mansoni	calcium-activated potassium channel	0.0104	0.0266	0.0241
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0032	0.0048
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.0169	0.0147
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.0169	0.0169
Brugia malayi	Pre-SET motif family protein	0.0212	0.0621	0.405
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Mycobacterium ulcerans	beta-lactamase	0.0074	0.0169	0.5827
Schistosoma mansoni	twik family of potassium channels-related	0.0104	0.0266	0.0241
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0104	0.0266	0.1639
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.0169	0.0949
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0044	0.0018
Brugia malayi	jmjC domain containing protein	0.0037	0.0047	0.0147
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0104	0.0266	0.1639
Brugia malayi	beta-lactamase family protein	0.0074	0.0169	0.0975
Echinococcus multilocularis	potassium channel subfamily K 8	0.0104	0.0266	0.0257
Schistosoma mansoni	calcium-activated potassium channel	0.1958	0.6347	0.6338
Onchocerca volvulus	Huntingtin homolog	0.0125	0.0335	0.2243
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.0252	0.154
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.0252	0.154
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0052	0.0096	0.2714
Onchocerca volvulus	Alhambra homolog	0.0031	0.0026	0.0004
Brugia malayi	follicle stimulating hormone receptor	0.0478	0.1495	1
Leishmania major	potassium channel subunit-like protein	0.0104	0.0266	1
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.0169	0.5948
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0026	0.0022
Trypanosoma brucei	protein kinase, putative	0.0052	0.0096	0.2714
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0096	0.0928
Echinococcus granulosus	mitogen activated protein kinase 3	0.0052	0.0096	0.0074
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0032	0.0048
Giardia lamblia	Pyruvate kinase	0.0033	0.0032	0.0269
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.0169	0.5827
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.0169	0.0949
Plasmodium falciparum	potassium channel	0.0104	0.0266	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.0169	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0029	0.0019
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0169	0.5827
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0044	0.0489
Brugia malayi	jmjC domain containing protein	0.01	0.0254	0.1555
Echinococcus multilocularis	mitogen activated protein kinase	0.0052	0.0096	0.0086
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0079	0.0053
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0169	0.0144
Echinococcus multilocularis	calcium activated potassium channel variant	0.0104	0.0266	0.0257
Brugia malayi	hypothetical protein	0.0104	0.0266	0.1639
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0029	0.0019
Plasmodium falciparum	potassium channel	0.0104	0.0266	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0047	0.0047
Schistosoma mansoni	hypothetical protein	0.0031	0.0029	0.0003
Onchocerca volvulus		0.0104	0.0266	0.1746
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0104	0.0266	0.1639
Loa Loa (eye worm)	hypothetical protein	0.03	0.091	0.091
Echinococcus granulosus	GPCR family 2	0.0031	0.0029	0.0007
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0096	0.0928
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0104	0.0266	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus multilocularis	potassium channel subfamily K 8	0.0104	0.0266	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0104	0.0266	0.0257
Mycobacterium ulcerans	ion transport protein	0.0104	0.0266	1
Schistosoma mansoni	twik family of potassium channels-related	0.0104	0.0266	0.0241
Echinococcus granulosus	microtubule associated protein 2	0.0702	0.223	0.2213
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0044	0.0022
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0104	0.0266	0.1639
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0044	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0169	0.0169
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0079	0.0362
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0104	0.0266	1
Onchocerca volvulus		0.0104	0.0266	0.1746
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0029	0.0007
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0104	0.0266	0.0245
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0104	0.0266	0.1639
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0026	0.0022
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0079	0.0057
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0074	0.0169	0.5827
Echinococcus multilocularis	peregrin	0.0031	0.0026	0.0016
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0104	0.0266	0.1639
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0032	0.029
Brugia malayi	MAP kinase sur-1	0.0052	0.0096	0.0479
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0032	0.5
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0032	0.0032
Onchocerca volvulus		0.0104	0.0266	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Onchocerca volvulus		0.0104	0.0266	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0335	0.0335
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0104	0.0266	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0047	0.0025
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0029	0.0024
Schistosoma mansoni	twik family of potassium channels-related	0.0104	0.0266	0.0241
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0104	0.0266	0.1639
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0044	0.0489
Schistosoma mansoni	twik family of potassium channels-related	0.0104	0.0266	0.0241
Onchocerca volvulus		0.0104	0.0266	0.1746
Trypanosoma cruzi	ion transport protein, putative	0.0104	0.0266	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0169	0.1991
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.01	0.0254	0.0244
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0044	0.0489
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0169	0.0144
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0169	0.1991
Schistosoma mansoni	twik family of potassium channels-related	0.0104	0.0266	0.0241
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0025	0.0004
Giardia lamblia	Kinase, CMGC MAPK	0.0052	0.0096	0.291
Trypanosoma cruzi	hypothetical protein, conserved	0.0104	0.0266	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0047	0.0022
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0079	0.0053
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0169	0.1991
Brugia malayi	hypothetical protein	0.0451	0.1405	0.9384
Schistosoma mansoni	twik family of potassium channels-related	0.0104	0.0266	0.0241
Loa Loa (eye worm)	uncoordinated protein 58	0.0104	0.0266	0.0266
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0104	0.0266	0.0245
Brugia malayi	hypothetical protein	0.0104	0.0266	0.1639
Leishmania major	calcium/potassium channel (CAKC), putative	0.0104	0.0266	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0052	0.0096	0.0086
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0044	0.0167
Trichomonas vaginalis	set domain proteins, putative	0.0241	0.0717	1
Echinococcus multilocularis	potassium channel subfamily K	0.0104	0.0266	0.0257
Echinococcus granulosus	pyruvate kinase	0.0033	0.0032	0.0011
Onchocerca volvulus		0.0241	0.0717	0.5012
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.03	0.091	0.091
Schistosoma mansoni	pyruvate kinase	0.0033	0.0032	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0169	0.1991
Echinococcus granulosus	twik family of potassium channels	0.0104	0.0266	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0169	0.0169
Leishmania major	hypothetical protein, conserved	0.0104	0.0266	1
Echinococcus multilocularis	muscleblind protein 1	0.03	0.091	0.0902
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.0169	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0104	0.0266	0.3418
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0079	0.0053
Onchocerca volvulus		0.0451	0.1405	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0266	0.0266
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0032	0.0022
Echinococcus granulosus	PHD finger protein rhinoceros	0.0031	0.0026	0.0004
Loa Loa (eye worm)	TWK-7 protein	0.0104	0.0266	0.0266
Loa Loa (eye worm)	PHD-finger family protein	0.0031	0.0026	0.0026
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0047	0.0022
Schistosoma mansoni	twik family of potassium channels-related	0.0104	0.0266	0.0241
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0169	0.5827
Echinococcus granulosus	peregrin	0.0031	0.0026	0.0004
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0096	0.0928
Echinococcus granulosus	pyruvate kinase	0.0033	0.0032	0.0011
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1668	0.5397	0.5392
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0052	0.0096	0.2714
Schistosoma mansoni	hypothetical protein	0.3071	1	1
Schistosoma mansoni	microtubule-associated protein tau	0.0702	0.223	0.221
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0104	0.0266	0.1639
Toxoplasma gondii	ion channel protein	0.0104	0.0266	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0029	0.0003
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0104	0.0266	0.1639
Echinococcus granulosus	calcium activated potassium channel variant	0.0104	0.0266	0.0245
Schistosoma mansoni	twik family of potassium channels-related	0.0104	0.0266	0.0241
Brugia malayi	Inositol-1	0.0036	0.0044	0.0125
Onchocerca volvulus	Huntingtin homolog	0.0125	0.0335	0.2243

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 678642