Detailed information for compound 710078

Basic information

Technical information
  • TDR Targets ID: 710078
  • Name: ZINC02552236
  • MW: 314.763 | Formula: C18H15ClO3
  • H donors: 0 H acceptors: 1 LogP: 5.04 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc2c(c1)oc(=O)c(c2)c1ccc(cc1)Cl
  • InChi: 1S/C18H15ClO3/c1-2-9-21-15-8-5-13-10-16(18(20)22-17(13)11-15)12-3-6-14(19)7-4-12/h3-8,10-11H,2,9H2,1H3
  • InChiKey: MLRDBBHAYSGHNR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0022 0.0241 0.0244
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1451 0.1601
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.049 0.053
Brugia malayi pyruvate kinase, muscle isozyme 0.0052 0.1138 0.1252
Trichomonas vaginalis glutaminase, putative 0.027 0.7648 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0683 0.0977
Schistosoma mansoni coup transcription factor 0.003 0.049 0.053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.2123 0.2914
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.049 0.053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0153 0.4169 0.539
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0022 0.0241 0.0244
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.8477 1
Echinococcus multilocularis pyruvate kinase 0.0126 0.336 0.335
Echinococcus granulosus pyruvate kinase 0.0126 0.336 0.335
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.2123 0.2914
Brugia malayi Ets-domain containing protein 0.0076 0.1874 0.2074
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0314 0.8985 1
Schistosoma mansoni ferritin 0.0017 0.0101 0.0096
Loa Loa (eye worm) steroid hormone receptor 0.003 0.049 0.0545
Brugia malayi nuclear receptor NHR-88 0.003 0.049 0.053
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1451 0.1601
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0144 0.0199
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Trichomonas vaginalis pyruvate kinase, putative 0.0246 0.6935 0.9055
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.049 0.053
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0367 0.0387
Loa Loa (eye worm) acetyltransferase 0.0314 0.8985 1
Plasmodium vivax ornithine aminotransferase, putative 0.0022 0.0241 0.0144
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0322 0.0327
Schistosoma mansoni ferritin light chain 0.0017 0.0101 0.0096
Echinococcus multilocularis pyruvate kinase 0.0126 0.336 0.335
Plasmodium falciparum pyruvate kinase 0.0246 0.6935 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.4712 0.5245
Loa Loa (eye worm) glutaminase 2 0.027 0.7648 0.8512
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Trypanosoma cruzi pyruvate kinase 2, putative 0.0246 0.6935 0.8149
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0022 0.0241 0.034
Trichomonas vaginalis bromodomain-containing protein, putative 0.0092 0.2353 0.2984
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0545
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0022 0.0241 0.034
Brugia malayi hypothetical protein 0.0016 0.0065 0.0057
Brugia malayi hypothetical protein 0.0016 0.0065 0.0057
Chlamydia trachomatis pyruvate kinase 0.0246 0.6935 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.8477 1
Plasmodium vivax pyruvate kinase, putative 0.0246 0.6935 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0065 0.0057
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0241 0.0221
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.049 0.0476
Mycobacterium ulcerans polyketide synthase 0.0026 0.0367 0.0387
Echinococcus granulosus tar DNA binding protein 0.0062 0.1451 0.1439
Loa Loa (eye worm) pyruvate kinase 0.0246 0.6935 0.7718
Echinococcus multilocularis geminin 0.0198 0.55 0.5493
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.4271 0.6156
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0144 0.0129
Loa Loa (eye worm) hypothetical protein 0.0065 0.1543 0.1718
Giardia lamblia Pyruvate kinase 0.0246 0.6935 1
Echinococcus granulosus pyruvate kinase 0.0126 0.336 0.335
Onchocerca volvulus 0.0023 0.0274 0.0374
Onchocerca volvulus Bile acid receptor homolog 0.003 0.049 0.0686
Schistosoma mansoni ferritin 0.0017 0.0101 0.0096
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0545
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0241 0.0227
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0092 0.2353 0.3331
Echinococcus granulosus FTZ F1 alpha 0.003 0.049 0.0476
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0101 0.0036
Onchocerca volvulus Pyruvate kinase homolog 0.0246 0.6935 1
Leishmania major pyruvate kinase 0.0246 0.6935 0.8149
Onchocerca volvulus 0.0051 0.1114 0.1589
Loa Loa (eye worm) pyruvate kinase 0.0246 0.6935 0.7718
Toxoplasma gondii exonuclease III APE 0.0019 0.0144 0.0115
Mycobacterium ulcerans thioesterase 0.002 0.02 0.0166
Mycobacterium ulcerans hypothetical protein 0.0153 0.4169 0.5407
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0367 0.0387
Onchocerca volvulus Pyruvate kinase homolog 0.0246 0.6935 1
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0545
Echinococcus granulosus pyruvate kinase 0.0126 0.336 0.335
Loa Loa (eye worm) hypothetical protein 0.0051 0.1114 0.124
Schistosoma mansoni hypothetical protein 0.0198 0.55 0.6115
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.049 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.049 0.053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.049 0.0476
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0179 0.0138
Echinococcus multilocularis Aminotransferase class III 0.0022 0.0241 0.0227
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.049 0.0476
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.8477 1
Mycobacterium ulcerans acetylornithine aminotransferase 0.0022 0.0241 0.0221
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0014 0.0016
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0022 0.0241 0.0221
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0322 0.0327
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0101 0.0039
Echinococcus granulosus pyruvate kinase 0.0246 0.6935 0.693
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0092 0.2353 0.3253
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0367 0.0521
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0545
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0322 0.0342
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.049 0.053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.3796 0.4383
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0274 0.0304
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0014 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0274 0.0289
Trypanosoma brucei pyruvate kinase 1, putative 0.0246 0.6935 0.8149
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.049 0.053
Mycobacterium ulcerans hypothetical protein 0.0157 0.4271 0.5542
Brugia malayi Steroid receptor seven-up type 2 0.003 0.049 0.053
Brugia malayi nuclear hormone receptor 0.003 0.049 0.053
Schistosoma mansoni glutaminase 0.027 0.7648 0.851
Echinococcus multilocularis pyruvate kinase 0.0194 0.5387 0.5381
Echinococcus multilocularis ferritin 0.0017 0.0101 0.0087
Echinococcus granulosus histone acetyltransferase KAT2B 0.0306 0.8721 0.8719
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0299 0.0423
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0022 0.0241 0.034
Plasmodium vivax pyruvate kinase 2, putative 0.0126 0.336 0.4736
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.049 0.0476
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.2123 0.4332
Schistosoma mansoni apoferritin-2 0.0017 0.0101 0.0096
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.8477 1
Mycobacterium tuberculosis Probable aminotransferase 0.0153 0.4169 0.6009
Echinococcus granulosus pyruvate kinase 0.0246 0.6935 0.693
Onchocerca volvulus Pyruvate kinase homolog 0.0246 0.6935 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0144 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.084 0.0835
Schistosoma mansoni thyroid hormone receptor 0.003 0.049 0.053
Toxoplasma gondii hypothetical protein 0.0048 0.1024 0.1396
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.084 0.0835
Loa Loa (eye worm) pyruvate kinase 0.0052 0.1138 0.1266
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0299 0.0423
Loa Loa (eye worm) DR-78 0.0014 0.0014 0.0016
Brugia malayi Ets-domain containing protein 0.0076 0.1874 0.2074
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0367 0.0521
Schistosoma mansoni ferritin 0.0017 0.0101 0.0096
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.049 0.0686
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.049 0.053
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0322 0.0455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.049 0.0545
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.1113 0.1163
Brugia malayi glutaminase DH11.1 0.027 0.7648 0.851
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.049 0.0476
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0976 0.1072
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.1874 0.2086
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0101 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1451 0.1601
Brugia malayi TAR-binding protein 0.0062 0.1451 0.1601
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.049 0.053
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0367 0.0427
Mycobacterium ulcerans pyruvate kinase 0.0246 0.6935 0.9058
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0367 0.0427
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0065 0.0073
Brugia malayi RNA binding protein 0.0062 0.1451 0.1601
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.1874 0.1863
Schistosoma mansoni pyruvate kinase 0.0126 0.336 0.373
Mycobacterium leprae Probable pyruvate kinase PykA 0.0246 0.6935 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0144 0.0057
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0065 0.0051
Brugia malayi Pyruvate kinase, muscle isozyme 0.0246 0.6935 0.7715
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.049 0.053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Trypanosoma cruzi pyruvate kinase 2, putative 0.0246 0.6935 0.8149
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.02 0.0279
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0367 0.0521
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0022 0.0241 0.034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.049 0.053
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0153 0.4169 0.5407
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0367 0.0427
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0322 0.0361
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.3796 0.4383
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.049 0.0476
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0274 0.0386
Schistosoma mansoni hypothetical protein 0.0198 0.55 0.6115
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1451 0.1601
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0314 0.8985 0.8983
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.049 0.0545
Brugia malayi acetyltransferase, GNAT family protein 0.0314 0.8985 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0179 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.049 0.053
Schistosoma mansoni thyroid hormone receptor 0.003 0.049 0.053
Schistosoma mansoni pyruvate kinase 0.0246 0.6935 0.7715
Echinococcus multilocularis pyruvate kinase 0.0246 0.6935 0.693
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0322 0.0455
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.3796 0.4383
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1451 0.1615
Schistosoma mansoni nuclear hormone receptor 0.003 0.049 0.053
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.049 0.0476
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.049 0.0545
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.049 0.0476
Brugia malayi ecdysteroid receptor 0.003 0.049 0.053
Brugia malayi nuclear receptor RXR 0.0016 0.0065 0.0057
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0101 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.049 0.053
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.049 0.053
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0322 0.0455
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0545
Trypanosoma brucei pyruvate kinase 1 0.0246 0.6935 0.8149
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0179 0.0138
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.02 0.0183
Loa Loa (eye worm) RNA binding protein 0.0062 0.1451 0.1615
Brugia malayi Pyruvate kinase, M2 isozyme 0.0246 0.6935 0.7715
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0188 0.0263
Schistosoma mansoni ferritin light chain 0.0017 0.0101 0.0096
Echinococcus granulosus Aminotransferase class III 0.0022 0.0241 0.0227
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.049 0.0545
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0322 0.0361
Mycobacterium ulcerans L-lysine aminotransferase 0.0022 0.0241 0.0221
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0065 0.0051
Brugia malayi pyruvate kinase 0.0052 0.1138 0.1252
Loa Loa (eye worm) glutaminase 0.027 0.7648 0.8512
Echinococcus granulosus ferritin 0.0017 0.0101 0.0087
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0116 0.0158
Onchocerca volvulus 0.003 0.049 0.0686
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.049 0.0476
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.084 0.0835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.049 0.0545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.049 0.0545
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0908 0.1292
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0073
Giardia lamblia Pyruvate kinase 0.0126 0.336 0.4736
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0073
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0144 0.3047
Echinococcus multilocularis expressed protein 0.0017 0.0101 0.0087
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.049 0.053
Echinococcus granulosus ornithine aminotransferase 0.0022 0.0241 0.0227
Schistosoma mansoni pyruvate kinase 0.0246 0.6935 0.7715
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0073
Echinococcus multilocularis tumor protein p63 0.0348 1 1
Plasmodium falciparum pyruvate kinase 2 0.0126 0.336 0.4736
Schistosoma mansoni ap endonuclease 0.0019 0.0144 0.0144
Echinococcus granulosus histone acetyltransferase KAT2B 0.0092 0.2353 0.2342
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1451 0.1439
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.049 0.053
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0022 0.0241 0.0244
Brugia malayi Fli-1 protein 0.0232 0.6525 0.7258
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0322 0.0327
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0111 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.049 0.053
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0101 0.0137
Echinococcus multilocularis FTZ F1 alpha 0.003 0.049 0.0476
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0683 0.0804
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.049 0.0545
Leishmania major pyruvate kinase 0.0246 0.6935 0.8149
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0367 0.044
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0312 0.0347
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0153 0.4169 0.5969
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0022 0.0241 1
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0545
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.1114 0.1226
Loa Loa (eye worm) pyruvate kinase-PB 0.0171 0.4712 0.5245
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0683 0.0888
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0153 0.4169 0.6009
Loa Loa (eye worm) pyruvate kinase 0.0246 0.6935 0.7718
Onchocerca volvulus 0.0043 0.0863 0.1226
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.049 0.0476
Schistosoma mansoni apoferritin-2 0.0017 0.0101 0.0096
Loa Loa (eye worm) hypothetical protein 0.0246 0.6935 0.7718
Brugia malayi steroid hormone receptor 0.003 0.049 0.053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.049 0.053
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0144 0.0092
Mycobacterium ulcerans thioesterase TesA 0.002 0.02 0.0166
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.049 0.053
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1451 0.1615
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.049 0.0686
Mycobacterium ulcerans polyketide synthase 0.0024 0.0322 0.0327
Echinococcus multilocularis pyruvate kinase 0.0126 0.336 0.335
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0022 0.0241 0.0221
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0144 0.0057
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.049 0.053
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0246 0.6935 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0144 0.016
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.049 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.049 0.053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.084 0.0835
Loa Loa (eye worm) fli-1 protein 0.0232 0.6525 0.7262
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.049 0.0476
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.049 0.0476
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.049 0.053
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1451 0.1601
Schistosoma mansoni ferritin 0.0017 0.0101 0.0096
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0241 0.0221
Entamoeba histolytica pyruvate kinase, putative 0.0171 0.4712 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0092 0.2353 0.3331
Loa Loa (eye worm) hypothetical protein 0.003 0.049 0.0545
Echinococcus multilocularis pyruvate kinase 0.0246 0.6935 0.693
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.049 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.049 0.053
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0074 0.1813 0.2005
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.0241 0.0253
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0073
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0241 0.0227
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0065 0.0057
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0144 0.0144
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0022 0.0241 0.0253
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.049 0.0476
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.049 0.053
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0065 0.0057
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0092 0.2353 0.2984
Schistosoma mansoni gabp alpha 0.0076 0.1874 0.2074
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.1874 0.1863
Loa Loa (eye worm) hypothetical protein 0.0041 0.0819 0.0911
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.049 0.053
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1451 0.1601
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0065 0.0057
Echinococcus granulosus geminin 0.0198 0.55 0.5493
Schistosoma mansoni ets-related 0.0232 0.6525 0.7258
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Schistosoma mansoni ap endonuclease 0.0019 0.0144 0.0144
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0683 0.0977
Echinococcus granulosus expressed protein 0.0017 0.0101 0.0087
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0016
Mycobacterium ulcerans glutaminase 0.027 0.7648 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0014 0.0016
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0022 0.0241 0.0257
Trichomonas vaginalis pyruvate kinase, putative 0.0246 0.6935 0.9055
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0144 0.0129
Toxoplasma gondii pyruvate kinase PyKII 0.0126 0.336 0.4797
Toxoplasma gondii pyruvate kinase PyK1 0.0246 0.6935 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0322 0.0327
Plasmodium falciparum ornithine aminotransferase 0.0022 0.0241 0.0144

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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