Detailed information for compound 683064

Basic information

Technical information
  • TDR Targets ID: 683064
  • Name: 2-[3-[[(4-ethylphenyl)amino]methyl]-6,7-dimet hoxy-2-oxoquinolin-1-yl]-N-(2-methylphenyl)ac etamide
  • MW: 485.574 | Formula: C29H31N3O4
  • H donors: 2 H acceptors: 2 LogP: 5.01 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2cc(CNc3ccc(cc3)CC)c(=O)n(c2cc1OC)CC(=O)Nc1ccccc1C
  • InChi: 1S/C29H31N3O4/c1-5-20-10-12-23(13-11-20)30-17-22-14-21-15-26(35-3)27(36-4)16-25(21)32(29(22)34)18-28(33)31-24-9-7-6-8-19(24)2/h6-16,30H,5,17-18H2,1-4H3,(H,31,33)
  • InChiKey: CLKRJVOGOYNHKM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-[[(4-ethylphenyl)amino]methyl]-6,7-dimethoxy-2-oxo-1-quinolyl]-N-(2-methylphenyl)acetamide
  • 2-[3-[[(4-ethylphenyl)amino]methyl]-2-keto-6,7-dimethoxy-1-quinolyl]-N-(2-methylphenyl)acetamide
  • 2-[3-[[(4-ethylphenyl)amino]methyl]-6,7-dimethoxy-2-oxo-quinolin-1-yl]-N-(2-methylphenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Alhambra homolog 0.0031 0.0109 0.0389
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.1166 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.1213
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0149 0.0993
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0131 0.0191
Loa Loa (eye worm) RNA binding protein 0.0063 0.039 0.0358
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.006 0.1213
Schistosoma mansoni tar DNA-binding protein 0.0063 0.039 0.0758
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0381 0.074
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2425 1
Brugia malayi Carboxylesterase family protein 0.0022 0.0033 0.0019
Entamoeba histolytica hypothetical protein 0.0035 0.0148 0.065
Schistosoma mansoni chromobox protein 0.0146 0.1116 0.2168
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0049 0.0094
Trypanosoma cruzi polo-like protein kinase, putative 0.0199 0.1574 0.6402
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1063 0.4243
Trichomonas vaginalis CAMK family protein kinase 0.0199 0.1574 0.7862
Brugia malayi PAS domain containing protein 0.0048 0.0258 0.0244
Echinococcus multilocularis cpg binding protein 0.003 0.0104 0.014
Echinococcus granulosus chromobox protein 1 0.0146 0.1116 0.2118
Trichomonas vaginalis chromobox protein, putative 0.0146 0.1116 0.5525
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.039 0.0358
Echinococcus multilocularis GPCR, family 2 0.0033 0.0131 0.0191
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0283 0.0945
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0109 0.0077
Schistosoma mansoni kinase 0.0101 0.0723 0.1405
Brugia malayi jmjC domain containing protein 0.0039 0.018 0.0166
Giardia lamblia Kinase, PLK 0.0199 0.1574 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0105 0.0758 0.0727
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.018 0.0351
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0283 0.0944
Entamoeba histolytica hypothetical protein 0.0034 0.0139 0.0593
Loa Loa (eye worm) hypothetical protein 0.0064 0.0401 0.0369
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0109 0.0149
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0156 0.0407
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.1213
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.01 0.0132
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0156 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0139 0.054
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0033 0.0064
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0049 0.0034
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.1732 0.1705
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0283 0.1276
Echinococcus multilocularis peregrin 0.0031 0.0109 0.0149
Schistosoma mansoni cpg binding protein 0.003 0.0104 0.0203
Brugia malayi Cytochrome P450 family protein 0.0022 0.0034 0.002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0083
Echinococcus granulosus tar DNA binding protein 0.0063 0.039 0.0699
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0116 0.0162
Loa Loa (eye worm) hypothetical protein 0.0149 0.1143 0.1113
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0283 0.0945
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0199 0.1574 0.1546
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0049 0.0079
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.039 0.0377
Brugia malayi hypothetical protein 0.0484 0.4059 0.4051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0231 0.0449
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0283 0.0489
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0203 0.0607
Loa Loa (eye worm) acetylcholinesterase 1 0.0131 0.0984 0.0954
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0258 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0346 0.1598
Echinococcus multilocularis muscleblind protein 0.0149 0.1143 0.217
Trichomonas vaginalis chromobox protein, putative 0.0146 0.1116 0.5525
Schistosoma mansoni hypothetical protein 0.0031 0.0109 0.0213
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0105 0.0369
Schistosoma mansoni inositol monophosphatase 0.0036 0.0156 0.0303
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.076 0.0747
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0283 0.0489
Entamoeba histolytica hypothetical protein 0.0035 0.0148 0.065
Echinococcus multilocularis chromobox protein 1 0.0146 0.1116 0.2118
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0016
Schistosoma mansoni cpg binding protein 0.003 0.0104 0.0203
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.1574 0.3058
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.006 0.0398
Onchocerca volvulus 0.0035 0.0149 0.0592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0231 0.0449
Trypanosoma brucei protein kinase, putative 0.0051 0.0283 0.0945
Schistosoma mansoni hypothetical protein 0.0033 0.0131 0.0254
Echinococcus granulosus cpg binding protein 0.003 0.0104 0.014
Echinococcus multilocularis survival motor neuron protein 1 0.0484 0.4059 0.7874
Schistosoma mansoni tar DNA-binding protein 0.0063 0.039 0.0758
Echinococcus granulosus chromobox protein 1 0.0146 0.1116 0.2118
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0116 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0049 0.0079
Schistosoma mansoni microtubule-associated protein tau 0.0609 0.5146 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0123 0.5
Schistosoma mansoni hypothetical protein 0.0099 0.07 0.1361
Echinococcus multilocularis carboxylesterase 5A 0.0131 0.0984 0.186
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0016
Brugia malayi beta-NAC-like protein 0.0034 0.0139 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0063 0.039 0.0758
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0116 0.0162
Toxoplasma gondii hypothetical protein 0.0048 0.0257 0.7551
Echinococcus granulosus Chromo domain 0.0024 0.0049 0.003
Plasmodium vivax SET domain protein, putative 0.0032 0.0116 0.7439
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0231 0.0388
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0049 0.0079
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0105 0.0369
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0139 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0079 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0139 0.054
Loa Loa (eye worm) TAR-binding protein 0.0063 0.039 0.0358
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0123 0.0767
Schistosoma mansoni tar DNA-binding protein 0.0063 0.039 0.0758
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.076 0.0747
Trichomonas vaginalis hypothetical protein 0.0024 0.0049 0.0079
Schistosoma mansoni fatty acid binding protein 0.0077 0.0513 0.0996
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0049 0.0079
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0283 0.1276
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0723 0.1349
Entamoeba histolytica serine/threonine protein kinase, putative 0.0199 0.1574 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0049 0.0094
Loa Loa (eye worm) heterochromatin protein 1 0.0146 0.1116 0.1087
Brugia malayi MH2 domain containing protein 0.0105 0.0758 0.0745
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0049 0.0079
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0156 0.0703
Echinococcus multilocularis chromobox protein 2 0.0024 0.0049 0.003
Mycobacterium ulcerans hypothetical protein 0.0156 0.1202 1
Brugia malayi Inositol-1 0.0036 0.0156 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0199 0.1574 0.7862
Echinococcus multilocularis transcription factor btf3 0.0034 0.0139 0.0207
Brugia malayi Muscleblind-like protein 0.0149 0.1143 0.113
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.018 0.0288
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0049 0.0094
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0156 0.5
Schistosoma mansoni fatty acid binding protein 0.0077 0.0513 0.0996
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0215 0.0356
Echinococcus multilocularis acetylcholinesterase 0.0131 0.0984 0.186
Echinococcus multilocularis acetylcholinesterase 0.0131 0.0984 0.186
Onchocerca volvulus 0.0024 0.0049 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0105 0.0369
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.07 0.0687
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0156 0.0407
Echinococcus multilocularis geminin 0.0341 0.2814 0.5438
Schistosoma mansoni acetylcholinesterase 0.0022 0.0033 0.0064
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0049 0.003
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0033 0.0064
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0139 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0156 0.0303
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0149 0.0227
Onchocerca volvulus Serine\/threonine kinase homolog 0.0199 0.1574 0.7862
Trypanosoma cruzi polo-like protein kinase, putative 0.0199 0.1574 0.6402
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0034 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0139 0.054
Schistosoma mansoni survival motor neuron protein 0.0099 0.07 0.1361
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0166 0.026
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0199 0.1574 0.3014
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0199 0.1574 0.6402
Brugia malayi PHD-finger family protein 0.0031 0.0109 0.0095
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0149 0.0135
Schistosoma mansoni single-minded 0.0048 0.0258 0.0501
Trichomonas vaginalis CAMK family protein kinase 0.0199 0.1574 0.7862
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0156 0.3893
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0063 0.0058
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0283 0.0945
Echinococcus granulosus Chromobox protein 3 0.0024 0.0049 0.003
Brugia malayi MAP kinase sur-1 0.0051 0.0283 0.0269
Schistosoma mansoni hypothetical protein 0.0072 0.0469 0.0911
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0131 0.0117
Echinococcus granulosus single minded 2 0.0035 0.0149 0.0227
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0156 0.0407
Echinococcus granulosus fatty acid binding protein FABP2 0.0077 0.0513 0.0938
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0109 0.2206
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0049 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0116 0.0225
Schistosoma mansoni hypothetical protein 0.0341 0.2814 0.5467
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0131 0.0984 0.1912
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0131 0.0191
Brugia malayi Protein cec-1. 0.0024 0.0049 0.0034
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0109 0.0213
Brugia malayi Carboxylesterase family protein 0.0022 0.0033 0.0019
Loa Loa (eye worm) hypothetical protein 0.0131 0.0984 0.0954
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0109 0.0149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0116 0.0225
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0131 0.0191
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0231 0.0199
Leishmania major basic transcription factor 3a, putative 0.0034 0.0139 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0063 0.039 0.0758
Loa Loa (eye worm) hypothetical protein 0.0106 0.076 0.0729
Brugia malayi Pre-SET motif family protein 0.0032 0.0116 0.0102
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.1134 0.1104
Loa Loa (eye worm) hypothetical protein 0.0033 0.0131 0.0098
Echinococcus multilocularis chromobox protein 1 0.0146 0.1116 0.2118
Brugia malayi Heterochromatin protein 1 0.0146 0.1116 0.1103
Loa Loa (eye worm) inositol-1 0.0036 0.0156 0.0123
Loa Loa (eye worm) transcription factor SMAD2 0.0105 0.0758 0.0727
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0049 0.003
Echinococcus granulosus microtubule associated protein 2 0.0609 0.5146 1
Loa Loa (eye worm) carboxylesterase 0.0131 0.0984 0.0954
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0131 0.0191
Trichomonas vaginalis chromobox protein, putative 0.0088 0.0609 0.2941
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0063 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.018 0.0148
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.009 0.0057
Echinococcus granulosus fatty acid binding protein FABP2 0.0077 0.0513 0.0938
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0116 0.2441
Brugia malayi TAR-binding protein 0.0063 0.039 0.0377
Schistosoma mansoni hypothetical protein 0.0035 0.0148 0.0287
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0131 0.0098
Echinococcus granulosus peregrin 0.0031 0.0109 0.0149
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.018 0.0351
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0016
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.2425 1
Schistosoma mansoni hypothetical protein 0.0033 0.0131 0.0254
Trichomonas vaginalis CAMK family protein kinase 0.0199 0.1574 0.7862
Brugia malayi hypothetical protein 0.0035 0.0148 0.0134
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0049 0.0079
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0723 0.1349
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1202 1
Echinococcus multilocularis fatty acid binding protein FABP2 0.0077 0.0513 0.0938
Entamoeba histolytica hypothetical protein 0.0035 0.0148 0.065
Loa Loa (eye worm) hypothetical protein 0.0149 0.1143 0.1113
Schistosoma mansoni hypothetical protein 0.0033 0.0131 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0555 0.2663
Onchocerca volvulus 0.0064 0.0401 0.1875
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0346 0.1598
Brugia malayi hypothetical protein 0.0161 0.1242 0.123
Schistosoma mansoni transcription factor btf3 0.0034 0.0139 0.027
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0203 0.0607
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0063 0.0122
Loa Loa (eye worm) helicase 0.0024 0.0049 0.0016
Loa Loa (eye worm) hypothetical protein 0.0072 0.0469 0.0437
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0199 0.1574 0.3014
Onchocerca volvulus 0.0099 0.07 0.3404
Trichomonas vaginalis chromobox protein, putative 0.0088 0.0609 0.2941
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0283 0.0489
Trichomonas vaginalis set domain proteins, putative 0.0247 0.1993 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0283 0.0945
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0283 0.0489
Echinococcus granulosus transcription factor btf3 0.0034 0.0139 0.0207
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0156 0.0627
Brugia malayi Carboxylesterase family protein 0.0022 0.0033 0.0019
Echinococcus granulosus survival motor neuron protein 1 0.0484 0.4059 0.7874
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0283 0.055
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0283 0.0251
Schistosoma mansoni chromobox protein 0.0146 0.1116 0.2168
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0469 0.0455
Schistosoma mansoni chromobox protein 0.0024 0.0049 0.0094
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0231 0.0388
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0283 0.0945
Loa Loa (eye worm) hypothetical protein 0.0161 0.1242 0.1213
Trichomonas vaginalis CAMK family protein kinase 0.0199 0.1574 0.7862
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0555 0.2663
Echinococcus multilocularis Chromo domain 0.0024 0.0049 0.003
Echinococcus granulosus acetylcholinesterase 0.0131 0.0984 0.186
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0148 0.0224
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.07 0.3404
Trichomonas vaginalis CAMK family protein kinase 0.0199 0.1574 0.7862
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0283 0.0945
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0049 0.0079
Brugia malayi hypothetical protein 0.0024 0.0049 0.0034
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0139 0.0593
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0105 0.0369
Loa Loa (eye worm) hypothetical protein 0.0131 0.0984 0.0954
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0079 0.0234
Brugia malayi serine/threonine-protein kinase plk-2 0.0199 0.1574 0.1562
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0075 0.0213
Entamoeba histolytica hypothetical protein 0.0035 0.0148 0.065
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0397 0.0365
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0541 0.1052
Echinococcus granulosus carboxylesterase 5A 0.0131 0.0984 0.186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0116 0.0225
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0088 0.0609 0.2941
Brugia malayi Carboxylesterase family protein 0.0131 0.0984 0.0971
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0105 0.0369
Schistosoma mansoni cpg binding protein 0.0029 0.009 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0049 0.0079
Brugia malayi hypothetical protein 0.0022 0.0033 0.0019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0324 1
Brugia malayi CHD4 protein 0.0026 0.0063 0.0049
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0283 0.8512
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1063 0.4243
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0109 0.2206
Echinococcus granulosus muscleblind protein 0.0149 0.1143 0.217
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0215 0.0356
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0105 0.0369
Echinococcus multilocularis microtubule associated protein 2 0.0609 0.5146 1
Plasmodium falciparum phd finger protein, putative 0.0031 0.0109 0.6725
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0283 0.1276
Onchocerca volvulus 0.0056 0.0325 0.1488
Echinococcus granulosus geminin 0.0341 0.2814 0.5438
Schistosoma mansoni hypothetical protein 0.0033 0.0131 0.0254
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1063 0.4243
Brugia malayi SET domain containing protein 0.0026 0.0064 0.005
Loa Loa (eye worm) hypothetical protein 0.0053 0.0302 0.027
Loa Loa (eye worm) hypothetical protein 0.0082 0.0555 0.0524
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0049 0.0034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0131 0.0117
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0049 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0231 0.0388
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0049 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0027
Brugia malayi hypothetical protein 0.0025 0.006 0.0045
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0139 0.0106
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0148 0.0287
Echinococcus multilocularis fatty acid binding protein FABP2 0.0077 0.0513 0.0938
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0033 0.0064
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0156 0.1051
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0063 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0016
Schistosoma mansoni hypothetical protein 0.0024 0.0049 0.0094
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0139 0.0336
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0283 0.0945
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0105 0.0369
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0156 0.024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.076 0.0729
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0156 0.0407
Onchocerca volvulus 0.0024 0.0049 0.0079
Brugia malayi Carboxylesterase family protein 0.0131 0.0984 0.0971
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0156 0.0627
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0105 0.0369
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0082 0.0555 0.2663
Schistosoma mansoni gliotactin 0.0022 0.0033 0.0064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0016
Loa Loa (eye worm) hypothetical protein 0.0484 0.4059 0.404
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0231 0.0388
Brugia malayi CXXC zinc finger family protein 0.0029 0.009 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0049 0.0079
Schistosoma mansoni hypothetical protein 0.0341 0.2814 0.5467
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0049 0.0034
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0033 0.0064
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0139 0.3281
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0049 0.0079
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.2425 1
Onchocerca volvulus 0.0029 0.009 0.0291
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0203 0.0607
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0109 0.6725
Echinococcus multilocularis tar DNA binding protein 0.0063 0.039 0.0699
Echinococcus granulosus chromobox protein 2 0.0024 0.0049 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0283 0.1276
Brugia malayi RNA binding protein 0.0063 0.039 0.0377
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0033 0.0064
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0148 0.0224
Trichomonas vaginalis CAMK family protein kinase 0.0199 0.1574 0.7862
Brugia malayi jmjC domain containing protein 0.0101 0.0723 0.071
Loa Loa (eye worm) hypothetical protein 0.0031 0.0109 0.0077
Brugia malayi Bromodomain containing protein 0.0031 0.0109 0.0095
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0049 0.0079
Onchocerca volvulus 0.0247 0.1993 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0139 0.0336
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0156 0.0627
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0016
Trypanosoma brucei polo-like protein kinase 0.0199 0.1574 0.6402
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0231 0.0217
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1143 0.217
Schistosoma mansoni chromobox protein 0.0024 0.0049 0.0094
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2425 1
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0283 0.1187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0231 0.0449
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0056 0.0325 0.0631
Brugia malayi hypoxia-induced factor 1 0.0148 0.1134 0.1121
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.07 0.3404
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0049 0.0079
Echinococcus granulosus acetylcholinesterase 0.0131 0.0984 0.186
Brugia malayi chromobox protein homolog 3 0.0082 0.0555 0.0542
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0049 0.0079
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0203 0.0607
Brugia malayi Carboxylesterase family protein 0.0022 0.0033 0.0019
Brugia malayi Pre-SET motif family protein 0.0217 0.1732 0.1721
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0139 1
Echinococcus granulosus GPCR family 2 0.0033 0.0131 0.0191
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0049 0.0034

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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