Detailed information for compound 705532

Basic information

Technical information
  • TDR Targets ID: 705532
  • Name: N-(4-fluorophenyl)-1-phenyl-6-piperidin-1-ylp yrazolo[4,5-e]pyrimidin-4-amine
  • MW: 388.441 | Formula: C22H21FN6
  • H donors: 1 H acceptors: 3 LogP: 5.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Nc1nc(nc2c1cnn2c1ccccc1)N1CCCCC1
  • InChi: 1S/C22H21FN6/c23-16-9-11-17(12-10-16)25-20-19-15-24-29(18-7-3-1-4-8-18)21(19)27-22(26-20)28-13-5-2-6-14-28/h1,3-4,7-12,15H,2,5-6,13-14H2,(H,25,26,27)
  • InChiKey: OCRXAYBBQHVOJI-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(4-fluorophenyl)-1-phenyl-6-(1-piperidyl)pyrazolo[4,5-e]pyrimidin-4-amine
  • N-(4-fluorophenyl)-1-phenyl-6-(1-piperidyl)-4-pyrazolo[4,5-e]pyrimidinamine
  • (4-fluorophenyl)-(1-phenyl-6-piperidino-pyrazolo[4,5-e]pyrimidin-4-yl)amine
  • N-(4-fluorophenyl)-1-phenyl-6-piperidin-1-yl-pyrazolo[4,5-e]pyrimidin-4-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0515 0.2209
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Brugia malayi Major Facilitator Superfamily protein 0.0064 0.0251 0.1094
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0035 0.0102
Trichomonas vaginalis myo-inositol transporter, putative 0.0064 0.0251 0.1049
Trypanosoma cruzi hexose transporter 0.0141 0.0653 0.8722
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Trypanosoma brucei THT1 - hexose transporter, putative 0.0141 0.0653 0.8722
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0025 0.005 0.017
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0025 0.005 0.0528
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0404
Schistosoma mansoni sugar transporter 0.0064 0.0251 0.1049
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.0235 0.3038
Leishmania major hypothetical protein, conserved 0.0064 0.0251 0.325
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0659 0.284
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0115 0.0453
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0453 0.2292 1
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Trypanosoma brucei glucose transporter, putative 0.0141 0.0653 0.8722
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0136 0.0629 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.0235 0.3038
Trichomonas vaginalis sugar transporter, putative 0.0141 0.0653 0.2815
Onchocerca volvulus 0.0064 0.0251 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0046 0.0466
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0023 0.0035 0.0317
Entamoeba histolytica hypothetical protein 0.0101 0.0447 0.6652
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0171 0.0748
Toxoplasma gondii lysine-tRNA ligase 0.0101 0.0447 0.0658
Giardia lamblia Sugar-proton symporter 0.0064 0.0251 0.346
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0515 0.6847
Schistosoma mansoni lysyl-tRNA synthetase 0.0101 0.0447 0.1909
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0139 0.0646 0.2821
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0136 0.0629 0.2709
Trichomonas vaginalis glucose transporter, putative 0.0141 0.0653 0.2815
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Leishmania major glucose transporter/membrane transporter D2, putative 0.0141 0.0653 0.8722
Loa Loa (eye worm) hypothetical protein 0.006 0.0232 0.0968
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Echinococcus granulosus calcium dependent protein kinase 0.013 0.0599 0.2576
Loa Loa (eye worm) acetyltransferase 0.0142 0.0659 0.284
Onchocerca volvulus 0.0064 0.0251 1
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0251 0.1049
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Toxoplasma gondii sugar transporter ST1 0.0064 0.0251 0.0361
Toxoplasma gondii ABC1 family protein 0.0036 0.0104 0.0139
Plasmodium vivax threonine--tRNA ligase, putative 0.0025 0.005 0.0039
Brugia malayi Major Facilitator Superfamily protein 0.0064 0.0251 0.1094
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0158 0.0747 1
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0251 0.1049
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.0235 0.3038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0104 0.064
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0046 0.0466
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0515 0.2209
Brugia malayi Sugar transporter family protein 0.0064 0.0251 0.1094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0171 0.0702
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0515 0.2209
Trypanosoma cruzi sugar transporter, putative 0.0064 0.0251 0.325
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Mycobacterium ulcerans lipase LipD 0.0036 0.0104 0.1432
Onchocerca volvulus 0.0064 0.0251 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0139 0.0647 0.0636
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0078 0.0067
Plasmodium vivax glycine--tRNA ligase, putative 0.0025 0.005 0.0039
Brugia malayi hypothetical protein 0.0064 0.0251 0.1094
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Trypanosoma brucei glucose transporter, putative 0.0141 0.0653 0.8722
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0104 0.0404
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0056 0.0209 0.0867
Giardia lamblia Kinase, CMGC MAPK 0.0061 0.0235 0.319
Brugia malayi lysyl-tRNA synthetase 0.0101 0.0447 0.195
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Trypanosoma brucei glucose transporter, putative 0.0141 0.0653 0.8722
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0086 0.0367 0.5587
Trichomonas vaginalis sugar transport protein, putative 0.0064 0.0251 0.1049
Plasmodium falciparum lysine--tRNA ligase 0.0101 0.0447 0.0436
Schistosoma mansoni glucose transport protein 0.0453 0.2292 1
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0023 0.0035 0.0317
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0139 0.0647 0.096
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0139 0.0647 0.0636
Loa Loa (eye worm) beta-lactamase 0.0036 0.0104 0.0404
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0235 0.098
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0064 0.0251 0.1049
Schistosoma mansoni protein kinase 0.0139 0.0646 0.2785
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0078 0.0471
Onchocerca volvulus 0.0064 0.0251 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0046 0.0034
Loa Loa (eye worm) hypothetical protein 0.011 0.0496 0.2123
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0101 0.0447 0.5917
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Onchocerca volvulus 0.0064 0.0251 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0139 0.0646 0.2785
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Mycobacterium leprae Probable lipase LipE 0.0036 0.0104 0.1157
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0064 0.0251 0.0239
Giardia lamblia Prolyl-tRNA synthetase 0.0136 0.0629 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0046 0.0034
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0104 0.0404
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0136 0.0629 0.2746
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0515 0.6847
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0104 0.0404
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0515 0.4466
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.0235 0.3038
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0078 0.0067
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.0235 0.0338
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Entamoeba histolytica protein kinase, putative 0.0139 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Trichomonas vaginalis esterase, putative 0.0036 0.0104 0.0404
Brugia malayi Cell death protein 3 precursor 0.006 0.0232 0.1013
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0078 0.0101
Brugia malayi beta-lactamase 0.0036 0.0104 0.0452
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0536 0.2302
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0515 0.78
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0078 0.0294
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0064 0.0251 0.2007
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0139 0.0646 0.2785
Loa Loa (eye worm) hypothetical protein 0.0101 0.0447 0.1909
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0104 0.0404
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0101 0.0447 0.1909
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Echinococcus multilocularis calcium dependent protein kinase 0.013 0.0599 0.2576
Trypanosoma brucei glucose transporter, putative 0.0141 0.0653 0.8722
Schistosoma mansoni protein kinase 0.0139 0.0646 0.2785
Schistosoma mansoni glucose transport protein 0.0453 0.2292 1
Echinococcus granulosus glycyl tRNA synthetase 0.0025 0.005 0.017
Echinococcus multilocularis caspase 2 0.006 0.0232 0.0968
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0078 0.0709
Trichomonas vaginalis sugar transporter, putative 0.0141 0.0653 0.2815
Mycobacterium tuberculosis Conserved protein 0.0036 0.0104 0.064
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0139 0.0646 0.2785
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0294
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0404
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0104 0.1157
Leishmania major lysyl-tRNA synthetase, putative 0.0101 0.0447 0.5917
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0453 0.2292 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0294
Brugia malayi 6-phosphofructokinase 0.0114 0.0515 0.2248
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0023 0.0035 0.0317
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0104 0.0404
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0515 0.78
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Leishmania major glucose transporter, lmgt2 0.0141 0.0653 0.8722
Onchocerca volvulus 0.0064 0.0251 1
Brugia malayi Sugar transporter family protein 0.0064 0.0251 0.1094
Schistosoma mansoni caspase-7 (C14 family) 0.006 0.0232 0.0968
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.005 0.0528
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Brugia malayi 6-phosphofructokinase 0.0114 0.0515 0.2248
Leishmania major hypothetical protein, conserved 0.0025 0.0046 0.0466
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0158 0.0747 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0117 0.1115
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Plasmodium vivax sugar transporter, putative 0.0064 0.0251 0.0239
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0104 0.0404
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Trypanosoma brucei glucose transporter, putative 0.0141 0.0653 0.8722
Onchocerca volvulus 0.0042 0.0137 0.2297
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0136 0.0629 0.2709
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0035 0.0317
Schistosoma mansoni hypothetical protein 0.0453 0.2292 1
Onchocerca volvulus 0.0064 0.0251 1
Onchocerca volvulus 0.0064 0.0251 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0171 0.0702
Toxoplasma gondii protein kinase, putative 0.1281 0.663 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0453 0.2292 1
Trypanosoma brucei glucose transporter, putative 0.0141 0.0653 0.8722
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0025 0.005 0.017
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0078 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0653 0.2815
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0171 0.0702
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0046 0.0466
Trypanosoma cruzi hexose transporter, putative 0.0141 0.0653 0.8722
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0048 0.0168 0.2781
Schistosoma mansoni glucose transporter 0.0064 0.0251 0.1049
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0135 0.0542
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.0235 0.098
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0659 0.284
Trypanosoma brucei THT1 - hexose transporter, putative 0.0141 0.0653 0.8722
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0453 0.2292 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0453 0.2292 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0235 0.3038
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.005 0.0528
Echinococcus multilocularis solute carrier family 22 0.0064 0.0251 0.1049
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.0747 1
Onchocerca volvulus 0.0064 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.017
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0136 0.0629 0.9712
Plasmodium falciparum calcium-dependent protein kinase 1 0.0139 0.0647 0.0636
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0139 0.0647 0.096
Trypanosoma brucei THT1 - hexose transporter, putative 0.0141 0.0653 0.8722
Echinococcus granulosus geminin 0.0166 0.0784 0.339
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0025 0.005 0.017
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.0235 0.3038
Loa Loa (eye worm) hypothetical protein 0.0136 0.0629 0.2709
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0104 0.064
Plasmodium falciparum calcium-dependent protein kinase 4 0.0139 0.0647 0.0636
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0139 0.0646 0.2785
Echinococcus granulosus caspase 2 0.006 0.0232 0.0968
Leishmania major glucose transporter, lmgt3 0.0141 0.0653 0.8722
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.1082
Toxoplasma gondii facilitative glucose transporter GT1 0.0453 0.2292 0.3446
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0104 0.0092
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0104 0.1252
Entamoeba histolytica protein kinase, putative 0.0139 0.0646 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0078 0.0067
Leishmania major protein kinase, putative 0.0139 0.0646 0.8629
Schistosoma mansoni hypothetical protein 0.0042 0.0137 0.0552
Leishmania major myo-inositol/proton symporter (MIT) 0.0064 0.0251 0.325
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0135 0.0542
Plasmodium vivax proline--tRNA ligase, putative 0.0158 0.0747 0.0737
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.1082
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0025 0.005 0.0219
Brugia malayi phosphofructokinase 0.0114 0.0515 0.2248
Mycobacterium ulcerans integral membrane transport protein 0.0064 0.0251 0.4493
Echinococcus multilocularis solute carrier family 22 0.0064 0.0251 0.1049
Loa Loa (eye worm) hypothetical protein 0.0136 0.0629 0.2709
Brugia malayi MH2 domain containing protein 0.0118 0.0536 0.234
Mycobacterium ulcerans beta-lactamase 0.0036 0.0104 0.1432
Brugia malayi major facilitator superfamily protein 0.0064 0.0251 0.1094
Mycobacterium tuberculosis Conserved protein 0.0036 0.0104 0.064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0171 0.0702
Echinococcus multilocularis synaptic vesicle 2 protein 0.0064 0.0251 0.1049
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0078 0.0067
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0064 0.0251 0.4493
Onchocerca volvulus Cell death protein 3 homolog 0.006 0.0232 0.874
Schistosoma mansoni glucose transport protein 0.0453 0.2292 1
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.0235 0.098
Echinococcus granulosus Sugar transporter ERD6 protein 0.0064 0.0251 0.1049
Echinococcus granulosus solute carrier family 22 0.0064 0.0251 0.1049
Plasmodium falciparum hexose transporter 0.0453 0.2292 0.2283
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.0235 0.098
Echinococcus granulosus lysyl tRNA synthetase 0.0101 0.0447 0.1909
Trypanosoma cruzi hexose transporter, putative 0.0141 0.0653 0.8722
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0136 0.0629 0.2709
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0453 0.2292 1
Trypanosoma brucei glucose transporter, putative 0.0141 0.0653 0.8722
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0135 0.0124
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0117 0.0105
Schistosoma mansoni protein kinase 0.0139 0.0646 0.2785
Loa Loa (eye worm) sugar transporter 0.0064 0.0251 0.1049
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0294
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Toxoplasma gondii transporter, major facilitator family protein 0.0064 0.0251 0.0361
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.0235 0.098
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0101 0.0447 0.6932
Chlamydia trachomatis lysine--tRNA ligase 0.0101 0.0447 1
Onchocerca volvulus 0.0064 0.0251 1
Toxoplasma gondii glycyl-tRNA synthetase 0.0025 0.005 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0104 0.0404
Brugia malayi hypothetical protein 0.0038 0.0115 0.0501
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0171 0.0702
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.1082
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0035 0.0317
Schistosoma mansoni glycyl-tRNA synthetase 0.0025 0.005 0.017
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0515 0.2209
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0025 0.005 0.017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0115 0.0453
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Plasmodium falciparum mitogen-activated protein kinase 2 0.0733 0.3757 0.375
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0139 0.0646 0.2785
Schistosoma mansoni sugar transporter 0.0064 0.0251 0.1049
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0139 0.0646 0.2785
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0135 0.0187
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0064 0.0251 0.1049
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0104 0.1252
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0404
Leishmania major glucose transporter, lmgt1 0.0141 0.0653 0.8722
Giardia lamblia Lysyl-tRNA synthetase 0.0101 0.0447 0.6849
Brugia malayi MAP kinase sur-1 0.0061 0.0235 0.1025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0235 0.3038
Trichomonas vaginalis CAMK family protein kinase 0.0139 0.0646 0.2785
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0235 0.098
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0453 0.2292 1
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0235 0.098
Schistosoma mansoni hypothetical protein 0.0166 0.0784 0.339
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0251 0.1049
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Echinococcus multilocularis solute carrier family 22 0.0064 0.0251 0.1049
Plasmodium vivax CDK-related protein kinase 6, putative 0.1924 1 1
Giardia lamblia Hexose transporter 0.0064 0.0251 0.346
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0078 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0453 0.2292 1
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0251 0.1049
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0104 0.1252
Onchocerca volvulus Putative transporter 0.0064 0.0251 1
Trypanosoma brucei glucose transporter 2A 0.0141 0.0653 0.8722
Echinococcus multilocularis General substrate transporter 0.0389 0.1958 0.8536
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0035 0.0102
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0115 0.0453
Mycobacterium ulcerans sugar transporter 0.0064 0.0251 0.4493
Echinococcus granulosus solute carrier family 22 0.0064 0.0251 0.1049
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0046 0.0052
Echinococcus granulosus solute carrier family 22 0.0064 0.0251 0.1049
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Mycobacterium ulcerans hypothetical protein 0.0036 0.0104 0.1432
Loa Loa (eye worm) hypothetical protein 0.0042 0.0137 0.0552
Plasmodium vivax hexose transporter 0.0453 0.2292 0.2283
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0638 0.2748
Brugia malayi hypothetical protein 0.0025 0.0046 0.02
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0515 0.2209
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0011 0.005
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0104 0.1432
Leishmania major hypothetical protein, conserved 0.0023 0.0035 0.0317
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0104 0.064
Onchocerca volvulus 0.0064 0.0251 1
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0515 0.2209
Trichomonas vaginalis sugar transporter, putative 0.0141 0.0653 0.2815
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0064 0.0251 0.2007
Onchocerca volvulus 0.0064 0.0251 1
Trypanosoma brucei glucose transporter, putative 0.0141 0.0653 0.8722
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0086 0.0367 0.3087
Trypanosoma cruzi glucose transporter, putative 0.0064 0.0251 0.325
Trypanosoma cruzi hexose transporter, putative 0.0141 0.0653 0.8722
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0515 0.2209
Loa Loa (eye worm) hypothetical protein 0.0025 0.0046 0.0151
Brugia malayi beta-lactamase family protein 0.0036 0.0104 0.0452
Echinococcus granulosus Threonyl tRNA synthetase C 0.0025 0.005 0.017
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0104 0.064
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0137 0.0552
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0235 0.098
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0136 0.0629 0.2709
Trypanosoma brucei sugar transporter, putative 0.0064 0.0251 0.325
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0135 0.0542
Plasmodium falciparum calcium-dependent protein kinase 5 0.0139 0.0647 0.0636
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0136 0.0629 0.2746
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0104 0.0404
Echinococcus granulosus solute carrier family 22 0.0064 0.0251 0.1049
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0078 0.0604
Leishmania major threonyl-tRNA synthetase, putative 0.0025 0.005 0.0528
Loa Loa (eye worm) major facilitator superfamily transporter 0.0064 0.0251 0.1049
Trypanosoma cruzi hexose transporter, putative 0.0077 0.0319 0.4184
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0025 0.005 0.0145
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0515 0.2209
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0078 0.0101
Trichomonas vaginalis glucose transporter, putative 0.0141 0.0653 0.2815
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0139 0.0646 0.8629
Echinococcus multilocularis solute carrier family 22 0.0064 0.0251 0.1049
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0064 0.0251 0.325
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0404
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0136 0.0629 0.2709
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0139 0.0646 0.2785
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0139 0.0646 0.2785
Loa Loa (eye worm) major facilitator superfamily transporter 0.0064 0.0251 0.1049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1111 1
Brugia malayi major facilitator superfamily protein 0.0064 0.0251 0.1094
Schistosoma mansoni hypothetical protein 0.0038 0.0115 0.0453
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0139 0.0646 0.2785
Onchocerca volvulus 0.0064 0.0251 1
Onchocerca volvulus 0.0064 0.0251 1
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0025 0.005 0.0219
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0089 0.0381 0.1623
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0646 0.2785
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0064 0.0251 0.4493
Brugia malayi Major Facilitator Superfamily protein 0.0064 0.0251 0.1094
Schistosoma mansoni hypothetical protein 0.0166 0.0784 0.339
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0294
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0515 0.6847
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0078 0.0485
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0046 0.0034
Plasmodium falciparum threonine--tRNA ligase 0.0025 0.005 0.0039
Brugia malayi glycyl-tRNA synthetase 0.0025 0.005 0.0219
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.0747 1
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0025 0.005 0.0324
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0515 1
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0023 0.0035 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Plasmodium falciparum protein kinase 7 0.1281 0.663 0.6626
Brugia malayi hypothetical protein 0.0042 0.0137 0.0599
Chlamydia trachomatis proline--tRNA ligase 0.0048 0.0168 0.2978
Brugia malayi Cam kinase protein 1 0.0139 0.0646 0.2821
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0035 0.0102
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0235 0.098
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0137 0.0552
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0104 0.1432
Brugia malayi hypothetical protein 0.0064 0.0251 0.1094
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Loa Loa (eye worm) hypothetical protein 0.0139 0.0646 0.2785
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0025 0.005 0.0059
Treponema pallidum prolyl-tRNA synthetase 0.0048 0.0168 0.2539
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0515 0.2209
Echinococcus multilocularis glycyl tRNA synthetase 0.0025 0.005 0.017
Schistosoma mansoni lysyl-tRNA synthetase 0.0101 0.0447 0.1909
Trypanosoma brucei protein kinase, putative 0.0061 0.0235 0.3038
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0515 0.78
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0294
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0104 0.0452
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0515 0.2209
Brugia malayi beta-lactamase family protein 0.0036 0.0104 0.0452
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0104 0.064
Loa Loa (eye worm) hypothetical protein 0.0036 0.0104 0.0404
Brugia malayi Sugar transporter family protein 0.0453 0.2292 1
Onchocerca volvulus 0.0064 0.0251 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0064 0.0251 1
Leishmania major hypothetical protein, conserved 0.0036 0.0104 0.1252
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0104 0.0404
Onchocerca volvulus 0.0064 0.0251 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0139 0.0647 0.096
Echinococcus multilocularis geminin 0.0166 0.0784 0.339
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0733 0.3757 0.375
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0139 0.0646 0.2785
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0251 0.1049
Brugia malayi hypothetical protein 0.0064 0.0251 0.1094
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0101 0.0447 0.5917
Plasmodium vivax lysine--tRNA ligase, putative 0.0101 0.0447 0.0436
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.0235 0.098
Echinococcus granulosus General substrate transporter 0.0389 0.1958 0.8536
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0251 0.1049
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0453 0.2292 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0104 0.064
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0294
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0515 0.2209
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0536 0.2302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0171 0.0702
Plasmodium falciparum proline--tRNA ligase 0.0158 0.0747 0.0737
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0653 0.2815
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0251 0.325
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0515 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0158 0.0747 0.1112
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0101 0.0447 0.8576
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0104 0.064
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0025 0.005 0.0324
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0101 0.0447 0.8576
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0117 0.1148
Plasmodium falciparum calcium-dependent protein kinase 3 0.0139 0.0647 0.0636
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0104 0.0404
Echinococcus granulosus synaptic vesicle 2 protein 0.0064 0.0251 0.1049
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.0747 1
Toxoplasma gondii sugar transporter ST3 0.0064 0.0251 0.0361
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0515 0.8083
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0251 0.1049
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0104 0.064
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0139 0.0647 0.0636
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0086 0.0367 0.3087
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0171 0.0702
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0733 0.3757 0.566
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0139 0.0647 0.0636
Trypanosoma brucei glucose transporter 1E 0.0141 0.0653 0.8722
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0659 0.2875
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Toxoplasma gondii sugar transporter ST2 0.0064 0.0251 0.0361
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.1082
Loa Loa (eye worm) sugar transporter 0.0453 0.2292 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0135 0.0187
Echinococcus multilocularis lysyl tRNA synthetase 0.0101 0.0447 0.1909
Schistosoma mansoni sugar transporter 0.0064 0.0251 0.1049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0171 0.0702
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0025 0.005 0.0528
Schistosoma mansoni sugar transporter 0.0064 0.0251 0.1049
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.1049
Plasmodium vivax calcium-dependent protein kinase, putative 0.0139 0.0647 0.0636
Leishmania major hypothetical protein, conserved 0.0023 0.0035 0.0317
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0025 0.005 0.0262

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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