Detailed information for compound 702949

Basic information

Technical information
  • TDR Targets ID: 702949
  • Name: AP-501/43091404
  • MW: 279.315 | Formula: C12H13N3O3S
  • H donors: 1 H acceptors: 3 LogP: 1.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)c1snnc1C)OC
  • InChi: 1S/C12H13N3O3S/c1-7-11(19-15-14-7)12(16)13-9-6-8(17-2)4-5-10(9)18-3/h4-6H,1-3H3,(H,13,16)
  • InChiKey: CCCHFEKAPCNJCB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • ZINC00385485

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0422 0.0656
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Loa Loa (eye worm) hypothetical protein 0.0058 0.1195 0.1565
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3559 0.565
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0033 0.0036
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0712 0.0712
Trichomonas vaginalis hypothetical protein 0.0006 0.0033 0.0095
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0025 0.0063
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.0288 0.0288
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0403 0.1671
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.061 0.2557
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0599 0.2508
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.2357 1
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0216 0.0327
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0327 0.1347
Plasmodium vivax sugar transporter, putative 0.0014 0.0216 0.0201
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0403 0.1671
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Echinococcus granulosus caspase 2 0.0058 0.1195 0.1173
Schistosoma mansoni glucose transport protein 0.0102 0.2158 0.2158
Brugia malayi phosphofructokinase 0.0111 0.2357 1
Toxoplasma gondii protein kinase, putative 0.0288 0.6292 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0288 0.1182
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0403 0.0398
Brugia malayi CXXC zinc finger family protein 0.0032 0.0608 0.2497
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.2357 0.2337
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0576 0.241
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0576 0.0552
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Schistosoma mansoni hypothetical protein 0.0456 1 1
Schistosoma mansoni hypothetical protein 0.0343 0.7501 0.7501
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Brugia malayi hypothetical protein 0.0014 0.0216 0.0817
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.1064 0.1041
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.1064 0.1041
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2357 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0118 0.0093
Brugia malayi Sugar transporter family protein 0.0014 0.0216 0.0817
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.1064 0.4488
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Echinococcus granulosus importin subunit beta 1 0.0032 0.061 0.0587
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0547 0.0523
Loa Loa (eye worm) hypothetical protein 0.0025 0.0449 0.0567
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0688 0.07
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.2357 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0191
Plasmodium vivax transportin, putative 0.0006 0.0033 0.0008
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis translational activator gcn1 0.0006 0.0033 0.0008
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.06 0.0769
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1064 0.4488
Plasmodium vivax importin-beta 2, putative 0.0032 0.061 0.0618
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0547 0.0523
Echinococcus multilocularis caspase 2 0.0058 0.1195 0.1173
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0216 0.0875
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0806 0.0782
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0216 0.0875
Giardia lamblia Sugar-proton symporter 0.0014 0.0216 0.1836
Trichomonas vaginalis ran, putative 0.0024 0.0422 0.1755
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Entamoeba histolytica protein kinase, putative 0.0032 0.06 0.2466
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0018 0.0288 0.0263
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2357 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0288 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2357 0.3119
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Schistosoma mansoni protein kinase 0.0032 0.06 0.06
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0688 0.2889
Schistosoma mansoni hypothetical protein 0.0037 0.0712 0.0712
Schistosoma mansoni cpg binding protein 0.0034 0.0648 0.0648
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0216 0.0875
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0403 0.0378
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0191
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0216 0.0191
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0422 0.0398
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0601 0.0607
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0422 0.1755
Plasmodium falciparum metacaspase 1 0.0018 0.0288 0.0277
Echinococcus granulosus snurportin 1 0.0343 0.7501 0.7494
Schistosoma mansoni glucose transport protein 0.0102 0.2158 0.2158
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Echinococcus multilocularis importin 5 0.0006 0.0033 0.0008
Loa Loa (eye worm) hypothetical protein 0.0041 0.0806 0.1044
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0216 0.0817
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0403 0.3633
Entamoeba histolytica hypothetical protein 0.0037 0.0712 0.2945
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Onchocerca volvulus 0.0041 0.0806 0.6021
Schistosoma mansoni hypothetical protein 0.0041 0.0806 0.0806
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0688 0.2889
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0074 0.0074
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.1064 0.4488
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0806 0.0782
Brugia malayi Cell death protein 3 precursor 0.0058 0.1195 0.5018
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2357 0.2357
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0138 0.0482
Trypanosoma cruzi metacaspase, putative 0.0018 0.0288 0.1182
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0562 0.2304
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2357 0.2357
Brugia malayi major facilitator superfamily protein 0.0014 0.0216 0.0817
Entamoeba histolytica HEAT repeat domain containing protein 0.0006 0.0033 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0599 0.2508
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0216 0.0216
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0138 0.0542
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0476 0.1983
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0599 0.2508
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.1064 0.1041
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0281 0.1154
Toxoplasma gondii sugar transporter ST2 0.0014 0.0216 0.0327
Loa Loa (eye worm) phosphofructokinase 0.0111 0.2357 0.3119
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0875
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0216 0.0875
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1064 0.4488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0945 0.0945
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0216 0.0817
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0422 0.1755
Schistosoma mansoni glucose transport protein 0.0102 0.2158 0.2158
Echinococcus multilocularis cpg binding protein 0.0034 0.0648 0.0624
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0601 0.0607
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0576 0.2362
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0327 0.1347
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0422 0.0531
Leishmania major hypothetical protein, conserved 0.0014 0.0216 0.0875
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0138 0.2091
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0688 0.2889
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.1195 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0601 0.0607
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.1064 0.1676
Schistosoma mansoni caspase-3 (C14 family) 0.0018 0.0288 0.0288
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0191
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.06 0.2513
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0403 0.0403
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Schistosoma mansoni cpg binding protein 0.0032 0.0608 0.0608
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0403 0.1671
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2357 1
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0562 0.0567
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0601 0.0607
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0074 0.0049
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0476 0.1983
Brugia malayi RNA, U transporter 1 0.0091 0.1923 0.8141
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.034 0.1406
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0025 0.0063
Trypanosoma brucei Metacaspase-4 0.0018 0.0288 0.1182
Loa Loa (eye worm) hypothetical protein 0.0031 0.0576 0.0737
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0422 0.3824
Schistosoma mansoni protein kinase 0.0032 0.06 0.06
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0025 0.0024
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0601 0.0939
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0403 0.1671
Leishmania major hypothetical protein, conserved 0.0006 0.0033 0.0095
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Entamoeba histolytica Ran family GTPase 0.0024 0.0422 0.1703
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0403 0.1671
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0576 0.0576
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0059 0.0206
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Echinococcus multilocularis importin subunit beta 1 0.0032 0.061 0.0587
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0403 0.1671
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.06 0.06
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.1064 0.1041
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0562 0.0879
Schistosoma mansoni hypothetical protein 0.0102 0.2158 0.2158
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0216
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2357 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.06 0.2466
Plasmodium falciparum hexose transporter 0.0102 0.2158 0.2251
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0288 0.0442
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0688 0.2889
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2158 0.2138
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0688 0.1079
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0599 0.2508
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Schistosoma mansoni importin-beta 2 0.0006 0.0033 0.0033
Brugia malayi hypothetical protein 0.0041 0.0806 0.3346
Leishmania major protein kinase, putative 0.0032 0.06 0.2513
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Loa Loa (eye worm) histone methyltransferase 0.001 0.0118 0.0124
Entamoeba histolytica hypothetical protein 0.0037 0.0712 0.2945
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0875
Giardia lamblia Hexose transporter 0.0014 0.0216 0.1836
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0216 0.0255
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0216 0.0875
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.061 0.2557
Echinococcus granulosus cpg binding protein 0.0034 0.0648 0.0624
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0599 0.2508
Echinococcus granulosus caspase 0.0018 0.0288 0.0263
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma cruzi metacaspase, putative 0.0018 0.0288 0.1182
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0422 0.0398
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0712 0.0688
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0562 0.0879
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0403 0.1671
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.1195 0.1195
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0216 0.0875
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0288 0.1126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0422 0.1755
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2158 0.3418
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.061 0.0955
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0562 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0601 0.0939
Brugia malayi hypothetical protein 0.0037 0.0712 0.2945
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis transportin 1 0.0006 0.0033 0.0008
Brugia malayi major facilitator superfamily protein 0.0014 0.0216 0.0817
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0403 0.0403
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0025 0.0063
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Entamoeba histolytica hypothetical protein 0.0037 0.0712 0.2945
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0601 0.0607
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0074 0.0049
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0033 0.001
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.06 0.0576
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0608 0.0779
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0576 0.0576
Entamoeba histolytica hypothetical protein 0.0026 0.0476 0.1932
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0599 0.2508
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0025 0.0025
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2357 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.1064 0.4488
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1064 0.4488
Trypanosoma brucei metacaspase 0.0018 0.0288 0.1182
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0216 0.0191
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0191
Brugia malayi hypothetical protein 0.0014 0.0216 0.0817
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2357 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0576 0.5304
Trypanosoma brucei metacaspase MCA2 0.0018 0.0288 0.1182
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0191
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0562 0.0567
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0601 0.0607
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Trypanosoma brucei metacaspase 5, putative 0.0018 0.0288 0.1182
Schistosoma mansoni importin beta-1 0.0032 0.061 0.061
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0576 0.2362
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma brucei glucose transporter 1E 0.0032 0.0599 0.2508
Echinococcus granulosus caspase 8 0.0018 0.0288 0.0263
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Brugia malayi 6-phosphofructokinase 0.0111 0.2357 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Plasmodium falciparum protein kinase 7 0.0288 0.6292 0.6616
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0018 0.0288 0.0263
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1064 0.4488
Brugia malayi 6-phosphofructokinase 0.0111 0.2357 1
Echinococcus multilocularis snurportin 1 0.0343 0.7501 0.7494
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0945 0.0922
Loa Loa (eye worm) hypothetical protein 0.0023 0.0403 0.0505
Leishmania major glucose transporter, lmgt2 0.0032 0.0599 0.2508
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0216
Plasmodium falciparum protein kinase 6 0.0433 0.9497 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.1064 0.4488
Trypanosoma brucei sugar transporter, putative 0.0014 0.0216 0.0875
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0033 0.0036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0118 0.0093
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0086 0.0323
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0422 0.0419
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0599 0.2508
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0216 0.0875
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0403 0.1618
Brugia malayi Cam kinase protein 1 0.0032 0.06 0.2466
Brugia malayi MAP kinase sur-1 0.0053 0.1064 0.4453
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0216 0.0875
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Plasmodium vivax metacaspase 1, putative 0.0018 0.0288 0.0277
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0025 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 0.9497 1
Plasmodium vivax hexose transporter 0.0102 0.2158 0.2251
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.1064 0.1389
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2158 0.9151
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0562 0.2352
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0599 0.2508
Entamoeba histolytica hypothetical protein 0.0023 0.0403 0.1618
Trypanosoma brucei protein kinase, putative 0.0053 0.1064 0.4488
Toxoplasma gondii sugar transporter ST1 0.0014 0.0216 0.0327
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0599 0.2508
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Echinococcus granulosus transportin 1 0.0006 0.0033 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0176 0.0202
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0327 0.1347
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0562 0.0567
Brugia malayi kap beta 3 protein 0.0006 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.1064 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0191
Plasmodium falciparum metacaspase-like protein 0.0018 0.0288 0.0277
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.2357 1
Brugia malayi Sugar transporter family protein 0.0014 0.0216 0.0817
Trypanosoma brucei glucose transporter 2A 0.0032 0.0599 0.2508
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0033 0.001
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.2357 0.2337
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1242 0.1961
Trypanosoma brucei metacaspase MCA3 0.0018 0.0288 0.1182
Onchocerca volvulus 0.0032 0.0608 0.3999
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2158 0.2138
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0216 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Schistosoma mansoni cpg binding protein 0.0034 0.0648 0.0648
Echinococcus granulosus importin 5 0.0006 0.0033 0.0008
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0216 0.0191
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0216 0.0191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0945 0.0945
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0403 0.0624
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.2357 1
Trypanosoma cruzi metacaspase, putative 0.0018 0.0288 0.1182
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0601 0.0607
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0216 0.0817
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Entamoeba histolytica protein kinase, putative 0.0032 0.06 0.2466
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0576 0.241
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2357 1
Echinococcus granulosus General substrate transporter 0.0088 0.184 0.1819
Plasmodium falciparum transportin 0.0006 0.0033 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2357 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0576 0.2362
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0216 0.0875
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0562 0.2304
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.06 0.2513
Echinococcus multilocularis dnaJ subfamily B 0.0456 1 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0025 0.0063
Echinococcus granulosus translational activator gcn1 0.0006 0.0033 0.0008
Echinococcus multilocularis caspase 8 0.0018 0.0288 0.0263
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0216
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0476 0.1983
Leishmania major GTP-binding protein, putative 0.0024 0.0422 0.1755
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3559 0.3731
Entamoeba histolytica hypothetical protein 0.0037 0.0712 0.2945
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0599 0.2508
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0006 0.0033 0.0095
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Schistosoma mansoni sugar transporter 0.0014 0.0216 0.0216
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0422 0.1703
Trichomonas vaginalis helicase, putative 0.0007 0.0059 0.0206
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0403 0.0378
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0576 0.0552
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0422 0.0419
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0403 0.0398
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3559 0.3731
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0059 0.0206
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0074 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Schistosoma mansoni glucose transporter 0.0014 0.0216 0.0216
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0343 0.7501 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0562 0.5173
Trypanosoma cruzi metacaspase, putative 0.0018 0.0288 0.1182
Loa Loa (eye worm) hypothetical protein 0.0032 0.061 0.0783
Schistosoma mansoni protein kinase 0.0032 0.06 0.06
Loa Loa (eye worm) hypothetical protein 0.0031 0.0576 0.0737
Echinococcus granulosus solute carrier family 22 0.0014 0.0216 0.0191
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0562 0.0879
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0216 0.0875
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0255
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Echinococcus multilocularis solute carrier family 22 0.0014 0.0216 0.0191
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0476 0.1983
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0288 0.1182
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0599 0.2508
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.2357 1
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0288 0.0288
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0945 0.123
Echinococcus multilocularis caspase 0.0018 0.0288 0.0263
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1064 0.1064
Brugia malayi hypothetical protein 0.0014 0.0216 0.0817
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Schistosoma mansoni ran 0.0024 0.0422 0.0422
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0216 0.0875
Echinococcus multilocularis General substrate transporter 0.0088 0.184 0.1819
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.06 0.0576
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1064 0.4488
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0288 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Leishmania major glucose transporter, lmgt1 0.0032 0.0599 0.2508
Loa Loa (eye worm) hypothetical protein 0.0018 0.0288 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0875
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0712 0.0688
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0945 0.0922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0945 0.0922
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0025 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0562 0.2352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0945 0.0945
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2357 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Loa Loa (eye worm) hypothetical protein 0.0032 0.06 0.0769
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0875
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2357 0.3119
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0562 1
Leishmania major metacaspase, putative 0.0018 0.0288 0.1182
Toxoplasma gondii sugar transporter ST3 0.0014 0.0216 0.0327
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0945 0.3943
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0599 0.2508
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1064 0.4488
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0074 0.0049
Brugia malayi Importin beta-1 subunit 0.0032 0.061 0.2509
Leishmania major glucose transporter, lmgt3 0.0032 0.0599 0.2508
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0403 0.7023
Schistosoma mansoni ran 0.0024 0.0422 0.0422
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0216 0.0875
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0115 0.0384
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.06 0.0769
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0059 0.0206
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Mycobacterium ulcerans sugar transporter 0.0014 0.0216 0.0875
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0288 0.0277
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0688 0.2889
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0599 0.2508
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0216 0.0255
Leishmania major importin beta-1 subunit, putative 0.0026 0.0476 0.1983
Loa Loa (eye worm) sugar transporter 0.0014 0.0216 0.0255
Plasmodium falciparum importin beta, putative 0.0032 0.061 0.0618
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1403 0.1403
Trypanosoma brucei glucose transporter, putative 0.0032 0.0599 0.2508
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0288 0.1182
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0601 0.0607
Brugia malayi Sugar transporter family protein 0.0102 0.2158 0.9146
Trypanosoma cruzi hexose transporter 0.0032 0.0599 0.2508
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182
Loa Loa (eye worm) sugar transporter 0.0102 0.2158 0.2852
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0562 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0059 0.0206
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0601 0.0939
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0601 0.0607
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0216 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0599 0.2508
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0216 0.0875
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.1064 0.4488
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0945 0.0922
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0688 0.07
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0216 0.0875
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0288 0.1182

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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