Detailed information for compound 731332

Basic information

Technical information
  • TDR Targets ID: 731332
  • Name: 4-chloro-3-[[2-[[5-(3,5-dimethoxyphenyl)-1,3, 4-oxadiazol-2-yl]thio]-1-oxoethyl]amino]benzo ic acid methyl ester
  • MW: 463.891 | Formula: C20H18ClN3O6S
  • H donors: 1 H acceptors: 4 LogP: 3.58 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)cc(c1)c1nnc(o1)SCC(=O)Nc1cc(ccc1Cl)C(=O)OC
  • InChi: 1S/C20H18ClN3O6S/c1-27-13-6-12(7-14(9-13)28-2)18-23-24-20(30-18)31-10-17(25)22-16-8-11(19(26)29-3)4-5-15(16)21/h4-9H,10H2,1-3H3,(H,22,25)
  • InChiKey: MDKRNEYPTRCPDN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-3-[[2-[[5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]thio]acetyl]amino]benzoic acid methyl ester
  • CBKinase1_024177
  • CBKinase1_011777
  • methyl 4-chloro-3-[[2-[[5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]amino]benzoate
  • methyl 4-chloro-3-[2-[[5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoylamino]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0128 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0688 0.1613
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0128 0.0108
Echinococcus granulosus cpg binding protein 0.0062 0.0737 0.0909
Mycobacterium ulcerans acetylornithine aminotransferase 0.0048 0.0534 0.0929
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2343 0.4922
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0057
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0042 0.0446 0.7934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Plasmodium vivax importin-beta 2, putative 0.0028 0.0249 0.1116
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0099 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0057
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0048 0.0534 0.0452
Trichomonas vaginalis importin beta-1, putative 0.0023 0.017 0.0357
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1425 0.2992
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0198 0.029
Echinococcus multilocularis GPCR, family 2 0.0064 0.0764 0.0945
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0099 0.0231
Loa Loa (eye worm) hypothetical protein 0.0109 0.1425 0.3339
Brugia malayi hypothetical protein 0.0038 0.0396 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0764 0.1879
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.1425 0.1813
Schistosoma mansoni cpg binding protein 0.0062 0.0737 0.0909
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.3659 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0128 0.0895
Loa Loa (eye worm) hypothetical protein 0.0201 0.2775 0.6504
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0048 0.0534 0.0452
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0128 0.0057
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0139 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0109 0.0229
Onchocerca volvulus 0.0058 0.0688 0.231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.117 0.1478
Schistosoma mansoni ferritin 0.0042 0.0446 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Schistosoma mansoni ferritin 0.0042 0.0446 0.0527
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0198 0.1361
Loa Loa (eye worm) hypothetical protein 0.0109 0.1425 0.3339
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2479 0.5205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0191 0.0106
Schistosoma mansoni ran 0.0021 0.0139 0.0123
Schistosoma mansoni ferritin 0.0042 0.0446 0.0527
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0128 0.0895
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0048 0.0534 0.075
Trichomonas vaginalis helicase, putative 0.0013 0.0027 0.0057
Echinococcus granulosus expressed protein 0.0042 0.0446 0.0527
Loa Loa (eye worm) hypothetical protein 0.0064 0.0764 0.1791
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.0057
Entamoeba histolytica hypothetical protein 0.0038 0.0396 1
Trichomonas vaginalis ferritin, putative 0.0042 0.0446 0.0937
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0615 0.3898
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1425 1
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.1844 0.4909
Loa Loa (eye worm) hypothetical protein 0.0024 0.0191 0.0448
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1425 0.1813
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0128 0.0218
Loa Loa (eye worm) RNA binding protein 0.0192 0.2642 0.6191
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0109 0.2631
Echinococcus multilocularis Aminotransferase class III 0.0048 0.0534 0.0642
Mycobacterium tuberculosis Conserved protein 0.0109 0.1425 0.135
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0615 0.3898
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0254
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0615 0.4321
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.017 0.0538
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0128 0.0895
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0191 0.0106
Loa Loa (eye worm) hypothetical protein 0.0109 0.1425 0.3339
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.017 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0128 0.0895
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0128 0.0218
Echinococcus multilocularis ferritin 0.0042 0.0446 0.0527
Brugia malayi hypothetical protein 0.0035 0.0338 0.0684
Echinococcus multilocularis dna polymerase kappa 0.002 0.0128 0.0108
Mycobacterium ulcerans lipase LipD 0.0109 0.1425 0.284
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0109 0.0023
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.1425 0.135
Leishmania major hypothetical protein, conserved 0.0053 0.0615 0.3898
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.1425 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0057
Onchocerca volvulus 0.0109 0.1425 0.573
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0764 0.1879
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0099 0.0692
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0109 0.0084
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.1453 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0128 0.0895
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2343 0.4922
Schistosoma mansoni cpg binding protein 0.0062 0.0737 0.0909
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0128 0.0042
Schistosoma mansoni ran 0.0021 0.0139 0.0123
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0109 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3659 0.7684
Leishmania major importin beta-1 subunit, putative 0.0023 0.017 0.0538
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0139 0.0123
Brugia malayi RNA binding protein 0.0192 0.2642 0.7146
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0109 0.0356
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0191 0.0194
Schistosoma mansoni hypothetical protein 0.0024 0.0184 0.0182
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2343 0.4922
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1425 0.2992
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0191 0.0699
Mycobacterium leprae Probable lipase LipE 0.0109 0.1425 0.2698
Plasmodium falciparum ornithine aminotransferase 0.0048 0.0534 0.8414
Schistosoma mansoni hypothetical protein 0.0534 0.7651 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.0236
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0048 0.0534 0.0929
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1647 0.2106
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0191 0.0194
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.117 0.3018
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0099 0.007
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0139 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Echinococcus multilocularis geminin 0.0534 0.7651 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0615 0.1443
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0042 0.0446 0.0363
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.2343 1
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2642 0.3413
Trypanosoma brucei unspecified product 0.0014 0.0036 0.0254
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0191 0.0194
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.1425 0.3732
Treponema pallidum bacterioferrin (TpF1) 0.0042 0.0446 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.0236
Mycobacterium tuberculosis Conserved protein 0.0109 0.1425 0.135
Echinococcus granulosus Aminotransferase class III 0.0048 0.0534 0.0642
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0128 0.0268
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0048 0.0534 0.1233
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0057
Entamoeba histolytica hypothetical protein 0.0038 0.0396 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0615 1
Plasmodium vivax ornithine aminotransferase, putative 0.0048 0.0534 0.3272
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0128 0.0218
Echinococcus granulosus dna polymerase eta 0.002 0.0128 0.0108
Schistosoma mansoni hypothetical protein 0.0038 0.0396 0.0461
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0099 0.007
Schistosoma mansoni ferritin light chain 0.0042 0.0446 0.0527
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0198 0.1388
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0099 0.007
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0048 0.0534 0.0642
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0139 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.2642 0.6191
Loa Loa (eye worm) hypothetical protein 0.0021 0.0147 0.0344
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0139 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2343 0.4922
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.1425 0.3339
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0128 0.0895
Entamoeba histolytica hypothetical protein 0.0023 0.017 0.2396
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0191 0.0194
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0048 0.0534 0.0929
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0254
Schistosoma mansoni DNA polymerase eta 0.002 0.0128 0.0108
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0184 0.0182
Echinococcus granulosus snurportin 1 0.0303 0.4267 0.555
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0128 0.0093
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0128 0.0108
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0764 0.0945
Schistosoma mansoni apoferritin-2 0.0042 0.0446 0.0527
Schistosoma mansoni cpg binding protein 0.0058 0.0688 0.0845
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0048 0.0534 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0764 0.0945
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0128 0.0268
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0101 0.0015
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0048 0.0534 0.3674
Echinococcus granulosus GPCR family 2 0.0064 0.0764 0.0945
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Mycobacterium tuberculosis Conserved protein 0.0109 0.1425 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Leishmania major GTP-binding protein, putative 0.0021 0.0139 0.0304
Giardia lamblia DINP protein human, muc B family 0.002 0.0128 0.7182
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0139 0.0975
Echinococcus granulosus tar DNA binding protein 0.0192 0.2642 0.3413
Loa Loa (eye worm) hypothetical protein 0.002 0.0128 0.0299
Schistosoma mansoni apoferritin-2 0.0042 0.0446 0.0527
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0128 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1425 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0128 0.0108
Echinococcus granulosus geminin 0.0534 0.7651 1
Onchocerca volvulus 0.0109 0.1425 0.573
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0191 0.3111
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.1425 0.135
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0048 0.0534 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0109 0.0767
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0057
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0128 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2343 0.4922
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0198 0.02
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.0057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0109 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0191 0.0699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0191 0.0194
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0191 0.0699
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.2775 0.752
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.1425 0.284
Trypanosoma brucei unspecified product 0.002 0.0128 0.0895
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0249 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Echinococcus multilocularis ornithine aminotransferase 0.0048 0.0534 0.0642
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0191 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Mycobacterium leprae conserved hypothetical protein 0.0109 0.1425 0.2698
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0109 0.0018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0191 0.0194
Mycobacterium ulcerans bacterioferritin BfrA 0.0042 0.0446 0.0741
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2642 0.3413
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0109 0.008
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0191 0.0272
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0048 0.0534 0.075
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0396 0.0461
Echinococcus granulosus ferritin 0.0042 0.0446 0.0527
Brugia malayi beta-lactamase family protein 0.0109 0.1425 0.3732
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3659 0.7684
Brugia malayi beta-lactamase family protein 0.0109 0.1425 0.3732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0198 0.0415
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0337 0.4762 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0128 0.0895
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.0236
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0191 0.3111
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0337 0.4762 1
Toxoplasma gondii ABC1 family protein 0.0109 0.1425 0.9802
Leishmania major DNA polymerase kappa, putative 0.002 0.0128 0.0218
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0615 0.3888
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.1425 0.135
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.2479 0.5205
Loa Loa (eye worm) hypothetical protein 0.0109 0.1425 0.3339
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0099 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0764 0.0945
Mycobacterium ulcerans bacterioferritin BfrB 0.0042 0.0446 0.0741
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3659 0.7684
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0128 0.0299
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0099 0.007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0764 0.1791
Schistosoma mansoni hypothetical protein 0.0064 0.0764 0.0945
Mycobacterium ulcerans hypothetical protein 0.0024 0.0191 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.117 0.1478
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0099 0.007
Entamoeba histolytica hypothetical protein 0.0025 0.0198 0.3328
Schistosoma mansoni ferritin light chain 0.0042 0.0446 0.0527
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0128 0.0218
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0128 0.0108
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.1425 0.1813
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0099 0.007
Toxoplasma gondii exonuclease III APE 0.0019 0.0109 0.0751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Schistosoma mansoni ferritin 0.0042 0.0446 0.0527
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0098 0.0069
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0042 0.0446 0.0558
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0198 0.0748
Loa Loa (eye worm) hypothetical protein 0.0028 0.0249 0.0582
Schistosoma mansoni hypothetical protein 0.0064 0.0764 0.0945
Trypanosoma brucei unspecified product 0.0014 0.0036 0.0254
Echinococcus multilocularis snurportin 1 0.0303 0.4267 0.555
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.1425 0.135
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0764 0.0945
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.117 0.2742
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0057
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0048 0.0534 0.0452
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.117 0.1478
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0128 0.0895
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0249 0.171
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0128 0.0895
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3659 0.7684
Echinococcus granulosus importin subunit beta 1 0.0028 0.0249 0.0267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.117 0.1478
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.2775 0.752
Loa Loa (eye worm) hypothetical protein 0.0109 0.1425 0.3339
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0057
Loa Loa (eye worm) beta-lactamase 0.0109 0.1425 0.3339
Schistosoma mansoni ap endonuclease 0.0019 0.0109 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0128 0.0895
Brugia malayi TAR-binding protein 0.0192 0.2642 0.7146
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0128 0.0895
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0109 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3659 0.7684
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0147 0.0363
Brugia malayi CXXC zinc finger family protein 0.0058 0.0688 0.1666
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0184 0.0182
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0615 0.4235
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0109 0.0084
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0198 0.02
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.0236
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1425 0.2992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Schistosoma mansoni importin beta-1 0.0028 0.0249 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.117 0.1478
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0048 0.0534 0.075
Entamoeba histolytica Ran family GTPase 0.0021 0.0139 0.1352
Onchocerca volvulus 0.0109 0.1425 0.573
Brugia malayi RNA, U transporter 1 0.0081 0.1014 0.258
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0057
Echinococcus multilocularis cpg binding protein 0.0062 0.0737 0.0909
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.4267 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0396 0.0461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0109 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0615 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0109 0.0229
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0139 0.0304
Mycobacterium tuberculosis Probable aminotransferase 0.0337 0.4762 0.4716
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1425 0.1813
Loa Loa (eye worm) hypothetical protein 0.0109 0.1425 0.3339
Plasmodium vivax hypothetical protein, conserved 0.0109 0.1425 1
Schistosoma mansoni hypothetical protein 0.0534 0.7651 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0099 0.0692
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.1425 0.135
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0099 0.0692
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0036 0.0254
Leishmania major hypothetical protein, conserved 0.0109 0.1425 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.117 0.1478
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0128 0.0042
Echinococcus multilocularis ornithine aminotransferase 0.0048 0.0534 0.0642
Echinococcus granulosus ornithine aminotransferase 0.0048 0.0534 0.0642
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0128 0.0895
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0098 0.0229
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0139 0.0741
Mycobacterium ulcerans hypothetical protein 0.0337 0.4762 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2642 0.3413
Brugia malayi Importin beta-1 subunit 0.0028 0.0249 0.0432
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0048 0.0534 0.0452
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0128 0.0895
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0139 0.0125
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0198 0.02
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0099 0.0012
Schistosoma mansoni hypothetical protein 0.0303 0.4267 0.555
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.1425 0.135
Schistosoma mansoni ap endonuclease 0.0019 0.0109 0.0084
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1425 0.2992
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.2642 0.7146
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.3659 0.8576
Loa Loa (eye worm) hypothetical protein 0.0024 0.0191 0.0448
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0048 0.0534 0.0929
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.1425 0.284
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0099 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0027 0.0057
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0099 0.0692
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0109 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0191 0.3111
Echinococcus granulosus dna polymerase kappa 0.002 0.0128 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2642 0.3413
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0099 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0128 0.0895
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0109 0.0164
Loa Loa (eye worm) hypothetical protein 0.0024 0.0191 0.0448
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0128 0.0971
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0337 0.4762 1
Echinococcus multilocularis tar DNA binding protein 0.0192 0.2642 0.3413
Plasmodium falciparum importin beta, putative 0.0028 0.0249 0.2871
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.117 0.1478
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0042 0.0446 0.0363
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3659 0.7684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0098 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.0057
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0099 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Brugia malayi beta-lactamase 0.0109 0.1425 0.3732
Schistosoma mansoni hypothetical protein 0.0137 0.1844 0.2365
Mycobacterium ulcerans hypothetical protein 0.0109 0.1425 0.284
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.2775 0.6504
Leishmania major DNA polymerase eta, putative 0.002 0.0128 0.0218
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0048 0.0534 0.0929
Echinococcus multilocularis expressed protein 0.0042 0.0446 0.0527
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.1425 0.135
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0191 0.0194
Echinococcus multilocularis dna polymerase eta 0.002 0.0128 0.0108
Mycobacterium ulcerans beta-lactamase 0.0109 0.1425 0.284
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0099 0.0679
Loa Loa (eye worm) hypothetical protein 0.0018 0.0101 0.0236
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.017 0.0357
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2343 0.4922
Loa Loa (eye worm) TAR-binding protein 0.0192 0.2642 0.6191
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0396 0.0461
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0128 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Schistosoma mansoni hypothetical protein 0.0064 0.0764 0.0945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Trichomonas vaginalis ran, putative 0.0021 0.0139 0.0292
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0139 0.0325
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2642 0.3413
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1425 0.2992
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0249 0.1745
Mycobacterium ulcerans L-lysine aminotransferase 0.0048 0.0534 0.0929
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2343 0.4922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Loa Loa (eye worm) hypothetical protein 0.0137 0.1844 0.4323
Schistosoma mansoni hypothetical protein 0.0064 0.0764 0.0945
Entamoeba histolytica hypothetical protein 0.0038 0.0396 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0099 0.0207
Trichomonas vaginalis esterase, putative 0.0109 0.1425 0.2992
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0139 0.0956
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0191 0.0272
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0249 0.1745
Brugia malayi hypothetical protein 0.0053 0.0615 0.1462
Entamoeba histolytica hypothetical protein 0.0038 0.0396 1
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0337 0.4762 0.4716

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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