Detailed information for compound 709683

Basic information

Technical information
  • TDR Targets ID: 709683
  • Name: N-(2-chloro-4-nitrophenyl)-5-fluoro-3-methyl- 1-benzofuran-2-carboxamide
  • MW: 348.713 | Formula: C16H10ClFN2O4
  • H donors: 1 H acceptors: 3 LogP: 4.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)c(C)c(o2)C(=O)Nc1ccc(cc1Cl)[N+](=O)[O-]
  • InChi: 1S/C16H10ClFN2O4/c1-8-11-6-9(18)2-5-14(11)24-15(8)16(21)19-13-4-3-10(20(22)23)7-12(13)17/h2-7H,1H3,(H,19,21)
  • InChiKey: FQGRDMFZWWXJHV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-chloro-4-nitro-phenyl)-5-fluoro-3-methyl-benzofuran-2-carboxamide
  • N-(2-chloro-4-nitrophenyl)-5-fluoro-3-methyl-2-benzofurancarboxamide
  • N-(2-chloro-4-nitro-phenyl)-5-fluoro-3-methyl-1-benzofuran-2-carboxamide
  • ZINC05028180

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus solute carrier family 22 0.0015 0.0134 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.027 0.1768
Echinococcus multilocularis solute carrier family 22 0.0015 0.0134 0.0136
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1869 0.19
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.1529 1
Loa Loa (eye worm) hypothetical protein 0.0319 0.6942 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0636 0.4162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0514 0.0522
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0541 0.3539
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.078 0.0793
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.1529 0.1529
Entamoeba histolytica hypothetical protein 0.0024 0.0332 0.0447
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0541 0.069
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0677 0.0688
Echinococcus multilocularis solute carrier family 22 0.0015 0.0134 0.0136
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0164 0.0298
Brugia malayi AF-10 protein 0.0009 0.0003 0.0004
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.076 0.1061
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1869 0.19
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0541 0.3539
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0541 0.069
Onchocerca volvulus 0.0319 0.6942 1
Mycobacterium ulcerans sugar transporter 0.0015 0.0134 0.0139
Schistosoma mansoni hypothetical protein 0.0042 0.0745 0.077
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0063 0.0091
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0517 0.0525
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0164 0.1071
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0134 0.0193
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0636 0.4162
Loa Loa (eye worm) hypothetical protein 0.0101 0.2066 0.2976
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0164 0.0167
Loa Loa (eye worm) hypothetical protein 0.0054 0.1002 0.1443
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.027 0.1768
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.2066 0.2976
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0834 0.0862
Brugia malayi hypothetical protein 0.0319 0.6942 1
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0063 0.0414
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0134 0.0136
Schistosoma mansoni hypothetical protein 0.0032 0.0514 0.0531
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.076 0.4972
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0134 0.0136
Brugia malayi hypothetical protein 0.0119 0.2456 0.3539
Schistosoma mansoni ap endonuclease 0.002 0.025 0.0258
Leishmania major glucose transporter, lmgt1 0.0033 0.0541 0.3539
Brugia malayi Bromodomain containing protein 0.0028 0.0429 0.0618
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0003
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0003 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.027 0.1768
Brugia malayi CXXC zinc finger family protein 0.0031 0.0489 0.0705
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Schistosoma mansoni cpg binding protein 0.0033 0.0529 0.0547
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.027 0.135
Echinococcus granulosus expressed conserved protein 0.0096 0.1951 0.1983
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.22 0.2236
Schistosoma mansoni glutaminase 0.0279 0.6041 0.6243
Echinococcus granulosus geminin 0.0352 0.7681 0.7807
Schistosoma mansoni sugar transporter 0.0015 0.0134 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.027 0.1768
Loa Loa (eye worm) hypothetical protein 0.0033 0.0532 0.0766
Schistosoma mansoni glucose transport protein 0.0107 0.22 0.2273
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0517 0.1451
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0517 0.0745
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.027 0.0275
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.027 0.0231
Echinococcus multilocularis dnaJ subfamily B 0.0442 0.9677 0.9836
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.9839 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.22 0.2236
Echinococcus granulosus solute carrier family 22 0.0015 0.0134 0.0136
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.2126 0.2197
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0134 0.0874
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.027 0.0367
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Schistosoma mansoni glucose transport protein 0.0107 0.22 0.2273
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0541 0.069
Entamoeba histolytica protein kinase, putative 0.0033 0.0532 0.1532
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.027 0.1768
Brugia malayi hypothetical protein 0.005 0.0915 0.1318
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0834 0.1202
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0164 0.0167
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1103 0.1589
Trypanosoma brucei unspecified product 0.0015 0.0123 0.0804
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.027 0.0231
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.078 0.1095
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.1529 0.1529
Echinococcus multilocularis protein dispatched 1 0.005 0.0919 0.0934
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.2066 0.2976
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.2578 0.3714
Loa Loa (eye worm) histone methyltransferase 0.001 0.001 0.0015
Schistosoma mansoni hypothetical protein 0.0042 0.0745 0.077
Trypanosoma brucei unspecified product 0.0015 0.0123 0.0804
Trichomonas vaginalis ap endonuclease, putative 0.002 0.025 0.0197
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0532 0.0532
Leishmania major protein kinase, putative 0.0033 0.0532 0.3478
Loa Loa (eye worm) hypothetical protein 0.0026 0.0382 0.055
Loa Loa (eye worm) hypothetical protein 0.0119 0.2456 0.3539
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0541 0.069
Leishmania major DNA polymerase kappa, putative 0.0021 0.027 0.1768
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0164 0.1071
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1146 0.1739
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1146 0.1165
Toxoplasma gondii sugar transporter ST2 0.0015 0.0134 0.0203
Echinococcus granulosus dna polymerase eta 0.0021 0.027 0.0275
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.027 0.1768
Echinococcus granulosus General substrate transporter 0.0092 0.1862 0.1892
Mycobacterium ulcerans glutaminase 0.0279 0.6041 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.025 0.036
Brugia malayi hypothetical protein 0.0015 0.0134 0.0193
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.027 0.0275
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.22 0.3339
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0636 0.4162
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.078 0.1124
Echinococcus multilocularis dna polymerase kappa 0.0021 0.027 0.0275
Loa Loa (eye worm) glutaminase 2 0.0279 0.6041 0.8702
Loa Loa (eye worm) hypothetical protein 0.0021 0.027 0.0389
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0332 0.0343
Brugia malayi PHD-finger family protein 0.0028 0.0429 0.0618
Brugia malayi glutaminase DH11.1 0.0279 0.6041 0.8702
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0429 0.0436
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0164 0.0167
Echinococcus granulosus cpg binding protein 0.0033 0.0529 0.0538
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0203 0.1329
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.027 0.1768
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0134 0.0138
Schistosoma mansoni hypothetical protein 0.0032 0.0514 0.0531
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0834 0.0848
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.076 0.0773
Echinococcus multilocularis peregrin 0.0028 0.0429 0.0436
Brugia malayi hypothetical protein 0.0015 0.0134 0.0193
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0514 0.074
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0541 0.3539
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0514 0.074
Echinococcus granulosus dnaJ subfamily B 0.0442 0.9677 0.9836
Schistosoma mansoni glucose transport protein 0.0107 0.22 0.2273
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.025 0.1634
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0049 0.0881 0.1269
Brugia malayi major facilitator superfamily protein 0.0015 0.0134 0.0193
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0429 0.0443
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0134 0.0203
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0332 0.2173
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0541 0.069
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0332 0.0338
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.209 0.3011
Echinococcus granulosus solute carrier family 22 0.0015 0.0134 0.0136
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0532 0.0532
Schistosoma mansoni cpg binding protein 0.0033 0.0529 0.0547
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.22 0.2236
Loa Loa (eye worm) hypothetical protein 0.0032 0.0517 0.0745
Loa Loa (eye worm) hypothetical protein 0.0032 0.0514 0.074
Schistosoma mansoni hypothetical protein 0.0032 0.0514 0.0531
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.076 0.0786
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0063 0.0091
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0541 0.3539
Schistosoma mansoni hypothetical protein 0.0028 0.0429 0.0443
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.004 0.004
Brugia malayi Cytochrome P450 family protein 0.0012 0.0063 0.0091
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0602 0.0622
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0602 0.0611
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.027 0.1768
Echinococcus granulosus GPCR family 2 0.0032 0.0514 0.0522
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0681 0.0692
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.076 0.4972
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1443 0.1491
Entamoeba histolytica protein kinase, putative 0.0033 0.0532 0.1532
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0532 0.0532
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0134 0.0139
Trypanosoma brucei glucose transporter 2A 0.0033 0.0541 0.3539
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.22 0.2236
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.027 0.1768
Loa Loa (eye worm) hypothetical protein 0.0044 0.078 0.1124
Brugia malayi Sugar transporter family protein 0.0107 0.22 0.3169
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.22 0.3498
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0251 0.1163
Plasmodium falciparum mitogen-activated protein kinase 2 0.0174 0.3681 0.3681
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0517 0.0745
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0429 0.0651
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0164 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0123 0.0804
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.027 0.1768
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0517 0.0649
Brugia malayi CHE-14 protein 0.0044 0.078 0.1124
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.22 0.2236
Schistosoma mansoni protein kinase 0.0033 0.0532 0.055
Trypanosoma brucei glucose transporter 1E 0.0033 0.0541 0.3539
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.2066 0.2976
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.3539
Echinococcus multilocularis General substrate transporter 0.0092 0.1862 0.1892
Schistosoma mansoni patched 1 0.0044 0.078 0.0806
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0486 0.0494
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0332 0.0504
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.027 0.0367
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.076 0.0773
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.025 0.1856
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.027 0.1768
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.076 0.0786
Onchocerca volvulus 0.0031 0.0489 0.0523
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.0541
Loa Loa (eye worm) hypothetical protein 0.0119 0.2456 0.3539
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0003 0.0004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0514 0.0522
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.22 0.2236
Schistosoma mansoni hypothetical protein 0.0035 0.0573 0.0592
Schistosoma mansoni hypothetical protein 0.0032 0.0514 0.0531
Echinococcus multilocularis expressed conserved protein 0.0096 0.1951 0.1983
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0134 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.027 0.1768
Leishmania major DNA polymerase eta, putative 0.0021 0.027 0.1768
Entamoeba histolytica hypothetical protein 0.004 0.0681 0.2341
Echinococcus multilocularis solute carrier family 22 0.0015 0.0134 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0834 0.0862
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0134 0.0874
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0489 0.0705
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0541 0.069
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.3539
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0164 0.1071
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0541 0.069
Schistosoma mansoni sugar transporter 0.0015 0.0134 0.0138
Schistosoma mansoni sugar transporter 0.0015 0.0134 0.0138
Schistosoma mansoni hypothetical protein 0.004 0.0681 0.0703
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0061
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.0541
Entamoeba histolytica hypothetical protein 0.004 0.0681 0.2341
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.3539
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0332 0.2173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0834 0.0848
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0332 0.0338
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0134 0.0193
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0532 0.055
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0636 0.4162
Toxoplasma gondii protein kinase, putative 0.0304 0.6589 1
Brugia malayi Cytochrome P450 family protein 0.0012 0.0063 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1267 0.131
Leishmania major hypothetical protein, conserved 0.0077 0.1529 1
Schistosoma mansoni sugar transporter 0.0015 0.0134 0.0138
Schistosoma mansoni hypothetical protein 0.0042 0.0745 0.077
Echinococcus multilocularis protein patched 0.0044 0.078 0.0793
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0332 0.3169
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0834 0.0848
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0134 0.0193
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0164 0.0167
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.111 0.1685
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0541 0.3539
Toxoplasma gondii sugar transporter ST3 0.0015 0.0134 0.0203
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.025 0.0254
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.076 0.0773
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.076 0.4972
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0134 0.0136
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0164 0.1071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.027 0.1768
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0514 0.0522
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0834 0.1202
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0532 0.0808
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.027 0.135
Loa Loa (eye worm) hypothetical protein 0.0043 0.076 0.1095
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0332 0.0471
Leishmania major cytochrome p450-like protein 0.0012 0.0063 0.0414
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.9839 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.027 0.0111
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.027 0.0389
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1348 0.1941
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0063 0.0414
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0681 0.0703
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0517 0.0745
Schistosoma mansoni protein kinase 0.0033 0.0532 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0123 0.0804
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Loa Loa (eye worm) sugar transporter 0.0107 0.22 0.3169
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.1529 0.2321
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.027 0.1768
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0003 0.0017
Brugia malayi isocitrate dehydrogenase 0.0016 0.0164 0.0236
Loa Loa (eye worm) hypothetical protein 0.0028 0.0429 0.0618
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.0541
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.027 0.1768
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.027 0.0389
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0332 0.0479
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0164 0.0167
Brugia malayi Cam kinase protein 1 0.0033 0.0532 0.0766
Brugia malayi major facilitator superfamily protein 0.0015 0.0134 0.0193
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.025 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0681 0.0692
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.025 1
Loa Loa (eye worm) glutaminase 0.0279 0.6041 0.8702
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.0541
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.025 0.0333
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0332 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.076 0.0773
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0532 0.0808
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0134 0.0136
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0164 0.0167
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.076 0.1061
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0134 0.0139
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0636 0.0636
Schistosoma mansoni hypothetical protein 0.0352 0.7681 0.7938
Trypanosoma cruzi hexose transporter 0.0033 0.0541 0.3539
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0602 0.0867
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0677 0.0688
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.027 0.1768
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0174 0.3681 0.5586
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0429 0.0618
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.3539
Echinococcus granulosus neuropeptide s receptor 0.0449 0.9839 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.1529 1
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.2578 0.3714
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0332 0.2173
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1146 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0332 0.3046
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.076 0.1061
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.22 0.2236
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.004 0.004
Onchocerca volvulus Huntingtin homolog 0.0119 0.2456 0.3412
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.209 0.2124
Echinococcus multilocularis dna polymerase eta 0.0021 0.027 0.0275
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.025 0.0254
Brugia malayi Sugar transporter family protein 0.0015 0.0134 0.0193
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.076 1
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.076 0.0773
Schistosoma mansoni cpg binding protein 0.0031 0.0489 0.0506
Onchocerca volvulus Huntingtin homolog 0.0119 0.2456 0.3412
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0429 0.0651
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.025 0.1634
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1146 0.1829
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0164 0.0169
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0636 0.4162
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0214 0.0309
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0532 0.3478
Brugia malayi jmjC domain containing protein 0.0036 0.0602 0.0867
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0134 0.0193
Schistosoma mansoni hypothetical protein 0.0107 0.22 0.2273
Plasmodium falciparum hexose transporter 0.0107 0.22 0.22
Loa Loa (eye worm) hypothetical protein 0.0069 0.1348 0.1941
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0532 0.0532
Echinococcus granulosus dna polymerase kappa 0.0021 0.027 0.0275
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.9839 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0164 0.0236
Brugia malayi hypothetical protein 0.0077 0.1529 0.2203
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0562 0.0571
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.076 0.4972
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0517 0.0534
Echinococcus multilocularis cpg binding protein 0.0033 0.0529 0.0538
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0134 0.0874
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.1529 1
Brugia malayi PHD-finger family protein 0.0011 0.0042 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0045 0.0045
Plasmodium falciparum phd finger protein, putative 0.0028 0.0429 0.0429
Schistosoma mansoni DNA polymerase eta 0.0021 0.027 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0123 0.0804
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0429 0.0436
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.027 0.0389
Entamoeba histolytica hypothetical protein 0.004 0.0681 0.2341
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.025 0.036
Echinococcus granulosus peregrin 0.0028 0.0429 0.0436
Trichomonas vaginalis glutaminase, putative 0.0279 0.6041 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.025 0.1149
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0532 0.0532
Schistosoma mansoni hypothetical protein 0.0442 0.9677 1
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0063 0.0414
Brugia malayi hypothetical protein 0.004 0.0681 0.0981
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0541 0.3539
Brugia malayi Sugar transporter family protein 0.0015 0.0134 0.0193
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0532 0.0808
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.025 0.1634
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.027 0.0279
Trichomonas vaginalis ap endonuclease, putative 0.002 0.025 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.027 0.1768
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0636 0.0636
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0636 0.0966
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0532 0.0532
Echinococcus granulosus solute carrier family 22 0.0015 0.0134 0.0136
Trypanosoma brucei unspecified product 0.0021 0.027 0.1768
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0532 0.0541
Plasmodium falciparum protein kinase 7 0.0304 0.6589 0.6589
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0266 0.0224
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0514 0.074
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0602 0.0622
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.1529 0.1529
Loa Loa (eye worm) hypothetical protein 0.0024 0.0332 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.027 0.1768
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1146 0.1165
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0429 0.0429
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.027 0.0279
Loa Loa (eye worm) hypothetical protein 0.0077 0.1529 0.2203
Loa Loa (eye worm) hypothetical protein 0.0103 0.209 0.3011
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0517 0.6116
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0164 0.0236
Schistosoma mansoni glucose transporter 0.0015 0.0134 0.0138
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0063 0.0091
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0164 0.1071
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.0541
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.209 0.2124
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0174 0.3681 0.3681
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0003 0.0017
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0332 0.0471
Toxoplasma gondii sugar transporter ST1 0.0015 0.0134 0.0203
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.3539
Schistosoma mansoni hypothetical protein 0.0352 0.7681 0.7938
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0517 0.0534
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0532 0.0532
Brugia malayi MH2 domain containing protein 0.0124 0.2578 0.3714
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0164 0.0164
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0532 0.0766
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.0541
Plasmodium vivax CDK-related protein kinase 6, putative 0.0456 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.001 0.001
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0164 0.0164
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0063 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0834 0.0848
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0134 0.0874
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.076 0.2773
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0045 0.0045
Toxoplasma gondii exonuclease III APE 0.002 0.025 0.0379
Giardia lamblia DINP protein human, muc B family 0.0021 0.027 0.2181
Echinococcus multilocularis geminin 0.0352 0.7681 0.7807
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0514 0.0522
Schistosoma mansoni ap endonuclease 0.002 0.025 0.0258
Loa Loa (eye worm) sugar transporter 0.0015 0.0134 0.0193
Echinococcus multilocularis GPCR, family 2 0.0032 0.0514 0.0522
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0532 0.0674
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0486 0.0494
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0517 0.0525
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.027 0.1768
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.078 0.0793
Leishmania major glucose transporter, lmgt2 0.0033 0.0541 0.3539
Leishmania major glucose transporter, lmgt3 0.0033 0.0541 0.3539
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.027 0.1768
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0134 0.0193
Trypanosoma brucei sugar transporter, putative 0.0015 0.0134 0.0874
Schistosoma mansoni hypothetical protein 0.0042 0.0745 0.077
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0134 0.0139
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.025 0.025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.025 0.1634
Plasmodium vivax hexose transporter 0.0107 0.22 0.22
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0573 0.0583
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0332 0.0336
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.22 0.2236
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0175 0.0181
Entamoeba histolytica hypothetical protein 0.004 0.0681 0.2341
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0532 0.0766
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.209 1
Schistosoma mansoni protein kinase 0.0033 0.0532 0.055
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.076 0.0773
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Brugia malayi jmjC domain containing protein 0.0093 0.1869 0.2693
Plasmodium vivax sugar transporter, putative 0.0015 0.0134 0.0134
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0092 0.0132
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.3539
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.3539
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.0541
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0164 0.0249
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0332 0.0343
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1146 0.1829
Echinococcus granulosus Protein patched homolog 1 0.0044 0.078 0.0793
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0834 0.0862
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1146 0.1184
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1146 0.1184
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0532 0.0766
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0332 0.0332
Brugia malayi hypothetical protein 0.0015 0.0134 0.0193
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1146 0.7494
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0532 0.0532
Echinococcus multilocularis solute carrier family 22 0.0015 0.0134 0.0136
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0134 0.0874
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.3075 0.3125
Leishmania major hypothetical protein, conserved 0.0015 0.0134 0.0874
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.076 0.1095
Schistosoma mansoni hypothetical protein 0.0069 0.1348 0.1393
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0573 0.0583
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.3539
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0193
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0517 1
Giardia lamblia PHD finger protein 15 0.0028 0.0429 0.471
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.3075 0.3125
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0532 0.0532
Onchocerca volvulus Alhambra homolog 0.0028 0.0429 0.0433
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0251 0.1163
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1146 0.1829
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0541 0.3539

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.