Detailed information for compound 712169

Basic information

Technical information
  • TDR Targets ID: 712169
  • Name: 2-(4-methylpiperazin-1-yl)-N-(5-propyl-1,3,4- thiadiazol-2-yl)acetamide
  • MW: 283.393 | Formula: C12H21N5OS
  • H donors: 1 H acceptors: 3 LogP: 0.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nnc(s1)NC(=O)CN1CCN(CC1)C
  • InChi: 1S/C12H21N5OS/c1-3-4-11-14-15-12(19-11)13-10(18)9-17-7-5-16(2)6-8-17/h3-9H2,1-2H3,(H,13,15,18)
  • InChiKey: SWUJSZGMUWPTHN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methyl-1-piperazinyl)-N-(5-propyl-1,3,4-thiadiazol-2-yl)acetamide
  • 2-(4-methylpiperazin-1-yl)-N-(5-propyl-1,3,4-thiadiazol-2-yl)ethanamide
  • BAS 08205773

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phd/f-box containing protein 0.0039 0.013 0.019
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0168 0.0255
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.5071 1
Leishmania major hypothetical protein, conserved 0.0071 0.0515 1
Echinococcus granulosus jumonji domain containing 1A 0.0039 0.013 0.019
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0148 0.022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0515 0.0847
Echinococcus multilocularis lysine specific demethylase 5A 0.0146 0.1399 0.1382
Echinococcus granulosus JmjC domain containing protein 4 0.0039 0.013 0.019
Echinococcus multilocularis jumonji domain containing protein 0.0168 0.1658 0.1642
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.0247
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0044 0.0024
Mycobacterium ulcerans beta-lactamase 0.0071 0.0515 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0149 0.083
Echinococcus granulosus GPCR family 2 0.0032 0.0044 0.0041
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0149 0.0827
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0063 0.0092
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0131 0.0589
Echinococcus multilocularis peregrin 0.012 0.1098 0.1081
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0131 0.0235
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0148 0.1878
Schistosoma mansoni pyruvate kinase 0.0033 0.0063 0.0075
Brugia malayi AF-10 protein 0.0039 0.0136 0.0246
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0833 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0131 0.0653
Plasmodium vivax hypothetical protein, conserved 0.012 0.1098 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0515 0.1059
Trichomonas vaginalis chromobox protein, putative 0.007 0.0503 0.0923
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0515 1
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1332 0.1315
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0515 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0149 0.0274
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0095 0.0308
Trypanosoma brucei glucosidase, putative 0.0036 0.0095 0.0706
Echinococcus multilocularis pyruvate kinase 0.0033 0.0063 0.0044
Schistosoma mansoni jumonji domain containing protein 0.0313 0.3388 0.5769
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.0064
Echinococcus multilocularis pyruvate kinase 0.0033 0.0063 0.0044
Brugia malayi Heterochromatin protein 1 0.007 0.0503 0.1022
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0149 0.1905
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0095 0.0173
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0087 0.0067
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0148 0.0819
Schistosoma mansoni alpha glucosidase 0.0036 0.0095 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.1878
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0063 0.008
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0148 0.1878
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0515 0.0901
Schistosoma mansoni jumonji/arid domain-containing protein 0.0146 0.1399 0.2362
Brugia malayi hypothetical protein 0.0035 0.0087 0.0142
Loa Loa (eye worm) jmjC domain-containing protein 0.0146 0.1399 0.2927
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.025
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0515 0.0847
Echinococcus multilocularis dna polymerase kappa 0.004 0.0148 0.0129
Brugia malayi jmjC domain containing protein 0.0039 0.013 0.0234
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0405 0.0827
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.013 0.019
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0515 0.0901
Schistosoma mansoni ap endonuclease 0.0039 0.0131 0.0191
Schistosoma mansoni hypothetical protein 0.0041 0.015 0.0224
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0149 0.0274
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0148 0.1878
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0479 0.0971
Echinococcus multilocularis GPCR, family 2 0.0032 0.0044 0.0024
Schistosoma mansoni hypothetical protein 0.0032 0.0044 0.0041
Plasmodium vivax JmjC domain containing protein 0.0039 0.013 0.0648
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0039 0.0136 0.0704
Brugia malayi Inositol-1 0.004 0.0149 0.0274
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0136 0.0704
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0405 0.066
Loa Loa (eye worm) jmjC domain-containing protein 0.0249 0.262 0.5506
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0087 0.0115
Loa Loa (eye worm) PHD-finger family protein 0.012 0.1098 0.2292
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0405 0.0827
Schistosoma mansoni chromobox protein 0.007 0.0503 0.0828
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0149 0.0836
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0515 1
Brugia malayi CHE-14 protein 0.0042 0.0168 0.0315
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0149 0.013
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0131 0.0111
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0131 0.1498
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0136 0.0704
Echinococcus multilocularis protein dispatched 1 0.0048 0.0239 0.022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0515 0.1047
Onchocerca volvulus 0.0487 0.545 1
Echinococcus multilocularis jumonji domain containing 1A 0.0039 0.013 0.0111
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0515 0.0901
Echinococcus granulosus lysine specific demethylase 6a 0.0039 0.013 0.019
Onchocerca volvulus 0.0071 0.0515 0.0911
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.0479 0.9219
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.1878
Brugia malayi beta-lactamase family protein 0.0071 0.0515 0.1047
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.1878
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0833 0.1393
Echinococcus multilocularis chromobox protein 1 0.007 0.0503 0.0484
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0148 0.0272
Schistosoma mansoni hypothetical protein 0.0068 0.0479 0.0786
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0063 0.008
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0405 0.0386
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0095 0.0129
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0148 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.1878
Brugia malayi jmjC domain containing protein 0.0039 0.013 0.0234
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0136 0.1614
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0095 0.0706
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0039 0.013 0.019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.002 0.0014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0515 0.0901
Brugia malayi jmjC domain containing protein 0.0039 0.013 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0515 0.0847
Echinococcus granulosus jumonji domain containing protein 0.0168 0.1658 0.2806
Toxoplasma gondii ABC1 family protein 0.0071 0.0515 0.4359
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.012 0.1098 0.1847
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0148 0.0129
Loa Loa (eye worm) RNA binding protein 0.0062 0.0405 0.0827
Brugia malayi follicle stimulating hormone receptor 0.0256 0.2712 0.5695
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0131 0.0653
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.159 0.2688
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.159 0.3329
Loa Loa (eye worm) hypothetical protein 0.0071 0.0515 0.1059
Onchocerca volvulus 0.0094 0.078 0.14
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1774
Onchocerca volvulus 0.0071 0.0515 0.0911
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0394 0.435 0.4339
Brugia malayi Pre-SET motif family protein 0.0428 0.4748 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0515 0.1059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0398 0.0647
Loa Loa (eye worm) hypothetical protein 0.0033 0.0063 0.0106
Echinococcus granulosus pyruvate kinase 0.0033 0.0063 0.0075
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0833 0.0815
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0148 0.1878
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0172 0.0316
Loa Loa (eye worm) hypothetical protein 0.0071 0.0515 0.1059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0534 0.0881
Echinococcus granulosus chromobox protein 1 0.007 0.0503 0.0828
Brugia malayi jmjC domain containing protein 0.0039 0.013 0.0234
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0095 0.0076
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0148 0.0169
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.159 0.332
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0131 0.1498
Echinococcus granulosus PHD finger protein rhinoceros 0.012 0.1098 0.1847
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0131 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0163 0.0303
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0099 0.0071
Echinococcus multilocularis chromobox protein 1 0.007 0.0503 0.0484
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.4748 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0515 0.0944
Mycobacterium ulcerans hypothetical protein 0.0071 0.0515 1
Brugia malayi beta-lactamase 0.0071 0.0515 0.1047
Loa Loa (eye worm) hypothetical protein 0.0052 0.0281 0.0565
Loa Loa (eye worm) hypothetical protein 0.0068 0.0479 0.0983
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0515 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.026
Loa Loa (eye worm) hypothetical protein 0.0068 0.0479 0.0984
Loa Loa (eye worm) hypothetical protein 0.0071 0.0515 0.1059
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0148 0.1878
Loa Loa (eye worm) intermediate filament protein 0.003 0.002 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0398 0.0647
Schistosoma mansoni hypothetical protein 0.012 0.1098 0.1847
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0172 0.0316
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0143 0.1364 0.2302
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0515 0.0944
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0515 0.0496
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0099 0.0789
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0042 0.0163 0.0245
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0095 0.0175
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0063 0.0106
Echinococcus multilocularis phd:f box containing protein 0.0039 0.013 0.0111
Schistosoma mansoni patched 1 0.0042 0.0168 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0405 0.066
Mycobacterium tuberculosis Conserved protein 0.0071 0.0515 0.0901
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0039 0.013 0.1485
Mycobacterium leprae Probable lipase LipE 0.0071 0.0515 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0168 0.0328
Brugia malayi PHD-finger family protein 0.0039 0.0136 0.0246
Echinococcus granulosus expressed conserved protein 0.0092 0.0762 0.1272
Brugia malayi chromobox protein homolog 3 0.0039 0.0136 0.0247
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0149 0.1905
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0063 0.0106
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0148 0.1878
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0294 0.3162 0.6651
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0149 0.1905
Schistosoma mansoni hypothetical protein 0.0032 0.0044 0.0041
Giardia lamblia PHD finger protein 15 0.012 0.1098 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0039 0.013 0.0648
Echinococcus granulosus dna polymerase eta 0.0068 0.0479 0.0787
Loa Loa (eye worm) hypothetical protein 0.0098 0.0833 0.1731
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0515 0.0944
Schistosoma mansoni hypothetical protein 0.0041 0.015 0.0224
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0095 0.0175
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0294 0.3162 0.6647
Schistosoma mansoni hypothetical protein 0.0032 0.0044 0.0041
Brugia malayi beta-lactamase family protein 0.0071 0.0515 0.1047
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.013 0.0247
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0515 1
Schistosoma mansoni hypothetical protein 0.0039 0.0136 0.02
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0131 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.1878
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0095 0.016
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0063 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.013 0.0247
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0515 0.0901
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0131 0.0653
Echinococcus granulosus lysine specific demethylase 5A 0.0146 0.1399 0.2362
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0515 0.4359
Echinococcus granulosus high voltage activated calcium channel beta 0.0143 0.1364 0.2302
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0398 0.0379
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0148 0.1878
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0148 0.1878
Loa Loa (eye worm) hypothetical protein 0.012 0.1098 0.2292
Echinococcus granulosus phd:f box containing protein 0.0039 0.013 0.019
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0405 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0168 0.0309
Schistosoma mansoni phosphatidylserine receptor 0.0039 0.013 0.019
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0149 0.0222
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0131 0.0191
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0131 0.024
Echinococcus granulosus tar DNA binding protein 0.0062 0.0405 0.066
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0095 0.0706
Trichomonas vaginalis set domain proteins, putative 0.0487 0.545 1
Echinococcus multilocularis expressed conserved protein 0.0092 0.0762 0.0744
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0044 0.0024
Onchocerca volvulus 0.0073 0.0534 0.0947
Loa Loa (eye worm) inositol-1 0.004 0.0149 0.0287
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0131 0.1498
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1332 0.2248
Echinococcus multilocularis geminin 0.0522 0.5859 0.5851
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0168 0.0149
Brugia malayi RNA binding protein 0.0062 0.0405 0.0815
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0148 0.1878
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.013 0.0111
Schistosoma mansoni hypothetical protein 0.0035 0.0087 0.0115
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0039 0.013 0.0648
Leishmania major DNA polymerase eta, putative 0.0068 0.0479 0.9219
Loa Loa (eye worm) hypothetical protein 0.0031 0.0035 0.0047
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0044 0.0051
Schistosoma mansoni alpha-glucosidase 0.0139 0.1322 0.223
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.1878
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0063 0.0092
Brugia malayi Pre-SET motif family protein 0.0061 0.0398 0.0799
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0515 0.0944
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0833 0.172
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0515 0.0944
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0851 0.1423
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0063 0.0116
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0148 0.1878
Loa Loa (eye worm) hypothetical protein 0.0206 0.2119 0.4448
Brugia malayi jmjC domain containing protein 0.0146 0.1399 0.2917
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0405 0.0815
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0515 0.0901
Trichomonas vaginalis chromobox protein, putative 0.007 0.0503 0.0923
Giardia lamblia DINP protein human, muc B family 0.004 0.0148 0.0819
Brugia malayi TAR-binding protein 0.0062 0.0405 0.0815
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.0014
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0148 0.0285
Schistosoma mansoni jumonji/arid domain-containing protein 0.0146 0.1399 0.2362
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0063 0.0116
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0148 0.022
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0394 0.435 0.7416
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0405 0.066
Brugia malayi PHD-finger family protein 0.012 0.1098 0.2281
Schistosoma mansoni hypothetical protein 0.0522 0.5859 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0172 0.028
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0095 0.0175
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0371 0.0601
Plasmodium falciparum phd finger protein, putative 0.012 0.1098 1
Schistosoma mansoni inositol monophosphatase 0.004 0.0149 0.0222
Echinococcus granulosus pyruvate kinase 0.0033 0.0063 0.0075
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0515 0.0901
Schistosoma mansoni ap endonuclease 0.0039 0.0131 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0405 0.066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0853 0.1763
Echinococcus granulosus geminin 0.0522 0.5859 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.159 0.1573
Mycobacterium ulcerans lipase LipD 0.0071 0.0515 1
Plasmodium vivax SET domain protein, putative 0.0061 0.0398 0.3229
Echinococcus granulosus dna polymerase kappa 0.004 0.0148 0.022
Echinococcus multilocularis JmjC domain containing protein 4 0.0039 0.013 0.0111
Echinococcus multilocularis PHD finger protein rhinoceros 0.012 0.1098 0.1081
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0149 0.1897
Schistosoma mansoni hypothetical protein 0.0522 0.5859 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.0515 0.0901
Brugia malayi Bromodomain containing protein 0.012 0.1098 0.2281
Loa Loa (eye worm) hypothetical protein 0.0039 0.013 0.0247
Leishmania major DNA polymerase kappa, putative 0.004 0.0148 0.1878
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0131 0.1498
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0853 0.1774
Loa Loa (eye worm) hypothetical protein 0.0061 0.0398 0.0812
Echinococcus granulosus chromobox protein 1 0.007 0.0503 0.0828
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0149 0.1905
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0095 0.0175
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0131 0.024
Onchocerca volvulus 0.0071 0.0515 0.0911
Schistosoma mansoni jumonji domain containing protein 0.0039 0.013 0.019
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.0479 0.0972
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0398 0.0379
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.0479 0.9219
Toxoplasma gondii PHD-finger domain-containing protein 0.012 0.1098 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0515 0.1059
Echinococcus multilocularis lysine specific demethylase 6a 0.0039 0.013 0.0111
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0503 0.1034
Echinococcus multilocularis dna polymerase eta 0.0068 0.0479 0.0461
Loa Loa (eye worm) hypothetical protein 0.0039 0.0136 0.026
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.1878
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0044 0.0041
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0853 0.1763
Schistosoma mansoni inositol monophosphatase 0.004 0.0149 0.0222
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0148 0.0272
Schistosoma mansoni alpha-glucosidase 0.0139 0.1322 0.223
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0039 0.013 0.1485
Schistosoma mansoni hypothetical protein 0.0041 0.015 0.0224
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0095 0.0175
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0044 0.0041
Onchocerca volvulus Alhambra homolog 0.012 0.1098 0.1986
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.1878
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.1878
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0044 0.0064
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0044 0.0051
Trichomonas vaginalis esterase, putative 0.0071 0.0515 0.0944
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0136 0.1614
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0148 0.0272
Loa Loa (eye worm) beta-lactamase 0.0071 0.0515 0.1059
Toxoplasma gondii PHD-finger domain-containing protein 0.012 0.1098 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0095 0.0175
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0095 0.011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0398 0.0647
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.013 0.0247
Echinococcus granulosus peregrin 0.012 0.1098 0.1847
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0063 0.0106
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0149 0.0274
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0095 0.0175
Schistosoma mansoni hypothetical protein 0.0041 0.015 0.0224
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0168 0.0255
Leishmania major DNA polymerase eta, putative 0.004 0.0149 0.1897
Mycobacterium tuberculosis Conserved protein 0.0071 0.0515 0.0901
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.159 0.1573
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0131 0.1498
Onchocerca volvulus 0.0031 0.0035 0.0029
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0149 0.1905
Plasmodium falciparum JmjC domain-containing protein, putative 0.0039 0.013 0.0648
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0131 0.0135
Echinococcus multilocularis high voltage activated calcium channel beta 0.0143 0.1364 0.1347
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0149 1
Brugia malayi jmjC domain containing protein 0.0394 0.435 0.9159
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0095 0.011
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0095 0.0175
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0398 0.0647
Echinococcus multilocularis protein patched 0.0042 0.0168 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0148 0.1878
Schistosoma mansoni pyruvate kinase 0.0033 0.0063 0.0075
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0039 0.013 0.1485
Chlamydia trachomatis pyruvate kinase 0.0033 0.0063 0.5
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0095 0.0706
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.2712 0.57
Trypanosoma brucei unspecified product 0.004 0.0148 0.1878
Schistosoma mansoni DNA polymerase eta 0.0068 0.0479 0.0787
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0136 0.0704
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0136 0.0215
Schistosoma mansoni chromobox protein 0.007 0.0503 0.0828
Toxoplasma gondii exonuclease III APE 0.0039 0.0131 0.0653
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0515 0.1059
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0398 0.3229
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0095 0.0175
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0515 1
Schistosoma mansoni hypothetical protein 0.0032 0.0044 0.0041
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0168 0.0328
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0148 0.0169
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0087 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0136 0.025
Leishmania major hypothetical protein, conserved 0.0039 0.013 0.1485
Schistosoma mansoni protein phosphatase 2C 0.0039 0.013 0.019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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