Detailed information for compound 694190

Basic information

Technical information
  • TDR Targets ID: 694190
  • Name: N-(2,8-dimethyl-4-oxopyrido[1,2-a]pyrimidin-3 -yl)-2,2,2-trifluoroacetamide
  • MW: 285.222 | Formula: C12H10F3N3O2
  • H donors: 1 H acceptors: 2 LogP: 0.92 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccn2c(c1)nc(c(c2=O)NC(=O)C(F)(F)F)C
  • InChi: 1S/C12H10F3N3O2/c1-6-3-4-18-8(5-6)16-7(2)9(10(18)19)17-11(20)12(13,14)15/h3-5H,1-2H3,(H,17,20)
  • InChiKey: BZKYXULLENTHMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,8-dimethyl-4-oxo-pyrido[1,2-a]pyrimidin-3-yl)-2,2,2-trifluoro-acetamide
  • N-(2,8-dimethyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl)-2,2,2-trifluoroacetamide
  • 2,2,2-trifluoro-N-(4-keto-2,8-dimethyl-pyrido[1,2-a]pyrimidin-3-yl)acetamide
  • N-(2,8-dimethyl-4-oxo-pyrido[1,2-a]pyrimidin-3-yl)-2,2,2-trifluoro-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0014 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0204 0.0204
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0227 0.0355 0.1059
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0016 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1031 0.1811 0.5496
Plasmodium vivax SET domain protein, putative 0.0061 0.0054 0.0163
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.1846 0.329 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0039 0.012
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0039 0.012
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0016 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0039 0.012
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0014 0.0029
Loa Loa (eye worm) hypothetical protein 0.0032 0 0.0002
Toxoplasma gondii ABC1 family protein 0.0039 0.0014 0.0042
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0039 0.012
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0016 0.0049
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0039 0.012
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0045 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0016 0.0049
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0016 0.0014
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0014 0.002
Echinococcus multilocularis microtubule associated protein 2 0.5548 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0204 0.0204
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0125 0.0379
Schistosoma mansoni microtubule-associated protein tau 0.5548 1 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.0297 0.0297
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0067 0.0204
Brugia malayi MH2 domain containing protein 0.0243 0.0384 0.1168
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0842 0.147 0.147
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.1846 0.329 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0016 0.0016
Trypanosoma brucei unspecified product 0.004 0.0016 0.0014
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0045 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0054 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0016 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0014 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0063 0.0151
Onchocerca volvulus 0.0484 0.082 0.5771
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0039 0.0014 0.002
Onchocerca volvulus 0.0039 0.0014 0.0097
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.009 0.0105 0.0299
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0016 0.0049
Loa Loa (eye worm) hypothetical protein 0.004 0.0016 0.0049
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.0714 0.217
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.0252 0.0765
Brugia malayi glutathione reductase 0.009 0.0105 0.032
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0204 0.0313 0.0933
Brugia malayi Latrophilin receptor protein 2 0.0032 0 0.0002
Schistosoma mansoni inositol monophosphatase 0.004 0.0015 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0204 0.0622
Plasmodium falciparum glutathione reductase 0.009 0.0105 0.032
Loa Loa (eye worm) thioredoxin reductase 0.009 0.0105 0.032
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0015 0.0045
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0816 0.1422 0.4321
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.0384 0.1168
Brugia malayi beta-lactamase family protein 0.0039 0.0014 0.0042
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0016 0.0016
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0816 0.1422 0.4309
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0042
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0015 0.0045
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0012 0.0012
Brugia malayi hypothetical protein 0.0034 0.0005 0.0016
Echinococcus multilocularis neuropeptide s receptor 0.0925 0.162 0.162
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0016 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0054 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0054 0.0054
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0016 0.0016
Echinococcus multilocularis thioredoxin glutathione reductase 0.009 0.0106 0.0106
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0014 0.002
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0014 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0204 0.0204
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0015 0.0039
Trypanosoma cruzi trypanothione reductase, putative 0.009 0.0105 0.032
Echinococcus granulosus neuropeptide s receptor 0.0925 0.162 0.162
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0033 0.0033
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1846 0.329 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0067 0.0204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0204 0.0204
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0227 0.0355 0.1059
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0016 0.0049
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.1846 0.329 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0016 0.0027
Onchocerca volvulus 0.0039 0.0014 0.0097
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0042
Brugia malayi hypothetical protein 0.0053 0.0039 0.012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0014 0.0014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0204 0.0313 0.0933
Onchocerca volvulus 0.0245 0.0388 0.2726
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0015 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0204 0.0204
Schistosoma mansoni alpha-glucosidase 0.0147 0.0209 0.0209
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0014 0.002
Brugia malayi mbt repeat family protein 0.005 0.0033 0.01
Brugia malayi Thioredoxin reductase 0.009 0.0105 0.032
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0045 0.0045
Trypanosoma brucei GMP reductase 0.1846 0.329 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0014 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0014
Trypanosoma cruzi GMP reductase 0.1846 0.329 1
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0014 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0014
Mycobacterium tuberculosis Probable oxidoreductase 0.0227 0.0355 0.1059
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0014 0.0007
Mycobacterium tuberculosis Probable reductase 0.0204 0.0313 0.0933
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0014 0.0029
Leishmania major hypothetical protein, conserved 0.0053 0.0039 0.012
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.1846 0.329 1
Mycobacterium leprae Probable lipase LipE 0.0039 0.0014 0.002
Brugia malayi Pre-SET motif family protein 0.0061 0.0054 0.0163
Onchocerca volvulus 0.0039 0.0014 0.0097
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0016 0.0007
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.1846 0.329 0.329
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0045 0.0045
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0204 0.0313 0.0933
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0033 0.0231
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1846 0.329 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0012 0.0035
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0816 0.1422 0.4297
Onchocerca volvulus Putative GMP reductase 0.0816 0.1422 1
Echinococcus granulosus dna polymerase eta 0.004 0.0016 0.0016
Trypanosoma brucei trypanothione reductase 0.009 0.0105 0.0286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0204 0.0204
Schistosoma mansoni cellular tumor antigen P53 0.0245 0.0388 0.0388
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0016 0.0027
Mycobacterium tuberculosis Conserved protein 0.0039 0.0014 0.002
Plasmodium vivax glutathione reductase, putative 0.009 0.0105 0.032
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0014 0.0029
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0204 0.0313 0.0933
Onchocerca volvulus 0.005 0.0033 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0014 0.0042
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0063 0.0171
Echinococcus granulosus dna polymerase kappa 0.004 0.0016 0.0016
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0033 0.0033
Leishmania major guanosine monophosphate reductase 0.1846 0.329 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0204 0.0313 0.0933
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0054 0.0163
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0014 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0014 0.0014
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0252 0.0252
Mycobacterium tuberculosis Conserved protein 0.0039 0.0014 0.002
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0063 0.0063
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0016 0.0049
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0016 0.0049
Schistosoma mansoni alpha-glucosidase 0.0147 0.0209 0.0209
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0063 0.0063
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0045 0.0137
Echinococcus multilocularis dna polymerase kappa 0.004 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0042
Brugia malayi follicle stimulating hormone receptor 0.0245 0.0388 0.1178
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0204 0.0622
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0016 0.0056
Toxoplasma gondii IMP dehydrogenas 0.1846 0.329 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0016 0.0049
Leishmania major inosine-5-monophosphate dehydrogenase 0.1846 0.329 1
Loa Loa (eye worm) glutathione reductase 0.009 0.0105 0.032
Loa Loa (eye worm) beta-lactamase 0.0039 0.0014 0.0042
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0125 0.0379
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0063 0.0151
Brugia malayi GMP reductase 0.0816 0.1422 0.4321
Schistosoma mansoni alpha glucosidase 0.0038 0.0012 0.0012
Leishmania major DNA polymerase kappa, putative 0.004 0.0016 0.0049
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0033 0.0033
Loa Loa (eye worm) inositol-1 0.004 0.0015 0.0045
Mycobacterium tuberculosis Probable dehydrogenase 0.0204 0.0313 0.0933
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0014
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0015 0.0015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0012 0.0035
Leishmania major trypanothione reductase 0.009 0.0105 0.032
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.0396 0.1183
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.01 0.0125 0.0379
Brugia malayi mbt repeat family protein 0.005 0.0033 0.01
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.1846 0.329 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0042
Loa Loa (eye worm) MBCTL1 0.0056 0.0045 0.0137
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1846 0.329 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1846 0.329 1
Schistosoma mansoni hypothetical protein 0.0069 0.0067 0.0067
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0012 0.0035
Echinococcus multilocularis tumor protein p63 0.1675 0.298 0.298
Plasmodium falciparum thioredoxin reductase 0.009 0.0105 0.032
Schistosoma mansoni hypothetical protein 0.0301 0.0489 0.0489
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0816 0.1422 0.4321
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0063 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0014
Schistosoma mansoni inositol monophosphatase 0.004 0.0015 0.0015
Onchocerca volvulus 0.0061 0.0054 0.0377
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1846 0.329 1
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.1846 0.329 0.329
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0016 0.0016
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0014 0.0014
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0039 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0014
Echinococcus granulosus neuropeptide receptor A26 0.0925 0.162 0.162
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.0252 0.0765
Leishmania major hypothetical protein, conserved 0.0039 0.0014 0.0042
Plasmodium vivax thioredoxin reductase, putative 0.009 0.0105 0.032
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0014 0.002
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0016 0.0007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0227 0.0355 0.1059
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0054 0.0054
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0016 0.0014
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.0384 0.1168
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0014
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.1846 0.329 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0014
Echinococcus multilocularis dna polymerase eta 0.004 0.0016 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0014 0.0029
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0033 0.0033
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0033 0.0033
Toxoplasma gondii thioredoxin reductase 0.009 0.0105 0.032
Giardia lamblia DINP protein human, muc B family 0.004 0.0016 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0049 0.0049
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0054 0.0054
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.1031 0.1811 0.5496
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0015 0.6993
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0014 0.0014
Echinococcus multilocularis neuropeptide receptor A26 0.0925 0.162 0.162
Brugia malayi beta-lactamase family protein 0.0039 0.0014 0.0042
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0012 0.0035
Brugia malayi Inositol-1 0.004 0.0015 0.0045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0042
Trichomonas vaginalis esterase, putative 0.0039 0.0014 0.0029
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0015 0.0039
Brugia malayi Pre-SET motif family protein 0.0425 0.0714 0.217
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0045 0.0045
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0015 0.0039
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0252 0.0252
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0063 0.0151
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0063 0.0063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0 0.0002
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0016 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0014 0.0042
Loa Loa (eye worm) hypothetical protein 0.0245 0.0388 0.1178
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0 0.0002
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.1846 0.329 0.329
Echinococcus granulosus thioredoxin glutathione reductase 0.009 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.005 0.0033 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0014 0.0042
Loa Loa (eye worm) GMP reductase 0.0816 0.1422 0.4321
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0039 0.012
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0033 0.0033
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0015 0.0015
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.0297 0.0297
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0125 0.0379
Trichomonas vaginalis set domain proteins, putative 0.0484 0.082 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0063 0.0063
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0245 0.0388 0.1178
Loa Loa (eye worm) IMP dehydrogenase 1 0.1846 0.329 1
Onchocerca volvulus 0.0099 0.0122 0.0855
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0061 0.0054 0.0163
Echinococcus granulosus tumor protein p63 0.1675 0.298 0.298
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0014 0.0042
Brugia malayi beta-lactamase 0.0039 0.0014 0.0042
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0033 0.0033
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0016 0.0049
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.1846 0.329 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0015 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0204 0.0204
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0063 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0014 0.0042
Loa Loa (eye worm) hypothetical protein 0.0056 0.0045 0.0137
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0039 0.012
Trypanosoma cruzi GMP reductase 0.1846 0.329 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0054 0.0054
Leishmania major DNA polymerase eta, putative 0.004 0.0016 0.0049
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0015 0.0045
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0033 0.01
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0012 0.0035
Schistosoma mansoni DNA polymerase eta 0.004 0.0016 0.0016
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0015 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.0014

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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