TDR Targets

Basic information

Technical information

TDR Targets ID: 716964
Name: 4-chloro-2,5-dimethoxy-N-[2-(trifluoromethyl) phenyl]benzenesulfonamide
MW: 395.781 | Formula: C15H13ClF3NO4S
H donors: 1 H acceptors: 2 LogP: 3.9 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(Cl)c(cc1S(=O)(=O)Nc1ccccc1C(F)(F)F)OC
InChi: 1S/C15H13ClF3NO4S/c1-23-12-8-14(13(24-2)7-10(12)16)25(21,22)20-11-6-4-3-5-9(11)15(17,18)19/h3-8,20H,1-2H3
InChiKey: KETWMFLRCYJQPI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

T5968808
ZINC06700675

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.003	0.0453	0.1519
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0015	0.0058	0.0069
Echinococcus granulosus	jumonji domain containing protein	0.0027	0.0378	0.1417
Trichomonas vaginalis	rotamase, putative	0.0022	0.0237	0.0237
Schistosoma mansoni	rab6-interacting	0.0013	0.0007	0.0009
Plasmodium falciparum	phd finger protein, putative	0.0019	0.0175	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.004	0.0727	0.2438
Echinococcus granulosus	lysine specific demethylase 5A	0.0025	0.0318	0.1192
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0737	0.1004
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0079	0.1754	0.6569
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0136	0.3292	0.4486
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0059	0.008
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0915	0.3065
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0055	0.113	0.1354
Loa Loa (eye worm)	PHD-finger family protein	0.0019	0.0175	0.0587
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0059	0.008
Brugia malayi	jmjC domain containing protein	0.0025	0.0318	0.1067
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.0318	0.1067
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0086	0.1958	0.5287
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0719	0.2691
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0059	0.0197
Echinococcus multilocularis	zinc finger protein	0.0013	0.0005	0.0018
Schistosoma mansoni	hypothetical protein	0.0013	0.0007	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0339	0.1137
Echinococcus granulosus	lipoxygenase domain containing protein	0.0013	0.0007	0.0028
Echinococcus granulosus	RUN	0.0013	0.0007	0.0028
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0079	0.1754	0.6569
Schistosoma mansoni	transcription factor LCR-F1	0.0034	0.0572	0.0686
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0288	0.7339	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0021	0.0216	0.0993
Schistosoma mansoni	zinc finger protein	0.0013	0.0005	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0415	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0055	0.113	0.3786
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0075	0.1647	0.6167
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0075	0.1647	0.6167
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0288	0.7339	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0737	0.1004
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0059	0.022
Onchocerca volvulus		0.0125	0.2983	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0059	0.0197
Schistosoma mansoni	rotamase	0.0022	0.0251	0.0301
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0022	0.0237	0.0323
Schistosoma mansoni	polycystin 1-related	0.0013	0.0007	0.0009
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0125	0.2983	0.2983
Brugia malayi	Bromodomain containing protein	0.005	0.0991	0.332
Toxoplasma gondii	hypothetical protein	0.0046	0.0896	0.5271
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0125	0.2983	0.2983
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0059	0.008
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0024	0.0296	0.1108
Schistosoma mansoni	lipoxygenase	0.0055	0.1123	0.1346
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0019	0.0175	0.021
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0216	0.0295
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0022	0.0237	0.0323
Schistosoma mansoni	hypothetical protein	0.0019	0.0175	0.021
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0024	0.0296	0.1108
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0013	0.0007	0.0028
Brugia malayi	Doublecortin family protein	0.0013	0.0007	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0546	0.1829
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0737	0.1004
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0251	0.0251
Echinococcus granulosus	zinc finger protein	0.0013	0.0005	0.0018
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0125	0.2983	1
Toxoplasma gondii	MAPEG family protein	0.0075	0.1647	1
Schistosoma mansoni	jumonji domain containing protein	0.0051	0.1006	0.1206
Toxoplasma gondii	PHD-finger domain-containing protein	0.0019	0.0175	0.0734
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0038	0.0682	0.0682
Entamoeba histolytica	hypothetical protein	0.0034	0.0572	0.0572
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0034	0.0572	0.2142
Entamoeba histolytica	hypothetical protein	0.0034	0.0572	0.0572
Brugia malayi	jmjC domain containing protein	0.0064	0.1355	0.4542
Echinococcus multilocularis	lysine specific demethylase 5A	0.0024	0.0284	0.1065
Entamoeba histolytica	hypothetical protein	0.0034	0.0572	0.0572
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0022	0.0237	0.0323
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0055	0.113	0.423
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	0.0326	0.8341	1
Brugia malayi	ImpB/MucB/SamB family protein	0.003	0.0453	0.1519
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0125	0.2983	0.2983
Onchocerca volvulus	Alhambra homolog	0.0019	0.0175	0.0564
Schistosoma mansoni	DNA polymerase eta	0.003	0.0453	0.0543
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0152	0.3703	1
Schistosoma mansoni	hypothetical protein	0.0055	0.113	0.1354
Echinococcus multilocularis	dna polymerase eta	0.003	0.0453	0.1697
Echinococcus multilocularis	jumonji domain containing protein	0.0027	0.0378	0.1417
Echinococcus granulosus	peregrin	0.0021	0.0217	0.0814
Echinococcus multilocularis	peregrin	0.0021	0.0217	0.0814
Loa Loa (eye worm)	apoptosis regulator protein	0.0055	0.113	0.3786
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0007	0.0025
Leishmania major	DNA polymerase eta, putative	0.003	0.0453	0.0617
Echinococcus multilocularis	Polycystic kidney disease protein	0.0013	0.0007	0.0028
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0059	0.008
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0125	0.2983	1
Brugia malayi	hypothetical protein	0.0013	0.0007	0.0025
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0059	0.3051
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0381	0.1278
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0055	0.113	0.3786
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0136	0.3292	0.4486
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0125	0.2983	0.2983
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0049	0.0973	0.1326
Echinococcus granulosus	dna polymerase eta	0.003	0.0453	0.1697
Schistosoma mansoni	hypothetical protein	0.0055	0.113	0.1354
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0025	0.0318	0.0382
Echinococcus granulosus	lipoxygenase domain containing protein	0.0013	0.0007	0.0028
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0059	0.022
Schistosoma mansoni	lipoxygenase	0.0079	0.1754	0.2103
Echinococcus multilocularis	RUN	0.0013	0.0007	0.0028
Brugia malayi	hypothetical protein	0.0034	0.0572	0.1917
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0059	0.0158
Schistosoma mansoni	apoptosis regulator bax	0.0055	0.113	0.1354
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0013	0.0007	0.0028
Leishmania major	hypothetical protein, conserved	0.0038	0.0682	0.093
Brugia malayi	Bromodomain containing protein	0.0021	0.0217	0.0729
Schistosoma mansoni	hypothetical protein	0.0014	0.0024	0.0028
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0022	0.0251	0.0841
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0059	0.022
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0125	0.2983	0.2983
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0064	0.1355	0.5074
Plasmodium vivax	hypothetical protein, conserved	0.0019	0.0175	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.003	0.0453	0.0617
Schistosoma mansoni	hypothetical protein	0.0034	0.0572	0.0686
Brugia malayi	hypothetical protein	0.0013	0.0007	0.0025
Schistosoma mansoni	loxhd1	0.0013	0.0007	0.0009
Echinococcus granulosus	fetal alzheimer antigen falz	0.0015	0.0058	0.0216
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0125	0.2983	0.2983
Toxoplasma gondii	peptidylprolyl isomerase	0.0022	0.0237	0.1122
Echinococcus granulosus	Polycystic kidney disease protein	0.0013	0.0007	0.0028
Schistosoma mansoni	hypothetical protein	0.0113	0.267	0.3201
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0034	0.0572	0.2142
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0038	0.0682	0.093
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0038	0.0682	0.0682
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0055	0.113	0.423
Echinococcus granulosus	geminin	0.0113	0.267	1
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0059	0.3051
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0125	0.2983	0.2983
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0059	0.007
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0719	0.2691
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0007	0.0025
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0059	0.022
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0682	0.093
Brugia malayi	Bromodomain containing protein	0.0026	0.0338	0.1133
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0059	0.022
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0025	0.0318	0.0382
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0125	0.2983	0.2983
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0737	0.1004
Brugia malayi	PHD-finger family protein	0.0019	0.0175	0.0587
Loa Loa (eye worm)	doublecortin family protein	0.0013	0.0007	0.0025
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0015	0.0058	0.0216
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.0237	0.0237
Schistosoma mansoni	hypothetical protein	0.0113	0.267	0.3201
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0682	0.093
Echinococcus granulosus	expressed protein	0.0022	0.0251	0.0939
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0125	0.2983	1
Trichomonas vaginalis	rotamase, putative	0.0022	0.0251	0.0251
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0059	0.008
Mycobacterium ulcerans	hypothetical protein	0.0152	0.3703	1
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0055	0.113	0.423
Schistosoma mansoni	rab6-interacting	0.0013	0.0007	0.0009
Trypanosoma brucei	DNA polymerase eta, putative	0.003	0.0453	0.0617
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0019	0.0175	0.0656
Echinococcus multilocularis	geminin	0.0113	0.267	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0064	0.1355	0.5074
Toxoplasma gondii	PHD-finger domain-containing protein	0.0019	0.0175	0.0734
Entamoeba histolytica	hypothetical protein	0.0034	0.0572	0.0572
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0136	0.3292	0.4486
Leishmania major	DNA polymerase eta, putative	0.0021	0.0216	0.0295
Giardia lamblia	PHD finger protein 15	0.0019	0.0175	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0175	0.0587
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0055	0.113	0.423
Loa Loa (eye worm)	PHD-finger family protein	0.0014	0.0024	0.008
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0388	1	1
Leishmania major	mitochondrial DNA polymerase beta	0.0288	0.7339	1
Schistosoma mansoni	hypothetical protein	0.0055	0.113	0.1354
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0288	0.7339	1
Echinococcus multilocularis	expressed protein	0.0022	0.0251	0.0939
Echinococcus granulosus	PHD finger protein rhinoceros	0.0019	0.0175	0.0656
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0125	0.2983	0.8056
Schistosoma mansoni	microsomal glutathione s-transferase	0.0075	0.1647	0.1974
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0022	0.0237	0.0323
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0059	0.0197
Schistosoma mansoni	bromodomain containing protein	0.0042	0.0782	0.0938
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0059	0.022
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0022	0.0251	0.0841
Brugia malayi	PHD-finger family protein	0.0017	0.01	0.0335

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 716964