Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Gonadotropin-releasing hormone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | GnHR receptor homolog | Get druggable targets OG5_131719 | All targets in OG5_131719 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0446 | 0.0513 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0114 | 0.1234 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.0402 | 0.3152 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0042 | 0.0402 | 0.0383 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0084 | 0.0102 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0019 | 0.0022 |
Giardia lamblia | Kinesin-5 | 0.0114 | 0.1234 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0764 | 0.8691 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0114 | 0.1234 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0114 | 0.1234 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0063 | 0.0361 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0063 | 0.0044 |
Echinococcus multilocularis | kinesin family 1 | 0.0878 | 1 | 1 |
Brugia malayi | GnHR receptor homolog | 0.0558 | 0.6334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0038 | 0.0156 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0084 | 0.0533 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0063 | 0.0073 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0008 | 0.0019 | 0.0022 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0084 | 0.0533 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0084 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0008 | 0.0019 | 0.0022 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0084 | 0.0533 |
Plasmodium vivax | kinesin-5 | 0.0114 | 0.1234 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0019 | 0.0022 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0063 | 0.0044 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.0084 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0114 | 0.1234 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.0371 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0063 | 0.0073 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0084 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0114 | 0.1234 | 0.1419 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0019 | 0.0022 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.0371 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0339 | 0.2633 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0008 | 0.0019 | 0.0022 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0084 | 0.0102 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0063 | 0.0069 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0446 | 0.0513 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0063 | 0.0044 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0063 | 0.0044 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0042 | 0.0402 | 0.0606 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0084 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0114 | 0.1234 | 0.1923 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0042 | 0.0402 | 0.0383 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 0.0084 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 200 nM | Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cells | ChEMBL. | 10937733 |
IC50 (functional) | = 200 nM | Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cells | ChEMBL. | 10937733 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.