Detailed information for compound 701527

Basic information

Technical information
  • TDR Targets ID: 701527
  • Name: 8-(4-methoxyphenyl)sulfonyl-4-thiophen-2-ylsu lfonyl-1-oxa-4,8-diazaspiro[4.5]decane
  • MW: 458.572 | Formula: C18H22N2O6S3
  • H donors: 0 H acceptors: 4 LogP: 2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)S(=O)(=O)N1CCC2(CC1)OCCN2S(=O)(=O)c1cccs1
  • InChi: 1S/C18H22N2O6S3/c1-25-15-4-6-16(7-5-15)28(21,22)19-10-8-18(9-11-19)20(12-13-26-18)29(23,24)17-3-2-14-27-17/h2-7,14H,8-13H2,1H3
  • InChiKey: VJSSRQCLMZCRBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-(4-methoxyphenyl)sulfonyl-4-(2-thienylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tsg101-related 0.0063 0.1924 0.4281
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.1202 0.1175
Echinococcus granulosus expressed protein 0.0009 0.022 0.0434
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0003 0.0031 0.0061
Entamoeba histolytica calmodulin, putative 0.0004 0.0042 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0003 0.0031 0.0061
Entamoeba histolytica calcium binding family protein 0.0004 0.0041 0.0011
Echinococcus granulosus ubiquitin specific peptidase c family 0.0003 0.0031 0.0061
Trypanosoma cruzi calmodulin, putative 0.0004 0.0042 0.0034
Trichomonas vaginalis calmodulin, putative 0.0004 0.0042 0.0011
Schistosoma mansoni reticulocalbin 0.0004 0.0042 0.0092
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0003 0.0031 0.0068
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.4848 1
Echinococcus granulosus troponin i 0.0116 0.3608 0.7108
Wolbachia endosymbiont of Brugia malayi ankyrin repeat-containing protein 0.0012 0.0298 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0003 0.0031 0.0061
Trypanosoma brucei polo-like protein kinase 0.0103 0.3183 1
Schistosoma mansoni ef hand domain family member A2 0.0004 0.0041 0.0091
Schistosoma mansoni rab 0.0004 0.0041 0.0091
Schistosoma mansoni mitochondrial solute carrier 0.0004 0.0041 0.0091
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0003 0.0031 0.0061
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Echinococcus multilocularis muscleblind protein 0.0163 0.5076 1
Schistosoma mansoni apoferritin-2 0.0009 0.022 0.0489
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.3183 0.6271
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0329 0.0299
Schistosoma mansoni hypothetical protein 0.0043 0.1303 0.29
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.0003 0.0031 0.0061
Schistosoma mansoni troponin I 0.0116 0.3608 0.803
Brugia malayi hypothetical protein 0.0003 0.0031 0.0061
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0004 0.0042 0.0011
Trypanosoma cruzi Polycystin cation channel, putative 0.0006 0.0116 0.027
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.4848 1
Trypanosoma cruzi calmodulin, putative 0.0004 0.0042 0.0034
Echinococcus multilocularis Polycystic kidney disease protein 0.0006 0.0116 0.0228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1303 0.2568
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0003 0.0031 0.0061
Echinococcus granulosus calumenin 0.0004 0.0042 0.0082
Trypanosoma brucei centrin, putative 0.0004 0.0041 0.0033
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0004 0.0041 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Schistosoma mansoni hypothetical protein 0.0004 0.0042 0.0092
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0004 0.0041 0.0033
Entamoeba histolytica calmodulin, putative 0.0004 0.0041 0.0011
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0004 0.0041 0.0082
Trichomonas vaginalis calcium binding protein, putative 0.0004 0.0041 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.0003 0.0031 0.0061
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0003 0.0031 0.0068
Echinococcus multilocularis ferritin 0.0009 0.022 0.0434
Trichomonas vaginalis calcineurin B subunit, putative 0.0004 0.0041 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0892 0.273
Echinococcus granulosus calbindin 32 0.0004 0.0041 0.0082
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Brugia malayi hypothetical protein 0.002 0.055 0.1084
Giardia lamblia Protein 21.1 0.0012 0.0298 0.0268
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0003 0.0031 0.0061
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0003 0.0031 0.0061
Echinococcus multilocularis muscleblind protein 1 0.0163 0.5076 1
Leishmania major centrin, putative 0.0004 0.0041 0.0033
Schistosoma mansoni mucolipin 0.0071 0.2175 0.4841
Echinococcus multilocularis calumenin 0.0004 0.0042 0.0082
Echinococcus multilocularis ATP binding cassette sub family G 0.0006 0.0132 0.0259
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Giardia lamblia ABC transporter 0.0006 0.0129 0.0099
Entamoeba histolytica ABC transporter, putative 0.0006 0.0132 0.0101
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0051 0.1558 0.1532
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0003 0.0031 0.0068
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0318 1 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0003 0.0031 0.0061
Trichomonas vaginalis ferritin, putative 0.0009 0.022 0.019
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0004 0.0042 0.0082
Onchocerca volvulus 0.0004 0.0042 0.0024
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.1202 0.2369
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0003 0.0031 0.0068
Toxoplasma gondii calmodulin CAM1 0.0004 0.0041 0.0122
Echinococcus granulosus calmodulin 0.0004 0.0041 0.0082
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0003 0.0031 0.0068
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 16 0.0003 0.0031 0.0061
Leishmania major calmodulin-like protein 0.0004 0.0041 0.0033
Loa Loa (eye worm) calmodulin-like protein 0.0004 0.0042 0.0082
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Trichomonas vaginalis calmodulin, putative 0.0004 0.0041 0.0011
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.1202 0.3716
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0003 0.0031 0.0068
Schistosoma mansoni hypothetical protein 0.0006 0.0116 0.0257
Schistosoma mansoni hypothetical protein 0.0006 0.0116 0.0257
Brugia malayi ABC transporter family protein 0.0005 0.0101 0.0198
Schistosoma mansoni neuronal calcium sensor 0.0004 0.0042 0.0092
Trypanosoma brucei Component of motile flagella 41 0.0004 0.0041 0.0033
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0003 0.0031 0.0061
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0004 0.0041 0.0091
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.1202 0.2369
Schistosoma mansoni peptidase 0.0004 0.0042 0.0091
Schistosoma mansoni calpain-7 (C02 family) 0.0003 0.0031 0.0068
Echinococcus granulosus muscleblind protein 0.0163 0.5076 1
Trichomonas vaginalis calmodulin, putative 0.0004 0.0041 0.0011
Echinococcus multilocularis EF hand domain containing family member A2 0.0004 0.0041 0.0082
Brugia malayi Coelomocyte uptake defective protein 5 0.0071 0.2175 0.4286
Entamoeba histolytica hypothetical protein 0.0013 0.0329 0.0299
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0003 0.0031 0.0061
Echinococcus multilocularis centrin 2 0.0004 0.0042 0.0082
Schistosoma mansoni calmodulin 0.0004 0.0041 0.0091
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0003 0.0031 0.0061
Leishmania major calmodulin, putative 0.0004 0.0042 0.0034
Trypanosoma cruzi caltractin, putative 0.0004 0.0041 0.0033
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0003 0.0031 0.0061
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Schistosoma mansoni ferritin light chain 0.0009 0.022 0.0489
Schistosoma mansoni neuronal calcium sensor 0.0004 0.0042 0.0092
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.3183 0.6271
Schistosoma mansoni ferritin 0.0009 0.022 0.0489
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Echinococcus multilocularis mucolipin 3 0.0071 0.2175 0.4286
Trichomonas vaginalis calmodulin, putative 0.0004 0.0042 0.0011
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0003 0.0031 0.0061
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0004 0.0041 0.0082
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0003 0.0031 0.0061
Trypanosoma brucei calmodulin, putative 0.0004 0.0042 0.0034
Onchocerca volvulus 0.0012 0.0298 0.0598
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0003 0.0031 0.0068
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0004 0.0041 0.0091
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0003 0.0031 0.0061
Schistosoma mansoni mucolipin 0.0065 0.1987 0.4422
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0003 0.0031 0.0061
Echinococcus multilocularis calcium uptake protein 1 0.0004 0.0041 0.0082
Loa Loa (eye worm) EF hand family protein 0.0004 0.0041 0.0082
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0004 0.0042 0.0011
Toxoplasma gondii EFHC1, putative 0.0004 0.0041 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0329 0.0945
Trypanosoma cruzi I/6 autoantigen, putative 0.0004 0.0041 0.0033
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0003 0.0031 0.0061
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0003 0.0031 0.0061
Leishmania major calmodulin-like protein 0.0004 0.0041 0.0033
Loa Loa (eye worm) troponin 0.0069 0.2111 0.4159
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0003 0.0031 0.0061
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0003 0.0031 0.0068
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3183 0.3162
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0004 0.0041 0.0091
Trypanosoma cruzi centrin, putative 0.0004 0.0041 0.0033
Trypanosoma brucei protein I/6 0.0004 0.0041 0.0033
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0003 0.0031 0.0061
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.1202 0.3716
Brugia malayi hypothetical protein 0.0069 0.2111 0.4159
Brugia malayi EF hand family protein 0.0004 0.0042 0.0082
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.1202 0.2675
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0116 0.027
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0892 1
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0003 0.0031 0.0061
Leishmania major programmed cell death 6 protein-like protein 0.0004 0.0042 0.0034
Brugia malayi Troponin T 0.0069 0.2111 0.4159
Loa Loa (eye worm) hypothetical protein 0.0116 0.3608 0.7108
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.1202 0.2369
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3183 0.3162
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Echinococcus granulosus neuronal calcium sensor 0.0004 0.0042 0.0082
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0004 0.0041 0.0091
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0006 0.0132 0.0319
Schistosoma mansoni troponin t invertebrate 0.0144 0.4493 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 47 0.0003 0.0031 0.0061
Onchocerca volvulus 0.0012 0.0298 0.0598
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1303 0.2568
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0003 0.0031 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Echinococcus granulosus calcium activated potassium channel 0.0002 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0329 0.0299
Brugia malayi hypothetical protein 0.0076 0.2324 0.458
Brugia malayi Muscleblind-like protein 0.0163 0.5076 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 47 0.0003 0.0031 0.0061
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Loa Loa (eye worm) hypothetical protein 0.0012 0.0298 0.0587
Trypanosoma cruzi I/6 autoantigen, putative 0.0004 0.0041 0.0033
Toxoplasma gondii calcium-dependent protein kinase 0.0004 0.0052 0.0245
Echinococcus multilocularis polycystic kidney disease protein 2 0.0006 0.0116 0.0228
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0003 0.0031 0.0061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0298 0.0587
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0892 1
Schistosoma mansoni calmodulin related calcium binding protein 0.0004 0.0042 0.0092
Echinococcus multilocularis expressed protein 0.0009 0.022 0.0434
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Loa Loa (eye worm) programmed cell death protein 6 0.0004 0.0041 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3183 0.3162
Schistosoma mansoni ferritin 0.0009 0.022 0.0489
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0116 0.027
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3183 0.3162
Trypanosoma cruzi calmodulin, putative 0.0004 0.0041 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0892 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.1202 0.2369
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.3183 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.1202 0.1175
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0003 0.0031 0.0061
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0003 0.0031 0.0068
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.1202 0.1175
Loa Loa (eye worm) hypothetical protein 0.0012 0.0298 0.0587
Loa Loa (eye worm) hypothetical protein 0.0004 0.0041 0.0082
Echinococcus granulosus neurocalcin 0.0004 0.0042 0.0082
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0003 0.0031 0.0061
Trichomonas vaginalis hypothetical protein 0.0037 0.1095 0.1068
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.022 0.0188
Echinococcus granulosus 5'partial|Ubiquitin carboxyl terminal hydrolase 48 0.0003 0.0031 0.0061
Trichomonas vaginalis calmodulin, putative 0.0004 0.0042 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.1202 0.2675
Loa Loa (eye worm) ion channel NompC 0.0014 0.0365 0.0719
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0003 0.0031 0.0068
Plasmodium vivax ABC transporter G family member 2, putative 0.0006 0.0132 0.1169
Trichomonas vaginalis calcium binding protein, putative 0.0004 0.0042 0.0011
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Echinococcus multilocularis calpain A 0.0004 0.0041 0.0082
Entamoeba histolytica hypothetical protein 0.0043 0.1303 0.1276
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1202 0.1175
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3183 0.3162
Echinococcus granulosus EF HAND 1 calcium binding site 0.0004 0.0042 0.0082
Loa Loa (eye worm) hypothetical protein 0.0163 0.5076 1
Toxoplasma gondii hypothetical protein 0.0006 0.0116 0.0988
Echinococcus multilocularis neurocalcin 0.0004 0.0042 0.0082
Schistosoma mansoni hypothetical protein 0.0116 0.3608 0.803
Trichomonas vaginalis calmodulin-2, putative 0.0004 0.0041 0.0011
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Brugia malayi EF hand family protein 0.0004 0.0041 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Schistosoma mansoni kinase 0.0052 0.1582 0.3521
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0041 0.0011
Echinococcus granulosus polycystic kidney disease protein 2 0.0006 0.0116 0.0228
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.3183 0.7064
Entamoeba histolytica hypothetical protein 0.0043 0.1303 0.1276
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0004 0.0041 0.0082
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.022 0.0188
Echinococcus multilocularis calmodulin 0.0004 0.0042 0.0082
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.1202 0.2369
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0003 0.0031 0.0061
Leishmania major protein kinase, putative 0.0004 0.0052 0.0068
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0003 0.0031 0.0068
Plasmodium falciparum centrin-1 0.0004 0.0042 0.0125
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0004 0.0052 0.0068
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 24 0.0003 0.0031 0.0061
Trichomonas vaginalis centrin, putative 0.0004 0.0041 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0298 0.0587
Trypanosoma brucei ABC transporter, putative 0.0006 0.0132 0.0319
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0024 0.0694 0.2105
Schistosoma mansoni centrin-related 0.0004 0.0042 0.0092
Echinococcus multilocularis expressed protein 0.0003 0.0031 0.0061
Trypanosoma brucei caltractin, putative 0.0004 0.0041 0.0033
Schistosoma mansoni neuronal calcium sensor 0.0004 0.0041 0.0091
Brugia malayi Troponin T 0.0069 0.2111 0.4159
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.3183 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0003 0.0031 0.0061
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0004 0.0042 0.0034
Echinococcus granulosus mucolipin 3 0.0071 0.2175 0.4286
Schistosoma mansoni tsg101-related 0.0051 0.1558 0.3467
Trichomonas vaginalis myosin light chain 1, putative 0.0004 0.0041 0.0011
Trypanosoma brucei I/6 autoantigen 0.0004 0.0041 0.0033
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.1202 0.2369
Echinococcus multilocularis transient receptor potential cation channel 0.0002 0.000000034471 0.000000067913
Plasmodium falciparum ABC transporter G family member 2 0.0006 0.0132 0.1169
Schistosoma mansoni hypothetical protein 0.0004 0.0041 0.0091
Trichomonas vaginalis calcium binding protein, putative 0.0004 0.0042 0.0011
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0892 0.273
Trichomonas vaginalis calcium binding protein, putative 0.0004 0.0042 0.0011
Trypanosoma cruzi Polycystin cation channel, putative 0.0006 0.0116 0.027
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0003 0.0031 0.0068
Trypanosoma cruzi centrin, putative 0.0004 0.0041 0.0033
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0003 0.0031 0.0068
Entamoeba histolytica calcium-binding protein, putative 0.0004 0.0041 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.2111 0.4159
Schistosoma mansoni troponin I 0.0116 0.3608 0.803
Echinococcus multilocularis neuronal calcium sensor 0.0004 0.0042 0.0082
Trypanosoma brucei ATP-binding cassette protein, putative 0.0006 0.0132 0.0319
Schistosoma mansoni polycystin 1-related 0.0006 0.0116 0.0257
Onchocerca volvulus Troponin I homolog 0.0116 0.3608 0.8016
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Leishmania major centrin, putative 0.0004 0.0041 0.0033
Trypanosoma cruzi ABC transporter, putative 0.0006 0.0132 0.0319
Onchocerca volvulus 0.0012 0.0298 0.0598
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0329 0.0945
Echinococcus granulosus EF hand domain containing family member A2 0.0004 0.0041 0.0082
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 24 0.0003 0.0031 0.0061
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Brugia malayi Troponin family protein 0.0116 0.3608 0.7108
Loa Loa (eye worm) hypothetical protein 0.0012 0.0298 0.0587
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0003 0.0031 0.0068
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Echinococcus granulosus Ubiquitin carboxyl terminal hydrolase 48 0.0003 0.0031 0.0061
Echinococcus granulosus polycystin 2 0.0006 0.0116 0.0228
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.1202 0.3716
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 16 0.0003 0.0031 0.0061
Schistosoma mansoni troponin I 0.0116 0.3608 0.803
Brugia malayi Troponin I 0.0116 0.3608 0.7108
Leishmania major hypothetical protein, conserved 0.0006 0.0116 0.027
Loa Loa (eye worm) ABC transporter 0.0005 0.0101 0.0198
Entamoeba histolytica grainin, putative 0.0004 0.0041 0.0011
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0004 0.0052 0.0068
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0069 0.2111 0.4661
Echinococcus multilocularis programmed cell death protein 0.0004 0.0041 0.0082
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.1202 0.2369
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0003 0.0031 0.0061
Echinococcus multilocularis ATP binding cassette sub family G 0.0006 0.0132 0.0259
Echinococcus granulosus ATP binding cassette sub family G 0.0006 0.0132 0.0259
Echinococcus granulosus ferritin 0.0009 0.022 0.0434
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.1202 0.1175
Loa Loa (eye worm) troponin T 0.0069 0.2111 0.4159
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Schistosoma mansoni reticulocalbin 0.0004 0.0041 0.0091
Trypanosoma cruzi centrin-3 0.0004 0.0041 0.0033
Toxoplasma gondii troponin c, isotype gamma, putative 0.0004 0.0041 0.0122
Giardia lamblia Fructose-bisphosphate aldolase 0.0318 1 1
Plasmodium vivax centrin-1, putative 0.0004 0.0042 0.0125
Schistosoma mansoni centrin 0.0004 0.0042 0.0092
Echinococcus granulosus programmed cell death protein 0.0004 0.0041 0.0082
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0076 0.2324 0.458
Brugia malayi hypothetical protein 0.0043 0.1303 0.2568
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Schistosoma mansoni apoferritin-2 0.0009 0.022 0.0489
Leishmania major i/6 autoantigen-like protein 0.0004 0.0041 0.0033
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.3183 0.6271
Echinococcus multilocularis transient receptor potential cation channel 0.0002 0.000000034471 0.000000067913
Echinococcus granulosus ATP binding cassette sub family G 0.0006 0.0132 0.0259
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0144 0.4493 0.8852
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3183 0.3162
Leishmania major calcineurin B subunit, putative 0.0004 0.0042 0.0034
Echinococcus granulosus ATP binding cassette sub family G 0.0006 0.0132 0.0259
Schistosoma mansoni ABC transporter 0.0005 0.0101 0.0223
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.1539 0.1513
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0004 0.0052 0.0068
Loa Loa (eye worm) hypothetical protein 0.003 0.0892 0.1756
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0003 0.0031 0.0061
Trichomonas vaginalis calcium binding proteins, putative 0.0004 0.0042 0.0011
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Leishmania major hypothetical protein, conserved 0.0024 0.0694 0.2105
Echinococcus multilocularis troponin i 0.0116 0.3608 0.7108
Entamoeba histolytica hypothetical protein 0.0043 0.1303 0.1276
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0004 0.0052 0.0248
Loa Loa (eye worm) hypothetical protein 0.004 0.1202 0.2369
Schistosoma mansoni calmodulin 0.0004 0.0041 0.0091
Entamoeba histolytica hypothetical protein 0.0013 0.0329 0.0299
Trichomonas vaginalis calmodulin, putative 0.0004 0.0041 0.0011
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.022 0.0257
Onchocerca volvulus 0.0004 0.0041 0.0023
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0003 0.0031 0.0061
Leishmania major hypothetical protein, conserved 0.0004 0.0041 0.0033
Trichomonas vaginalis calmodulin, putative 0.0004 0.0042 0.0011
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Echinococcus granulosus calcium uptake protein 1 0.0004 0.0041 0.0082
Echinococcus granulosus ubiquitin specific peptidase 30 (C19 family) 0.0003 0.0031 0.0061
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0004 0.0041 0.0033
Toxoplasma gondii centrin, putative 0.0004 0.0042 0.0125
Schistosoma mansoni calpain-7 (C02 family) 0.0003 0.0031 0.0068
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Leishmania major hypothetical protein, conserved 0.003 0.0892 0.273
Schistosoma mansoni hypothetical protein 0.0003 0.0031 0.0068
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.1202 0.3716
Toxoplasma gondii centrin 0.0004 0.0042 0.0125
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0003 0.0031 0.0068
Brugia malayi Troponin T 0.0069 0.2111 0.4159
Echinococcus granulosus EF hand domain containing family member A2 0.0004 0.0041 0.0082
Brugia malayi ion channel NompC 0.0012 0.0303 0.0598
Leishmania major calmodulin, putative 0.0004 0.0041 0.0033
Echinococcus multilocularis calcium activated potassium channel 0.0002 0.0006 0.0011
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0004 0.0042 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0003 0.0031 0.0068
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.3183 1
Brugia malayi ion channel NompC 0.0014 0.0365 0.0719
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Trichomonas vaginalis calmodulin, putative 0.0004 0.0042 0.0011
Echinococcus multilocularis calbindin 32 0.0004 0.0041 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Toxoplasma gondii EF hand domain-containing protein 0.0004 0.0041 0.0122
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0003 0.0031 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Trichomonas vaginalis calcineurin B subunit, putative 0.0004 0.0042 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0003 0.0031 0.0068
Echinococcus granulosus transient receptor potential cation channel 0.0002 0.000000034471 0.000000067913
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0003 0.0031 0.0068
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0003 0.0031 0.0061
Entamoeba histolytica hypothetical protein 0.0013 0.0329 0.0299
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0003 0.0031 0.0068
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0003 0.0031 0.0061
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0006 0.0132 0.1169
Loa Loa (eye worm) hypothetical protein 0.0116 0.3608 0.7108
Leishmania major hypothetical protein, conserved 0.0004 0.0041 0.0033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0298 0.0587
Trichomonas vaginalis centrin, putative 0.0004 0.0042 0.0011
Trypanosoma brucei Polycystin cation channel, putative 0.0006 0.0116 0.027
Schistosoma mansoni ferritin 0.0009 0.022 0.0489
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0076 0.2324 0.458
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Echinococcus granulosus calpain A 0.0004 0.0041 0.0082
Echinococcus multilocularis programmed cell death protein 0.0004 0.0041 0.0082
Schistosoma mansoni ferritin light chain 0.0009 0.022 0.0489
Schistosoma mansoni tsg101-related 0.0063 0.1924 0.4281
Loa Loa (eye worm) hypothetical protein 0.0012 0.0298 0.0587
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0003 0.0031 0.0061
Entamoeba histolytica grainin 2 0.0004 0.0041 0.0011
Treponema pallidum fructose-bisphosphate aldolase 0.0318 1 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.022 0.0257
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.036 0.071
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Loa Loa (eye worm) hypothetical protein 0.0076 0.2324 0.458
Echinococcus multilocularis EF hand domain containing family member A2 0.0004 0.0041 0.0082
Leishmania major phospholipase c-like protein 0.0004 0.0041 0.0033
Echinococcus multilocularis ATP binding cassette sub family G 0.0006 0.0132 0.0259
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.1539 0.1513
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.3183 0.3162
Giardia lamblia Hypothetical protein 0.0004 0.0041 0.0011
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Trypanosoma brucei calmodulin, putative 0.0004 0.0042 0.0034
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Giardia lamblia Kinase, PLK 0.0103 0.3183 0.3162
Echinococcus multilocularis Ubiquitin carboxyl terminal hydrolase 48 0.0003 0.0031 0.0061
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0144 0.4493 1
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0042 0.0011
Brugia malayi hypothetical protein 0.003 0.0892 0.1756
Trichomonas vaginalis calmodulin, putative 0.0004 0.0042 0.0011
Trypanosoma brucei centrin, putative 0.0004 0.0042 0.0034
Echinococcus granulosus Polycystic kidney disease protein 0.0006 0.0116 0.0228
Schistosoma mansoni hypothetical protein 0.0005 0.0098 0.0218
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0003 0.0031 0.0061
Leishmania major centrin, putative,caltractin, putative 0.0004 0.0042 0.0034
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Trypanosoma brucei hypothetical protein, conserved 0.0004 0.0042 0.0034
Entamoeba histolytica hypothetical protein, conserved 0.0004 0.0041 0.0011
Echinococcus granulosus centrin 2 0.0004 0.0042 0.0082
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.4848 1
Entamoeba histolytica hypothetical protein 0.0043 0.1303 0.1276
Schistosoma mansoni ferritin 0.0009 0.022 0.0489
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1303 0.29
Toxoplasma gondii hypothetical protein 0.0008 0.0183 0.1765
Echinococcus granulosus oncosphere protein Tso22e 0.0144 0.4493 0.8852
Trypanosoma brucei centrin-3 0.0004 0.0041 0.0033
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0006 0.0132 0.0292
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0013 0.0329 0.0945
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0004 0.0041 0.0033
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0892 0.273
Loa Loa (eye worm) mucolipin 1 0.0071 0.2175 0.4286
Schistosoma mansoni troponin I 0.0116 0.3608 0.803
Loa Loa (eye worm) hypothetical protein 0.0012 0.0298 0.0587
Brugia malayi Calmodulin-like protein 0.0004 0.0042 0.0082
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0024 0.0694 0.2105
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.3183 0.7084
Entamoeba histolytica hypothetical protein 0.0013 0.0329 0.0299
Brugia malayi calcium-binding protein 0.0004 0.0041 0.0082
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0003 0.0031 0.0061
Onchocerca volvulus 0.0004 0.0041 0.0023
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.3183 0.6271
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0892 1
Plasmodium vivax hypothetical protein, conserved 0.0004 0.0041 0.0122
Echinococcus multilocularis calmodulin 0.0004 0.0041 0.0082
Brugia malayi ubiquitin specific protease 14 0.0003 0.0031 0.0061
Trypanosoma brucei mitochondrial calcium uptake 1 0.0004 0.0041 0.0033
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0003 0.0031 0.0061
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0006 0.0132 0.0319
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0004 0.0041 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 1 1
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0004 0.0042 0.0011
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0006 0.0132 0.0319
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.3183 0.3162
Brugia malayi programmed cell death protein 6 0.0004 0.0042 0.0082
Loa Loa (eye worm) troponin I 0.0116 0.3608 0.7108
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.036 0.071
Schistosoma mansoni hypothetical protein 0.0014 0.036 0.0801
Loa Loa (eye worm) hypothetical protein 0.0163 0.5076 1
Schistosoma mansoni neuronal calcium sensor 0.0004 0.0042 0.0092
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0003 0.0031 0.0061
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0061
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0003 0.0031 0.0061

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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