Detailed information for compound 679376

Basic information

Technical information
  • TDR Targets ID: 679376
  • Name: STK130056
  • MW: 442.329 | Formula: C20H16BrN3O2S
  • H donors: 3 H acceptors: 2 LogP: 4.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NC(=S)Nc1ccc(cc1)NC(=O)c1cccc2c1cccc2Br
  • InChi: 1S/C20H16BrN3O2S/c1-12(25)22-20(27)24-14-10-8-13(9-11-14)23-19(26)17-6-2-5-16-15(17)4-3-7-18(16)21/h2-11H,1H3,(H,23,26)(H2,22,24,25,27)
  • InChiKey: HTVNNBOYHLHIND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0049 0.0479 0.1432
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0034 0.03 0.0294
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0036 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0049 0.0479 0.0751
Trypanosoma cruzi beta tubulin, putative 0.0019 0.0119 1
Leishmania major beta tubulin 0.0019 0.0119 1
Echinococcus multilocularis glutamate receptor 2 0.0034 0.03 0.0294
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0626 0.1871
Loa Loa (eye worm) hypothetical protein 0.02 0.2281 0.6816
Mycobacterium ulcerans putative regulatory protein 0.0033 0.0286 0.4903
Loa Loa (eye worm) glutamate receptor 2 0.0023 0.0162 0.0484
Leishmania major beta tubulin 0.0019 0.0119 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0012 0.0031 0.0093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0265
Leishmania major beta tubulin 0.0019 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0479 0.1432
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0049 0.0479 0.1432
Schistosoma mansoni aryl hydrocarbon receptor 0.0045 0.0424 0.0662
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0031 0.2171
Onchocerca volvulus 0.0049 0.0479 0.1352
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0089 0.0082
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0031 0.2171
Onchocerca volvulus 0.0049 0.0479 0.1352
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0093
Echinococcus multilocularis lamin 0.0014 0.0056 0.0049
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0095 0.014
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0049 0.0479 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0089 0.7309
Entamoeba histolytica acyl-coA synthetase, putative 0.0012 0.0036 0.0151
Schistosoma mansoni intermediate filament proteins 0.0014 0.0056 0.0078
Echinococcus multilocularis tubulin beta 1 chain 0.0019 0.0119 0.0112
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0012 0.0031 0.0024
Echinococcus granulosus receptor type guanylyl cyclase 0.0012 0.0031 0.0039
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.029 0.3346 0.5304
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0023 0.0162 0.0156
Loa Loa (eye worm) glutamate receptor 1 0.0023 0.0162 0.0484
Loa Loa (eye worm) hypothetical protein 0.0049 0.0479 0.1432
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0089 0.7309
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0049 0.0479 0.0751
Loa Loa (eye worm) serotonin transporter b 0.029 0.3346 1
Echinococcus multilocularis beta tubulin 0.0019 0.0119 0.0112
Loa Loa (eye worm) hypothetical protein 0.0014 0.0056 0.0167
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0095 0.1865
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0093
Loa Loa (eye worm) BEN-1 protein 0.0019 0.0119 0.0355
Echinococcus multilocularis NMDA receptor 0.0023 0.0162 0.0156
Leishmania major beta tubulin 0.0019 0.0119 1
Schistosoma mansoni lamin 0.0014 0.0056 0.0078
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0036 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0031 0.2171
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0036 0.0621
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0014 0.0056 0.0167
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0089 0.013
Loa Loa (eye worm) hypothetical protein 0.0049 0.0479 0.1432
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0089 0.013
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0031 0.2171
Onchocerca volvulus 0.0014 0.0056 0.0075
Schistosoma mansoni sodium-dependent amino acid transporter 0.0049 0.0479 0.0751
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0092
Trypanosoma cruzi extracellular receptor, putative 0.0012 0.0031 0.2176
Schistosoma mansoni hypothetical protein 0.0224 0.2562 0.4058
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0036 0.0089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0093
Brugia malayi Glutamate receptor 2 precursor 0.0023 0.0162 0.0466
Echinococcus granulosus beta tubulin 0.0019 0.0119 0.0178
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0036 0.0089
Loa Loa (eye worm) hypothetical protein 0.0268 0.3088 0.9227
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0012 0.0036 0.0621
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0031 0.2171
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0023 0.0162 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0031 0.2171
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0031 0.0039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0276 0.3178 0.3173
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0031 0.2171
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0095 0.7862
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0089 0.0265
Schistosoma mansoni glutamate receptor kainate 0.0023 0.0162 0.0247
Echinococcus multilocularis glutamate receptor 2 0.0023 0.0162 0.0156
Toxoplasma gondii hypothetical protein 0.0049 0.0479 1
Chlamydia trachomatis glutamine binding protein 0.0058 0.0583 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0012 0.0031 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0265
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0049 0.0479 0.0751
Leishmania major beta tubulin 0.0019 0.0119 1
Schistosoma mansoni glutamate receptor NMDA 0.0023 0.0162 0.0247
Loa Loa (eye worm) hypothetical protein 0.0174 0.1963 0.5867
Brugia malayi bHLH-PAS transcription factor 0.0033 0.0286 0.0836
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0031 0.2171
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0012 0.0031 0.0024
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0626 0.0984
Echinococcus granulosus metabotropic glutamate receptor 5 0.0012 0.0031 0.0039
Echinococcus granulosus atrial natriuretic peptide receptor 0.0012 0.0031 0.0039
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0089 0.0082
Echinococcus granulosus intermediate filament protein 0.0014 0.0056 0.0078
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0049 0.0479 0.1415
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0058 0.0583 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0049 0.0479 0.0751
Echinococcus granulosus tyrosine kinase 0.0012 0.0031 0.0039
Schistosoma mansoni hypothetical protein 0.0023 0.0162 0.0247
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0095 0.0088
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0049 0.0479 0.0473
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0049 0.0479 0.0751
Leishmania major protein kinase, putative 0.0012 0.0031 0.2171
Schistosoma mansoni tubulin subunit beta 0.0019 0.0119 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0031 0.2171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0036 0.0621
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0058 0.0583 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0012 0.0031 0.0093
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.001 0.0007 0.0113
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0049 0.0479 0.0751
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0095 0.1977
Schistosoma mansoni metabotropic glutamate receptor 0.0012 0.0031 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0095 0.0088
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0031 0.0039
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0049 0.0479 0.0473
Echinococcus granulosus sodium and chloride dependent glycine 0.0049 0.0479 0.0751
Echinococcus multilocularis tubulin subunit beta 0.0019 0.0119 0.0112
Brugia malayi hypothetical protein 0.0217 0.2472 0.7383
Brugia malayi isocitrate dehydrogenase 0.0017 0.0095 0.0264
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0089 0.0265
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0031 0.0092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0093
Treponema pallidum sodium- and chloride- dependent transporter 0.029 0.3346 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.029 0.3346 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0031 0.0024
Brugia malayi jmjC domain containing protein 0.0016 0.0089 0.0245
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0174 0.1963 1
Echinococcus granulosus glutamate receptor 2 0.0034 0.03 0.0466
Schistosoma mansoni sodium/chloride dependent transporter 0.0049 0.0479 0.0751
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0108
Trypanosoma brucei beta tubulin 0.0019 0.0119 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0089 0.1847
Brugia malayi Glutamate receptor 1 precursor 0.0023 0.0162 0.0466
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0031 0.2171
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0036 0.0621
Plasmodium vivax JmjC domain containing protein 0.0016 0.0089 0.1847
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0089 0.013
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0031 0.2171
Leishmania major 4-coumarate:coa ligase-like protein 0.0012 0.0036 0.264
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0095 0.7862
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0049 0.0479 0.0751
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0095 0.0088
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.0119 0.0178
Echinococcus granulosus glutamate NMDA receptor subunit 0.0023 0.0162 0.0247
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0095 0.0264
Schistosoma mansoni hypothetical protein 0.0538 0.6304 1
Loa Loa (eye worm) hypothetical protein 0.029 0.3346 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0095 0.1626
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0626 0.0984
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0058 0.0583 0.1725
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0049 0.0479 0.0751
Loa Loa (eye worm) norepinephrine transporter 0.029 0.3346 1
Leishmania major beta tubulin 0.0019 0.0119 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0031 0.2171
Entamoeba histolytica acyl-CoA synthetase, putative 0.0012 0.0036 0.0151
Loa Loa (eye worm) hypothetical protein 0.0049 0.0479 0.1432
Brugia malayi Tubulin beta-1 chain 0.0019 0.0119 0.0336
Schistosoma mansoni single-minded 0.0045 0.0424 0.0662
Entamoeba histolytica tubulin family protein 0.0019 0.0119 0.0573
Trypanosoma brucei beta tubulin 0.0019 0.0119 1
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0089 0.013
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0012 0.0031 0.0093
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0012 0.0036 0.0621
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0089 0.013
Onchocerca volvulus 0.0049 0.0479 0.1352
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0049 0.0479 0.1432
Leishmania major 4-coumarate:coa ligase-like protein 0.0012 0.0036 0.264
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.0119 0.0112
Loa Loa (eye worm) glutamate receptor 0.0012 0.0031 0.0093
Schistosoma mansoni glutamate receptor AMPA 0.0023 0.0162 0.0247
Brugia malayi bZIP transcription factor family protein 0.0276 0.3178 0.9495
Echinococcus multilocularis musashi 0.0014 0.0056 0.0049
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0089 0.1733
Echinococcus multilocularis tyrosine kinase 0.0012 0.0031 0.0024
Schistosoma mansoni tubulin subunit beta 0.0019 0.0119 0.0178
Leishmania major beta tubulin 0.0019 0.0119 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0089 0.0082
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0034 0.03 0.0466
Brugia malayi hypothetical protein 0.0149 0.1673 0.4989
Echinococcus granulosus tubulin beta 1 chain 0.0019 0.0119 0.0178
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0095 0.7862
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0095 0.0283
Schistosoma mansoni ATP-binding cassette transporter 0.0023 0.0162 0.0247
Entamoeba histolytica tubulin family protein 0.0019 0.0119 0.0573
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.0119 0.0178
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0023 0.0162 0.0156
Brugia malayi jmjC domain containing protein 0.0016 0.0089 0.0245
Leishmania major beta tubulin 0.0019 0.0119 1
Brugia malayi Guanylyl cyclase protein 23 0.0012 0.0031 0.0073
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.0119 0.0178
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0049 0.0479 0.8224
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0049 0.0479 0.0751
Brugia malayi hypoxia-induced factor 1 0.0138 0.1535 0.4576
Mycobacterium ulcerans hypothetical protein 0.0012 0.0036 0.0621
Echinococcus granulosus tubulin subunit beta 0.0019 0.0119 0.0178
Plasmodium falciparum transporter, putative 0.0049 0.0479 1
Loa Loa (eye worm) hypothetical protein 0.02 0.2281 0.6816
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0049 0.0479 0.1415
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0093
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0095 0.7862
Echinococcus granulosus lamin dm0 0.0014 0.0056 0.0078
Plasmodium vivax tubulin beta chain, putative 0.0019 0.0119 0.2477
Schistosoma mansoni hypothetical protein 0.0538 0.6304 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0049 0.0479 0.0751
Leishmania major beta tubulin 0.0019 0.0119 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0058 0.0583 0.1725
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0012 0.0036 0.0621
Leishmania major beta tubulin 0.0019 0.0119 1
Giardia lamblia Beta tubulin 0.0019 0.0119 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0031 0.2171
Brugia malayi hypothetical protein 0.0049 0.0479 0.1415
Loa Loa (eye worm) hypothetical protein 0.029 0.3346 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.001 0.0007 0.0138
Loa Loa (eye worm) tubulin beta-1 chain 0.0019 0.0119 0.0355
Leishmania major beta tubulin 0.0019 0.0119 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0031 0.2171
Loa Loa (eye worm) RGC/RGC protein kinase 0.0012 0.0031 0.0093
Trichomonas vaginalis tubulin epsilon chain, putative 0.0019 0.0119 1
Echinococcus multilocularis lamin dm0 0.0014 0.0056 0.0049
Brugia malayi hypothetical protein 0.0012 0.0031 0.0073
Leishmania major hypothetical protein, conserved 0.0016 0.0089 0.7309
Trypanosoma brucei beta tubulin 0.0019 0.0119 1
Echinococcus multilocularis jun protein 0.0276 0.3178 0.3173
Toxoplasma gondii beta-tubulin, putative 0.0019 0.0119 0.2372
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0276 0.3178 0.5036
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0036 0.0089
Toxoplasma gondii hypothetical protein 0.0049 0.0479 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0012 0.0031 0.0024
Schistosoma mansoni sodium/chloride dependent transporter 0.029 0.3346 0.5304
Schistosoma mansoni jun-related protein 0.0224 0.2562 0.4058
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0031 0.2171
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0023 0.0162 0.0156
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0089 0.0265
Trypanosoma brucei beta tubulin 0.0019 0.0119 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.0119 0.0112
Schistosoma mansoni lamin 0.0014 0.0056 0.0078
Giardia lamblia Beta tubulin 0.0019 0.0119 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0034 0.03 0.0294
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0626 0.0984
Loa Loa (eye worm) tubulin beta-2A chain 0.0019 0.0119 0.0355
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.0119 0.0178
Loa Loa (eye worm) BEN-1 protein 0.0019 0.0119 0.0355
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0049 0.0479 1
Loa Loa (eye worm) hypothetical protein 0.029 0.3346 1
Schistosoma mansoni tyrosine kinase 0.0012 0.0031 0.0039
Brugia malayi beta-tubulin, identical 0.0019 0.0119 0.0336
Giardia lamblia Beta tubulin 0.0019 0.0119 1
Onchocerca volvulus 0.0014 0.0056 0.0075
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0031 0.2171
Schistosoma mansoni tubulin subunit beta 0.0019 0.0119 0.0178
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0095 0.1865
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0012 0.0031 0.0073
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0031 0.0024
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.0119 0.0112
Echinococcus granulosus serotonin transporter 0.029 0.3346 0.5304
Brugia malayi jmjC domain containing protein 0.0016 0.0089 0.0245
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0019 0.0119 0.0112
Brugia malayi metabotropic glutamate receptor type 2 0.0012 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0093
Loa Loa (eye worm) beta-tubulin 0.0019 0.0119 0.0355
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0089 0.013
Trichomonas vaginalis tubulin, putative 0.0019 0.0119 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0049 0.0479 0.0751
Entamoeba histolytica acyl-CoA synthetase, putative 0.0012 0.0036 0.0151
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.0119 0.0112
Brugia malayi jmjC domain containing protein 0.0062 0.0626 0.1855
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.001 0.0007 0.0113
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0089 0.0082
Leishmania major beta tubulin 0.0019 0.0119 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0081 0.0852 0.0846
Echinococcus multilocularis sodium and chloride dependent glycine 0.0049 0.0479 0.0473
Brugia malayi Receptor family ligand binding region containing protein 0.0012 0.0031 0.0073
Echinococcus multilocularis sodium and chloride dependent glycine 0.0049 0.0479 0.0473
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0049 0.0479 0.1415
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0034 0.03 0.0466
Brugia malayi Intermediate filament tail domain containing protein 0.0014 0.0056 0.0148
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0012 0.0036 0.0621
Plasmodium falciparum tubulin beta chain 0.0019 0.0119 0.2477
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0626 0.062
Brugia malayi Metabotropic glutamate receptor precursor. 0.0012 0.0031 0.0073
Schistosoma mansoni tubulin subunit beta 0.0019 0.0119 0.0178
Schistosoma mansoni glutamate receptor AMPA 0.0023 0.0162 0.0247
Schistosoma mansoni tubulin subunit beta 0.0019 0.0119 0.0178
Loa Loa (eye worm) hypoxia-induced factor 1 0.0138 0.1535 0.4587
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0012 0.0036 0.0621
Toxoplasma gondii beta tubulin 0.0019 0.0119 0.2372
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0012 0.0031 0.0531
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0174 0.1963 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.0119 0.0112
Schistosoma mansoni glutamate receptor kainate 0.0023 0.0162 0.0247
Leishmania major beta tubulin 0.0019 0.0119 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0089 0.7309
Entamoeba histolytica hypothetical protein 0.0012 0.0031 0.0125
Leishmania major beta tubulin 0.0019 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0479 0.1432
Brugia malayi PAS domain containing protein 0.0045 0.0424 0.1249
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0095 0.7862
Echinococcus granulosus phd:f box containing protein 0.0016 0.0089 0.013
Echinococcus multilocularis serotonin transporter 0.029 0.3346 0.3342
Trichomonas vaginalis tubulin epsilon chain, putative 0.0019 0.0119 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0058 0.0583 1
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0012 0.0031 0.0093
Echinococcus granulosus beta tubulin 0.0019 0.0119 0.0178
Echinococcus multilocularis nmda type glutamate receptor 0.0012 0.0031 0.0024
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.0119 0.0178
Echinococcus granulosus tubulin beta 4A class IVa 0.0019 0.0119 0.0178
Loa Loa (eye worm) tubulin beta-4 chain 0.0019 0.0119 0.0355
Echinococcus multilocularis nmda type glutamate receptor 0.0081 0.0852 0.0846
Plasmodium falciparum amino acid transporter, putative 0.0049 0.0479 1
Trichomonas vaginalis tubulin beta chain, putative 0.0019 0.0119 1
Brugia malayi jmjC domain containing protein 0.0062 0.0626 0.1855
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0095 0.1977
Loa Loa (eye worm) intermediate filament protein 0.0014 0.0056 0.0167
Echinococcus granulosus sodium and chloride dependent glycine 0.0049 0.0479 0.0751
Echinococcus granulosus single minded 2 0.0033 0.0286 0.0443
Schistosoma mansoni glutamate receptor kainate 0.0023 0.0162 0.0247
Toxoplasma gondii beta-1 tubulin, putative 0.0019 0.0119 0.2372
Echinococcus granulosus geminin 0.0538 0.6304 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0036 0.0621
Loa Loa (eye worm) solute carrier family 6 member 4 0.029 0.3346 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0049 0.0479 0.0751
Schistosoma mansoni tubulin subunit beta 0.0019 0.0119 0.0178
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0089 0.0082
Echinococcus multilocularis receptor type guanylyl cyclase 0.0012 0.0031 0.0024
Echinococcus granulosus lamin 0.0014 0.0056 0.0078
Leishmania major beta tubulin 0.0019 0.0119 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0012 0.0036 0.264
Schistosoma mansoni glutamate receptor NMDA 0.0034 0.03 0.0466
Echinococcus granulosus nmda type glutamate receptor 0.0012 0.0031 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0626 0.0984
Onchocerca volvulus 0.0217 0.2472 0.7364
Echinococcus multilocularis glutamate receptor 2 0.0012 0.0031 0.0024
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0049 0.0479 0.0473
Schistosoma mansoni protein kinase 0.0012 0.0031 0.0039
Leishmania major extracellular receptor, putative 0.0012 0.0031 0.2176
Loa Loa (eye worm) RGC/RGC protein kinase 0.0012 0.0031 0.0093
Trichomonas vaginalis tubulin alpha chain, putative 0.0019 0.0119 1
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0089 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0093
Brugia malayi jmjC domain containing protein 0.0016 0.0089 0.0245
Brugia malayi intermediate filament protein 0.0014 0.0056 0.0148
Leishmania major protein kinase, putative 0.0012 0.0031 0.2171
Plasmodium vivax amine transporter, putative 0.0049 0.0479 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0626 0.0984
Schistosoma mansoni tyrosine kinase 0.0012 0.0031 0.0039
Echinococcus multilocularis beta tubulin 0.0019 0.0119 0.0112
Echinococcus granulosus glutamate receptor 2 0.0012 0.0031 0.0039
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0049 0.0479 0.1415
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0089 0.013
Echinococcus granulosus jun protein 0.0276 0.3178 0.5036
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0031 0.2171
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0023 0.0162 0.0156
Onchocerca volvulus 0.0033 0.0286 0.0768
Echinococcus granulosus glutamate receptor subunit protein glur 0.0023 0.0162 0.0247
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0023 0.0162 0.0247
Echinococcus multilocularis transfer RNA-Lys 0.0033 0.0286 0.0279
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0095 0.014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0265
Loa Loa (eye worm) hypothetical protein 0.0049 0.0479 0.1432
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0034 0.03 0.0466
Leishmania major beta tubulin 0.0019 0.0119 1
Echinococcus multilocularis geminin 0.0538 0.6304 0.6301
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0034 0.03 0.0466
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0049 0.0479 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0089 0.1733
Leishmania major beta tubulin 0.0019 0.0119 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0034 0.03 0.0294
Schistosoma mansoni metabotropic glutamate receptor 0.0012 0.0031 0.0039
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0158
Brugia malayi Receptor family ligand binding region containing protein 0.0012 0.0031 0.0073
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0479 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.001 0.0007 0.0138
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0023 0.0162 0.0247
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0034 0.03 0.0294
Echinococcus granulosus nmda type glutamate receptor 0.0081 0.0852 0.1342
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0089 0.013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0095 0.0088
Trichomonas vaginalis tubulin gamma chain, putative 0.0019 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0093
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.001 0.0007 0.002
Onchocerca volvulus 0.0012 0.0036 0.0016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.001 0.0007 0.5
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0031 0.2171
Loa Loa (eye worm) tubulin beta chain 0.0019 0.0119 0.0355
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0049 0.0479 0.0751
Loa Loa (eye worm) hypothetical protein 0.0149 0.1673 0.4999
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0626 0.062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0095 0.0088
Onchocerca volvulus 0.029 0.3346 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0108
Leishmania major beta tubulin 0.0019 0.0119 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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