TDR Targets

Basic information

Technical information

TDR Targets ID: 680376
Name: (E)-N-(1-phenylethyl)-3-(4-propoxyphenyl)prop -2-enamide
MW: 309.402 | Formula: C20H23NO2
H donors: 1 H acceptors: 1 LogP: 4.39 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCOc1ccc(cc1)C=CC(=O)NC(c1ccccc1)C
InChi: 1S/C20H23NO2/c1-3-15-23-19-12-9-17(10-13-19)11-14-20(22)21-16(2)18-7-5-4-6-8-18/h4-14,16H,3,15H2,1-2H3,(H,21,22)/b14-11+
InChiKey: CLHOLHMGLHWWSU-SDNWHVSQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(1-phenylethyl)-3-(4-propoxyphenyl)prop-2-enamide
(E)-N-(1-phenylethyl)-3-(4-propoxyphenyl)acrylamide
N-(1-phenylethyl)-3-(4-propoxyphenyl)acrylamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.019	0.1646	0.1634
Leishmania major	homoserine kinase, putative	0.0105	0.0883	0.2416
Entamoeba histolytica	galactokinase, putative	0.0296	0.2591	1
Schistosoma mansoni	mevalonate kinase	0.0105	0.0883	0.0883
Trypanosoma cruzi	polo-like protein kinase, putative	0.0283	0.2474	0.9482
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.019	0.1646	1
Trichomonas vaginalis	CAMK family protein kinase	0.0283	0.2474	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.019	0.1646	0.1646
Echinococcus multilocularis	cpg binding protein	0.0029	0.0202	0.0202
Mycobacterium ulcerans	homoserine kinase	0.0105	0.0883	0.2416
Loa Loa (eye worm)	hypothetical protein	0.019	0.1646	0.1633
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.019	0.1646	0.1634
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0283	0.2474	0.2474
Schistosoma mansoni	sodium/chloride dependent transporter	0.019	0.1646	0.1646
Trichomonas vaginalis	galactokinase, putative	0.0061	0.0482	0.0673
Toxoplasma gondii	GHMP kinase, putative	0.0105	0.0883	0.3814
Trypanosoma brucei	galactokinase-like protein, putative	0.0191	0.1654	0.616
Trypanosoma cruzi	mevalonate kinase, putative	0.0105	0.0883	0.2416
Trypanosoma brucei	mevalonate kinase, putative	0.0105	0.0883	0.2548
Schistosoma mansoni	cpg binding protein	0.0029	0.0202	0.0202
Plasmodium falciparum	transporter, putative	0.019	0.1646	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.019	0.1646	0.1634
Treponema pallidum	galactokinase	0.0251	0.219	0.0026
Trichomonas vaginalis	CAMK family protein kinase	0.0283	0.2474	1
Brugia malayi	mevalonate kinase family protein	0.0105	0.0883	0.087
Trypanosoma cruzi	galactokinase, putative	0.0251	0.219	0.8222
Trichomonas vaginalis	galactokinase, putative	0.0149	0.1275	0.4386
Onchocerca volvulus		0.019	0.1646	0.1486
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0466	0.0437
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.019	0.1646	0.1633
Treponema pallidum	sodium- and chloride- dependent transporter	0.1121	1	1
Echinococcus granulosus	diphosphomevalonate decarboxylase	0.0045	0.0338	0.0338
Echinococcus multilocularis	galactokinase	0.0296	0.2591	0.2591
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.019	0.1646	0.1646
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.1121	1	1
Leishmania major	phosphomevalonate kinase protein, putative	0.0105	0.0883	0.2416
Plasmodium vivax	hypothetical protein, conserved	0.019	0.1646	1
Trichomonas vaginalis	CAMK family protein kinase	0.014	0.1193	0.4003
Mycobacterium ulcerans	phosphomevalonate kinase	0.0105	0.0883	0.2416
Onchocerca volvulus		0.0045	0.0338	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0338	0.0324
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0466	0.0567
Trichomonas vaginalis	galactokinase, putative	0.0149	0.1275	0.4386
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0883	0.0869
Loa Loa (eye worm)	hypothetical protein	0.1121	1	1
Plasmodium vivax	amine transporter, putative	0.019	0.1646	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.019	0.1646	0.1646
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.019	0.1646	0.1646
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0188	0.0174
Giardia lamblia	Kinase, PLK	0.0283	0.2474	1
Mycobacterium ulcerans	mevalonate kinase, Erg12	0.0105	0.0883	0.2416
Trypanosoma brucei	phosphomevalonate kinase protein, putative	0.0105	0.0883	0.2548
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.019	0.1646	0.1646
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0466	0.0466
Trichomonas vaginalis	galactokinase, putative	0.0149	0.1275	0.4386
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.019	0.1646	1
Trypanosoma cruzi	galactokinase, putative	0.0296	0.2591	1
Schistosoma mansoni	serine/threonine protein kinase	0.0283	0.2474	0.2474
Wolbachia endosymbiont of Brugia malayi	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	0.0249	0.217	0.5
Toxoplasma gondii	hypothetical protein	0.019	0.1646	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0469	0.0469
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.019	0.1646	0.1646
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.019	0.1646	0.1646
Leishmania major	galactokinase-like protein	0.0296	0.2591	1
Trypanosoma cruzi	fucose kinase, putative	0.0061	0.0482	0.0638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.019	0.1646	0.1633
Echinococcus multilocularis	N acetylgalactosamine kinase	0.0149	0.1275	0.1275
Echinococcus multilocularis	sodium and chloride dependent glycine	0.019	0.1646	0.1646
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0283	0.2474	0.2474
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.019	0.1646	1
Giardia lamblia	Mevalonate kinase	0.0105	0.0883	0.2548
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0466	0.0567
Trypanosoma brucei	polo-like protein kinase	0.0283	0.2474	1
Trichomonas vaginalis	galactokinase, putative	0.0149	0.1275	0.4386
Trypanosoma cruzi	galactokinase, putative	0.0296	0.2591	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.1646	0.1633
Trichomonas vaginalis	CAMK family protein kinase	0.014	0.1193	0.4003
Brugia malayi	diphosphomevalonate decarboxylase family protein	0.0045	0.0338	0.0325
Echinococcus granulosus	N acetylgalactosamine kinase	0.0149	0.1275	0.1275
Mycobacterium ulcerans	hypothetical protein	0.0107	0.09	0.2494
Schistosoma mansoni	cpg binding protein	0.0029	0.0202	0.0202
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0466	0.0567
Onchocerca volvulus		0.019	0.1646	0.1486
Trichomonas vaginalis	CAMK family protein kinase	0.0283	0.2474	1
Mycobacterium ulcerans	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	0.0249	0.217	0.8133
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.019	0.1646	0.1646
Loa Loa (eye worm)	hypothetical protein	0.019	0.1646	0.1633
Loa Loa (eye worm)	hypothetical protein	0.019	0.1646	0.1633
Loa Loa (eye worm)	hypothetical protein	0.1121	1	1
Onchocerca volvulus		0.019	0.1646	0.1486
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.019	0.1646	0.1646
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0466	0.0567
Mycobacterium tuberculosis	Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)	0.0143	0.1225	0.3938
Echinococcus multilocularis	serotonin transporter	0.1121	1	1
Brugia malayi	hypothetical protein	0.019	0.1646	0.1634
Loa Loa (eye worm)	norepinephrine transporter	0.1121	1	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1121	1	1
Schistosoma mansoni	kinase	0.0144	0.1227	0.1227
Echinococcus multilocularis	Mevalonate galactokinase	0.0105	0.0883	0.0883
Mycobacterium ulcerans	galactokinase	0.0296	0.2591	1
Echinococcus granulosus	Mevalonate galactokinase	0.0105	0.0883	0.0883
Echinococcus multilocularis	diphosphomevalonate decarboxylase	0.0045	0.0338	0.0338
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.019	0.1646	0.1646
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.019	0.1646	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0283	0.2474	0.9482
Trypanosoma cruzi	galactokinase-like protein, putative	0.0251	0.219	0.8222
Schistosoma mansoni	galactokinase	0.0149	0.1275	0.1275
Mycobacterium leprae	Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)	0.0249	0.217	1
Echinococcus granulosus	galactokinase	0.0296	0.2591	0.2591
Toxoplasma gondii	hypothetical protein	0.019	0.1646	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.019	0.1646	0.1646
Trichomonas vaginalis	CAMK family protein kinase	0.0283	0.2474	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0283	0.2474	0.2463
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.019	0.1646	0.1646
Trichomonas vaginalis	CAMK family protein kinase	0.0283	0.2474	1
Schistosoma mansoni	diphosphomevalonate decarboxylase	0.0045	0.0338	0.0338
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0466	0.0466
Schistosoma mansoni	sodium/chloride dependent transporter	0.1121	1	1
Trypanosoma cruzi	fucose kinase, putative	0.0061	0.0482	0.0638
Echinococcus granulosus	cpg binding protein	0.0029	0.0202	0.0202
Mycobacterium tuberculosis	Possible D-alpha-D-heptose-7-phosphate kinase HddA	0.0105	0.0883	0.2416
Loa Loa (eye worm)	galactokinase	0.0149	0.1275	0.1262
Trichomonas vaginalis	CAMK family protein kinase	0.0283	0.2474	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.019	0.1646	0.1633
Leishmania major	mevalonate kinase, putative	0.0105	0.0883	0.2416
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0015	0.0015
Trypanosoma brucei	homoserine kinase	0.0105	0.0883	0.2548
Loa Loa (eye worm)	solute carrier family 6 member 4	0.1121	1	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.019	0.1646	0.1646
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.019	0.1646	0.1646
Brugia malayi	galactokinase family protein	0.0149	0.1275	0.1263
Mycobacterium tuberculosis	Probable galactokinase GalK (galactose kinase)	0.0296	0.2591	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0283	0.2474	0.233
Echinococcus granulosus	serotonin transporter	0.1121	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0466	0.0567
Toxoplasma gondii	GHMP kinase, N-terminal domain-containing protein	0.0149	0.1275	0.6996
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0188	0.0173
Onchocerca volvulus		0.1121	1	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.019	0.1646	0.1646
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.019	0.1646	0.1634
Loa Loa (eye worm)	hypothetical protein	0.019	0.1646	0.1633
Schistosoma mansoni	cpg binding protein	0.0028	0.0188	0.0188
Trypanosoma cruzi	polo-like protein kinase, putative	0.0283	0.2474	0.9482
Loa Loa (eye worm)	serotonin transporter b	0.1121	1	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.019	0.1646	0.1646
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.019	0.1646	0.1646
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.019	0.1646	0.1646
Trypanosoma cruzi	homoserine kinase	0.0105	0.0883	0.2416
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.019	0.1646	0.1633
Trypanosoma cruzi	homoserine kinase	0.0105	0.0883	0.2416
Trichomonas vaginalis	CAMK family protein kinase	0.0283	0.2474	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.019	0.1646	0.1646
Plasmodium falciparum	amino acid transporter, putative	0.019	0.1646	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0283	0.2474	0.2464
Schistosoma mansoni	sodium/chloride dependent transporter	0.0191	0.1654	0.1654

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 680376