Detailed information for compound 694113

Basic information

Technical information
  • TDR Targets ID: 694113
  • Name: N-[[1-(4-fluorophenyl)tetrazol-5-yl]methyl]-4 -methoxybenzenesulfonamide
  • MW: 363.367 | Formula: C15H14FN5O3S
  • H donors: 1 H acceptors: 5 LogP: 1.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)S(=O)(=O)NCc1nnnn1c1ccc(cc1)F
  • InChi: 1S/C15H14FN5O3S/c1-24-13-6-8-14(9-7-13)25(22,23)17-10-15-18-19-20-21(15)12-4-2-11(16)3-5-12/h2-9,17H,10H2,1H3
  • InChiKey: SOTHACYFTYRZQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[1-(4-fluorophenyl)tetrazol-5-yl]methyl]-4-methoxy-benzenesulfonamide
  • N-[[1-(4-fluorophenyl)-5-tetrazolyl]methyl]-4-methoxybenzenesulfonamide
  • N-[[1-(4-fluorophenyl)-1,2,3,4-tetrazol-5-yl]methyl]-4-methoxy-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.0421 0.1551
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0078 0.0078
Brugia malayi MH2 domain containing protein 0.0239 0.0421 0.1551
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0089 0.0311
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0078 0.0808
Mycobacterium ulcerans beta-lactamase 0.0073 0.0078 0.025
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.008 0.0829
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0078 0.0808
Plasmodium falciparum thioredoxin reductase 0.0091 0.0115 0.0102
Onchocerca volvulus 0.0478 0.0913 0.7895
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0117 0.1239
Trypanosoma brucei unspecified product 0.0041 0.0011 0.0024
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0467 0.0889 0.3275
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0117 0.0117
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1342 0.2691 1
Brugia malayi Inositol-1 0.0074 0.008 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Loa Loa (eye worm) IMP dehydrogenase 1 0.1342 0.2691 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0078 0.025
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0078 0.0808
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.0413 0.0413
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.008 0.0829
Brugia malayi hypothetical protein 0.0078 0.0089 0.0314
Loa Loa (eye worm) glutathione reductase 0.0091 0.0115 0.0413
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.008 0.028
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0087
Mycobacterium leprae Probable lipase LipE 0.0073 0.0078 0.0054
Plasmodium falciparum glutathione reductase 0.0091 0.0115 0.0102
Toxoplasma gondii hypothetical protein 0.0047 0.0025 0.0076
Echinococcus granulosus neuropeptide receptor A26 0.0967 0.1918 0.1918
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0073 0.0078 0.0276
Schistosoma mansoni microtubule-associated protein tau 0.4894 1 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.1342 0.2691 0.2691
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0022 0.0185
Brugia malayi beta-lactamase 0.0073 0.0078 0.0276
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.1342 0.2691 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0052 0.0052
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0073 0.0078 0.0276
Trichomonas vaginalis set domain proteins, putative 0.0478 0.0913 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0091 0.0115 0.0387
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0052 0.0052
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0011 0.0024
Giardia lamblia Kinase, PLK 0.0092 0.0117 1
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0078 0.025
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0052 0.0052
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0013 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.1342 0.2691 0.2691
Echinococcus granulosus dna polymerase kappa 0.0041 0.0011 0.0011
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0028 0.0028
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0028 0.0028
Onchocerca volvulus 0.0073 0.0078 0.0453
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0041 0.0138
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0078 0.0078
Mycobacterium ulcerans hypothetical protein 0.0073 0.0078 0.025
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0078 0.025
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0078 0.0078
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0078 0.0276
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0055 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0078 0.0089 0.0314
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0073 0.0078 0.0276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0413 0.0413
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0011 0.007
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0593 0.1149 0.426
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0089 0.0311
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1342 0.2691 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0011 0.0565
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.004 0.0131
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0117 0.0419
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0011 0.0024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0207 0.0355 0.1282
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0071 0.0071
Schistosoma mansoni inositol monophosphatase 0.0074 0.008 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0413 0.0413
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0207 0.0355 0.1106
Echinococcus multilocularis neuropeptide receptor A26 0.0967 0.1918 0.1918
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.1342 0.2691 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0078 0.0276
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0117 0.1239
Brugia malayi glutathione reductase 0.0091 0.0115 0.0413
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.1342 0.2691 1
Schistosoma mansoni inositol monophosphatase 0.0074 0.008 0.008
Echinococcus granulosus tumor protein p63 0.1324 0.2654 0.2654
Loa Loa (eye worm) MBCTL1 0.0055 0.0041 0.0138
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0005 0.0005
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.1342 0.2691 0.2691
Onchocerca volvulus 0.0098 0.0129 0.0903
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0071 0.0071
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0011 0.0011
Echinococcus granulosus neuropeptide s receptor 0.0967 0.1918 0.1918
Loa Loa (eye worm) hypothetical protein 0.0194 0.0327 0.1201
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0071 0.0245
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0041 0.0041
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0073 0.0078 0.0276
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0117 0.1239
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.042 0.0793 0.2936
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0117 1
Loa Loa (eye worm) GMP reductase 0.0593 0.1149 0.426
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.0241 0.0241
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0275 0.1008
Brugia malayi beta-lactamase family protein 0.0073 0.0078 0.0276
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0011 0.0011
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.008 0.028
Plasmodium vivax thioredoxin reductase, putative 0.0091 0.0115 0.0239
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0028 0.0087
Brugia malayi GMP reductase 0.0593 0.1149 0.426
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.008 0.0829
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0236 0.0413 0.1522
Mycobacterium tuberculosis Conserved protein 0.0073 0.0078 0.025
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0011 0.0024
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.0531 0.196
Brugia malayi TAR-binding protein 0.0062 0.0055 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0117 0.1239
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0078 0.025
Leishmania major hypothetical protein, conserved 0.0078 0.0089 0.0311
Brugia malayi RNA binding protein 0.0062 0.0055 0.0188
Toxoplasma gondii thioredoxin reductase 0.0091 0.0115 0.041
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.008 0.6695
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0231 0.0403 0.1288
Trypanosoma cruzi GMP reductase 0.1342 0.2691 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0117 0.0421
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0593 0.1149 0.4244
Mycobacterium tuberculosis Conserved protein 0.0073 0.0078 0.025
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0011 0.0024
Brugia malayi Thioredoxin reductase 0.0091 0.0115 0.0413
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0055 0.0055
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.032 0.032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.004 0.0131
Brugia malayi mbt repeat family protein 0.0048 0.0028 0.0087
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0531 0.196
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0028 0.0028
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0214 0.0777
Trypanosoma brucei trypanothione reductase 0.0091 0.0115 0.041
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0117 0.0421
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0117 0.0117
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.018 0.018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0275 0.0275
Leishmania major inosine-5-monophosphate dehydrogenase 0.1342 0.2691 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0117 0.0419
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0078 0.0808
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0117 0.1239
Brugia malayi Pre-SET motif family protein 0.006 0.0052 0.0178
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0011 0.0026
Mycobacterium ulcerans hypothetical protein 0.0154 0.0246 0.0875
Trypanosoma brucei polo-like protein kinase 0.0092 0.0117 0.0419
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0041 0.0011 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0413 0.0413
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0117 0.1239
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0011 0.0011
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.008 0.028
Loa Loa (eye worm) hypothetical protein 0.0054 0.004 0.0131
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.1342 0.2691 1
Onchocerca volvulus 0.006 0.0052 0.0219
Mycobacterium tuberculosis Probable oxidoreductase 0.0231 0.0403 0.146
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0005 0.0005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0207 0.0355 0.1282
Schistosoma mansoni cellular tumor antigen P53 0.0194 0.0327 0.0327
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.1342 0.2691 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0052 0.0052
Echinococcus multilocularis dna polymerase eta 0.0041 0.0011 0.0011
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0041 0.0041
Brugia malayi hypothetical protein 0.005 0.0032 0.0102
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0207 0.0355 0.1282
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.1342 0.2691 1
Trypanosoma brucei GMP reductase 0.1342 0.2691 1
Schistosoma mansoni DNA polymerase eta 0.0041 0.0011 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0071 0.0222
Loa Loa (eye worm) hypothetical protein 0.0055 0.0041 0.0138
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0064 0.0198
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0214 0.0777
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0013 0.0029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.0413 0.0413
Echinococcus multilocularis thioredoxin glutathione reductase 0.0091 0.0116 0.0116
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0078 0.025
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0052 0.0052
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0089 0.0311
Schistosoma mansoni hypothetical protein 0.0037 0.0004 0.0004
Plasmodium vivax glutathione reductase, putative 0.0091 0.0115 0.0239
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.1342 0.2691 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0422 0.1553
Schistosoma mansoni hypothetical protein 0.0122 0.018 0.018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.008 0.028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0214 0.0777
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0071 0.0071
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1342 0.2691 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0531 0.196
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0052 0.0175
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0117 0.0419
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0078 0.0273
Echinococcus multilocularis neuropeptide s receptor 0.0967 0.1918 0.1918
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0241 0.0241
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.004 0.0131
Leishmania major hypothetical protein, conserved 0.0073 0.0078 0.0273
Leishmania major guanosine monophosphate reductase 0.1342 0.2691 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0275 0.1008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0055 0.0055
Mycobacterium tuberculosis Conserved protein 0.0073 0.0078 0.025
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0041 0.0041
Onchocerca volvulus Putative GMP reductase 0.0593 0.1149 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.0413 0.0413
Loa Loa (eye worm) beta-lactamase 0.0073 0.0078 0.0276
Brugia malayi mbt repeat family protein 0.0048 0.0028 0.0087
Trichomonas vaginalis esterase, putative 0.0073 0.0078 0.0808
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.008 0.008
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0207 0.0355 0.1282
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0011 0.007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0071 0.0222
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0078 0.025
Schistosoma mansoni alpha-glucosidase 0.0145 0.0227 0.0227
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0117 0.0802
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0055 0.0188
Brugia malayi Pre-SET motif family protein 0.042 0.0793 0.2936
Schistosoma mansoni alpha glucosidase 0.0037 0.0005 0.0005
Schistosoma mansoni alpha-glucosidase 0.0145 0.0227 0.0227
Schistosoma mansoni kinase 0.0047 0.0024 0.0024
Onchocerca volvulus 0.0194 0.0327 0.2671
Loa Loa (eye worm) hypothetical protein 0.0073 0.0078 0.0276
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1342 0.2691 1
Leishmania major DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Mycobacterium ulcerans lipase LipD 0.0073 0.0078 0.025
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0078 0.025
Leishmania major DNA polymerase eta, putative 0.0041 0.0011 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0078 0.0273
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0028 0.0028
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0078 0.025
Onchocerca volvulus 0.0073 0.0078 0.0453
Trypanosoma cruzi GMP reductase 0.1342 0.2691 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0071 0.0222
Schistosoma mansoni hypothetical protein 0.0294 0.0533 0.0533
Loa Loa (eye worm) thioredoxin reductase 0.0091 0.0115 0.0413
Loa Loa (eye worm) RNA binding protein 0.0062 0.0055 0.0188
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1342 0.2691 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0022 0.0185
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0078 0.025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0055 0.0188
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0048 0.0048
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0055 0.0188
Mycobacterium tuberculosis Probable reductase 0.0207 0.0355 0.1282
Mycobacterium tuberculosis Probable dehydrogenase 0.0207 0.0355 0.1282
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0117 0.0117
Echinococcus multilocularis microtubule associated protein 2 0.4894 1 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.0055 0.0055
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0749 0.147 0.5444
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0749 0.147 0.5353
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0013 0.0029
Loa Loa (eye worm) inositol-1 0.0074 0.008 0.0283
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0078 0.0273
Echinococcus granulosus dna polymerase eta 0.0041 0.0011 0.0011
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.008 0.028
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0011 0.0026
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0178
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.008 0.0257
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.0531 0.196
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0231 0.0403 0.146
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0071 0.0245
Brugia malayi follicle stimulating hormone receptor 0.024 0.0422 0.1553
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0041 0.0041
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0275 0.0275
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0117 0.1239
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0011 0.0011
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0078 0.0054
Toxoplasma gondii ABC1 family protein 0.0073 0.0078 0.0273
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0041 0.0041
Onchocerca volvulus 0.0073 0.0078 0.0453
Leishmania major trypanothione reductase 0.0091 0.0115 0.041
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.0275 0.0275
Echinococcus multilocularis tumor protein p63 0.1324 0.2654 0.2654
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0028 0.0028
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.008 0.008
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0011 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0011 0.0024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0031 0.0098
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.0421 0.1551
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0241 0.0241
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0078 0.01
Brugia malayi beta-lactamase family protein 0.0073 0.0078 0.0276
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.018 0.018
Trypanosoma cruzi trypanothione reductase, putative 0.0091 0.0115 0.041
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0593 0.1149 0.426
Loa Loa (eye worm) hypothetical protein 0.0073 0.0078 0.0276
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0011 0.0024
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0028 0.0028
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0089 0.0138
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0078 0.0808
Toxoplasma gondii IMP dehydrogenas 0.1342 0.2691 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0882 0.1743 0.1743
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0078 0.0078
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0071 0.0222
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0593 0.1149 0.4128
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0011 0.0011
Echinococcus granulosus thioredoxin glutathione reductase 0.0091 0.0116 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0055 0.0055
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0231 0.0403 0.146
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0055 0.0055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0246 0.0875
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0005 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0052 0.0052
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0089 0.0311
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0236 0.0413 0.1522
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0013 0.0029
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0028 0.0028

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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