Detailed information for compound 723778

Basic information

Technical information
  • TDR Targets ID: 723778
  • Name: 1-[2-(difluoromethoxy)-5-methylphenyl]-3-(3-n itrophenyl)thiourea
  • MW: 353.344 | Formula: C15H13F2N3O3S
  • H donors: 2 H acceptors: 2 LogP: 4.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(Nc1cc(C)ccc1OC(F)F)Nc1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C15H13F2N3O3S/c1-9-5-6-13(23-14(16)17)12(7-9)19-15(24)18-10-3-2-4-11(8-10)20(21)22/h2-8,14H,1H3,(H2,18,19,24)
  • InChiKey: HRMUEBJQPOLIRJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(difluoromethoxy)-5-methyl-phenyl]-3-(3-nitrophenyl)thiourea
  • IVK/1635720
  • ZINC02858647

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transient receptor potential channel 0.0064 0.1221 0.5333
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0823 0.3624
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0222 0.3811
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.227 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0185 0.3737 0.3724
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0021 0.0218
Schistosoma mansoni hypothetical protein 0.0016 0.021 0.0838
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0419 0.5783
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.1836 0.8088
Trypanosoma brucei sugar transporter, putative 0.0016 0.0222 0.303
Schistosoma mansoni sugar transporter 0.0016 0.0222 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Giardia lamblia Hexose transporter 0.0016 0.0222 0.346
Onchocerca volvulus 0.047 0.9651 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0185 0.3737 0.5643
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.1118 0.4924
Echinococcus granulosus Threonyl tRNA synthetase C 0.0006 0.0021 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.003 0.0368
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.1118 0.4924
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.1118 0.4876
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0222 0.0238
Echinococcus granulosus glycyl tRNA synthetase 0.0006 0.0021 0.0094
Onchocerca volvulus 0.0023 0.0372 0.0356
Brugia malayi Latrophilin receptor protein 2 0.0016 0.021 0.0223
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0372 0.5125
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0823 0.3564
Loa Loa (eye worm) sugar transporter 0.0115 0.227 0.2663
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0626 0.0643
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.003 0.0421
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0021 0.0262
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0617 0.2648
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0222 0.0225
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.1903 0.8368
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0339 0.5864
Leishmania major hypothetical protein, conserved 0.0016 0.0222 0.303
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0222 0.0327
Onchocerca volvulus 0.0016 0.0222 0.02
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.003 0.001
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0419 0.6849
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.003 0.001
Leishmania major protein kinase, putative 0.0035 0.0617 0.855
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0249 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0419 0.0471
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0823 0.3564
Plasmodium falciparum hexose transporter 0.0115 0.227 0.2253
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.003 0.0368
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0021 0.0274
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0617 0.0597
Chlamydia trachomatis proline--tRNA ligase 0.0012 0.014 0.2978
Onchocerca volvulus 0.0016 0.0222 0.02
Brugia malayi AMP-binding enzyme family protein 0.0007 0.003 0.001
Entamoeba histolytica protein kinase, putative 0.0035 0.0617 0.9408
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0823 0.3624
Trypanosoma brucei glucose transporter, putative 0.0036 0.0626 0.868
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.003 0.0368
Toxoplasma gondii propionate-CoA ligase 0.0007 0.003 0.0036
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0222 0.303
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.003 0.0334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0823 0.3624
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0721 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0115 0.227 0.3424
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0617 0.855
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0249 0.5737
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0291 0.3994
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0637 0.2806
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0721 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0617 0.0705
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0372 0.5648
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.003 0.0334
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.003 0.0421
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0602 0.2652
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Toxoplasma gondii protein kinase, putative 0.0324 0.6619 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1118 0.1298
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0222 0.0225
Trypanosoma brucei glucose transporter, putative 0.0036 0.0626 0.868
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0222 0.3811
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.1118 0.4876
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0617 0.0705
Trypanosoma brucei glucose transporter, putative 0.0036 0.0626 0.868
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.021 0.0924
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.227 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0222 0.303
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.023 0.3942
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.227 0.2348
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0222 0.0225
Echinococcus multilocularis solute carrier family 22 0.0016 0.0222 0.0979
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0222 0.0238
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Loa Loa (eye worm) hypothetical protein 0.0033 0.057 0.065
Onchocerca volvulus 0.0016 0.0222 0.02
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.003 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0626 0.0643
Loa Loa (eye worm) hypothetical protein 0.0036 0.0637 0.0729
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0617 0.2717
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.003 0.0368
Loa Loa (eye worm) hypothetical protein 0.0017 0.0249 0.027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0468 0.0529
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.1903 0.8384
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0372 0.5541
Plasmodium vivax sugar transporter, putative 0.0016 0.0222 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Loa Loa (eye worm) inositol-1 0.0037 0.0654 0.075
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.003 0.0334
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0654 0.9074
Schistosoma mansoni sugar transporter 0.0016 0.0222 0.0894
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0823 0.0949
Echinococcus granulosus solute carrier family 22 0.0016 0.0222 0.0979
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.227 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.003 0.0421
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0626 0.0643
Leishmania major glucose transporter, lmgt1 0.0036 0.0626 0.868
Leishmania major glucose transporter, lmgt2 0.0036 0.0626 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0222 0.0225
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.003 0.0368
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0222 0.0894
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.003 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0626 0.0643
Trypanosoma brucei glucose transporter, putative 0.0036 0.0626 0.868
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0654 0.2883
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0823 0.0949
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.1903 0.8384
Loa Loa (eye worm) sugar transporter 0.0016 0.0222 0.0238
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0626 0.868
Brugia malayi hypothetical protein 0.0016 0.0222 0.0238
Onchocerca volvulus 0.0016 0.0222 0.02
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Schistosoma mansoni glucose transporter 0.0016 0.0222 0.0894
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0006 0.001 0.0072
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0626 0.868
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Schistosoma mansoni transient receptor potential channel 0.0097 0.1903 0.8368
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0372 0.5648
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0249 0.0229
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0222 0.0979
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.014 0.2067
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.003 0.0368
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0222 0.303
Onchocerca volvulus 0.0016 0.0222 0.02
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0637 0.0729
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1221 0.5377
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0419 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0419 0.6373
Loa Loa (eye worm) hypothetical protein 0.0049 0.0907 0.1048
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.0721 0.1081
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0419 0.0625
Trypanosoma brucei glucose transporter 2A 0.0036 0.0626 0.868
Loa Loa (eye worm) hypothetical protein 0.0034 0.0602 0.0688
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0602 0.2652
Brugia malayi Sugar transporter family protein 0.0016 0.0222 0.0238
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0021 0.0218
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Schistosoma mansoni protein kinase 0.0035 0.0617 0.2648
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0617 0.0597
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0354 0.0361
Schistosoma mansoni inositol monophosphatase 0.0037 0.0654 0.2815
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0372 0.6447
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0021 0.0024
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0419 0.1846
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.1118 0.4924
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0637 0.2806
Schistosoma mansoni sugar transporter 0.0016 0.0222 0.0894
Plasmodium vivax SET domain protein, putative 0.0059 0.1118 0.1099
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1221 0.5377
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0222 0.0225
Schistosoma mansoni glucose transport protein 0.0115 0.227 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0021 0.0218
Echinococcus multilocularis solute carrier family 22 0.0016 0.0222 0.0979
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.003 0.0421
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.023 0.3942
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0372 0.5125
Onchocerca volvulus 0.0016 0.0222 0.02
Loa Loa (eye worm) hypothetical protein 0.0034 0.0584 0.0667
Onchocerca volvulus 0.0059 0.1118 0.1131
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0249 0.3759
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.003 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Brugia malayi Pre-SET motif family protein 0.0059 0.1118 0.1298
Onchocerca volvulus 0.0016 0.0222 0.02
Onchocerca volvulus 0.0016 0.0222 0.02
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0617 0.0597
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0222 0.0979
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.0572 0.2519
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0222 0.0225
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0617 0.0597
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0626 0.868
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.003 0.0368
Brugia malayi AMP-binding enzyme family protein 0.0007 0.003 0.001
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.003 0.0368
Schistosoma mansoni hypothetical protein 0.0016 0.021 0.0838
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0626 0.0643
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0372 0.5125
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0617 0.0597
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0222 0.303
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.003 0.0368
Schistosoma mansoni sugar transporter 0.0016 0.0222 0.0894
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.003 0.0334
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0617 0.0925
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0626 0.868
Onchocerca volvulus 0.0016 0.0222 0.02
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0007 0.003 0.0401
Leishmania major glucose transporter, lmgt3 0.0036 0.0626 0.868
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0574 0.9528
Trypanosoma brucei glucose transporter 1E 0.0036 0.0626 0.868
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.003 0.0421
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.003 0.0421
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0419 0.5783
Brugia malayi AMP-binding enzyme family protein 0.0007 0.003 0.001
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0617 0.2717
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0617 0.0925
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0339 0.5864
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0419 0.1769
Trypanosoma brucei glucose transporter, putative 0.0036 0.0626 0.868
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.023 0.3942
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.003 0.0008
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0249 0.429
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0602 0.0618
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0654 0.0673
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0115 0.227 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0654 0.9074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Loa Loa (eye worm) hypothetical protein 0.0061 0.1153 0.1341
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0602 0.2583
Onchocerca volvulus 0.0016 0.0222 0.02
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0823 0.3624
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.003 0.0334
Echinococcus granulosus solute carrier family 22 0.0016 0.0222 0.0979
Toxoplasma gondii sugar transporter ST3 0.0016 0.0222 0.0327
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0617 0.2717
Trypanosoma brucei glucose transporter, putative 0.0036 0.0626 0.868
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.003 0.0421
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.003 0.0025
Onchocerca volvulus 0.0016 0.0222 0.02
Mycobacterium ulcerans hypothetical protein 0.0023 0.0372 0.5648
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0419 0.0399
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0419 0.6932
Plasmodium falciparum mitogen-activated protein kinase 2 0.0185 0.3737 0.3724
Brugia malayi Cam kinase protein 1 0.0035 0.0617 0.0705
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.021 0.0924
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0602 0.2583
Plasmodium vivax hexose transporter 0.0115 0.227 0.2253
Entamoeba histolytica hypothetical protein 0.0026 0.0419 0.6284
Echinococcus multilocularis solute carrier family 22 0.0016 0.0222 0.0979
Echinococcus multilocularis General substrate transporter 0.0099 0.1935 0.8524
Brugia malayi Pre-SET motif family protein 0.0413 0.8465 1
Plasmodium falciparum proline--tRNA ligase 0.004 0.0721 0.0701
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.023 0.3942
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0626 0.868
Loa Loa (eye worm) hypothetical protein 0.0016 0.021 0.0223
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Loa Loa (eye worm) hypothetical protein 0.0023 0.0372 0.0415
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.003 0.0334
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0617 0.0705
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.227 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0372 0.6447
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0222 0.3339
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0626 0.0643
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0372 0.5541
Loa Loa (eye worm) hypothetical protein 0.0007 0.003 0.001
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.003 0.013
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0617 0.0597
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0021 0.024
Entamoeba histolytica protein kinase, putative 0.0035 0.0617 0.9408
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0721 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0021 0.0218
Brugia malayi major facilitator superfamily protein 0.0016 0.0222 0.0238
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0584 0.0667
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Brugia malayi hypothetical protein 0.0016 0.0222 0.0238
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0222 0.0979
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0021 0.024
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0222 0.3175
Trichomonas vaginalis set domain proteins, putative 0.047 0.9651 1
Schistosoma mansoni hypothetical protein 0.0016 0.021 0.0838
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0654 0.0981
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.003 0.001
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0617 0.0925
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0419 0.0471
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.003 0.0036
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.003 0.0008
Schistosoma mansoni transient receptor potential channel 0.0064 0.1221 0.5333
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0372 0.6143
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0721 1
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0006 0.0021 0.0094
Mycobacterium ulcerans sugar transporter 0.0016 0.0222 0.3339
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.003 0.013
Echinococcus multilocularis solute carrier family 22 0.0016 0.0222 0.0979
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.021 0.0223
Toxoplasma gondii sugar transporter ST1 0.0016 0.0222 0.0327
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0617 0.2717
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.021 0.0924
Brugia malayi Sugar transporter family protein 0.0115 0.227 0.2663
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0654 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.1118 0.1681
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1221 0.5377
Loa Loa (eye worm) hypothetical protein 0.0023 0.0372 0.0415
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0222 0.0238
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0413 0.8465 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0721 1
Giardia lamblia Sugar-proton symporter 0.0016 0.0222 0.346
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0602 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0617 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0222 0.0238
Loa Loa (eye worm) hypothetical protein 0.0097 0.1903 0.2228
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0222 0.3339
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0654 0.9074
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0222 0.0225
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0617 0.2717
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0372 0.5648
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0602 0.9174
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Loa Loa (eye worm) oxidoreductase 0.0007 0.003 0.001
Onchocerca volvulus Putative transporter 0.0016 0.0222 0.02
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0617 0.2717
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1221 0.5377
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.1836 0.8088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0907 0.1048
Brugia malayi Sugar transporter family protein 0.0016 0.0222 0.0238
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.003 0.0368
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0617 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0626 0.0643
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0021 0.0218
Schistosoma mansoni protein kinase 0.0035 0.0617 0.2648
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0007 0.003 0.0401
Trypanosoma cruzi hexose transporter 0.0036 0.0626 0.868
Brugia malayi major facilitator superfamily protein 0.0016 0.0222 0.0238
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.227 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0222 0.0238
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.003 0.0368
Onchocerca volvulus 0.0016 0.0222 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0372 0.5648
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0021 0.0016
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0181 0.0189
Loa Loa (eye worm) hypothetical protein 0.0023 0.0372 0.0415
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.1072 0.4724
Schistosoma mansoni hypothetical protein 0.0115 0.227 1
Onchocerca volvulus 0.0016 0.0222 0.02
Loa Loa (eye worm) hypothetical protein 0.0017 0.0249 0.027
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.003 0.0334
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0115 0.227 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0249 0.027
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.003 0.0421
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0372 0.5541
Echinococcus granulosus General substrate transporter 0.0099 0.1935 0.8524
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0372 0.6143
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0602 0.0688
Plasmodium vivax CDK-related protein kinase 6, putative 0.0487 1 1
Echinococcus granulosus solute carrier family 22 0.0016 0.0222 0.0979
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.0572 0.2519
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0115 0.227 1
Echinococcus granulosus GPCR family 2 0.0016 0.021 0.0924
Loa Loa (eye worm) hypothetical protein 0.0017 0.0249 0.027
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0602 1
Schistosoma mansoni hypothetical protein 0.0016 0.021 0.0838
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.0721 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.021 0.0924
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0654 0.9074
Brugia malayi hypothetical protein 0.0016 0.0222 0.0238
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0654 0.0673
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0907 0.1048
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.003 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0222 0.0225
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.003 0.0368
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0372 0.0415
Plasmodium falciparum protein kinase 7 0.0324 0.6619 0.6612
Echinococcus multilocularis glycyl tRNA synthetase 0.0006 0.0021 0.0094
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.003 0.0368
Loa Loa (eye worm) hypothetical protein 0.0035 0.0617 0.0705
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0339 0.5587
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.003 0.0421
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0372 0.0415
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Toxoplasma gondii sugar transporter ST2 0.0016 0.0222 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Echinococcus granulosus solute carrier family 22 0.0016 0.0222 0.0979
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0617 0.2717
Schistosoma mansoni protein kinase 0.0035 0.0617 0.2648
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0372 0.0415
Loa Loa (eye worm) hypothetical protein 0.0007 0.003 0.001
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.003 0.0421
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.003 0.0131
Schistosoma mansoni glucose transport protein 0.0115 0.227 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.003 0.0368
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0617 0.0597
Schistosoma mansoni hypothetical protein 0.0034 0.0584 0.2503
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.003 0.0401
Schistosoma mansoni inositol monophosphatase 0.0037 0.0654 0.2815
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0419 0.5783
Onchocerca volvulus 0.0016 0.0222 0.02
Echinococcus multilocularis GPCR, family 2 0.0016 0.021 0.0924
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0372 0.5648
Schistosoma mansoni glucose transport protein 0.0115 0.227 1
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0222 0.3339
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0222 0.0201
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0654 0.2883
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0419 0.0399
Trypanosoma brucei glucose transporter, putative 0.0036 0.0626 0.868
Brugia malayi Inositol-1 0.0037 0.0654 0.075
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0654 0.0673
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0574 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.021 0.0223
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.003 0.0334
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0654 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0372 0.5648
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.003 0.0368
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.003 0.0025
Trypanosoma brucei glucose transporter, putative 0.0036 0.0626 0.868
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0823 0.3564
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.003 0.0334
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0021 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0372 0.5648
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0602 0.0688
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0419 0.1769
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.014 1
Onchocerca volvulus 0.0016 0.0222 0.02
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0654 1
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0626 0.868
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0222 0.0979
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0626 0.868
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0419 0.6373
Loa Loa (eye worm) hypothetical protein 0.0017 0.0249 0.027
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0222 0.303
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.003 0.001
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0617 0.2717
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.003 0.0368
Brugia malayi AMP-binding enzyme family protein 0.0007 0.003 0.001
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Loa Loa (eye worm) hypothetical protein 0.0034 0.0602 0.0688
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.1118 0.4876
Onchocerca volvulus 0.0016 0.0222 0.02
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.1118 0.4876
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0222 0.0225
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0617 0.0634
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0419 0.0429
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0907 0.1048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0222 0.0238
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0419 0.1846

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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