Detailed information for compound 699221

Basic information

Technical information
  • TDR Targets ID: 699221
  • Name: 3-fluoro-N-[4-(2-methyl-4-oxoquinazolin-3-yl) phenyl]benzenesulfonamide
  • MW: 409.433 | Formula: C21H16FN3O3S
  • H donors: 1 H acceptors: 3 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)S(=O)(=O)Nc1ccc(cc1)n1c(C)nc2c(c1=O)cccc2
  • InChi: 1S/C21H16FN3O3S/c1-14-23-20-8-3-2-7-19(20)21(26)25(14)17-11-9-16(10-12-17)24-29(27,28)18-6-4-5-15(22)13-18/h2-13,24H,1H3
  • InChiKey: HIGHLYLRTZZASL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-fluoro-N-[4-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]benzenesulfonamide
  • 3-fluoro-N-[4-(2-methyl-4-oxo-3-quinazolinyl)phenyl]benzenesulfonamide
  • 3-fluoro-N-[4-(4-keto-2-methyl-quinazolin-3-yl)phenyl]benzenesulfonamide
  • ZINC04270393

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii thioredoxin reductase 0.0049 0.0765 0.119
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0622 0.0585
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0369 0.033
Loa Loa (eye worm) hypothetical protein 0.0033 0.0416 0.0641
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0227 0.2
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0227 0.0291
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0589
Giardia lamblia PHD finger protein 15 0.003 0.0369 0.909
Loa Loa (eye worm) hypothetical protein 0.0245 0.4943 0.763
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0064 0.0037
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0082 0.0589
Onchocerca volvulus Huntingtin homolog 0.0128 0.2444 0.3734
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.199 0.1959
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0424 0.5306
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Echinococcus granulosus neuropeptide receptor A26 0.0483 1 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0424 0.5306
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0401 0.1076
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Entamoeba histolytica protein kinase, putative 0.0033 0.0416 0.1701
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.2369 1
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0373 0.0334
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.4943 0.4923
Echinococcus multilocularis GPCR, family 2 0.0031 0.0389 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.1105
Schistosoma mansoni hypothetical protein 0.0031 0.0389 0.1041
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.1105
Echinococcus granulosus geminin 0.0173 0.3401 0.3375
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.012 0.1105
Schistosoma mansoni protein kinase 0.0033 0.0416 0.1118
Brugia malayi PHD-finger family protein 0.003 0.0369 0.0511
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0064 0.0026
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.199 0.1959
Treponema pallidum NADH oxidase 0.0017 0.0082 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1166 0.1749
Loa Loa (eye worm) hypothetical protein 0.0052 0.0832 0.1283
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0151 0.0477
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.012 0.0238
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.012 0.0855
Schistosoma mansoni jumonji domain containing protein 0.0079 0.1407 0.4067
Schistosoma mansoni protein kinase 0.0033 0.0416 0.1118
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0465 0.0427
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0401 0.0562
Loa Loa (eye worm) hypothetical protein 0.0317 0.6479 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0456
Entamoeba histolytica protein kinase, putative 0.0033 0.0416 0.1701
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0416 0.0377
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0416 0.0404
Trypanosoma brucei unspecified product 0.0019 0.012 0.1105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0589
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0082 0.007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0589
Loa Loa (eye worm) hypothetical protein 0.0032 0.0401 0.062
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0389 0.0601
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0514 0.5065
Brugia malayi hypothetical protein 0.0128 0.2444 0.3734
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0977 0.0941
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0416 0.0617
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0127
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.012 0.0855
Loa Loa (eye worm) hypothetical protein 0.0128 0.2444 0.3772
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0401 0.0363
Plasmodium vivax hypothetical protein, conserved 0.003 0.0369 0.0353
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0227 0.5182
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0977 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0416 0.0377
Leishmania major glucose transporter, lmgt3 0.0033 0.0424 0.4106
Loa Loa (eye worm) hypothetical protein 0.0019 0.012 0.0185
Trypanosoma brucei glucose transporter, putative 0.0033 0.0424 0.5306
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0977 0.0941
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0977 1
Leishmania major trypanothione reductase 0.0049 0.0765 0.7737
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0401 0.1855
Schistosoma mansoni survival motor neuron protein 0.005 0.0786 0.222
Leishmania major glucose transporter, lmgt1 0.0033 0.0424 0.4106
Trypanosoma brucei glucose transporter, putative 0.0033 0.0424 0.5306
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0401 0.113
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1843 0.1811
Schistosoma mansoni hypothetical protein 0.0042 0.0605 0.1682
Plasmodium falciparum glutathione reductase 0.0049 0.0765 0.0779
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0977 0.1538
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.012 0.1105
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0589
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0064 0.0024
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0514 0.051
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0082 0.0183
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0373 0.0334
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0416 0.0617
Brugia malayi CHE-14 protein 0.0043 0.0638 0.0929
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.012 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0424 0.1973
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.1105
Entamoeba histolytica hypothetical protein 0.0035 0.0465 0.1984
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0424 0.1973
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.199 0.1959
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0064 0.0331
Brugia malayi Sugar transporter family protein 0.0107 0.199 0.3029
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.012 0.0238
Trypanosoma brucei glucose transporter 2A 0.0033 0.0424 0.5306
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.199 0.1959
Loa Loa (eye worm) hypothetical protein 0.0128 0.2444 0.3772
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0416 0.0404
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0416 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.1105
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0424 0.1973
Plasmodium falciparum protein kinase 7 0.0301 0.6134 0.6542
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0786 0.1159
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.2369 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0452 0.9355 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.012 0.0855
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1835 0.2832
Entamoeba histolytica hypothetical protein 0.0024 0.0227 0.0617
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0416 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0416 0.0377
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0064 0.0331
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.3388 0.3595
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0064 0.0024
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0064 0.0103
Brugia malayi hypothetical protein 0.0035 0.0465 0.066
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0401 0.0562
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0064 0.0098
Echinococcus multilocularis dna polymerase eta 0.0019 0.012 0.008
Brugia malayi Cam kinase protein 1 0.0033 0.0416 0.0584
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0505 0.0779
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.004 0.0061
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0416 0.0584
Schistosoma mansoni hypothetical protein 0.0042 0.0605 0.1682
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.012 0.0124
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0227 0.0188
Trypanosoma brucei glucose transporter, putative 0.0033 0.0424 0.5306
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0064 0.0331
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0082 0.0219
Echinococcus granulosus expressed conserved protein 0.0094 0.1729 0.1696
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.012 0.1105
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0082 0.1181
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0977 0.2788
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0082 0.0046
Plasmodium falciparum thioredoxin reductase 0.0017 0.0082 0.0046
Echinococcus multilocularis neuropeptide receptor A26 0.0483 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.2103 0.8859
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0416 0.0404
Entamoeba histolytica hypothetical protein 0.0035 0.0465 0.1984
Echinococcus multilocularis peregrin 0.003 0.0369 0.033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0589
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0227 0.0558
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0151 0.0477
Echinococcus granulosus General substrate transporter 0.0092 0.1671 0.1638
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0401 0.0363
Schistosoma mansoni hypothetical protein 0.0173 0.3401 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0082 0.0456
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0165 0.0641
Entamoeba histolytica hypothetical protein 0.0035 0.0465 0.1984
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0589
Plasmodium falciparum protein kinase 6 0.0452 0.9355 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0082 0.007
Trypanosoma cruzi hexose transporter 0.0033 0.0424 0.5306
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.199 0.1959
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.2103 0.8859
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0977 0.2788
Onchocerca volvulus Alhambra homolog 0.003 0.0369 0.0511
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0505 0.1384
Trypanosoma brucei glucose transporter, putative 0.0033 0.0424 0.5306
Echinococcus multilocularis expressed conserved protein 0.0094 0.1729 0.1696
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0064 0.0071
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0845 0.1304
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0082 1
Echinococcus granulosus dna polymerase eta 0.0019 0.012 0.008
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.2314 0.3571
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0227 0.0344
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0424 0.5306
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0064 0.0024
Leishmania major protein kinase, putative 0.0033 0.0416 0.4011
Trypanosoma brucei glucose transporter, putative 0.0033 0.0424 0.5306
Loa Loa (eye worm) sugar transporter 0.0107 0.199 0.3072
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.2103 0.8801
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.2103 0.8859
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0514 0.5065
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.1105
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0638 0.0601
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0622 0.0585
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0064 0.0026
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0082 0.0456
Schistosoma mansoni hypothetical protein 0.0042 0.0605 0.1682
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.012 0.1105
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0064 0.0024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0082 0.0589
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.1105
Schistosoma mansoni hypothetical protein 0.0042 0.0605 0.1682
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0227 0.2
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0401 0.1076
Brugia malayi MH2 domain containing protein 0.0122 0.2314 0.3531
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0227 0.0961
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0416 0.0377
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0416 0.5184
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0638 0.3068
Mycobacterium tuberculosis Probable reductase 0.0112 0.2103 0.8859
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0369 0.054
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0082 0.0046
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.004 0.0061
Schistosoma mansoni hypothetical protein 0.0031 0.0389 0.1041
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0227 0.0201
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0638 0.0601
Loa Loa (eye worm) hypothetical protein 0.0099 0.1835 0.2832
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0416 0.0404
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.1892 0.5511
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0416 0.0641
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1059 0.1634
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0389 0.0351
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0514 0.6546
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0465 0.1265
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0227 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0424 0.4106
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0424 0.5306
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0456
Onchocerca volvulus Huntingtin homolog 0.0128 0.2444 0.3734
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0589
Schistosoma mansoni glucose transport protein 0.0107 0.199 0.5804
Schistosoma mansoni hypothetical protein 0.0107 0.199 0.5804
Loa Loa (eye worm) glutathione reductase 0.0049 0.0765 0.118
Schistosoma mansoni DNA polymerase eta 0.0019 0.012 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.199 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0424 0.1973
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0389 0.0351
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.199 0.1959
Trypanosoma brucei glucose transporter 1E 0.0033 0.0424 0.5306
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.012 0.1105
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0424 0.1973
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.012 0.0344
Loa Loa (eye worm) hypothetical protein 0.0024 0.0227 0.0351
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0424 0.5306
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0227 0.0308
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0514 0.0779
Brugia malayi Bromodomain containing protein 0.003 0.0369 0.0511
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0369 0.0569
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0369 0.033
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.199 0.1959
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0105 0.0905
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0638 0.0985
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0505 0.0467
Brugia malayi isocitrate dehydrogenase 0.0016 0.0064 0.0037
Leishmania major DNA polymerase eta, putative 0.0019 0.012 0.0855
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.012 0.0344
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0505 0.1384
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0401 1
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0765 0.0779
Plasmodium falciparum phd finger protein, putative 0.003 0.0369 0.0353
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0514 0.6546
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0765 0.118
Onchocerca volvulus 0.005 0.0786 0.1159
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0416 0.0404
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0064 0.0039
Plasmodium vivax glutathione reductase, putative 0.0049 0.0765 0.0779
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.012 0.008
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.012 0.0124
Trypanosoma brucei trypanothione reductase 0.0049 0.0765 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0416 0.0404
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0465 0.0427
Entamoeba histolytica hypothetical protein 0.0035 0.0465 0.1984
Schistosoma mansoni hypothetical protein 0.0031 0.0389 0.1041
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0416 0.1927
Schistosoma mansoni hypothetical protein 0.0068 0.1166 0.335
Echinococcus multilocularis geminin 0.0173 0.3401 0.3375
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0977 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0416 0.0641
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0389 0.0543
Echinococcus multilocularis dna polymerase kappa 0.0019 0.012 0.008
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Schistosoma mansoni hypothetical protein 0.0035 0.0465 0.1265
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.012 0.0411
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0082 0.0219
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1843 0.1811
Schistosoma mansoni hypothetical protein 0.003 0.0369 0.0978
Schistosoma mansoni glucose transport protein 0.0107 0.199 0.5804
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0424 0.5306
Echinococcus granulosus peregrin 0.003 0.0369 0.033
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0424 0.1973
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Loa Loa (eye worm) hypothetical protein 0.0032 0.0401 0.062
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0227 0.0188
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0765 0.0728
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0589
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0227 0.0558
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0043
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0416 0.0617
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.2103 0.8859
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0227 0.0201
Giardia lamblia DINP protein human, muc B family 0.0019 0.012 0.2215
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.3388 0.5495
Toxoplasma gondii protein kinase, putative 0.0301 0.6134 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.012 0.0855
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.2103 0.8859
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1859 0.1826
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0082 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0416 0.1118
Schistosoma mansoni protein kinase 0.0033 0.0416 0.1118
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0082 0.0456
Plasmodium vivax hexose transporter 0.0107 0.199 0.2094
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.199 0.1959
Plasmodium falciparum hexose transporter 0.0107 0.199 0.2094
Echinococcus multilocularis neuropeptide s receptor 0.0483 1 1
Brugia malayi hypothetical protein 0.0317 0.6479 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0369 0.054
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Brugia malayi hypothetical protein 0.0245 0.4943 0.7615
Plasmodium falciparum thioredoxin reductase 0.0049 0.0765 0.0779
Loa Loa (eye worm) hypothetical protein 0.01 0.1859 0.2869
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0043
Trypanosoma brucei glucose transporter, putative 0.0033 0.0424 0.5306
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0227 0.2585
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.012 0.1105
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0227 0.2
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0389 0.0543
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.2314 0.3571
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0082 0.0589
Brugia malayi jmjC domain containing protein 0.0037 0.0505 0.0723
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0514 0.6546
Schistosoma mansoni hypothetical protein 0.0173 0.3401 1
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1859 0.2825
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0389 0.0351
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0424 0.1973
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0514 0.051
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0765 0.3114
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1859 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0064 0.0024
Leishmania major glucose transporter, lmgt2 0.0033 0.0424 0.4106
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.0369 0.0569
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0061
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.4943 0.4923
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1835 0.2788
Brugia malayi jmjC domain containing protein 0.01 0.1843 0.2801
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0082 0.0456
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0416 0.0377
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0401 0.162
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.012 0.1105
Echinococcus multilocularis General substrate transporter 0.0092 0.1671 0.1638
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0638 0.0985
Echinococcus granulosus GPCR family 2 0.0031 0.0389 0.0351
Schistosoma mansoni hypothetical protein 0.0031 0.0389 0.1041
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0424 0.5306
Trypanosoma brucei glucose transporter, putative 0.0033 0.0424 0.5306
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0369 0.0978
Echinococcus granulosus dna polymerase kappa 0.0019 0.012 0.008
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0082 0.0589
Echinococcus multilocularis protein dispatched 1 0.0049 0.0768 0.0731
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0082 0.0589
Schistosoma mansoni glucose transport protein 0.0107 0.199 0.5804
Onchocerca volvulus 0.0317 0.6479 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0274 0.0423
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.012 0.1105
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.2777 0.2748
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.1105
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.012 0.1105
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.3388 0.3595
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.1105
Schistosoma mansoni patched 1 0.0043 0.0638 0.1781
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0416 0.0404
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.199 0.3201
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.1105
Echinococcus multilocularis protein patched 0.0043 0.0638 0.0601
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0765 0.0728
Loa Loa (eye worm) hypothetical protein 0.0031 0.0389 0.0601
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0416 0.0377
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0064 0.0331
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0456
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0227 0.2585
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0064 0.0039
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.2369 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0416 0.0404
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0082 0.0046
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.012 0.008
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0416 0.0377
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0389 0.0351
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0505 0.0467
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0082 1
Loa Loa (eye worm) sugar transporter 0.0015 0.004 0.0061
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.2777 0.2748
Plasmodium falciparum glutathione reductase 0.0017 0.0082 0.0046
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.012 0.0185
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1835 0.2788
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0082 0.0066
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0977 0.4024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0977 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0064 0.0024
Schistosoma mansoni hypothetical protein 0.005 0.0786 0.222
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0064 0.0256
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0765 1
Brugia malayi glutathione reductase 0.0049 0.0765 0.1126
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.2369 1
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1859 0.1826
Brugia malayi Thioredoxin reductase 0.0049 0.0765 0.1126
Loa Loa (eye worm) hypothetical protein 0.0068 0.1166 0.1799
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0638 0.0601
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.012 0.1105

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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