Detailed information for compound 699989

Basic information

Technical information
  • TDR Targets ID: 699989
  • Name: ethyl 4-cyano-3-methyl-5-[(2-naphthalen-1-yla cetyl)amino]thiophene-2-carboxylate
  • MW: 378.444 | Formula: C21H18N2O3S
  • H donors: 1 H acceptors: 3 LogP: 5.14 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1sc(c(c1C)C#N)NC(=O)Cc1cccc2c1cccc2
  • InChi: 1S/C21H18N2O3S/c1-3-26-21(25)19-13(2)17(12-22)20(27-19)23-18(24)11-15-9-6-8-14-7-4-5-10-16(14)15/h4-10H,3,11H2,1-2H3,(H,23,24)
  • InChiKey: IDBOBXJHPIUVKY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-cyano-3-methyl-5-[[2-(1-naphthyl)acetyl]amino]thiophene-2-carboxylate
  • 4-cyano-3-methyl-5-[[2-(1-naphthyl)-1-oxoethyl]amino]-2-thiophenecarboxylic acid ethyl ester
  • 4-cyano-3-methyl-5-[[2-(1-naphthyl)acetyl]amino]thiophene-2-carboxylic acid ethyl ester
  • ethyl 4-cyano-3-methyl-5-(2-naphthalen-1-ylethanoylamino)thiophene-2-carboxylate
  • ZINC05145231

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0171 0.1691 0.7463
Leishmania major glucose transporter, lmgt1 0.007 0.0621 0.868
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0069 0.0611 0.2692
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0069 0.0612 0.0597
Giardia lamblia Prolyl-tRNA synthetase 0.0068 0.0597 1
Plasmodium vivax sugar transporter, putative 0.0032 0.0217 0.0201
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0069 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.0069 0.0611 0.2648
Plasmodium falciparum calcium-dependent protein kinase 4 0.0069 0.0612 0.0597
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0225 0.2266 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0151 0.0228
Trypanosoma brucei glucose transporter 1E 0.007 0.0621 0.868
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0013 0.0016 0.0377
Schistosoma mansoni protein kinase 0.0069 0.0611 0.2692
Schistosoma mansoni protein kinase 0.0069 0.0611 0.2692
Schistosoma mansoni glycyl-tRNA synthetase 0.0013 0.0016 0.0059
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1429 0.6306
Brugia malayi hypothetical protein 0.0032 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0255 0.1125
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0032 0.0217 0.303
Giardia lamblia Lysyl-tRNA synthetase 0.005 0.0414 0.6849
Echinococcus granulosus calcium dependent protein kinase 0.0065 0.0566 0.2492
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0068 0.0597 0.2634
Trypanosoma cruzi sugar transporter, putative 0.0032 0.0217 0.303
Echinococcus multilocularis glycyl tRNA synthetase 0.0013 0.0016 0.0059
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0255 0.1125
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0225 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Toxoplasma gondii sugar transporter ST1 0.0032 0.0217 0.0327
Toxoplasma gondii facilitative glucose transporter GT1 0.0225 0.2266 0.3424
Loa Loa (eye worm) hypothetical protein 0.0025 0.0151 0.06
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0068 0.0597 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.1066
Trypanosoma cruzi hexose transporter 0.007 0.0621 0.868
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0028 0.0175 0.0709
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0611 0.2692
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0079 0.0715 0.1081
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2271 1
Schistosoma mansoni sugar transporter 0.0032 0.0217 0.0948
Brugia malayi hypothetical protein 0.0032 0.0217 0.0894
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0255 0.6175
Echinococcus granulosus solute carrier family 22 0.0032 0.0217 0.0948
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0337 0.1486
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0217 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0069 0.0611 0.2692
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0068 0.0597 0.2583
Echinococcus multilocularis solute carrier family 22 0.0032 0.0217 0.0948
Echinococcus multilocularis solute carrier family 22 0.0032 0.0217 0.0948
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0299 0.0284
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0225 0.2266 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.007 0.0621 0.868
Leishmania major glucose transporter/membrane transporter D2, putative 0.007 0.0621 0.868
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0151 0.0135
Brugia malayi Cam kinase protein 1 0.0069 0.0611 0.2648
Trypanosoma brucei THT1 - hexose transporter, putative 0.007 0.0621 0.868
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0286 0.3994
Echinococcus granulosus Sugar transporter ERD6 protein 0.0032 0.0217 0.0948
Plasmodium vivax lysine--tRNA ligase, putative 0.005 0.0414 0.0399
Brugia malayi Sugar transporter family protein 0.0225 0.2266 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0255 0.1119
Trypanosoma cruzi hexose transporter, putative 0.007 0.0621 0.868
Echinococcus multilocularis solute carrier family 22 0.0032 0.0217 0.0948
Toxoplasma gondii lysine-tRNA ligase 0.005 0.0414 0.0625
Brugia malayi beta-lactamase family protein 0.0035 0.0255 0.1066
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Leishmania major hypothetical protein, conserved 0.0025 0.0151 0.2107
Echinococcus granulosus solute carrier family 22 0.0032 0.0217 0.0948
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1429 0.6284
Loa Loa (eye worm) hypothetical protein 0.005 0.0414 0.1769
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Plasmodium falciparum calcium-dependent protein kinase 1 0.0069 0.0612 0.0597
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0225 0.2266 1
Trypanosoma brucei glucose transporter 2A 0.007 0.0621 0.868
Echinococcus granulosus glycyl tRNA synthetase 0.0013 0.0016 0.0059
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0255 0.1125
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0255 0.3571
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0079 0.0715 1
Brugia malayi hypothetical protein 0.0016 0.0055 0.0176
Trypanosoma brucei glucose transporter, putative 0.007 0.0621 0.868
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0079 0.0715 1
Plasmodium vivax hexose transporter 0.0225 0.2266 0.2253
Toxoplasma gondii protein kinase, putative 0.0636 0.6617 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0013 0.0016 0.0377
Brugia malayi MH2 domain containing protein 0.0117 0.1121 0.4915
Toxoplasma gondii ABC1 family protein 0.0035 0.0255 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0956
Schistosoma mansoni sugar transporter 0.0032 0.0217 0.0948
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0225 0.2266 1
Schistosoma mansoni glucose transport protein 0.0225 0.2266 1
Toxoplasma gondii transporter, major facilitator family protein 0.0032 0.0217 0.0327
Trypanosoma brucei glucose transporter, putative 0.007 0.0621 0.868
Plasmodium falciparum proline--tRNA ligase 0.0079 0.0715 0.0701
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0255 0.1125
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0611 0.2692
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0337 0.0322
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0151 0.2107
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0134 1
Trichomonas vaginalis sugar transporter, putative 0.007 0.0621 0.274
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0079 0.0715 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0255 0.1127
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0032 0.0217 0.5239
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0069 0.0612 0.0597
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0225 0.2266 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0069 0.0611 0.2692
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.1066
Leishmania major myo-inositol/proton symporter (MIT) 0.0032 0.0217 0.303
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0956
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0069 0.0611 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0255 0.1125
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0043 0.0333 0.1468
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0217 0.0894
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0337 0.1478
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0255 0.1066
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0069 0.0611 0.855
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.1066
Entamoeba histolytica protein kinase, putative 0.0069 0.0611 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Brugia malayi lysyl-tRNA synthetase 0.005 0.0414 0.1769
Loa Loa (eye worm) hypothetical protein 0.0068 0.0597 0.2583
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Entamoeba histolytica hypothetical protein 0.005 0.0414 0.6679
Trichomonas vaginalis myo-inositol transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0217 0.0894
Plasmodium falciparum calcium-dependent protein kinase 3 0.0069 0.0612 0.0597
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0032 0.0217 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0151 0.2107
Chlamydia trachomatis lysine--tRNA ligase 0.005 0.0414 1
Echinococcus multilocularis calcium dependent protein kinase 0.0065 0.0566 0.2492
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0255 0.1066
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.005 0.0414 0.5783
Mycobacterium ulcerans integral membrane transport protein 0.0032 0.0217 0.5239
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0032 0.0217 0.0954
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0621 0.274
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0032 0.0217 0.5239
Loa Loa (eye worm) beta-lactamase 0.0035 0.0255 0.1066
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0217 0.0894
Trypanosoma brucei glucose transporter, putative 0.007 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Brugia malayi hypothetical protein 0.0032 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) sugar transporter 0.0225 0.2266 1
Plasmodium vivax proline--tRNA ligase, putative 0.0079 0.0715 0.0701
Trypanosoma brucei glucose transporter, putative 0.007 0.0621 0.868
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0068 0.0597 0.2627
Toxoplasma gondii sugar transporter ST2 0.0032 0.0217 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0621 0.274
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0255 0.4281
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Brugia malayi major facilitator superfamily protein 0.0032 0.0217 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0611 0.2699
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0414 0.1818
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0337 0.0509
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0013 0.0016 0.0024
Mycobacterium tuberculosis Conserved protein 0.0035 0.0255 0.1125
Onchocerca volvulus 0.0035 0.0255 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0068 0.0597 0.9752
Trichomonas vaginalis glucose transporter, putative 0.007 0.0621 0.274
Mycobacterium tuberculosis Conserved protein 0.0035 0.0255 0.1125
Trypanosoma brucei glucose transporter, putative 0.007 0.0621 0.868
Mycobacterium ulcerans lipase LipD 0.0035 0.0255 0.6175
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0255 0.1119
Loa Loa (eye worm) hypothetical protein 0.0068 0.0597 0.2583
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0079 0.0715 1
Brugia malayi major facilitator superfamily protein 0.0032 0.0217 0.0894
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0151 0.0135
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0032 0.0217 0.0201
Giardia lamblia Hexose transporter 0.0032 0.0217 0.346
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1429 0.6306
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Schistosoma mansoni glucose transporter 0.0032 0.0217 0.0948
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0414 0.1818
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0956
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.0134 0.3243
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0414 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0068 0.0597 0.2583
Echinococcus multilocularis lysyl tRNA synthetase 0.005 0.0414 0.1818
Chlamydia trachomatis proline--tRNA ligase 0.0024 0.0134 0.2978
Trypanosoma brucei glucose transporter, putative 0.007 0.0621 0.868
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1386 0.6114
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1121 0.4915
Echinococcus granulosus lysyl tRNA synthetase 0.005 0.0414 0.1818
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0255 0.1127
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0255 0.1125
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0069 0.0611 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) acetyltransferase 0.0146 0.1429 0.6284
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0032 0.0217 0.0948
Trypanosoma cruzi glucose transporter, putative 0.0032 0.0217 0.303
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0414 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0255 0.1127
Trypanosoma cruzi hexose transporter, putative 0.007 0.0621 0.868
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0364 0.3734 0.5643
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0218
Brugia malayi Sugar transporter family protein 0.0032 0.0217 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0069 0.0611 0.2692
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0079 0.0715 1
Trichomonas vaginalis glucose transporter, putative 0.007 0.0621 0.274
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0225 0.2266 1
Giardia lamblia Sugar-proton symporter 0.0032 0.0217 0.346
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0333 0.1468
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0013 0.0016 0.0218
Echinococcus granulosus Threonyl tRNA synthetase C 0.0013 0.0016 0.0059
Echinococcus granulosus solute carrier family 22 0.0032 0.0217 0.0948
Echinococcus granulosus synaptic vesicle 2 protein 0.0032 0.0217 0.0948
Plasmodium falciparum calcium-dependent protein kinase 2 0.0069 0.0612 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1121 0.4915
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0255 0.3571
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0337 0.0509
Plasmodium vivax calcium-dependent protein kinase, putative 0.0069 0.0612 0.0597
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0218
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0218
Plasmodium falciparum protein kinase 7 0.0636 0.6617 0.6612
Schistosoma mansoni sugar transporter 0.0032 0.0217 0.0948
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0013 0.0016 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium ulcerans beta-lactamase 0.0035 0.0255 0.6175
Toxoplasma gondii glycyl-tRNA synthetase 0.0013 0.0016 0.0024
Trypanosoma cruzi hexose transporter, putative 0.007 0.0621 0.868
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0299 0.4873
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.005 0.0414 0.6932
Brugia malayi Sugar transporter family protein 0.0032 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0055 0.0463 0.1987
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Plasmodium falciparum hexose transporter 0.0225 0.2266 0.2253
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0333 0.5587
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0611 0.2692
Schistosoma mansoni hypothetical protein 0.0171 0.1691 0.7463
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Plasmodium falciparum mitogen-activated protein kinase 2 0.0364 0.3734 0.3724
Leishmania major glucose transporter, lmgt3 0.007 0.0621 0.868
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0217 0.0956
Brugia malayi beta-lactamase family protein 0.0035 0.0255 0.1066
Echinococcus multilocularis General substrate transporter 0.0193 0.193 0.8519
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0299 0.4752
Onchocerca volvulus 0.0035 0.0255 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0151 0.0135
Schistosoma mansoni glucose transport protein 0.0225 0.2266 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0255 0.6175
Brugia malayi beta-lactamase 0.0035 0.0255 0.1066
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.007 0.0621 0.868
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0337 0.1486
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0255 0.3571
Trichomonas vaginalis sugar transporter, putative 0.007 0.0621 0.274
Trichomonas vaginalis sugar transport protein, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0255 0.1127
Trichomonas vaginalis sugar transporter, putative 0.007 0.0621 0.274
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.005 0.0414 0.5783
Echinococcus multilocularis synaptic vesicle 2 protein 0.0032 0.0217 0.0948
Leishmania major threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0218
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0068 0.0597 0.2627
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0255 0.1119
Brugia malayi hypothetical protein 0.0025 0.0151 0.06
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0068 0.0597 0.2627
Schistosoma mansoni protein kinase 0.0069 0.0611 0.2692
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium leprae Probable lipase LipE 0.0035 0.0255 0.4281
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.1066
Trypanosoma brucei sugar transporter, putative 0.0032 0.0217 0.303
Leishmania major glucose transporter, lmgt2 0.007 0.0621 0.868
Leishmania major lysyl-tRNA synthetase, putative 0.005 0.0414 0.5783
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Leishmania major protein kinase, putative 0.0069 0.0611 0.855
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0255 0.1119
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0069 0.0612 0.0597
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0611 0.2692
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0068 0.0597 0.2627
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0255 0.024
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0069 0.0612 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0956
Echinococcus granulosus General substrate transporter 0.0193 0.193 0.8519
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0032 0.0217 0.0948
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Leishmania major hypothetical protein, conserved 0.0035 0.0255 0.3571
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0255 0.1127
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0069 0.0612 0.0925
Plasmodium falciparum lysine--tRNA ligase 0.005 0.0414 0.0399
Echinococcus granulosus geminin 0.0171 0.1691 0.7463
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0255 0.1125
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.1066
Onchocerca volvulus 0.0035 0.0255 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0069
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0217 0.303
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0044 0.0348 0.1536
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0364 0.3734 0.3724
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Trypanosoma brucei glucose transporter, putative 0.007 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0013 0.0016 0.0069
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0069 0.0612 0.0925
Echinococcus granulosus solute carrier family 22 0.0032 0.0217 0.0948
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0611 0.2692
Entamoeba histolytica protein kinase, putative 0.0069 0.0611 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.1066
Echinococcus multilocularis solute carrier family 22 0.0032 0.0217 0.0948
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Schistosoma mansoni hypothetical protein 0.0225 0.2266 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0151 0.2107
Trichomonas vaginalis esterase, putative 0.0035 0.0255 0.1127
Plasmodium vivax CDK-related protein kinase 6, putative 0.0955 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0255 0.6175
Toxoplasma gondii sugar transporter ST3 0.0032 0.0217 0.0327
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Echinococcus multilocularis geminin 0.0171 0.1691 0.7463
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0032 0.0217 0.0954
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0225 0.2266 1
Leishmania major hypothetical protein, conserved 0.0032 0.0217 0.303
Schistosoma mansoni sugar transporter 0.0032 0.0217 0.0948
Trypanosoma brucei THT1 - hexose transporter, putative 0.007 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0225 0.2266 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0255 0.1125
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) sugar transporter 0.0032 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium ulcerans sugar transporter 0.0032 0.0217 0.5239
Schistosoma mansoni glucose transport protein 0.0225 0.2266 1
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0013 0.0016 0.0262
Plasmodium falciparum calcium-dependent protein kinase 5 0.0069 0.0612 0.0597
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.005 0.0414 0.1826

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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