Detailed information for compound 726073

Basic information

Technical information
  • TDR Targets ID: 726073
  • Name: N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-[(4-prop -2-enyl-5-pyridin-2-yl-1,2,4-triazol-3-yl)sul fanyl]acetamide
  • MW: 373.456 | Formula: C15H15N7OS2
  • H donors: 1 H acceptors: 6 LogP: 1.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1c(SCC(=O)Nc2nnc(s2)C)nnc1c1ccccn1
  • InChi: 1S/C15H15N7OS2/c1-3-8-22-13(11-6-4-5-7-16-11)19-21-15(22)24-9-12(23)17-14-20-18-10(2)25-14/h3-7H,1,8-9H2,2H3,(H,17,20,23)
  • InChiKey: DAVOZKGHVSNFFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-allyl-5-(2-pyridyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
  • 2-[[4-allyl-5-(2-pyridyl)-1,2,4-triazol-3-yl]thio]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
  • N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-[(4-prop-2-enyl-5-pyridin-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethanamide
  • IVK/4040050

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutathione reductase 0.0046 0.0042 0.0116
Plasmodium falciparum glutathione reductase 0.0046 0.0042 0.0111
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0026 0.0024
Brugia malayi Inositol-1 0.0039 0.0026 0.0068
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0056 0.0159
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.1327 0.3178 1
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.1327 0.3178 0.3174
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0022 0.0055
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0025 0.0028
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0076 0.0071
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0025 0.0028
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0214 0.0624
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0076 0.0071
Mycobacterium tuberculosis Conserved protein 0.0039 0.0025 0.0028
Brugia malayi Pre-SET motif family protein 0.0214 0.0453 0.1412
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1327 0.3178 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.1327 0.3178 0.3174
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0076 0.0073
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0346 0.0341
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0032 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0032 0.0048
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0022 0.0017
Trypanosoma cruzi GMP reductase 0.1327 0.3178 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0185 0.0534
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0026 0.0083
Giardia lamblia DINP protein human, muc B family 0.0042 0.0032 0.5
Loa Loa (eye worm) inositol-1 0.0039 0.0026 0.0068
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0058 0.0053
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0058 0.0389
Brugia malayi hypothetical protein 0.0051 0.0056 0.0159
Schistosoma mansoni alpha-glucosidase 0.0146 0.0288 0.0283
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0081 0.0177
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0163 0.0499
Loa Loa (eye worm) hypothetical protein 0.0052 0.0058 0.0167
Leishmania major hypothetical protein, conserved 0.0039 0.0025 0.0059
Onchocerca volvulus 0.0098 0.0171 0.1218
Schistosoma mansoni hypothetical protein 0.0033 0.0011 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0163 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0025 0.0059
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1327 0.3178 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0163 0.0161
Brugia malayi mbt repeat family protein 0.0052 0.0058 0.0167
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0025 0.0059
Trichomonas vaginalis set domain proteins, putative 0.0243 0.0525 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0025 0.0028
Echinococcus granulosus dna polymerase kappa 0.0042 0.0032 0.0029
Loa Loa (eye worm) MBCTL1 0.006 0.0076 0.0223
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1327 0.3178 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0026 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.006 0.0076 0.0223
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0163 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0032 0.0099
Trypanosoma brucei glucosidase, putative 0.0038 0.0022 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0032 0.0099
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.1327 0.3178 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0081 0.0076
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0026 0.0083
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0058 0.0053
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0026 0.0068
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0081 0.024
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0741 0.1743 0.5461
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0032 0.0099
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0032 0.0027
Loa Loa (eye worm) TK/ROR protein kinase 0.0031 0.0007 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0163 0.0499
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0032 0.0099
Schistosoma mansoni inositol monophosphatase 0.0039 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0039 0.0025 0.0064
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.0551 0.1722
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0022 0.0049
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0185 0.0534
Brugia malayi GMP reductase 0.0587 0.1365 0.4286
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0032 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0032 0.0099
Toxoplasma gondii ABC1 family protein 0.0039 0.0025 0.0064
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.0346 0.0344
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0185 0.0534
Schistosoma mansoni alpha glucosidase 0.0038 0.0022 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0081 0.0177
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0056 0.0154
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0032 0.0048
Trichomonas vaginalis esterase, putative 0.0039 0.0025 0.0059
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0032 0.0183
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.0346 0.1075
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.0453 0.1412
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0025 0.0059
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0042 0.004
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.1327 0.3178 1
Onchocerca volvulus 0.0039 0.0025 0.0149
Brugia malayi Protein kinase domain containing protein 0.0031 0.0007 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0032 0.002
Brugia malayi beta-lactamase 0.0039 0.0025 0.0064
Onchocerca volvulus 0.0039 0.0025 0.0149
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1327 0.3178 1
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0025 0.0028
Schistosoma mansoni microtubule-associated protein tau 0.4116 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0026 0.0062
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0587 0.1365 0.4286
Loa Loa (eye worm) hypothetical protein 0.0039 0.0025 0.0064
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0026 0.0083
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0025 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0056 0.0154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0163 0.0159
Loa Loa (eye worm) hypothetical protein 0.0103 0.0181 0.0555
Loa Loa (eye worm) hypothetical protein 0.0039 0.0025 0.0064
Loa Loa (eye worm) glutathione reductase 0.0046 0.0042 0.0116
Onchocerca volvulus 0.0103 0.0181 0.1295
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0081 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0025 0.0064
Schistosoma mansoni DNA polymerase eta 0.0042 0.0032 0.0027
Schistosoma mansoni hypothetical protein 0.0031 0.0007 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0042 0.0111
Trypanosoma brucei GMP reductase 0.1327 0.3178 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0587 0.1365 0.4249
Onchocerca volvulus Putative GMP reductase 0.0587 0.1365 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0025 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0032 0.0078
Echinococcus granulosus tissue type plasminogen activator 0.0031 0.0007 0.0005
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0026 0.4547
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0032 0.0084
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0185 0.0534
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0741 0.1743 0.5461
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0081 0.0177
Brugia malayi hypothetical protein 0.0033 0.0011 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0032 0.0078
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0032 0.0099
Mycobacterium tuberculosis Conserved protein 0.0039 0.0025 0.0028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0025 0.0064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0048 0.0136
Brugia malayi beta-lactamase family protein 0.0039 0.0025 0.0064
Toxoplasma gondii thioredoxin reductase 0.0046 0.0042 0.0116
Schistosoma mansoni hypothetical protein 0.0318 0.0708 0.0703
Trypanosoma brucei DNA polymerase eta, putative 0.0042 0.0032 0.0099
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0011 0.0018
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0081 0.0076
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0346 0.0341
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0025 0.0028
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0076 0.0223
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0032 0.0078
Echinococcus multilocularis tissue type plasminogen activator 0.0031 0.0007 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0048 0.0136
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0032 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0032 0.0099
Echinococcus multilocularis microtubule associated protein 2 0.4116 1 1
Echinococcus multilocularis tumor protein p63 0.0701 0.1646 0.1641
Brugia malayi Kringle domain containing protein 0.0031 0.0007 0.0006
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.1327 0.3178 1
Echinococcus granulosus dna polymerase eta 0.0042 0.0032 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0032 0.0183
Mycobacterium tuberculosis Probable reductase 0.0104 0.0185 0.0534
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0032 0.0099
Plasmodium falciparum thioredoxin reductase 0.0046 0.0042 0.0111
Trypanosoma brucei trypanothione reductase 0.0046 0.0042 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0025 0.0059
Echinococcus multilocularis dna polymerase eta 0.0042 0.0032 0.0027
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0025 0.0023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0025 0.002
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.0538 0.1679
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0032 0.0029
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1327 0.3178 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0026 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0032 0.0099
Trypanosoma brucei unspecified product 0.0042 0.0032 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0025 0.002
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0032 0.0027
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0056 0.0159
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.0346 0.1075
Schistosoma mansoni alpha-glucosidase 0.0146 0.0288 0.0283
Brugia malayi beta-lactamase family protein 0.0039 0.0025 0.0064
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0042 0.0081
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.1327 0.3178 1
Leishmania major DNA polymerase kappa, putative 0.0042 0.0032 0.0078
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0026 0.0004
Brugia malayi MH2 domain containing protein 0.0248 0.0538 0.1679
Loa Loa (eye worm) hypothetical protein 0.0051 0.0056 0.0159
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.0538 0.1679
Trypanosoma cruzi GMP reductase 0.1327 0.3178 1
Onchocerca volvulus 0.0052 0.0058 0.0389
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0026 0.0022
Mycobacterium leprae Probable lipase LipE 0.0039 0.0025 0.0028
Loa Loa (eye worm) hypothetical protein 0.0042 0.0032 0.0084
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0025 0.002
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0025 0.0028
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0031 0.0007 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0005 0.0003
Onchocerca volvulus 0.0039 0.0025 0.0149
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0022 0.0055
Plasmodium vivax glutathione reductase, putative 0.0046 0.0042 0.0116
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0587 0.1365 0.4286
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0026 0.0062
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0214 0.0624
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0042 0.0037
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0214 0.0624
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0032 0.0078
Leishmania major hypothetical protein, conserved 0.0051 0.0056 0.0154
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0025 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0032 0.0099
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0025 0.0059
Brugia malayi Thioredoxin reductase 0.0046 0.0042 0.0116
Toxoplasma gondii IMP dehydrogenas 0.1327 0.3178 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0163 0.0161
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0025 0.0028
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.1327 0.3178 1
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0058 0.0053
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0025 0.0028
Echinococcus granulosus tumor protein p63 0.0701 0.1646 0.1644
Onchocerca volvulus 0.0243 0.0525 0.3824
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0056 0.0175
Brugia malayi follicle stimulating hormone receptor 0.0254 0.0551 0.1722
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0032 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0081 0.0079
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0081 0.0205
Onchocerca volvulus 0.0031 0.0007 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0056 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0032 0.0099
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0022 0.0049
Leishmania major DNA polymerase eta, putative 0.0042 0.0032 0.0078
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0056 0.0154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0163 0.0159
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0025 0.0064
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0214 0.0624
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0032 0.0099
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0022 0.002
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.1327 0.3178 0.3176
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0058 0.0053
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0032 0.0078
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.185 0.1845
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0022 0.0049
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0181 0.0176
Loa Loa (eye worm) GMP reductase 0.0587 0.1365 0.4286
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.1327 0.3178 1
Leishmania major guanosine monophosphate reductase 0.1327 0.3178 1
Leishmania major trypanothione reductase 0.0046 0.0042 0.0111
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0026 0.0083
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0025 0.0064
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0048 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0163 0.0159
Loa Loa (eye worm) hypothetical protein 0.0033 0.0011 0.0018
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0206 0.0434 0.0429
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0022 0.0055
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0185 0.0534
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.0539 0.1653
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0058 0.0167
Loa Loa (eye worm) IMP dehydrogenase 1 0.1327 0.3178 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0025 0.008
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0058 0.0056
Brugia malayi mbt repeat family protein 0.0052 0.0058 0.0167
Leishmania major inosine-5-monophosphate dehydrogenase 0.1327 0.3178 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0081 0.0076
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0076 0.0071
Toxoplasma gondii kringle domain-containing protein 0.0031 0.0007 0.0006
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0076 0.0073
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0048 0.0136
Loa Loa (eye worm) hypothetical protein 0.0039 0.0025 0.0064
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0206 0.0434 0.0432
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0058 0.0053
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0185 0.0534
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0032 0.002
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0587 0.1365 0.4266
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0032 0.0084
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0042 0.0116
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0032 0.0078
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0025 0.0064
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0042 0.0116
Loa Loa (eye worm) beta-lactamase 0.0039 0.0025 0.0064

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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