TDR Targets

Basic information

Technical information

TDR Targets ID: 716964
Name: 4-chloro-2,5-dimethoxy-N-[2-(trifluoromethyl) phenyl]benzenesulfonamide
MW: 395.781 | Formula: C15H13ClF3NO4S
H donors: 1 H acceptors: 2 LogP: 3.9 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(Cl)c(cc1S(=O)(=O)Nc1ccccc1C(F)(F)F)OC
InChi: 1S/C15H13ClF3NO4S/c1-23-12-8-14(13(24-2)7-10(12)16)25(21,22)20-11-6-4-3-5-9(11)15(17,18)19/h3-8,20H,1-2H3
InChiKey: KETWMFLRCYJQPI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

T5968808
ZINC06700675

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0059	0.3051
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0064	0.1355	0.5074
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0022	0.0237	0.0323
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0059	0.022
Toxoplasma gondii	PHD-finger domain-containing protein	0.0019	0.0175	0.0734
Schistosoma mansoni	jumonji domain containing protein	0.0051	0.1006	0.1206
Leishmania major	DNA polymerase eta, putative	0.003	0.0453	0.0617
Echinococcus granulosus	geminin	0.0113	0.267	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0013	0.0007	0.0028
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0059	0.022
Brugia malayi	hypothetical protein	0.0034	0.0572	0.1917
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0022	0.0237	0.0323
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0251	0.0251
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0136	0.3292	0.4486
Giardia lamblia	PHD finger protein 15	0.0019	0.0175	0.0587
Echinococcus granulosus	peregrin	0.0021	0.0217	0.0814
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0059	0.0197
Schistosoma mansoni	zinc finger protein	0.0013	0.0005	0.0006
Schistosoma mansoni	hypothetical protein	0.0019	0.0175	0.021
Onchocerca volvulus		0.0125	0.2983	1
Schistosoma mansoni	hypothetical protein	0.0013	0.0007	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0339	0.1137
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0055	0.113	0.423
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0022	0.0237	0.0323
Schistosoma mansoni	DNA polymerase eta	0.003	0.0453	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0546	0.1829
Echinococcus granulosus	lipoxygenase domain containing protein	0.0013	0.0007	0.0028
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0125	0.2983	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0381	0.1278
Trypanosoma cruzi	DNA polymerase eta, putative	0.003	0.0453	0.0617
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0737	0.1004
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0079	0.1754	0.6569
Trichomonas vaginalis	rotamase, putative	0.0022	0.0237	0.0237
Schistosoma mansoni	hypothetical protein	0.0113	0.267	0.3201
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0125	0.2983	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0025	0.0318	0.1067
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0025	0.0318	0.0382
Loa Loa (eye worm)	PHD-finger family protein	0.0019	0.0175	0.0587
Entamoeba histolytica	hypothetical protein	0.0034	0.0572	0.0572
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0059	0.008
Schistosoma mansoni	polycystin 1-related	0.0013	0.0007	0.0009
Echinococcus granulosus	Polycystic kidney disease protein	0.0013	0.0007	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0915	0.3065
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0059	0.008
Trichomonas vaginalis	rotamase, putative	0.0022	0.0251	0.0251
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0013	0.0007	0.0028
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0038	0.0682	0.0682
Toxoplasma gondii	PHD-finger domain-containing protein	0.0019	0.0175	0.0734
Brugia malayi	PHD-finger family protein	0.0017	0.01	0.0335
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.0237	0.0237
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0015	0.0058	0.0216
Entamoeba histolytica	hypothetical protein	0.0034	0.0572	0.0572
Echinococcus granulosus	jumonji domain containing protein	0.0027	0.0378	0.1417
Schistosoma mansoni	hypothetical protein	0.0014	0.0024	0.0028
Brugia malayi	hypothetical protein	0.0013	0.0007	0.0025
Brugia malayi	jmjC domain containing protein	0.0064	0.1355	0.4542
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0125	0.2983	0.2983
Plasmodium vivax	hypothetical protein, conserved	0.0019	0.0175	1
Toxoplasma gondii	peptidylprolyl isomerase	0.0022	0.0237	0.1122
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0055	0.113	0.423
Echinococcus granulosus	expressed protein	0.0022	0.0251	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0007	0.0025
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0086	0.1958	0.5287
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0059	0.022
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0049	0.0973	0.1326
Loa Loa (eye worm)	doublecortin family protein	0.0013	0.0007	0.0025
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0034	0.0572	0.2142
Brugia malayi	ImpB/MucB/SamB family protein	0.003	0.0453	0.1519
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0059	0.007
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0075	0.1647	0.6167
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0022	0.0251	0.0841
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0059	0.008
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0055	0.113	0.423
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0038	0.0682	0.093
Brugia malayi	Bromodomain containing protein	0.005	0.0991	0.332
Echinococcus granulosus	lysine specific demethylase 5A	0.0025	0.0318	0.1192
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0125	0.2983	0.2983
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0152	0.3703	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0025	0.0318	0.0382
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0059	0.0158
Schistosoma mansoni	rab6-interacting	0.0013	0.0007	0.0009
Loa Loa (eye worm)	apoptosis regulator protein	0.0055	0.113	0.3786
Echinococcus multilocularis	expressed protein	0.0022	0.0251	0.0939
Schistosoma mansoni	transcription factor LCR-F1	0.0034	0.0572	0.0686
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0015	0.0058	0.0069
Echinococcus granulosus	lipoxygenase domain containing protein	0.0013	0.0007	0.0028
Echinococcus multilocularis	jumonji domain containing protein	0.0027	0.0378	0.1417
Entamoeba histolytica	hypothetical protein	0.0034	0.0572	0.0572
Schistosoma mansoni	apoptosis regulator bax	0.0055	0.113	0.1354
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0059	0.022
Schistosoma mansoni	bromodomain containing protein	0.0042	0.0782	0.0938
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0388	1	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0015	0.0058	0.0216
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0682	0.093
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0064	0.1355	0.5074
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0059	0.3051
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0125	0.2983	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0125	0.2983	0.2983
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0055	0.113	0.423
Loa Loa (eye worm)	jmjC domain-containing protein	0.004	0.0727	0.2438
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0125	0.2983	0.2983
Schistosoma mansoni	hypothetical protein	0.0055	0.113	0.1354
Leishmania major	hypothetical protein, conserved	0.0038	0.0682	0.093
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0059	0.022
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0125	0.2983	0.2983
Schistosoma mansoni	lipoxygenase	0.0055	0.1123	0.1346
Echinococcus multilocularis	RUN	0.0013	0.0007	0.0028
Leishmania major	DNA polymerase eta, putative	0.0021	0.0216	0.0295
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0682	0.093
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0719	0.2691
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0737	0.1004
Toxoplasma gondii	hypothetical protein	0.0046	0.0896	0.5271
Onchocerca volvulus	Alhambra homolog	0.0019	0.0175	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0175	0.0587
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0288	0.7339	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0059	0.008
Echinococcus multilocularis	Polycystic kidney disease protein	0.0013	0.0007	0.0028
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0059	0.022
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0024	0.0296	0.1108
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0216	0.0295
Schistosoma mansoni	microsomal glutathione s-transferase	0.0075	0.1647	0.1974
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0038	0.0682	0.0682
Entamoeba histolytica	hypothetical protein	0.0034	0.0572	0.0572
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0059	0.0197
Brugia malayi	Bromodomain containing protein	0.0021	0.0217	0.0729
Brugia malayi	PHD-finger family protein	0.0019	0.0175	0.0587
Schistosoma mansoni	hypothetical protein	0.0055	0.113	0.1354
Brugia malayi	jmjC domain containing protein	0.0025	0.0318	0.1067
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0034	0.0572	0.2142
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0022	0.0251	0.0841
Brugia malayi	hypothetical protein	0.0013	0.0007	0.0025
Schistosoma mansoni	lipoxygenase	0.0079	0.1754	0.2103
Schistosoma mansoni	rotamase	0.0022	0.0251	0.0301
Echinococcus multilocularis	dna polymerase eta	0.003	0.0453	0.1697
Loa Loa (eye worm)	PHD-finger family protein	0.0014	0.0024	0.008
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0737	0.1004
Echinococcus granulosus	dna polymerase eta	0.003	0.0453	0.1697
Brugia malayi	Doublecortin family protein	0.0013	0.0007	0.0025
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0079	0.1754	0.6569
Toxoplasma gondii	MAPEG family protein	0.0075	0.1647	1
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0125	0.2983	0.8056
Loa Loa (eye worm)	hypothetical protein	0.003	0.0453	0.1519
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0288	0.7339	1
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0055	0.113	0.1354
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0075	0.1647	0.6167
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0288	0.7339	1
Schistosoma mansoni	hypothetical protein	0.0055	0.113	0.1354
Trypanosoma brucei	DNA polymerase eta, putative	0.003	0.0453	0.0617
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0719	0.2691
Echinococcus multilocularis	lysine specific demethylase 5A	0.0024	0.0284	0.1065
Echinococcus multilocularis	peregrin	0.0021	0.0217	0.0814
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0019	0.0175	0.021
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0024	0.0296	0.1108
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0136	0.3292	0.4486
Schistosoma mansoni	loxhd1	0.0013	0.0007	0.0009
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0125	0.2983	0.2983
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	0.0326	0.8341	1
Mycobacterium ulcerans	hypothetical protein	0.0152	0.3703	1
Leishmania major	mitochondrial DNA polymerase beta	0.0288	0.7339	1
Echinococcus multilocularis	zinc finger protein	0.0013	0.0005	0.0018
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0737	0.1004
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0022	0.0237	0.0323
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0059	0.0197
Plasmodium falciparum	phd finger protein, putative	0.0019	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0007	0.0025
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0021	0.0216	0.0993
Echinococcus granulosus	zinc finger protein	0.0013	0.0005	0.0018
Echinococcus granulosus	RUN	0.0013	0.0007	0.0028
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0055	0.113	0.3786
Schistosoma mansoni	hypothetical protein	0.0113	0.267	0.3201
Brugia malayi	Bromodomain containing protein	0.0026	0.0338	0.1133
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0019	0.0175	0.0656
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0136	0.3292	0.4486
Echinococcus multilocularis	geminin	0.0113	0.267	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0125	0.2983	0.2983
Schistosoma mansoni	rab6-interacting	0.0013	0.0007	0.0009
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0125	0.2983	0.2983
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0059	0.008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0415	0.1392
Echinococcus granulosus	PHD finger protein rhinoceros	0.0019	0.0175	0.0656
Schistosoma mansoni	hypothetical protein	0.0034	0.0572	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0055	0.113	0.3786

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 716964